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J. Exp. Med.,
Volume 188, Number 4, August 17, 1998 779-784
By
From the * Department of Immunology and the Most T cells develop through the thymus, where they undergo positive and negative selection.
Some peripheral T cells are known to develop in the absence of thymus, but there is insufficient information about their selection. To analyze the selection of extrathymically developed
T cells, we reconstituted thymectomized male or female recipient mice with bone marrow
cells of mice transgenic for male H-Y antigen-specific T cell receptor (TCR). It was revealed that the T cells bearing self-antigen-specific TCR were not deleted in thymectomized male recipients. More importantly, the absence of H-Y antigen-specific T cells in thymectomized female recipients suggests positive selection of extrathymically developed T cells by the self-antigen. The extrathymically developed T cells in male mice expressed interleukin (IL)-2 receptor
Department of Virology, Medical Institute of
Bioregulation, Kyushu University, Fukuoka 812-8582, Japan
chain (IL-2R) and intermediate levels of CD3 (CD3int) but were natural killer cell
(NK)1.1
. They rapidly produced interferon 
but not IL-4 after TCR cross-linking. Furthermore, a similar pattern of cytokine production was observed in CD3intIL-2R+NK1.1 cells
in normal mice which have been shown to develop extrathymically. These results suggest that
extrathymically developed CD3intIL-2R+NK1.1 cells in normal mice are also positively selected by self-antigens.
chain;
inteferon
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