STAT3 Is Required for the gp130-mediated Full Activation of the c-myc Gene

doi:10.1084/jem.189.1.63

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J. Exp. Med., Volume 189, Number 1, January 4, 1999 63-73

STAT3 Is Required for the gp130-mediated Full Activation of the c-myc Gene

By Nobuo Kiuchi, Koichi Nakajima, Makoto Ichiba, Toshiyuki Fukada, Masahiro Narimatsu, Katsunori Mizuno, Masahiko Hibi, and Toshio Hirano

From the Division of Molecular Oncology, Biomedical Research Center, Osaka University Medical School, Suita, Osaka 565-0871, Japan

The signal transducers and activators of transcription (STAT) family members have been implicated in regulating the growth,differentiation, and death of normal and transformed cells inresponse to either extracellular stimuli, including cytokinesand growth factors, or intracellular tyrosine kinases. c-myc expressionis coordinately regulated by multiple signals in these diversecellular responses. We show that STAT3 mostly mediates the rapidactivation of the c-myc gene upon stimulation of the interleukin(IL)-6 receptor or gp130, a signal transducing subunit of thereceptor complexes for the IL-6 cytokine family. STAT3 does somost likely by binding to cis-regulatory region(s) of the c-mycgene. We show that STAT3 binds to a region overlapping with theE2F site in the c-myc promoter and this site is critical for thec-myc gene promoter- driven transcriptional activation by IL-6or gp130 signals. This is the first identification of the linkagebetween a member of the STAT family and the c-myc gene activation,and also explains how the IL-6 family of cytokines is capableof inducing the expression of the c-myc gene.

Key words: signal transducer and activator of transcription 3; c-myc; promoter; interleukin 6; gp130

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