Brief Definitive Reports

TACI Is a TRAF-interacting Receptor for TALL-1, a Tumor Necrosis Factor Family Member Involved in B Cell Regulation

Correspondence to: Hailing Hsu, Amgen, One Amgen Center Dr., Thousand Oaks, CA 91320. Tel:805-447-1165 Fax:805-447-1982 E-mail:hhsu{at}amgen.com.

We and others recently reported tumor necrosis factor (TNF) and apoptosis ligand–related leukocyte-expressed ligand 1 (TALL-1) as a novel member of the TNF ligand family that is functionally involved in B cell proliferation. Transgenic mice overexpressing TALL-1 have severe B cell hyperplasia and lupus-like autoimmune disease. Here, we describe expression cloning of a cell surface receptor for TALL-1 from a human Burkitt's lymphoma RAJI cell library. The cloned receptor is identical to the previously reported TNF receptor (TNFR) homologue transmembrane activator and calcium modulator and cyclophilin ligand (CAML) interactor (TACI). Murine TACI was subsequently isolated from the mouse B lymphoma A20 cells. Human and murine TACI share 54% identity overall. Human TACI exhibits high binding affinities to both human and murine TALL-1. Soluble TACI extracellular domain protein specifically blocks TALL-1–mediated B cell proliferation without affecting CD40- or lipopolysaccharide-mediated B cell proliferation in vitro. In addition, when injected into mice, soluble TACI inhibits antibody production to both T cell–dependent and –independent antigens. By yeast two-hybrid screening of a B cell library with TACI intracellular domain, we identified that, like many other TNFR family members, TACI intracellular domain interacts with TNFR-associated factor (TRAF)2, 5, and 6. Correspondingly, TACI activation in a B cell line results in nuclear factor B and c-Jun NH₂-terminal kinase activation. The identification and characterization of the receptor for TALL-1 provides useful information for the development of a treatment for B cell–mediated autoimmune diseases such as systemic lupus erythematosus.

Key Words: TACI, TNFR family, TALL-1, B cell stimulation, autoimmune disease

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

• Badr, G., Borhis, G., Lefevre, E. A., Chaoul, N., Deshayes, F., Dessirier, V., Lapree, G., Tsapis, A., Richard, Y. (2008). BAFF enhances chemotaxis of primary human B cells: a particular synergy between BAFF and CXCL13 on memory B cells. Blood 111: 2744-2754 [Abstract] [Full Text]  
• Darce, J. R., Arendt, B. K., Wu, X., Jelinek, D. F. (2007). Regulated Expression of BAFF-Binding Receptors during Human B Cell Differentiation. J. Immunol. 179: 7276-7286 [Abstract] [Full Text]  
• Grant, J. R., Moise, A. R., Jefferies, W. A. (2007). Identification of a Novel Immunosubversion Mechanism Mediated by a Virologue of the B-Lymphocyte Receptor TACI. CVI 14: 907-917 [Abstract] [Full Text]  
• Darce, J. R., Arendt, B. K., Chang, S. K., Jelinek, D. F. (2007). Divergent Effects of BAFF on Human Memory B Cell Differentiation into Ig-Secreting Cells. J. Immunol. 178: 5612-5622 [Abstract] [Full Text]  
• Yoshimoto, K., Takahashi, Y., Ogasawara, M., Setoyama, Y., Suzuki, K., Tsuzaka, K., Abe, T., Takeuchi, T. (2006). Aberrant expression of BAFF in T cells of systemic lupus erythematosus, which is recapitulated by a human T cell line, Loucy. Int Immunol 18: 1189-1196 [Abstract] [Full Text]  
• Mongini, P. K. A., Inman, J. K., Han, H., Fattah, R. J., Abramson, S. B., Attur, M. (2006). APRIL and BAFF Promote Increased Viability of Replicating Human B2 Cells via Mechanism Involving Cyclooxygenase 2.. J. Immunol. 176: 6736-6751 [Abstract] [Full Text]  
• Bischof, D., Elsawa, S. F., Mantchev, G., Yoon, J., Michels, G. E., Nilson, A., Sutor, S. L., Platt, J. L., Ansell, S. M., von Bulow, G., Bram, R. J. (2006). Selective activation of TACI by syndecan-2. Blood 107: 3235-3242 [Abstract] [Full Text]  
• Zhang, X., Park, C.-S., Yoon, S.-O., Li, L., Hsu, Y.-M., Ambrose, C., Choi, Y. S. (2005). BAFF supports human B cell differentiation in the lymphoid follicles through distinct receptors. Int Immunol 17: 779-788 [Abstract] [Full Text]  
• Ingold, K., Zumsteg, A., Tardivel, A., Huard, B., Steiner, Q.-G., Cachero, T. G., Qiang, F., Gorelik, L., Kalled, S. L., Acha-Orbea, H., Rennert, P. D., Tschopp, J., Schneider, P. (2005). Identification of proteoglycans as the APRIL-specific binding partners. J. Exp. Med. 201: 1375-1383 [Abstract] [Full Text]  
• Rahman, Z. S. M., Manser, T. (2004). B Cells Expressing Bcl-2 and a Signaling-Impaired BAFF-Specific Receptor Fail to Mature and Are Deficient in the Formation of Lymphoid Follicles and Germinal Centers. J. Immunol. 173: 6179-6188 [Abstract] [Full Text]  
• Stohl, W (2004). A therapeutic role for BLyS antagonists. Lupus 13: 317-322 [Abstract]  
• He, B., Chadburn, A., Jou, E., Schattner, E. J., Knowles, D. M., Cerutti, A. (2004). Lymphoma B Cells Evade Apoptosis through the TNF Family Members BAFF/BLyS and APRIL. J. Immunol. 172: 3268-3279 [Abstract] [Full Text]  
• Bharti, A. C., Takada, Y., Shishodia, S., Aggarwal, B. B. (2004). Evidence That Receptor Activator of Nuclear Factor (NF)-{kappa}B Ligand Can Suppress Cell Proliferation and Induce Apoptosis through Activation of a NF-{kappa}B-independent and TRAF6-dependent Mechanism. J. Biol. Chem. 279: 6065-6076 [Abstract] [Full Text]  
• Varfolomeev, E., Kischkel, F., Martin, F., Seshasayee, D., Wang, H., Lawrence, D., Olsson, C., Tom, L., Erickson, S., French, D., Schow, P., Grewal, I. S., Ashkenazi, A. (2004). APRIL-Deficient Mice Have Normal Immune System Development. Mol. Cell. Biol. 24: 997-1006 [Abstract] [Full Text]  
• Gorelik, L., Cutler, A. H., Thill, G., Miklasz, S. D., Shea, D. E., Ambrose, C., Bixler, S. A., Su, L., Scott, M. L., Kalled, S. L. (2004). Cutting Edge: BAFF Regulates CD21/35 and CD23 Expression Independent of Its B Cell Survival Function. J. Immunol. 172: 762-766 [Abstract] [Full Text]  
• Kern, C., Cornuel, J.-F., Billard, C., Tang, R., Rouillard, D., Stenou, V., Defrance, T., Ajchenbaum-Cymbalista, F., Simonin, P.-Y., Feldblum, S., Kolb, J.-P. (2004). Involvement of BAFF and APRIL in the resistance to apoptosis of B-CLL through an autocrine pathway. Blood 103: 679-688 [Abstract] [Full Text]  
• Schneider, K., Kothlow, S., Schneider, P., Tardivel, A., Gobel, T., Kaspers, B., Staeheli, P. (2004). Chicken BAFF--a highly conserved cytokine that mediates B cell survival. Int Immunol 16: 139-148 [Abstract] [Full Text]  
• Melchers, F (2003). Actions of BAFF in B cell maturation and its effects on the development of autoimmune disease. Ann Rheum Dis 62: ii25-27 [Abstract] [Full Text]  
• Rahman, Z. SM., Rao, S. P., Kalled, S. L., Manser, T. (2003). Normal Induction but Attenuated Progression of Germinal Center Responses in BAFF and BAFF-R Signaling-Deficient Mice. J. Exp. Med. 198: 1157-1169 [Abstract] [Full Text]  
• Pelletier, M., Thompson, J. S., Qian, F., Bixler, S. A., Gong, D., Cachero, T., Gilbride, K., Day, E., Zafari, M., Benjamin, C., Gorelik, L., Whitty, A., Kalled, S. L., Ambrose, C., Hsu, Y.-M. (2003). Comparison of Soluble Decoy IgG Fusion Proteins of BAFF-R and BCMA as Antagonists for BAFF. J. Biol. Chem. 278: 33127-33133 [Abstract] [Full Text]  
• Koyama, T., Tsukamoto, H., Masumoto, K., Himeji, D., Hayashi, K., Harada, M., Horiuchi, T. (2003). A novel polymorphism of the human APRIL gene is associated with systemic lupus erythematosus. Rheumatology (Oxford) 42: 980-985 [Abstract] [Full Text]  
• Vora, K. A., Wang, L. C., Rao, S. P., Liu, Z.-Y., Majeau, G. R., Cutler, A. H., Hochman, P. S., Scott, M. L., Kalled, S. L. (2003). Cutting Edge: Germinal Centers Formed in the Absence of B Cell-Activating Factor Belonging to the TNF Family Exhibit Impaired Maturation and Function. J. Immunol. 171: 547-551 [Abstract] [Full Text]  
• Wu, M., Xu, L.-G., Zhai, Z., Shu, H.-B. (2003). SINK Is a p65-interacting Negative Regulator of NF-{kappa}B-dependent Transcription. J. Biol. Chem. 278: 27072-27079 [Abstract] [Full Text]  
• Riccobene, T. A., Miceli, R. C., Lincoln, C., Knight, Y., Meadows, J., Stabin, M. G., Sung, C. (2003). Rapid and Specific Targeting of 125I-Labeled B Lymphocyte Stimulator to Lymphoid Tissues and B Cell Tumors in Mice. JNM 44: 422-433 [Abstract] [Full Text]  
• Buchsbaum, D. J., LoBuglio, A. F. (2003). Targeting of 125I-Labeled B Lymphocyte Stimulator. JNM 44: 434-436 [Full Text]  
• Xu, L.-G., Shu, H.-B. (2002). TNFR-Associated Factor-3 Is Associated With BAFF-R and Negatively Regulates BAFF-R-Mediated NF-{kappa}B Activation and IL-10 Production. J. Immunol. 169: 6883-6889 [Abstract] [Full Text]  
• Novak, A. J., Bram, R. J., Kay, N. E., Jelinek, D. F. (2002). Aberrant expression of B-lymphocyte stimulator by B chronic lymphocytic leukemia cells: a mechanism for survival. Blood 100: 2973-2979 [Abstract] [Full Text]  
• Xu, L.-G., Wu, M., Hu, J., Zhai, Z., Shu, H.-B. (2002). Identification of downstream genes up-regulated by the tumor necrosis factor family member TALL-1. J. Leukoc. Biol. 72: 410-416 [Abstract] [Full Text]  
• Mason, D., Andre, P., Bensussan, A., Buckley, C., Civin, C., Clark, E., de Haas, M., Goyert, S., Hadam, M., Hart, D., Horejsi, V., Meuer, S., Morrissey, J., Schwartz-Albiez, R., Shaw, S., Simmons, D., Uguccioni, M., van der Schoot, E., Vivier, E., Zola, H. (2002). CD antigens 2002. Blood 99: 3877-3880 [Full Text]  
• Huard, B., Schneider, P., Mauri, D., Tschopp, J., French, L. E. (2001). T Cell Costimulation by the TNF Ligand BAFF. J. Immunol. 167: 6225-6231 [Abstract] [Full Text]  
• Mason, D., Andre, P., Bensussan, A., Buckley, C., Civin, C., Clark, E., de Haas, M., Goyert, S., Hadam, M., Hart, D., Horejsi, V., Meuer, S., Morrissey, J., Schwartz-Albiez, R., Shaw, S., Simmons, D., Uguccioni, M., van der Schoot, E., Vivier, E., Zola, H. (2001). CD antigens 2001. J. Leukoc. Biol. 70: 685-690 [Abstract] [Full Text]  
• Mason, D., Andre, P., Bensussan, A., Buckley, C., Civin, C., Clark, E., de Haas, M., Goyert, S., Hadam, M., Hart, D., Horejsi, V., Meuer, S., Morrissey, J., Schwartz-Albiez, R., Shaw, S., Simmons, D., Uguccioni, M., van der Schoot, E., Vivier, E., Zola, H. (2001). CD Antigens 2001: Aims and Results of HLDA Workshops. Stem Cells 19: 556-562 [Full Text]  
• Xu, S., Lam, K.-P. (2001). B-Cell Maturation Protein, Which Binds the Tumor Necrosis Factor Family Members BAFF and APRIL, Is Dispensable for Humoral Immune Responses. Mol. Cell. Biol. 21: 4067-4074 [Abstract] [Full Text]  
• Ware, C. F. (2000). APRIL and BAFF Connect Autoimmunity and Cancer. J. Exp. Med. 192: F35-F38 [Full Text]  
• Batten, M., Groom, J., Cachero, T. G., Qian, F., Schneider, P., Tschopp, J., Browning, J. L., Mackay, F. (2000). BAFF Mediates Survival of Peripheral Immature B Lymphocytes. J. Exp. Med. 192: 1453-1466 [Abstract] [Full Text]  
• Do, R. K.G., Hatada, E., Lee, H., Tourigny, M. R., Hilbert, D., Chen-Kiang, S. (2000). Attenuation of Apoptosis Underlies B Lymphocyte Stimulator Enhancement of Humoral Immune Response. J. Exp. Med. 192: 953-964 [Abstract] [Full Text]  
• Wu, Y., Bressette, D., Carrell, J. A., Kaufman, T., Feng, P., Taylor, K., Gan, Y., Cho, Y. H., Garcia, A. D., Gollatz, E., Dimke, D., LaFleur, D., Migone, T. S., Nardelli, B., Wei, P., Ruben, S. M., Ullrich, S. J., Olsen, H. S., Kanakaraj, P., Moore, P. A., Baker, K. P. (2000). Tumor Necrosis Factor (TNF) Receptor Superfamily Member TACI Is a High Affinity Receptor for TNF Family Members APRIL and BLyS. J. Biol. Chem. 275: 35478-35485 [Abstract] [Full Text]  

Home | Help | Feedback | Subscriptions | Archive | Search

TABLE OF CONTENTS