The Absence of Interleukin 1 Receptor-related T1/ST2 Does Not Affect T Helper Cell Type 2 Development and Its Effector Function

doi:10.1084/jem.190.10.1541

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© The Rockefeller University Press, 0022-1007/1999/11/1541/ $5.00
The Journal of Experimental Medicine, Volume 190, Number 10, November 15, 1999 1541-1548

Brief Definitive Report

The Absence of Interleukin 1 Receptor–related T1/ST2 Does Not Affect T Helper Cell Type 2 Development and Its Effector Function

Katsuaki Hoshino^a,b, Shin-ichiro Kashiwamura^c, Kozo Kuribayashi^d, Taku Kodama^d, Tohru Tsujimura^e, Kenji Nakanishi^c, Tomohiro Matsuyama^d, Kiyoshi Takeda^a,b, and Shizuo Akira^a,b
^a Department of Host Defense, Research Institute for Microbial Diseases
^b Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Corporation, Osaka University, Osaka 565-0871, Japan
^c Institute for Advanced Medical Sciences, Hyogo College of Medicine, Hyogo 663-8501, Japan
^d Fifth Department of Internal Medicine, Hyogo College of Medicine, Hyogo 663-8501, Japan
^e Department of Pathology, Hyogo College of Medicine, Hyogo 663-8501, Japan

Correspondence to: Shizuo Akira, Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Yamada-oka 3-1, Suita, Osaka 565-0871, Japan. Tel:81-6-6879-8303 Fax:81-6-6879-8305 E-mail:sakira{at}biken.osaka-u.ac.jp.

T1/ST2, an orphan receptor with homology with the interleukin(IL)-1 receptor family, is expressed constitutively and stablyon the surface of T helper type 2 (Th2) cells, but not on Th1cells. T1/ST2 is also expressed on mast cells, which are criticalfor Th2-mediated effector responses. To evaluate whether T1/ST2is required for Th2 responses and mast cell function, we havegenerated T1/ST2-deficient (T1/ST2^-/-) mice and examined theroles of T1/ST2. Naive CD4⁺ T cells isolated from T1/ST2^-/-mice developed to Th2 cells in response to IL-4 in vitro. T1/ST2^-/-mice showed normal Th2 responses after infection with the helminthicparasite Nippostrongylus brasiliensis as well as in the mousemodel of allergen-induced airway inflammation. In addition,differentiation and function of bone marrow–derived culturedmast cells were unaffected. These findings demonstrate thatT1/ST2 does not play an essential role in development and functionof Th2 cells and mast cells.

Key Words: gene targeting, interleukin 1 receptor family, mast cell, asthma,T helper cells types 1 and 2

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