Follicular B Helper T Cells Express CXC Chemokine Receptor 5, Localize to B Cell Follicles, and Support Immunoglobulin Production

doi:10.1084/jem.192.11.1545

Published online 27 November 2000.

This Article

Full Text

Full Text (PDF)

Alert me when this article is cited

Citation Map

Services

Email this article

Similar articles in this journal

Similar articles in PubMed

Alert me to new content in the JEM

Download to citation manager

Citing Articles

Citing Articles via HighWire

Citing Articles via CrossRef

Citing Articles via Google Scholar

Google Scholar

Articles by Breitfeld, D.

Articles by Förster, R.

Search for Related Content

PubMed

PubMed Citation

Articles by Breitfeld, D.

Articles by Förster, R.

Pubmed/NCBI databases

Gene	GEO Profiles
HomoloGene	UniGene
Substance via MeSH

Social Bookmarking

What's this?

© The Rockefeller University Press, 0022-1007/2000/12/1545/ $5.00
The Journal of Experimental Medicine, Volume 192, Number 11, December 4, 2000 1545-1552

Original Article

Follicular B Helper T Cells Express CXC Chemokine Receptor 5, Localize to B Cell Follicles, and Support Immunoglobulin Production

Dagmar Breitfeld^a, Lars Ohl^a, Elisabeth Kremmer^b, Joachim Ellwart^b, Federica Sallusto^c, Martin Lipp^a, and Reinhold Förster^a
^a Molecular Tumor and Immunogenetics, Max-Delbrück Center for Molecular Medicine, 13092 Berlin, Germany
^b Institute of Molecular Immunology, GSF National Research Center for Environment and Health, 81377 München, Germany
^c Institute of Research in Biomedicine, 6500 Belinzona, Switzerland

Correspondence to: Reinhold Förster, Max-Delbrück Center for Molecular Medicine, Robert-Rössle Str. 10, D-13092 Berlin, Germany. Tel:49-30-9406-3330 Fax:49-30-9406-3884 E-mail:rfoerst{at}mdc-berlin.de.

Chemokines and their receptors have been identified as majorregulators controlling the functional organization of secondarylymphoid organs. Here we show that expression of CXC chemokinereceptor 5 (CXCR5), a chemokine receptor required for B cellhoming to B cell follicles, defines a novel subpopulation ofB helper T cells localizing to follicles. In peripheral bloodthese cells coexpress CD45RO and the T cell homing CC chemokinereceptor 7 (CCR7). In secondary lymphoid organs, CD4⁺CXCR5⁺cells lose expression of CCR7, which allows them to localizeto B cell follicles and germinal centers where they expresshigh levels of CD40 ligand (CD40L), a costimulatory moleculerequired for B cell activation and inducible costimulator (ICOS),a recently identified costimulatory molecule of the CD28 family.Thus, when compared with CD4⁺CD45RO⁺CXCR5^- cells, CD4⁺CD45RO⁺CXCR5⁺tonsillar T cells efficiently support the production of immunoglobulin(Ig)A and IgG. In contrast, analysis of the memory responserevealed that long-lasting memory cells are found within theCD4⁺CD45RO⁺CXCR5^- population, suggesting that CXCR5⁺CD4 cellsrepresent recently activated effector cells. Based on the characteristiclocalization within secondary lymphoid organs, we suggest toterm these cells "follicular B helper T cells" (T_FH).

Key Words: CXC chemokine receptor 5, CC chemokine receptor 7, T cell homing,germinal centers, T helper cells

Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Add to Reddit Reddit Add to Technorati Technorati What's this?

This article has been cited by other articles:

Britschgi, M. R., Link, A., Lissandrin, T. K. A., Luther, S. A. (2008). Dynamic Modulation of CCR7 Expression and Function on Naive T Lymphocytes In Vivo. J. Immunol. 181: 7681-7688 [Abstract] [Full Text]
Kamperschroer, C., Roberts, D. M., Zhang, Y., Weng, N.-p., Swain, S. L. (2008). SAP Enables T Cells to Help B Cells by a Mechanism Distinct from Th Cell Programming or CD40 Ligand Regulation. J. Immunol. 181: 3994-4003 [Abstract] [Full Text]
Nagashima, O., Harada, N., Usui, Y., Yamazaki, T., Yagita, H., Okumura, K., Takahashi, K., Akiba, H. (2008). B7-H3 Contributes to the Development of Pathogenic Th2 Cells in a Murine Model of Asthma. J. Immunol. 181: 4062-4071 [Abstract] [Full Text]
Avery, D. T., Bryant, V. L., Ma, C. S., de Waal Malefyt, R., Tangye, S. G. (2008). IL-21-Induced Isotype Switching to IgG and IgA by Human Naive B Cells Is Differentially Regulated by IL-4. J. Immunol. 181: 1767-1779 [Abstract] [Full Text]
Tesciuba, A. G., Shilling, R. A., Agarwal, M. D., Bandukwala, H. S., Clay, B. S., Moore, T. V., Weinstock, J. V., Welcher, A. A., Sperling, A. I. (2008). ICOS Costimulation Expands Th2 Immunity by Augmenting Migration of Lymphocytes to Draining Lymph Nodes. J. Immunol. 181: 1019-1024 [Abstract] [Full Text]
Watanabe, T., Suzuki, J., Mitsuo, A., Nakano, S., Tamayama, Y., Katagiri, A., Amano, H., Morimoto, S., Tokano, Y., Takasaki, Y. (2008). Striking alteration of some populations of T/B cells in systemic lupus erythematosus: relationship to expression of CD62L or some chemokine receptors. Lupus 17: 26-33 [Abstract]
Bryant, V. L., Ma, C. S., Avery, D. T., Li, Y., Good, K. L., Corcoran, L. M., de Waal Malefyt, R., Tangye, S. G. (2007). Cytokine-Mediated Regulation of Human B Cell Differentiation into Ig-Secreting Cells: Predominant Role of IL-21 Produced by CXCR5+ T Follicular Helper Cells. J. Immunol. 179: 8180-8190 [Abstract] [Full Text]
Lim, H. W., Kim, C. H. (2007). Loss of IL-7 Receptor {alpha} on CD4+ T Cells Defines Terminally Differentiated B Cell-Helping Effector T Cells in a B Cell-Rich Lymphoid Tissue. J. Immunol. 179: 7448-7456 [Abstract] [Full Text]
Haynes, N. M., Allen, C. D. C., Lesley, R., Ansel, K. M., Killeen, N., Cyster, J. G. (2007). Role of CXCR5 and CCR7 in Follicular Th Cell Positioning and Appearance of a Programmed Cell Death Gene-1High Germinal Center-Associated Subpopulation. J. Immunol. 179: 5099-5108 [Abstract] [Full Text]
Koguchi, Y., Thauland, T. J., Slifka, M. K., Parker, D. C. (2007). Preformed CD40 ligand exists in secretory lysosomes in effector and memory CD4+ T cells and is quickly expressed on the cell surface in an antigen-specific manner. Blood 110: 2520-2527 [Abstract] [Full Text]
Roncador, G., Verdes-Montenegro, J.-F. G., Tedoldi, S., Paterson, J. C., Klapper, W., Ballabio, E., Maestre, L., Pileri, S., Hansmann, M.-L., Piris, M. A., Mason, D. Y., Marafioti, T. (2007). Expression of two markers of germinal center T cells (SAP and PD-1) in angioimmunoblastic T-cell lymphoma. haematol 92: 1059-1066 [Abstract] [Full Text]
Peron, S., Pan-Hammarstrom, Q., Imai, K., Du, L., Taubenheim, N., Sanal, O., Marodi, L., Bergelin-Besancon, A., Benkerrou, M., de Villartay, J.-P., Fischer, A., Revy, P., Durandy, A. (2007). A primary immunodeficiency characterized by defective immunoglobulin class switch recombination and impaired DNA repair. JEM 204: 1207-1216 [Abstract] [Full Text]
Marinova, E., Han, S., Zheng, B. (2007). Germinal Center Helper T Cells Are Dual Functional Regulatory Cells with Suppressive Activity to Conventional CD4+ T Cells. J. Immunol. 178: 5010-5017 [Abstract] [Full Text]
Hsu, H.-C., Wu, Y., Yang, P., Wu, Q., Job, G., Chen, J., Wang, J., Accavitti-Loper, M. A. V., Grizzle, W. E., Carter, R. H., Mountz, J. D. (2007). Overexpression of Activation-Induced Cytidine Deaminase in B Cells Is Associated with Production of Highly Pathogenic Autoantibodies. J. Immunol. 178: 5357-5365 [Abstract] [Full Text]
Heller, F., Lindenmeyer, M. T., Cohen, C. D., Brandt, U., Draganovici, D., Fischereder, M., Kretzler, M., Anders, H.-J., Sitter, T., Mosberger, I., Kerjaschki, D., Regele, H., Schlondorff, D., Segerer, S. (2007). The Contribution of B Cells to Renal Interstitial Inflammation. Am. J. Pathol. 170: 457-468 [Abstract] [Full Text]
McCausland, M. M., Yusuf, I., Tran, H., Ono, N., Yanagi, Y., Crotty, S. (2007). SAP Regulation of Follicular Helper CD4 T Cell Development and Humoral Immunity Is Independent of SLAM and Fyn Kinase. J. Immunol. 178: 817-828 [Abstract] [Full Text]
Natkunam, Y. (2007). The Biology of the Germinal Center. ASH Education Book 2007: 210-215 [Abstract] [Full Text]
Caccamo, N., Battistini, L., Bonneville, M., Poccia, F., Fournie, J. J., Meraviglia, S., Borsellino, G., Kroczek, R. A., La Mendola, C., Scotet, E., Dieli, F., Salerno, A. (2006). CXCR5 Identifies a Subset of V{gamma}9V{delta}2 T Cells which Secrete IL-4 and IL-10 and Help B Cells for Antibody Production. J. Immunol. 177: 5290-5295 [Abstract] [Full Text]
Bossaller, L., Burger, J., Draeger, R., Grimbacher, B., Knoth, R., Plebani, A., Durandy, A., Baumann, U., Schlesier, M., Welcher, A. A., Peter, H. H., Warnatz, K. (2006). ICOS Deficiency Is Associated with a Severe Reduction of CXCR5+CD4 Germinal Center Th Cells. J. Immunol. 177: 4927-4932 [Abstract] [Full Text]
Marinova, E., Han, S., Zheng, B. (2006). Human germinal center T cells are unique Th cells with high propensity for apoptosis induction. Int Immunol 18: 1337-1345 [Abstract] [Full Text]
Krenacs, L., Schaerli, P., Kis, G., Bagdi, E. (2006). Phenotype of neoplastic cells in angioimmunoblastic T-cell lymphoma is consistent with activated follicular B helper T cells. Blood 108: 1110-1111 [Full Text]
Arguni, E., Arima, M., Tsuruoka, N., Sakamoto, A., Hatano, M., Tokuhisa, T. (2006). JunD/AP-1 and STAT3 are the major enhancer molecules for high Bcl6 expression in germinal center B cells. Int Immunol 18: 1079-1089 [Abstract] [Full Text]
Lee, B. P.-L., Chen, W., Shi, H., Der, S. D., Forster, R., Zhang, L. (2006). CXCR5/CXCL13 Interaction Is Important for Double-Negative Regulatory T Cell Homing to Cardiac Allografts. J. Immunol. 176: 5276-5283 [Abstract] [Full Text]
Crawford, A., MacLeod, M., Schumacher, T., Corlett, L., Gray, D. (2006). Primary T Cell Expansion and Differentiation In Vivo Requires Antigen Presentation by B Cells. J. Immunol. 176: 3498-3506 [Abstract] [Full Text]
Hase, K., Murakami, T., Takatsu, H., Shimaoka, T., Iimura, M., Hamura, K., Kawano, K., Ohshima, S., Chihara, R., Itoh, K., Yonehara, S., Ohno, H. (2006). The Membrane-Bound Chemokine CXCL16 Expressed on Follicle-Associated Epithelium and M Cells Mediates Lympho-Epithelial Interaction in GALT. J. Immunol. 176: 43-51 [Abstract] [Full Text]
Chtanova, T., Newton, R., Liu, S. M., Weininger, L., Young, T. R., Silva, D. G., Bertoni, F., Rinaldi, A., Chappaz, S., Sallusto, F., Rolph, M. S., Mackay, C. R. (2005). Identification of T Cell-Restricted Genes, and Signatures for Different T Cell Responses, Using a Comprehensive Collection of Microarray Datasets. J. Immunol. 175: 7837-7847 [Abstract] [Full Text]
Junt, T., Fink, K., Forster, R., Senn, B., Lipp, M., Muramatsu, M., Zinkernagel, R. M., Ludewig, B., Hengartner, H. (2005). CXCR5-Dependent Seeding of Follicular Niches by B and Th Cells Augments Antiviral B Cell Responses. J. Immunol. 175: 7109-7116 [Abstract] [Full Text]
Fritsch, R. D., Shen, X., Sims, G. P., Hathcock, K. S., Hodes, R. J., Lipsky, P. E. (2005). Stepwise Differentiation of CD4 Memory T Cells Defined by Expression of CCR7 and CD27. J. Immunol. 175: 6489-6497 [Abstract] [Full Text]
Lim, H. W., Hillsamer, P., Banham, A. H., Kim, C. H. (2005). Cutting Edge: Direct Suppression of B Cells by CD4+CD25+ Regulatory T Cells. J. Immunol. 175: 4180-4183 [Abstract] [Full Text]
Lane, P. (2005). Where you are is what you are. Blood 106: 1891-1892 [Full Text]
Hardtke, S., Ohl, L., Forster, R. (2005). Balanced expression of CXCR5 and CCR7 on follicular T helper cells determines their transient positioning to lymph node follicles and is essential for efficient B-cell help. Blood 106: 1924-1931 [Abstract] [Full Text]
Zaunders, J. J., Munier, M. L., Kaufmann, D. E., Ip, S., Grey, P., Smith, D., Ramacciotti, T., Quan, D., Finlayson, R., Kaldor, J., Rosenberg, E. S., Walker, B. D., Cooper, D. A., Kelleher, A. D., on behalf of the PHAEDRA Study Team, (2005). Early proliferation of CCR5+ CD38+++ antigen-specific CD4+ Th1 effector cells during primary HIV-1 infection. Blood 106: 1660-1667 [Abstract] [Full Text]
Akiba, H., Takeda, K., Kojima, Y., Usui, Y., Harada, N., Yamazaki, T., Ma, J., Tezuka, K., Yagita, H., Okumura, K. (2005). The Role of ICOS in the CXCR5+ Follicular B Helper T Cell Maintenance In Vivo. J. Immunol. 175: 2340-2348 [Abstract] [Full Text]
Mo, R., Chen, J., Grolleau-Julius, A., Murphy, H. S., Richardson, B. C., Yung, R. L. (2005). Estrogen Regulates CCR Gene Expression and Function in T Lymphocytes. J. Immunol. 174: 6023-6029 [Abstract] [Full Text]
Inamine, A., Takahashi, Y., Baba, N., Miyake, K., Tokuhisa, T., Takemori, T., Abe, R. (2005). Two waves of memory B-cell generation in the primary immune response. Int Immunol 17: 581-589 [Abstract] [Full Text]
Paoletti, S., Petkovic, V., Sebastiani, S., Danelon, M. G., Uguccioni, M., Gerber, B. O. (2005). A rich chemokine environment strongly enhances leukocyte migration and activities. Blood 105: 3405-3412 [Abstract] [Full Text]
Estes, J. D., Thacker, T. C., Hampton, D. L., Kell, S. A., Keele, B. F., Palenske, E. A., Druey, K. M., Burton, G. F. (2004). Follicular Dendritic Cell Regulation of CXCR4-Mediated Germinal Center CD4 T Cell Migration. J. Immunol. 173: 6169-6178 [Abstract] [Full Text]
Moser, B, Willimann, K (2004). Chemokines: role in inflammation and immune surveillance. Ann Rheum Dis 63: ii84-ii89 [Abstract] [Full Text]
Kim, C. H., Lim, H. W., Kim, J. R., Rott, L., Hillsamer, P., Butcher, E. C. (2004). Unique gene expression program of human germinal center T helper cells. Blood 104: 1952-1960 [Abstract] [Full Text]
Rivino, L., Messi, M., Jarrossay, D., Lanzavecchia, A., Sallusto, F., Geginat, J. (2004). Chemokine Receptor Expression Identifies Pre-T Helper (Th)1, Pre-Th2, and Nonpolarized Cells among Human CD4+ Central Memory T Cells. JEM 200: 725-735 [Abstract] [Full Text]
Smith, K. M., Brewer, J. M., Rush, C. M., Riley, J., Garside, P. (2004). In Vivo Generated Th1 Cells Can Migrate to B Cell Follicles to Support B Cell Responses. J. Immunol. 173: 1640-1646 [Abstract] [Full Text]
Chtanova, T., Tangye, S. G., Newton, R., Frank, N., Hodge, M. R., Rolph, M. S., Mackay, C. R. (2004). T Follicular Helper Cells Express a Distinctive Transcriptional Profile, Reflecting Their Role as Non-Th1/Th2 Effector Cells That Provide Help for B Cells. J. Immunol. 173: 68-78 [Abstract] [Full Text]
Perrier, P., Martinez, F. O., Locati, M., Bianchi, G., Nebuloni, M., Vago, G., Bazzoni, F., Sozzani, S., Allavena, P., Mantovani, A. (2004). Distinct Transcriptional Programs Activated by Interleukin-10 with or without Lipopolysaccharide in Dendritic Cells: Induction of the B Cell-Activating Chemokine, CXC Chemokine Ligand 13. J. Immunol. 172: 7031-7042 [Abstract] [Full Text]
Ito, T., Ishikawa, S., Sato, T., Akadegawa, K., Yurino, H., Kitabatake, M., Hontsu, S., Ezaki, T., Kimura, H., Matsushima, K. (2004). Defective B1 Cell Homing to the Peritoneal Cavity and Preferential Recruitment of B1 Cells in the Target Organs in a Murine Model for Systemic Lupus Erythematosus. J. Immunol. 172: 3628-3634 [Abstract] [Full Text]
Zaunders, J. J., Dyer, W. B., Wang, B., Munier, M. L., Miranda-Saksena, M., Newton, R., Moore, J., Mackay, C. R., Cooper, D. A., Saksena, N. K., Kelleher, A. D. (2004). Identification of circulating antigen-specific CD4+ T lymphocytes with a CCR5+, cytotoxic phenotype in an HIV-1 long-term nonprogressor and in CMV infection. Blood 103: 2238-2247 [Abstract] [Full Text]
Hase, H., Kanno, Y., Kojima, M., Hasegawa, K., Sakurai, D., Kojima, H., Tsuchiya, N., Tokunaga, K., Masawa, N., Azuma, M., Okumura, K., Kobata, T. (2004). BAFF/BLyS can potentiate B-cell selection with the B-cell coreceptor complex. Blood 103: 2257-2265 [Abstract] [Full Text]
Ali, M., Weinreich, M., Balcaitis, S., Cooper, C. J., Fink, P. J. (2003). Differential Regulation of Peripheral CD4+ T Cell Tolerance Induced by Deletion and TCR Revision. J. Immunol. 171: 6290-6296 [Abstract] [Full Text]
Brandes, M., Willimann, K., Lang, A. B., Nam, K.-H., Jin, C., Brenner, M. B., Morita, C. T., Moser, B. (2003). Flexible migration program regulates {gamma}{delta} T-cell involvement in humoral immunity. Blood 102: 3693-3701 [Abstract] [Full Text]
Barry, S. M., Zisoulis, D. G., Neal, J. W., Clipstone, N. A., Kansas, G. S. (2003). Induction of FucT-VII by the Ras/MAP kinase cascade in Jurkat T cells. Blood 102: 1771-1778 [Abstract] [Full Text]
Johansson-Lindbom, B., Ingvarsson, S., Borrebaeck, C. A. K. (2003). Germinal Centers Regulate Human Th2 Development. J. Immunol. 171: 1657-1666 [Abstract] [Full Text]
Fava, R. A., Notidis, E., Hunt, J., Szanya, V., Ratcliffe, N., Ngam-ek, A., de Fougerolles, A. R., Sprague, A., Browning, J. L. (2003). A Role for the Lymphotoxin/LIGHT Axis in the Pathogenesis of Murine Collagen-Induced Arthritis. J. Immunol. 171: 115-126 [Abstract] [Full Text]
Kim, C. H., Nagata, K., Butcher, E. C. (2003). Dendritic Cells Support Sequential Reprogramming of Chemoattractant Receptor Profiles During Naive to Effector T Cell Differentiation. J. Immunol. 171: 152-158 [Abstract] [Full Text]
Papadakis, K. A., Landers, C., Prehn, J., Kouroumalis, E. A., Moreno, S. T., Gutierrez-Ramos, J.-C., Hodge, M. R., Targan, S. R. (2003). CC Chemokine Receptor 9 Expression Defines a Subset of Peripheral Blood Lymphocytes with Mucosal T Cell Phenotype and Th1 or T-Regulatory 1 Cytokine Profile. J. Immunol. 171: 159-165 [Abstract] [Full Text]
Smith, K. M., Brewer, J. M., Webb, P., Coyle, A. J., Gutierrez-Ramos, C., Garside, P. (2003). Inducible Costimulatory Molecule-B7-Related Protein 1 Interactions Are Important for the Clonal Expansion and B Cell Helper Functions of Naive, Th1, and Th2 T Cells. J. Immunol. 170: 2310-2315 [Abstract] [Full Text]
Hill, N. J., Van Gunst, K., Sarvetnick, N. (2003). Th1 and Th2 Pancreatic Inflammation Differentially Affects Homing of Islet-Reactive CD4 Cells in Nonobese Diabetic Mice. J. Immunol. 170: 1649-1658 [Abstract] [Full Text]
Fillatreau, S., Gray, D. (2003). T Cell Accumulation in B Cell Follicles Is Regulated by Dendritic Cells and Is Independent of B Cell Activation. JEM 197: 195-206 [Abstract] [Full Text]
Beyer, T., Meyer-Hermann, M., Soff, G. (2002). A possible role of chemotaxis in germinal center formation. Int Immunol 14: 1369-1381 [Abstract] [Full Text]
Mojtabavi, N., Dekan, G., Stingl, G., Epstein, M. M. (2002). Long-Lived Th2 Memory in Experimental Allergic Asthma. J. Immunol. 169: 4788-4796 [Abstract] [Full Text]
Carlsen, H S, Baekkevold, E S, Johansen, F-E, Haraldsen, G, Brandtzaeg, P (2002). B cell attracting chemokine 1 (CXCL13) and its receptor CXCR5 are expressed in normal and aberrant gut associated lymphoid tissue. Gut 51: 364-371 [Abstract] [Full Text]
Estes, J. D., Keele, B. F., Tenner-Racz, K., Racz, P., Redd, M. A., Thacker, T. C., Jiang, Y., Lloyd, M. J., Gartner, S., Burton, G. F. (2002). Follicular Dendritic Cell-Mediated Up-Regulation of CXCR4 Expression on CD4 T Cells and HIV Pathogenesis. J. Immunol. 169: 2313-2322 [Abstract] [Full Text]
Chiu, B.-C., Shang, X.-Z., Stolberg, V. R., Komuniecki, E., Chensue, S. W. (2002). Population analysis of CD4+ T cell chemokine receptor transcript expression during in vivo type-1 (mycobacterial) and type-2 (schistosomal) immune responses. J. Leukoc. Biol. 72: 363-372 [Abstract] [Full Text]
Muller, G., Hopken, U. E., Stein, H., Lipp, M. (2002). Systemic immunoregulatory and pathogenic functions of homeostatic chemokine receptors. J. Leukoc. Biol. 72: 1-8 [Abstract] [Full Text]
Olson, T. S., Ley, K. (2002). Chemokines and chemokine receptors in leukocyte trafficking. Am. J. Physiol. Regul. Integr. Comp. Physiol. 283: R7-R28 [Abstract] [Full Text]
Bosshart, H., Ansell, S. M., Jelinek, D. F., Wettstein, P. J., Witzig, T. E. (2002). T Helper Cell Activation in B-Cell Lymphomas. JCO 20: 2904-2905 [Full Text]
Yoneyama, H., Narumi, S., Zhang, Y., Murai, M., Baggiolini, M., Lanzavecchia, A., Ichida, T., Asakura, H., Matsushima, K. (2002). Pivotal Role of Dendritic Cell-derived CXCL10 in the Retention of T Helper Cell 1 Lymphocytes in Secondary Lymph Nodes. JEM 195: 1257-1266 [Abstract] [Full Text]
Wu, M.-T., Hwang, S. T. (2002). CXCR5-Transduced Bone Marrow-Derived Dendritic Cells Traffic to B Cell Zones of Lymph Nodes and Modify Antigen-Specific Immune Responses. J. Immunol. 168: 5096-5102 [Abstract] [Full Text]
Yu, P., Wang, Y., Chin, R. K., Martinez-Pomares, L., Gordon, S., Kosco-Vibois, M. H., Cyster, J., Fu, Y.-X. (2002). B Cells Control the Migration of a Subset of Dendritic Cells into B Cell Follicles Via CXC Chemokine Ligand 13 in a Lymphotoxin-Dependent Fashion. J. Immunol. 168: 5117-5123 [Abstract] [Full Text]
Reinhart, T. A., Fallert, B. A., Pfeifer, M. E., Sanghavi, S., Capuano, S. III, Rajakumar, P., Murphey-Corb, M., Day, R., Fuller, C. L., Schaefer, T. M (2002). Increased expression of the inflammatory chemokine CXC chemokine ligand 9/monokine induced by interferon-gamma in lymphoid tissues of rhesus macaques during simian immunodeficiency virus infection and acquired immunodeficiency syndrome. Blood 99: 3119-3128 [Abstract] [Full Text]
Saito, K., Tanaka, T., Kanda, H., Ebisuno, Y., Izawa, D., Kawamoto, S., Okubo, K., Miyasaka, M. (2002). Gene Expression Profiling of Mucosal Addressin Cell Adhesion Molecule-1+ High Endothelial Venule Cells (HEV) and Identification of a Leucine-Rich HEV Glycoprotein as a HEV Marker. J. Immunol. 168: 1050-1059 [Abstract] [Full Text]
Henning, G., Ohl, L., Junt, T., Reiterer, P., Brinkmann, V., Nakano, H., Hohenberger, W., Lipp, M., Forster, R. (2001). CC Chemokine Receptor 7-dependent and -independent Pathways for Lymphocyte Homing: Modulation by FTY720. JEM 194: 1875-1881 [Abstract] [Full Text]
Schaerli, P., Loetscher, P., Moser, B. (2001). Cutting Edge: Induction of Follicular Homing Precedes Effector Th Cell Development. J. Immunol. 167: 6082-6086 [Abstract] [Full Text]
Forster, R., Ohl, L., Henning, G. (2001). Lessons Learned From Lymphocytes: CC Chemokine Receptor-7 Involved in Lymphogenic Metastasis of Melanoma. JNCI J Natl Cancer Inst 93: 1588-1589 [Full Text]
Kim, C. H., Rott, L. S., Clark-Lewis, I., Campbell, D. J., Wu, L., Butcher, E. C. (2001). Subspecialization of CXCR5+ T Cells: B Helper Activity Is Focused in a Germinal Center-localized Subset of CXCR5+ T Cells. JEM 193: 1373-1382 [Abstract] [Full Text]
Ishikawa, S., Sato, T., Abe, M., Nagai, S., Onai, N., Yoneyama, H., Zhang, Y.-y., Suzuki, T., Hashimoto, S.-i., Shirai, T., Lipp, M., Matsushima, K. (2001). Aberrant High Expression of B Lymphocyte Chemokine (BLC/CXCL13) by C11b+CD11c+ Dendritic Cells in Murine Lupus and Preferential Chemotaxis of B1 Cells Towards BLC. JEM 193: 1393-1402 [Abstract] [Full Text]
Baekkevold, E. S., Yamanaka, T., Palframan, R. T., Carlsen, H. S., Reinholt, F. P., von Andrian, U. H., Brandtzaeg, P., Haraldsen, G. (2001). The CCR7 Ligand ELC (CCL19) Is Transcytosed in High Endothelial Venules and Mediates T Cell Recruitment. JEM 193: 1105-1112 [Abstract] [Full Text]
Mackay, C. R. (2000). Follicular Homing T Helper (Th) Cells and the Th1/Th2 Paradigm. JEM 192: F31-F34 [Full Text]