Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents

This Article Full Text Full Text (PDF) PPT slides of all figures Alert me when this article is cited Citation Map Services Email this article Similar articles in this journal Similar articles in PubMed Alert me to new content in the JEM Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Weiss, J.M. Articles by Simon, J.C. Search for Related Content PubMed PubMed Citation Articles by Weiss, J.M. Articles by Simon, J.C. Pubmed/NCBI databases Gene GEO Profiles HomoloGene UniGene Substance via MeSH Social Bookmarking                      What's this?

¹ Department of Dermatology, University of Freiburg, D-79104 Freiburg, Germany
² Institute for Genetic Medicine, Hokkaido University, Sapporo 060-0815, Japan
³ Immuno-Biological Laboratory, Fujioka-shi, Gunma 375-0005, Japan
⁴ Center for Molecular Medicine, Maine Medical Center Research Institute, Portland, ME 04074

Address correspondence to Johannes M. Weiss, Department of Dermatology, University of Freiburg, Hauptstrasse 7, D-79104 Freiburg, Germany. Phone: 49-761-270-6701; Fax: 49-761-270-6829; E-mail: weiss{at}haut.ukl.uni-freiburg.de

Osteopontin (OPN) is a chemotactic protein that attracts immune cells, to inflammatory sites. The sensitization phase of allergic cutaneous contact hypersensitivity (CHS) requires the migration of Langerhans cells/dendritic cells (LCs/DCs) from skin to draining lymph nodes. Characterizing OPN function for LC/DC migration we found upregulated OPN expression in hapten sensitized skin and draining lymph nodes. OPN induces chemotactic LC/DC migration, initiates their emigration from the epidermis, and attracts LCs/DCs to draining lymph nodes by interacting with CD44 and v integrin. Furthermore, OPN-deficient mice have a significantly reduced CHS response that correlates with an impaired ability of OPN-deficient mice to attract LCs/DCs to draining lymph nodes. In conclusion, OPN is an important factor in the initiation of CHS by guiding LCs/DCs from skin into lymphatic organs.

Key Words: dendritic cells • Langerhans cells • integrins • CD44 • osteopontin

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

• Choi, S. T., Kim, J. H., Kang, E.-J., Lee, S.-W., Park, M.-C., Park, Y.-B., Lee, S.-K. (2008). Osteopontin might be involved in bone remodelling rather than in inflammation in ankylosing spondylitis. Rheumatology (Oxford) 0: ken385v1-ken385 [Abstract] [Full Text]  
• Kiefer, F. W., Zeyda, M., Todoric, J., Huber, J., Geyeregger, R., Weichhart, T., Aszmann, O., Ludvik, B., Silberhumer, G. R., Prager, G., Stulnig, T. M. (2008). Osteopontin Expression in Human and Murine Obesity: Extensive Local Up-Regulation in Adipose Tissue but Minimal Systemic Alterations. Endocrinology 149: 1350-1357 [Abstract] [Full Text]  
• Kon, S., Ikesue, M., Kimura, C., Aoki, M., Nakayama, Y., Saito, Y., Kurotaki, D., Diao, H., Matsui, Y., Segawa, T., Maeda, M., Kojima, T., Uede, T. (2008). Syndecan-4 protects against osteopontin-mediated acute hepatic injury by masking functional domains of osteopontin. J. Exp. Med. 205: 25-33 [Abstract] [Full Text]  
• Bennett, C. L., Noordegraaf, M., Martina, C. A. E., Clausen, B. E. (2007). Langerhans Cells Are Required for Efficient Presentation of Topically Applied Hapten to T Cells. J. Immunol. 179: 6830-6835 [Abstract] [Full Text]  
• Zoller, M., Gupta, P., Marhaba, R., Vitacolonna, M., Freyschmidt-Paul, P. (2007). Anti-CD44-mediated blockade of leukocyte migration in skin-associated immune diseases. J. Leukoc. Biol. 82: 57-71 [Abstract] [Full Text]  
• Kitamura, M., Iwabuchi, K., Kitaichi, N., Kon, S., Kitamei, H., Namba, K., Yoshida, K., Denhardt, D. T., Rittling, S. R., Ohno, S., Uede, T., Onoe, K. (2007). Osteopontin Aggravates Experimental Autoimmune Uveoretinitis in Mice. J. Immunol. 178: 6567-6572 [Abstract] [Full Text]  
• White, F. J, Burghardt, R. C, Hu, J., Joyce, M. M, Spencer, T. E, Johnson, G. A (2006). Secreted phosphoprotein 1 (osteopontin) is expressed by stromal macrophages in cyclic and pregnant endometrium of mice, but is induced by estrogen in luminal epithelium during conceptus attachment for implantation.. Reproduction 132: 919-929 [Abstract] [Full Text]  
• Sodek, J., Batista Da Silva, A. P., Zohar, R. (2006). Osteopontin and mucosal protection.. J. Dent. Res. 85: 404-415 [Abstract] [Full Text]  
• Natasha, T., Kuhn, M., Kelly, O., Rittling, S. R. (2006). Override of the Osteoclast Defect in Osteopontin-Deficient Mice by Metastatic Tumor Growth in the Bone. Am. J. Pathol. 168: 551-561 [Abstract] [Full Text]  
• Celetti, A., Testa, D., Staibano, S., Merolla, F., Guarino, V., Castellone, M. D., Iovine, R., Mansueto, G., Somma, P., De Rosa, G., Galli, V., Melillo, R. M., Santoro, M. (2005). Overexpression of the Cytokine Osteopontin Identifies Aggressive Laryngeal Squamous Cell Carcinomas and Enhances Carcinoma Cell Proliferation and Invasiveness. Clin. Cancer Res. 11: 8019-8027 [Abstract] [Full Text]  
• Abel, B., Freigang, S., Bachmann, M. F., Boschert, U., Kopf, M. (2005). Osteopontin Is Not Required for the Development of Th1 Responses and Viral Immunity. J. Immunol. 175: 6006-6013 [Abstract] [Full Text]  
• Sangaletti, S., Gioiosa, L., Guiducci, C., Rotta, G., Rescigno, M., Stoppacciaro, A., Chiodoni, C., Colombo, M. P. (2005). Accelerated dendritic-cell migration and T-cell priming in SPARC-deficient mice. J. Cell Sci. 118: 3685-3694 [Abstract] [Full Text]  
• Renkl, A. C., Wussler, J., Ahrens, T., Thoma, K., Kon, S., Uede, T., Martin, S. F., Simon, J. C., Weiss, J. M. (2005). Osteopontin functionally activates dendritic cells and induces their differentiation toward a Th1-polarizing phenotype. Blood 106: 946-955 [Abstract] [Full Text]  
• Kawamura, K., Iyonaga, K., Ichiyasu, H., Nagano, J., Suga, M., Sasaki, Y. (2005). Differentiation, Maturation, and Survival of Dendritic Cells by Osteopontin Regulation. CVI 12: 206-212 [Abstract] [Full Text]  
• Morimoto, J., Inobe, M., Kimura, C., Kon, S., Diao, H., Aoki, M., Miyazaki, T., Denhardt, D. T., Rittling, S., Uede, T. (2004). Osteopontin affects the persistence of {beta}-glucan-induced hepatic granuloma formation and tissue injury through two distinct mechanisms. Int Immunol 16: 477-488 [Abstract] [Full Text]  
• Tanaka, K., Morimoto, J., Kon, S., Kimura, C., Inobe, M., Diao, H., Hirschfeld, G., Weiss, J. M., Uede, T. (2004). Effect of Osteopontin Alleles on {beta}-Glucan-Induced Granuloma Formation in the Mouse Liver. Am. J. Pathol. 164: 567-575 [Abstract] [Full Text]  
• Guan, H., Zu, G., Xie, Y., Tang, H., Johnson, M., Xu, X., Kevil, C., Xiong, W.-C., Elmets, C., Rao, Y., Wu, J. Y., Xu, H. (2003). Neuronal Repellent Slit2 Inhibits Dendritic Cell Migration and the Development of Immune Responses. J. Immunol. 171: 6519-6526 [Abstract] [Full Text]  
• Johnson, G. A., Burghardt, R. C., Bazer, F. W., Spencer, T. E. (2003). Osteopontin: Roles in Implantation and Placentation. Biol. Reprod. 69: 1458-1471 [Abstract] [Full Text]  
• Yoshino, M., Yamazaki, H., Nakano, H., Kakiuchi, T., Ryoke, K., Kunisada, T., Hayashi, S.-I. (2003). Distinct antigen trafficking from skin in the steady and active states. Int Immunol 15: 773-779 [Abstract] [Full Text]  
• Myers, D. L., Harmon, K. J., Lindner, V., Liaw, L. (2003). Alterations of Arterial Physiology in Osteopontin-Null Mice. Arterioscler. Thromb. Vasc. Bio. 23: 1021-1028 [Abstract] [Full Text]  
• Jansson, M., Panoutsakopoulou, V., Baker, J., Klein, L., Cantor, H. (2002). Cutting Edge: Attenuated Experimental Autoimmune Encephalomyelitis in Eta-1/Osteopontin-Deficient Mice. J. Immunol. 168: 2096-2099 [Abstract] [Full Text]  
• Foxman, E. F., Zhang, M., Hurst, S. D., Muchamuel, T., Shen, D., Wawrousek, E. F., Chan, C.-C., Gery, I. (2002). Inflammatory Mediators in Uveitis: Differential Induction of Cytokines and Chemokines in Th1- Versus Th2-Mediated Ocular Inflammation. J. Immunol. 168: 2483-2492 [Abstract] [Full Text]  

Home | Help | Feedback | Subscriptions | Archive | Search

TABLE OF CONTENTS