FLICE-inhibitory Protein Expression during Macrophage Differentiation Confers Resistance to Fas-mediated Apoptosis

doi:10.1084/jem.190.11.1679

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© The Rockefeller University Press, 0022-1007/1999/12/1679/ $5.00
The Journal of Experimental Medicine, Volume 190, Number 11, December 6, 1999 1679-1688

Original Article

FLICE-inhibitory Protein Expression during Macrophage Differentiation Confers Resistance to Fas-mediated Apoptosis

Harris Perlman^a,c, Lisa J. Pagliari^a,b,c, Constantinos Georganas^a,c,d, Toshiaki Mano^e, Kenneth Walsh^e, and Richard M. Pope^a,b,c
^a Division of Rheumatology, Northwestern University Medical School, Chicago, Illinois 60611
^b Integrated Graduate Program in the Life Sciences, Northwestern University Medical School, Chicago, Illinois 60611
^c Chicagoland Veterans Administration Medical Center, Chicago, Illinois 60611
^d Department of Rheumatology, 251 Hellenic Airforce Veterans Administration General Hospital, Athens, Greece
^e Division of Cardiovascular Research, St. Elizabeth's Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02135

Correspondence to: Richard M. Pope, Division of Rheumatology, Department of Medicine, Northwestern University Medical School, 745 North Fairbanks Ct., Tarry 3-770, Chicago, IL 60611. Tel:312-503-8003 Fax:312-503-0994 E-mail:rmp158{at}nwu.edu.

Macrophages differentiated from circulating peripheral bloodmonocytes are essential for host immune responses and have beenimplicated in the pathogenesis of rheumatoid arthritis and atherosclerosis.In contrast to monocytes, macrophages are resistant to Fas-inducedcell death by an unknown mechanism. FLICE (Fas-associated deathdomain–like interleukin 1ß–converting enzyme)–inhibitoryprotein (Flip), a naturally occurring caspase-inhibitory proteinthat lacks the critical cysteine domain necessary for catalyticactivity, is a negative regulator of Fas-induced apoptosis.Here, we show that monocyte differentiation into macrophageswas associated with upregulation of Flip and a decrease in Fas-mediatedapoptosis. Overexpression of Flip protected monocytes from Fas-mediatedapoptosis, whereas acute Flip inhibition in macrophages inducedapoptosis. Addition of an antagonistic Fas ligand antibody toFlip antisense–treated macrophages rescued cultures fromapoptosis, demonstrating that endogenous Flip blocked Fas-inducedcell death. Thus, the expression of Flip in macrophages conferredresistance to Fas-mediated apoptosis, which may contribute tothe development of inflammatory disease.

Key Words: monocytes, macrophages, apoptosis, Flip, Fas

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