Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents

This Article Full Text Full Text (PDF) PPT slides of all figures Alert me when this article is cited Citation Map Services Email this article Similar articles in this journal Similar articles in PubMed Alert me to new content in the JEM Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Barchet, W. Articles by Kalinke, U. Search for Related Content PubMed PubMed Citation Articles by Barchet, W. Articles by Kalinke, U. Social Bookmarking                      What's this?

Virus-induced Interferon Production by a Dendritic Cell Subset in the Absence of Feedback Signaling In Vivo

¹ Mouse Biology Programme, EMBL-Monterotondo, I-00016 Monterotondo-Scalo (Roma), Italy
² Basel Institute for Immunology, CH-4005 Basel, Switzerland
³ Department of Pathology, University of Zürich, CH-8091 Zürich, Switzerland
⁴ Schering-Plough, Laboratory for Immunological Research, Dardilly T-69570, France

Address correspondence to Ulrich Kalinke, Dept. of Immunology, Paul-Ehrlich-Institute, Paul-Ehrlich-Str. 51-59, D-3225 Langen, Germany. Phone: 49-6103-77-2002/3; Fax: 49-6103-77-1253; E-mail: kalul{at}pei.de

An effective type I interferon (IFN-/ß) response is critical for the control of many viral infections. Here we show that in vesicular stomatitis virus (VSV)-infected mouse embryonic fibroblasts (MEFs) the production of IFN- is dependent on type I IFN receptor (IFNAR) triggering, whereas in infected mice early IFN- production is IFNAR independent. In VSV-infected mice type I IFN is produced by few cells located in the marginal zone of the spleen. Unlike other dendritic cell (DC) subsets, FACS^®-sorted CD11c^intCD11b^-GR-1⁺ DCs show high IFN- expression, irrespective of whether they were isolated from VSV-infected IFNAR-competent or -deficient mice. Thus, VSV preferentially activates a specialized DC subset presumably located in the marginal zone to produce high-level IFN- largely independent of IFNAR feedback signaling.

Key Words: IFN type I • virus infection • dendritic cell subsets • IFN regulatory factor 7 • type I IFN receptor

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

• Tilton, J. C., Manion, M. M., Luskin, M. R., Johnson, A. J., Patamawenu, A. A., Hallahan, C. W., Cogliano-Shutta, N. A., Mican, J. M., Davey, R. T. Jr., Kottilil, S., Lifson, J. D., Metcalf, J. A., Lempicki, R. A., Connors, M. (2008). Human Immunodeficiency Virus Viremia Induces Plasmacytoid Dendritic Cell Activation In Vivo and Diminished Alpha Interferon Production In Vitro. J. Virol. 82: 3997-4006 [Abstract] [Full Text]  
• Hughes, G. C., Thomas, S., Li, C., Kaja, M.-K., Clark, E. A. (2008). Cutting Edge: Progesterone Regulates IFN-{alpha} Production by Plasmacytoid Dendritic Cells. J. Immunol. 180: 2029-2033 [Abstract] [Full Text]  
• Waibler, Z., Anzaghe, M., Ludwig, H., Akira, S., Weiss, S., Sutter, G., Kalinke, U. (2007). Modified Vaccinia Virus Ankara Induces Toll-Like Receptor-Independent Type I Interferon Responses. J. Virol. 81: 12102-12110 [Abstract] [Full Text]  
• Hokeness-Antonelli, K. L., Crane, M. J., Dragoi, A. M., Chu, W.-M., Salazar-Mather, T. P. (2007). IFN-{alpha}beta-Mediated Inflammatory Responses and Antiviral Defense in Liver Is TLR9-Independent but MyD88-Dependent during Murine Cytomegalovirus Infection. J. Immunol. 179: 6176-6183 [Abstract] [Full Text]  
• Jewell, N. A., Vaghefi, N., Mertz, S. E., Akter, P., Peebles, R. S. Jr., Bakaletz, L. O., Durbin, R. K., Flano, E., Durbin, J. E. (2007). Differential Type I Interferon Induction by Respiratory Syncytial Virus and Influenza A Virus In Vivo. J. Virol. 81: 9790-9800 [Abstract] [Full Text]  
• Terenzi, F., White, C., Pal, S., Williams, B. R. G., Sen, G. C. (2007). Tissue-Specific and Inducer-Specific Differential Induction of ISG56 and ISG54 in Mice. J. Virol. 81: 8656-8665 [Abstract] [Full Text]  
• Bach, P., Kamphuis, E., Odermatt, B., Sutter, G., Buchholz, C. J., Kalinke, U. (2007). Vesicular Stomatitis Virus Glycoprotein Displaying Retrovirus-Like Particles Induce a Type I IFN Receptor-Dependent Switch to Neutralizing IgG Antibodies. J. Immunol. 178: 5839-5847 [Abstract] [Full Text]  
• Schleicher, U., Liese, J., Knippertz, I., Kurzmann, C., Hesse, A., Heit, A., Fischer, J. A.A., Weiss, S., Kalinke, U., Kunz, S., Bogdan, C. (2007). NK cell activation in visceral leishmaniasis requires TLR9, myeloid DCs, and IL-12, but is independent of plasmacytoid DCs. J. Exp. Med. 204: 893-906 [Abstract] [Full Text]  
• Zhou, S., Kurt-Jones, E. A., Fitzgerald, K. A., Wang, J. P., Cerny, A. M., Chan, M., Finberg, R. W. (2007). Role of MyD88 in Route-Dependent Susceptibility to Vesicular Stomatitis Virus Infection. J. Immunol. 178: 5173-5181 [Abstract] [Full Text]  
• Douagi, I., McInerney, G. M., Hidmark, A. S., Miriallis, V., Johansen, K., Svensson, L., Karlsson Hedestam, G. B. (2007). Role of Interferon Regulatory Factor 3 in Type I Interferon Responses in Rotavirus-Infected Dendritic Cells and Fibroblasts. J. Virol. 81: 2758-2768 [Abstract] [Full Text]  
• Lee, H. K., Lund, J. M., Ramanathan, B., Mizushima, N., Iwasaki, A. (2007). Autophagy-Dependent Viral Recognition by Plasmacytoid Dendritic Cells. Science 315: 1398-1401 [Abstract] [Full Text]  
• Koerner, I., Kochs, G., Kalinke, U., Weiss, S., Staeheli, P. (2007). Protective Role of Beta Interferon in Host Defense against Influenza A Virus. J. Virol. 81: 2025-2030 [Abstract] [Full Text]  
• Cervantes-Barragan, L., Zust, R., Weber, F., Spiegel, M., Lang, K. S., Akira, S., Thiel, V., Ludewig, B. (2007). Control of coronavirus infection through plasmacytoid dendritic-cell-derived type I interferon. Blood 109: 1131-1137 [Abstract] [Full Text]  
• Zhu, J., Martinez, J., Huang, X., Yang, Y. (2007). Innate immunity against vaccinia virus is mediated by TLR2 and requires TLR-independent production of IFN-{beta}. Blood 109: 619-625 [Abstract] [Full Text]  
• Thompson, L. J., Kolumam, G. A., Thomas, S., Murali-Krishna, K. (2006). Innate Inflammatory Signals Induced by Various Pathogens Differentially Dictate the IFN-I Dependence of CD8 T Cells for Clonal Expansion and Memory Formation. J. Immunol. 177: 1746-1754 [Abstract] [Full Text]  
• Ciavarra, R. P., Stephens, A., Nagy, S., Sekellick, M., Steel, C. (2006). Evaluation of Immunological Paradigms in a Virus Model: Are Dendritic Cells Critical for Antiviral Immunity and Viral Clearance?. J. Immunol. 177: 492-500 [Abstract] [Full Text]  
• Kotelkin, A., Belyakov, I. M., Yang, L., Berzofsky, J. A., Collins, P. L., Bukreyev, A. (2006). The NS2 Protein of Human Respiratory Syncytial Virus Suppresses the Cytotoxic T-Cell Response as a Consequence of Suppressing the Type I Interferon Response.. J. Virol. 80: 5958-5967 [Abstract] [Full Text]  
• Gerlach, N., Schimmer, S., Weiss, S., Kalinke, U., Dittmer, U. (2006). Effects of type I interferons on friend retrovirus infection.. J. Virol. 80: 3438-3444 [Abstract] [Full Text]  
• Civas, A., Genin, P., Morin, P., Lin, R., Hiscott, J. (2006). Promoter Organization of the Interferon-A Genes Differentially Affects Virus-induced Expression and Responsiveness to TBK1 and IKK{epsilon}. J. Biol. Chem. 281: 4856-4866 [Abstract] [Full Text]  
• Asselin-Paturel, C., Trinchieri, G. (2005). Production of type I interferons: plasmacytoid dendritic cells and beyond. J. Exp. Med. 202: 461-465 [Abstract] [Full Text]  
• Prakash, A., Smith, E., Lee, C.-k., Levy, D. E. (2005). Tissue-specific Positive Feedback Requirements for Production of Type I Interferon following Virus Infection. J. Biol. Chem. 280: 18651-18657 [Abstract] [Full Text]  
• Conzelmann, K.-K. (2005). Transcriptional Activation of Alpha/Beta Interferon Genes: Interference by Nonsegmented Negative-Strand RNA Viruses. J. Virol. 79: 5241-5248 [Full Text]  
• Schlender, J., Hornung, V., Finke, S., Gunthner-Biller, M., Marozin, S., Brzozka, K., Moghim, S., Endres, S., Hartmann, G., Conzelmann, K.-K. (2005). Inhibition of Toll-Like Receptor 7- and 9-Mediated Alpha/Beta Interferon Production in Human Plasmacytoid Dendritic Cells by Respiratory Syncytial Virus and Measles Virus. J. Virol. 79: 5507-5515 [Abstract] [Full Text]  
• Malmgaard, L., Melchjorsen, J., Bowie, A. G., Mogensen, S. C., Paludan, S. R. (2004). Viral Activation of Macrophages through TLR-Dependent and -Independent Pathways. J. Immunol. 173: 6890-6898 [Abstract] [Full Text]  
• Fallarino, F., Asselin-Paturel, C., Vacca, C., Bianchi, R., Gizzi, S., Fioretti, M. C., Trinchieri, G., Grohmann, U., Puccetti, P. (2004). Murine Plasmacytoid Dendritic Cells Initiate the Immunosuppressive Pathway of Tryptophan Catabolism in Response to CD200 Receptor Engagement. J. Immunol. 173: 3748-3754 [Abstract] [Full Text]  
• Schlecht, G., Garcia, S., Escriou, N., Freitas, A. A., Leclerc, C., Dadaglio, G. (2004). Murine plasmacytoid dendritic cells induce effector/memory CD8+ T-cell responses in vivo after viral stimulation. Blood 104: 1808-1815 [Abstract] [Full Text]  
• Nakamichi, K., Inoue, S., Takasaki, T., Morimoto, K., Kurane, I. (2004). Rabies Virus Stimulates Nitric Oxide Production and CXC Chemokine Ligand 10 Expression in Macrophages through Activation of Extracellular Signal-Regulated Kinases 1 and 2. J. Virol. 78: 9376-9388 [Abstract] [Full Text]  
• Dai, J., Megjugorac, N. J., Amrute, S. B., Fitzgerald-Bocarsly, P. (2004). Regulation of IFN Regulatory Factor-7 and IFN-{alpha} Production by Enveloped Virus and Lipopolysaccharide in Human Plasmacytoid Dendritic Cells. J. Immunol. 173: 1535-1548 [Abstract] [Full Text]  
• Tvinnereim, A. R., Hamilton, S. E., Harty, J. T. (2004). Neutrophil Involvement in Cross-Priming CD8+ T Cell Responses to Bacterial Antigens. J. Immunol. 173: 1994-2002 [Abstract] [Full Text]  
• Bjorck, P. (2004). Dendritic Cells Exposed to Herpes Simplex Virus In Vivo Do Not Produce IFN-{alpha} after Rechallenge with Virus In Vitro and Exhibit Decreased T Cell Alloreactivity. J. Immunol. 172: 5396-5404 [Abstract] [Full Text]  
• Lund, J. M., Alexopoulou, L., Sato, A., Karow, M., Adams, N. C., Gale, N. W., Iwasaki, A., Flavell, R. A. (2004). Recognition of single-stranded RNA viruses by Toll-like receptor 7. Proc. Natl. Acad. Sci. USA 101: 5598-5603 [Abstract] [Full Text]  
• Asselin-Paturel, C., Brizard, G., Pin, J.-J., Briere, F., Trinchieri, G. (2003). Mouse Strain Differences in Plasmacytoid Dendritic Cell Frequency and Function Revealed by a Novel Monoclonal Antibody. J. Immunol. 171: 6466-6477 [Abstract] [Full Text]  
• Lund, J., Sato, A., Akira, S., Medzhitov, R., Iwasaki, A. (2003). Toll-like Receptor 9-mediated Recognition of Herpes Simplex Virus-2 by Plasmacytoid Dendritic Cells. J. Exp. Med. 198: 513-520 [Abstract] [Full Text]  
• Aichele, P., Zinke, J., Grode, L., Schwendener, R. A., Kaufmann, S. H. E., Seiler, P. (2003). Macrophages of the Splenic Marginal Zone Are Essential for Trapping of Blood-Borne Particulate Antigen but Dispensable for Induction of Specific T Cell Responses. J. Immunol. 171: 1148-1155 [Abstract] [Full Text]  
• Sun, C.-M., Fiette, L., Tanguy, M., Leclerc, C., Lo-Man, R. (2003). Ontogeny and innate properties of neonatal dendritic cells. Blood 102: 585-591 [Abstract] [Full Text]  
• Kerkmann, M., Rothenfusser, S., Hornung, V., Towarowski, A., Wagner, M., Sarris, A., Giese, T., Endres, S., Hartmann, G. (2003). Activation with CpG-A and CpG-B Oligonucleotides Reveals Two Distinct Regulatory Pathways of Type I IFN Synthesis in Human Plasmacytoid Dendritic Cells. J. Immunol. 170: 4465-4474 [Abstract] [Full Text]  
• Brawand, P., Fitzpatrick, D. R., Greenfield, B. W., Brasel, K., Maliszewski, C. R., De Smedt, T. (2002). Murine Plasmacytoid Pre-Dendritic Cells Generated from Flt3 Ligand-Supplemented Bone Marrow Cultures Are Immature APCs. J. Immunol. 169: 6711-6719 [Abstract] [Full Text]  
• Schiavoni, G., Mattei, F., Sestili, P., Borghi, P., Venditti, M., Morse, H. C. III, Belardelli, F., Gabriele, L. (2002). ICSBP Is Essential for the Development of Mouse Type I Interferon-producing Cells and for the Generation and Activation of CD8{alpha}+ Dendritic Cells. J. Exp. Med. 196: 1415-1425 [Abstract] [Full Text]  
• Takauji, R., Iho, S., Takatsuka, H., Yamamoto, S., Takahashi, T., Kitagawa, H., Iwasaki, H., Iida, R., Yokochi, T., Matsuki, T. (2002). CpG-DNA-induced IFN-{alpha} production involves p38 MAPK-dependent STAT1 phosphorylation in human plasmacytoid dendritic cell precursors. J. Leukoc. Biol. 72: 1011-1019 [Abstract] [Full Text]  
• Levy, D. E. (2002). Whence Interferon? Variety in the Production of Interferon in Response to Viral Infection. J. Exp. Med. 195: F15-F18 [Full Text]  

Home | Help | Feedback | Subscriptions | Archive | Search

TABLE OF CONTENTS