Influenza Virus Lung Infection Protects from Respiratory Syncytial Virus-induced Immunopathology

doi:10.1084/jem.192.9.1317

Published online 6 November 2000.

This Article

	Full Text
	Full Text (PDF)
	Alert me when this article is cited
	Citation Map

Services

	Email this article
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new content in the JEM
	Download to citation manager

Citing Articles

	Citing Articles via HighWire
	Citing Articles via CrossRef
	Citing Articles via Google Scholar

Google Scholar

	Articles by Walzl, G.
	Articles by Hussell, T.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Walzl, G.
	Articles by Hussell, T.


Social Bookmarking

	What's this?

© The Rockefeller University Press, 0022-1007/2000/11/1317/ $5.00
The Journal of Experimental Medicine, Volume 192, Number 9, November 6, 2000 1317-1326

Original Article

Influenza Virus Lung Infection Protects from Respiratory Syncytial Virus–induced Immunopathology

Gerhard Walzl^b, Sabrina Tafuro^d, Paul Moss^c, Peter J.M. Openshaw^b, and Tracy Hussell^a
^a Department of Biochemistry, Centre for Molecular Microbiology and Infection, Imperial College of Science, Technology and Medicine, London SW7 2AZ, United Kingdom
^b Department of Respiratory Medicine, National Heart and Lung Institute at St Mary's Hospital, Edgbaston, Birmingham B15 2TS, United Kingdom
^c Cancer Research Campaign Institute for Cancer Studies, University of Birmingham, Edgbaston, Birmingham B15 2TS, United Kingdom
^d Molecular Immunology Group, Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, United Kingdom

Correspondence to: Tracy Hussell, Department of Biochemistry, Wellcome Centre for Molecular Microbiology and Infection, Imperial College of Science, Technology and Medicine, London SW7 2AZ, UK. Tel:44-20-7-594-3853 Fax:44-20-7-262-8913

The effect of infection history is ignored in most animal modelsof infectious disease. The attachment protein of respiratorysyncytial virus (RSV) induces T helper cell type 2–drivenpulmonary eosinophilia in mice similar to that seen in the failedinfant vaccinations in the 1960s. We show that previous influenzavirus infection of mice: (a) protects against weight loss, illness,and lung eosinophilia; (b) attenuates recruitment of inflammatorycells; and (c) reduces cytokine secretion caused by RSV attachmentprotein without affecting RSV clearance. This protective effectcan be transferred via influenza-immune splenocytes to naivemice and is long lived. Previous immunity to lung infectionclearly plays an important and underestimated role in subsequentvaccination and infection. The data have important implicationsfor the timing of vaccinations in certain patient groups, andmay contribute to variability in disease susceptibility observedin humans.

Key Words: viral immunology, murine model, eosinophils, major histocompatibilitycomplex tetramers, mucosal immunology

Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Add to Reddit Reddit Add to Technorati Technorati What's this?

This article has been cited by other articles:

Castilow, E. M., Olson, M. R., Meyerholz, D. K., Varga, S. M. (2008). Differential Role of Gamma Interferon in Inhibiting Pulmonary Eosinophilia and Exacerbating Systemic Disease in Fusion Protein-Immunized Mice Undergoing Challenge Infection with Respiratory Syncytial Virus. J. Virol. 82: 2196-2207 [Abstract] [Full Text]
Didierlaurent, A., Goulding, J., Patel, S., Snelgrove, R., Low, L., Bebien, M., Lawrence, T., van Rijt, L. S., Lambrecht, B. N., Sirard, J.-C., Hussell, T. (2008). Sustained desensitization to bacterial Toll-like receptor ligands after resolutionof respiratory influenza infection. J. Exp. Med. 205: 323-329 [Abstract] [Full Text]
Rennard, S. I., Higenbottam, T. (2007). Exacerbation-Free COPD: A Goal Too Far?. Proc Am Thorac Soc 4: 583-585 [Abstract] [Full Text]
Goulding, J., Snelgrove, R., Saldana, J., Didierlaurent, A., Cavanagh, M., Gwyer, E., Wales, J., Wissinger, E. L., Hussell, T. (2007). Respiratory Infections: Do We Ever Recover?. Proc Am Thorac Soc 4: 618-625 [Abstract] [Full Text]
Tritto, E., Muzzi, A., Pesce, I., Monaci, E., Nuti, S., Galli, G., Wack, A., Rappuoli, R., Hussell, T., De Gregorio, E. (2007). The Acquired Immune Response to the Mucosal Adjuvant LTK63 Imprints the Mouse Lung with a Protective Signature. J. Immunol. 179: 5346-5357 [Abstract] [Full Text]
Curtis, J. L., Freeman, C. M., Hogg, J. C. (2007). The Immunopathogenesis of Chronic Obstructive Pulmonary Disease: Insights from Recent Research. Proc Am Thorac Soc 4: 512-521 [Abstract] [Full Text]
Furze, R. C., Hussell, T., Selkirk, M. E. (2006). Amelioration of Influenza-Induced Pathology in Mice by Coinfection with Trichinella spiralis. Infect. Immun. 74: 1924-1932 [Abstract] [Full Text]
Rehermann, B., Shin, E.-C. (2005). Private aspects of heterologous immunity. J. Exp. Med. 201: 667-670 [Abstract] [Full Text]
Williams, A. E., Edwards, L., Humphreys, I. R., Snelgrove, R., Rae, A., Rappuoli, R., Hussell, T. (2004). Innate Imprinting by the Modified Heat-Labile Toxin of Escherichia coli (LTK63) Provides Generic Protection against Lung Infectious Disease. J. Immunol. 173: 7435-7443 [Abstract] [Full Text]
Chang, J., Choi, S. Y., Jin, H. T., Sung, Y. C., Braciale, T. J. (2004). Improved Effector Activity and Memory CD8 T Cell Development by IL-2 Expression during Experimental Respiratory Syncytial Virus Infection. J. Immunol. 172: 503-508 [Abstract] [Full Text]
Goonetilleke, N. P., McShane, H., Hannan, C. M., Anderson, R. J., Brookes, R. H., Hill, A. V. S. (2003). Enhanced Immunogenicity and Protective Efficacy Against Mycobacterium tuberculosis of Bacille Calmette-Guerin Vaccine Using Mucosal Administration and Boosting with a Recombinant Modified Vaccinia Virus Ankara. J. Immunol. 171: 1602-1609 [Abstract] [Full Text]
Walzl, G., Humphreys, I. R., Marshall, B. G., Edwards, L., Openshaw, P. J. M., Shaw, R. J., Hussell, T. (2003). Prior Exposure to Live Mycobacterium bovis BCG Decreases Cryptococcus neoformans-Induced Lung Eosinophilia in a Gamma Interferon-Dependent Manner. Infect. Immun. 71: 3384-3391 [Abstract] [Full Text]
Wohlleben, G., Muller, J., Tatsch, U., Hambrecht, C., Herz, U., Renz, H., Schmitt, E., Moll, H., Erb, K. J. (2003). Influenza A Virus Infection Inhibits the Efficient Recruitment of Th2 Cells into the Airways and the Development of Airway Eosinophilia. J. Immunol. 170: 4601-4611 [Abstract] [Full Text]
Chu, H. W., Honour, J. M., Rawlinson, C. A., Harbeck, R. J., Martin, R. J. (2003). Effects of Respiratory Mycoplasma pneumoniae Infection on Allergen-Induced Bronchial Hyperresponsiveness and Lung Inflammation in Mice. Infect. Immun. 71: 1520-1526 [Abstract] [Full Text]
Wedemeyer, H., Mizukoshi, E., Davis, A. R., Bennink, J. R., Rehermann, B. (2001). Cross-Reactivity between Hepatitis C Virus and Influenza A Virus Determinant-Specific Cytotoxic T Cells. J. Virol. 75: 11392-11400 [Abstract] [Full Text]