The Journal of Experimental Medicine
BioSymposia
  Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents
Published online 27 December 2000.
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Citation Map
Services
Right arrow Email this article
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new content in the JEM
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Dombrowicz, D.
Right arrow Articles by Capron, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Dombrowicz, D.
Right arrow Articles by Capron, M.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
© The Rockefeller University Press, 0022-1007/2001/1/25/ $5.00
The Journal of Experimental Medicine, Volume 193, Number 1, January 1, 2001 25-34

Original Article

Role of the High Affinity Immunoglobulin E Receptor in Bacterial Translocation and Intestinal Inflammation

David Dombrowicza, Sophie Nuttenc, Pierre Desreumauxc, Christel Neutd, Gérard Torpierb, Marc Peeterse, Jean-Frédéric Colombelc, and Monique Caprona
a Institut National de la Sante et de la Recherche Medicale U167, Institut Pasteur de Lille, 59019 Lille, France
b Institut National de la Sante et de la Recherche Medicale U325, Institut Pasteur de Lille, 59019 Lille, France
c Laboratoire de Recherche sur les Maladies Inflammatoires Intestinales et Département d'Hépatogastroenterologie, Centre Hospitalier Régional Universitaire de Lille, 59045 Lille, France
d Faculty of Pharmacy, University of Lille II, 59045 Lille, France
e Department of Gastroenterology, University Hospital Gasthuisberg, B-3000 Leuven, Belgium

Correspondence to: Monique Capron, INSERM U167, Institut Pasteur de Lille, 1 rue Professeur Calmette, BP245, 59019 Lille Cedex, France. Tel:33-320-87-79-62 Fax:33-320-87-78-88 E-mail:monique.capron{at}pasteur-lille.fr.

A role for immunoglobulin E and its high affinity receptor (Fc{epsilon}RI) in the control of bacterial pathogenicity and intestinal inflammation has been suggested, but relevant animal models are lacking. Here we compare transgenic mice expressing a humanized Fc{epsilon}RI (hFc{epsilon}RI), with a cell distribution similar to that in humans, to Fc{epsilon}RI-deficient animals. In hFc{epsilon}RI transgenic mice, levels of colonic interleukin 4 were higher, the composition of fecal flora was greatly modified, and bacterial translocation towards mesenteric lymph nodes was increased. In hFc{epsilon}RI transgenic mice, 2,4,6-tri-nitrobenzenesulfonic acid (TNBS)-induced colitis was also more pronounced, whereas Fc{epsilon}RI-deficient animals were protected from colitis, demonstrating that Fc{epsilon}RI can affect the onset of intestinal inflammation.

Key Words: immunoglobulin E receptor, bacterial translocation, intestinal permeability, inflammatory bowel disease, colitis


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?




  Home | Help | Feedback | Subscriptions | Archive | Search
TABLE OF CONTENTS