Molecular Cloning and Biological Characterization of a Novel Murine Lymphoid Growth Factor

doi:10.1084/jem.192.5.671

Published online 28 August 2000.

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© The Rockefeller University Press, 0022-1007/2000/9/671/ $5.00
The Journal of Experimental Medicine, Volume 192, Number 5, September 5, 2000 671-680

Original Article

Molecular Cloning and Biological Characterization of a Novel Murine Lymphoid Growth Factor

John E. Sims^a, Douglas E. Williams^a, Philip J. Morrissey^a, Kirsten Garka^a, Diane Foxworthe^a, Virginia Price^a, Sherree L. Friend^b, Andrew Farr^b, Mary A. Bedell^c, Nancy A. Jenkins^c, Neal G. Copeland^c, Kenneth Grabstein^a, and Raymond J. Paxton^a
^a Department of Molecular Biology, Department of Biological Sciences, and the Department of Protein Chemistry, Immunex Corporation, Seattle, Washington 98101
^b Department of Biological Structure, University of Washington, Seattle, Washington 98195
^c Mammalian Genetics Program, National Cancer Institute–Frederick Cancer Research and Development Center, Frederick, Maryland 21702

Correspondence to: John E. Sims, Immunex Corporation, 51 University St., Seattle, WA 98101. Tel:206-587-0430 Fax:206-233-9733 E-mail:sims{at}immunex.com.

Using a bioassay consisting of the proliferation of a murineB cell line, a cDNA of a gene whose product supports the growthof that cell line was isolated from a thymic stromal cell line.This factor, termed thymic stromal lymphopoietin (TSLP), isa protein of 140 amino acids. The gene encoding TSLP was mappedto murine chromosome 18. Purified recombinant TSLP supportedthe growth of pre-B cell colonies in vitro, but had no myelopoieticactivity. TSLP had comitogenic activity for fetal thymocytes,but was not as potent as interleukin 7 in lobe submersion cultures.Injection of TSLP into neonatal mice induced the expansion ofB220⁺BP-1⁺ pre-B cells.

Key Words: cytokine, B lymphocyte, growth factor, lymphocyte differentiation,DNA sequence

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