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J. Exp. Med.,
Volume 188, Number 6, September 21, 1998 1083-1089
By
From the * Division of Molecular Immunology, The National Institute for Medical Research, Mill Hill,
London NW7 1AA, United Kingdom; and CD4/CD8 lineage decision is an important event during T cell maturation in the thymus.
CD8 T cell differentiation usually requires corecognition of major histocompatibility complex
(MHC) class I by the T cell receptor (TCR) and CD8, whereas CD4 T cells differentiate as a
consequence of MHC class II recognition by the TCR and CD4. The involvement of specific
peptides in the selection of T cells expressing a particular TCR could be demonstrated so far
for the CD8 lineage only. We used mice transgenic for an MHC class II-restricted TCR to investigate the role of antagonistic peptides in CD4 T cell differentiation. Interestingly, antagonists blocked the development of CD4+ cells that normally differentiate in thymus organ culture from those mice, and they induced the generation of CD8+ cells in thymus organ culture
from mice impaired in CD4+ cell development (invariant chain-deficient mice). These results are in line with recent observations that antagonistic signals direct differentiation into the CD8
lineage, regardless of MHC specificity.
Gesellschaft für Biotechnologische Forschung, D-38124
Braunschweig, Germany
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