J. Exp. Med., Volume 189, Number 9, May 3, 1999 1451-1460

Type I Interferons (IFNs) Regulate Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) Expression on Human T Cells: A Novel Mechanism for the Antitumor Effects of  Type I IFNs

By Nobuhiko Kayagaki,^* Noriko Yamaguchi,^* Masafumi Nakayama,^* Hiroshi Eto,^§ Ko Okumura,^* and Hideo Yagita^*

From the ^* Department of Immunology, Juntendo University School of Medicine, Bunkyo-ku, Tokyo 113-8421, Japan;  Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Corporation (JST), Chiyoda-ku, Tokyo 101-0062, Japan; and the ^§ Department of Urology, Kobe University School of Medicine, Chuo-ku, Hyogo 650-0017, Japan

Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a proapoptotic member of the TNF family of type II membrane proteins, which constitutes one component of T cell cytotoxicity. In this study, we investigated the expression and function of TRAIL in human peripheral blood T (PBT) cells. Although freshly isolated PBT cells did not express a detectable level of TRAIL on their surface, a remarkable TRAIL expression was rapidly induced on the surface of both CD4⁺ and CD8⁺ PBT cells upon stimulation with anti-CD3 monoclonal antibody and type I interferons (IFNs). This enhancement of TRAIL expression was a unique feature of type I IFNs (IFN- and IFN-), and neither type II IFN (IFN-) nor various other cytokines enhanced TRAIL expression on anti-CD3-stimulated PBT cells. Type I IFNs have been used for clinical treatment of renal cell carcinomas (RCCs), and we found that most RCC cell lines were susceptible to TRAIL-induced apoptosis. Type I IFNs substantially augmented cytotoxic activity of anti-CD3-stimulated PBT cells against RCC cell lines in a TRAIL-dependent manner. These results indicate a unique feature of type I IFNs to regulate TRAIL-mediated T cell cytotoxicity, which may be involved in the antitumor effects of type I IFNs against various tumors.

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• Vidalain, P.-O., Azocar, O., Yagita, H., Rabourdin-Combe, C., Servet-Delprat, C. (2001). Cytotoxic Activity of Human Dendritic Cells Is Differentially Regulated by Double-Stranded RNA and CD40 Ligand. J. Immunol. 167: 3765-3772 [Abstract] [Full Text]  
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• Chou, A.-H., Tsai, H.-F., Lin, L.-L., Hsieh, S.-L., Hsu, P.-I, Hsu, P.-N. (2001). Enhanced Proliferation and Increased IFN-{gamma} Production in T Cells by Signal Transduced Through TNF-Related Apoptosis-Inducing Ligand. J. Immunol. 167: 1347-1352 [Abstract] [Full Text]  
• Chawla-Sarkar, M., Leaman, D. W., Borden, E. C. (2001). Preferential Induction of Apoptosis by Interferon (IFN)-{beta} Compared with IFN-{{alpha}}2: Correlation with TRAIL/Apo2L Induction in Melanoma Cell Lines. Clin. Cancer Res. 7: 1821-1831 [Abstract] [Full Text]  
• Ogawa, K., Tanaka, K., Ishii, A., Nakamura, Y., Kondo, S., Sugamura, K., Takano, S., Nakamura, M., Nagata, K. (2001). A Novel Serum Protein That Is Selectively Produced by Cytotoxic Lymphocytes. J. Immunol. 166: 6404-6412 [Abstract] [Full Text]  
• Pettersen, R. D., Bernard, G., Olafsen, M. K., Pourtein, M., Lie, S. O. (2001). CD99 Signals Caspase-Independent T Cell Death. J. Immunol. 166: 4931-4942 [Abstract] [Full Text]  
• Nieda, M., Nicol, A., Koezuka, Y., Kikuchi, A., Lapteva, N., Tanaka, Y., Tokunaga, K., Suzuki, K., Kayagaki, N., Yagita, H., Hirai, H., Juji, T. (2001). TRAIL expression by activated human CD4+V{alpha}24NKT cells induces in vitro and in vivo apoptosis of human acute myeloid leukemia cells. Blood 97: 2067-2074 [Abstract] [Full Text]  
• Smyth, M. J., Cretney, E., Takeda, K., Wiltrout, R. H., Sedger, L. M., Kayagaki, N., Yagita, H., Okumura, K. (2001). Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) Contributes to Interferon {{gamma}}-dependent Natural Killer Cell Protection from Tumor Metastasis. J. Exp. Med. 193: 661-670 [Abstract] [Full Text]  
• Miura, Y., Misawa, N., Maeda, N., Inagaki, Y., Tanaka, Y., Ito, M., Kayagaki, N., Yamamoto, N., Yagita, H., Mizusawa, H., Koyanagi, Y. (2001). Critical Contribution of Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) to Apoptosis of Human CD4+ T Cells in HIV-1-infected hu-PBL-NOD-SCID Mice. J. Exp. Med. 193: 651-660 [Abstract] [Full Text]  
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• Trinite, B., Voisine, C., Yagita, H., Josien, R. (2000). A Subset of Cytolytic Dendritic Cells in Rat. J. Immunol. 165: 4202-4208 [Abstract] [Full Text]  
• Ruiz-Ruiz, C., Muñoz-Pinedo, C., López-Rivas, A. (2000). Interferon-{{gamma}} Treatment Elevates Caspase-8 Expression and Sensitizes Human Breast Tumor Cells to a Death Receptor-induced Mitochondria-operated Apoptotic Program. Cancer Res. 60: 5673-5680 [Abstract] [Full Text]  
• Walczak, H., Bouchon, A., Stahl, H., Krammer, P. H. (2000). Tumor Necrosis Factor-related Apoptosis-inducing Ligand Retains Its Apoptosis-inducing Capacity on Bcl-2- or Bcl-xL-overexpressing Chemotherapy-resistant Tumor Cells. Cancer Res. 60: 3051-3057 [Abstract] [Full Text]  
• Reuben, J. M., Lee, B.-N., Johnson, H., Fritsche, H., Kantarjian, H. M., Talpaz, M. (2000). Restoration of Th1 Cytokine Synthesis by T Cells of Patients with Chronic Myelogenous Leukemia in Cytogenetic and Hematologic Remission with Interferon-{{alpha}}. Clin. Cancer Res. 6: 1671-1677 [Abstract] [Full Text]  
• Balachandran, S., Roberts, P. C., Kipperman, T., Bhalla, K. N., Compans, R. W., Archer, D. R., Barber, G. N. (2000). Alpha/Beta Interferons Potentiate Virus-Induced Apoptosis through Activation of the FADD/Caspase-8 Death Signaling Pathway. J. Virol. 74: 1513-1523 [Abstract] [Full Text]  
• Fanger, N. A., Maliszewski, C. R., Schooley, K., Griffith, T. S. (1999). Human Dendritic Cells Mediate Cellular Apoptosis via Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL). J. Exp. Med. 190: 1155-1164 [Abstract] [Full Text]  
• Varela, N., Munoz-Pinedo, C., Ruiz-Ruiz, C., Robledo, G., Pedroso, M., Lopez-Rivas, A. (2001). Interferon-gamma Sensitizes Human Myeloid Leukemia Cells to Death Receptor-mediated Apoptosis by a Pleiotropic Mechanism. J. Biol. Chem. 276: 17779-17787 [Abstract] [Full Text]  

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