The Journal of Experimental Medicine
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Published online 13 August 2001. doi:10.1084/jem.194.4.417
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© The Rockefeller University Press, 0022-1007/2001/8/417/ $5.00
The Journal of Experimental Medicine, Volume 194, Number 4, August 20, 2001 417-426

Original Article

Identification of the Transferrin Receptor as a Novel Immunoglobulin (Ig)A1 Receptor and Its Enhanced Expression on Mesangial Cells in IgA Nephropathy

Ivan C. Mouraa, Miguel N. Centellesa, Michelle Arcos-Fajardoa, Denise M. Malheirosb, James F. Collawnc, Max D. Cooperd, and Renato C. Monteiroa
a Institut National de la Santé et de la Recherche Médicale (INSERM) U25, Necker Hospital, Paris 75743 Cédex 15, France
b Division of Nephrology, University of São Paulo Medical School, São Paulo 01246, Brazil
c Department of Cell Biology, University of Alabama at Birmingham, Birmingham, AL 35294
d The Howard Hughes Medical Institute, University of Alabama at Birmingham, Birmingham, AL 35294

Correspondence to: Renato C. Monteiro, INSERM U25, Hôpital Necker, 161, rue de Sèvres, 75743 Paris Cédex 15, France. Tel:33-1-44 49-53-66 Fax:33-1-43-06-23-88 E-mail:monteiro{at}necker.fr.

The biological functions of immunoglobulin (Ig)A antibodies depend primarily on their interaction with cell surface receptors. Four IgA receptors are presently characterized. The Fc{alpha}RI (CD89) expressed by myeloid cells selectively binds IgA1 and IgA2 antibodies, whereas the poly-IgR, Fc{alpha}/µR, and asialoglycoprotein receptors bind other ligands in addition to IgA. IgA binding by mesangial cells, epithelial cells, and proliferating lymphocytes is also well documented, but the nature of the IgA receptors on these cells remains elusive. A monoclonal antibody (A24) is described here that specifically blocks IgA binding to epithelial and B lymphocyte cell lines. Both the A24 antibody and IgA1 myelomas bind a cell surface protein that is identified as the transferrin receptor (CD71). The transferrin receptor selectively binds IgA1 antibodies, monomeric better than polymeric forms, and the IgA1 binding is inhibitable by transferrin. Transferrin receptor expression is upregulated on cultured mesangial cells as well as on glomerular mesangial cells in patients with IgA nephropathy. The characterization of transferrin receptor as a novel IgA1 receptor on renal mesangial cells suggests its potential involvement in the pathogenesis of IgA nephropathy.

Key Words: transferrin receptor, IgA, Fc receptor, mesangial cells, IgA nephropathy


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