The Journal of Experimental Medicine
Avanti Polar Lipids
  Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Citation Map
Services
Right arrow Email this article
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new content in the JEM
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Aifantis, I.
Right arrow Articles by von Boehmer, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Aifantis, I.
Right arrow Articles by von Boehmer, H.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
J. Exp. Med., Volume 190, Number 1, July 5, 1999 141-144
Copyright © 1999 by The Rockefeller University Press.

Early T Cell Receptor ß Gene Expression Is Regulated by the Pre-T Cell Receptor–CD3 Complex

Iannis Aifantisa, Jacqueline Feinberga, Hans Jörg Fehlingc, James P. Di Santob, and Harald von Boehmera
a From the Institut National de la Santé et de la Recherche Médicale (INSERM) U373, Hôpital Necker-Enfants Malades, F-75730 Paris, France
b INSERM U429, CH-4005 Basel, Switzerland
c Basel Institute for Immunology, CH-4005 Basel, Switzerland

Correspondence to: Harald von Boehmer

We have examined the question of whether there is an additional checkpoint in T cell development that regulates T cell receptor (TCR)-ß expression in CD25+44- thymocytes by mechanisms that are independent of the pre-TCR. Our analysis in various mutant mice indicates that all changes in cytoplasmic TCR-ß expression can be accounted for by pre-TCR–dependent signal mediation, putting into question the function of a putative pro-TCR.

Key Words: lymphocyte development, pre-T cell receptor, cytoplasmic T cell receptor ß, clonotype-independent CD3 complex


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:



  Home | Help | Feedback | Subscriptions | Archive | Search
TABLE OF CONTENTS