B Cell Development in the Spleen Takes Place in Discrete Steps and Is Determined by the Quality of B Cell Receptor–derived Signals

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J. Exp. Med., Volume 190, Number 1, July 5, 1999 75-90
Copyright © 1999 by The Rockefeller University Press.

B Cell Development in the Spleen Takes Place in Discrete Steps and Is Determined by the Quality of B Cell Receptor–derived Signals

Florienne Loder^a, Bettina Mutschler^a, Robert J. Ray^c, Christopher J. Paige^c, Paschalis Sideras^d, Raul Torres^e, Marinus C. Lamers^b, and Rita Carsetti^a
^a From the Department of Molecular Immunology, Institute of Biology III, University of Freiburg, and the Max-Planck-Institute for Immunobiology, D-79108 Freiburg, Germany
^b Department of Developmental Immunology, Max-Planck-Institute for Immunobiology, D-79108 Freiburg, Germany
^c Wellesley Hospital Research Institute, Toronto, Ontario M4Y 1J3, Canada
^d Department of Applied Cellular and Molecular Biology, Umeå University, S-901 87 Umeå, Sweden
^e Basel Institute for Immunology, 4005 Basel, Switzerland

Correspondence to: Rita Carsetti

Only mature B lymphocytes can enter the lymphoid follicles ofspleen and lymph nodes and thus efficiently participate in theimmune response. Mature, long-lived B lymphocytes derive fromshort-lived precursors generated in the bone marrow. We showthat selection into the mature pool is an active process andtakes place in the spleen. Two populations of splenic B cellswere identified as precursors for mature B cells. TransitionalB cells of type 1 (T1) are recent immigrants from the bone marrow.They develop into the transitional B cells of type 2 (T2), whichare cycling and found exclusively in the primary follicles ofthe spleen. Mature B cells can be generated from T1 or T2 Bcells.

Key Words: B cell development, transitional B cells, spleen, CD45, Bruton'styrosine kinase

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