J. Exp. Med., Volume 188, Number 1, July 1, 1998 181-191

Epstein-Barr Virus-induced Molecule 1 Ligand Chemokine Is Expressed by Dendritic Cells in Lymphoid Tissues and Strongly Attracts Naive T Cells and Activated B Cells

By Vu N. Ngo, H. Lucy Tang, and Jason G. Cyster

From the Department of Microbiology and Immunology, University of California at San Francisco, San Francisco, California 94143-0414

Movement of T and B lymphocytes through secondary lymphoid tissues is likely to involve multiple cues that help the cells navigate to appropriate compartments. Epstein-Barr virus- induced molecule 1 (EBI-1) ligand chemokine (ELC/MIP3) is expressed constitutively within lymphoid tissues and may act as such a guidance cue. Here, we have isolated mouse ELC and characterized its expression pattern and chemotactic properties. ELC is expressed constitutively in dendritic cells within the T cell zone of secondary lymphoid tissues. Recombinant ELC was strongly chemotactic for naive (L-selectin^hi) CD4 T cells and for CD8 T cells and weakly attractive for resting B cells and memory (L-selectin^lo) CD4 T cells. After activation through the B cell receptor, the chemotactic response of B cells was enhanced. Like its human counterpart, murine ELC stimulated cells transfected with EBI-1/CC chemokine receptor 7 (CCR7). Our findings suggest a central role for ELC in promoting encounters between recirculating T cells and dendritic cells and in the migration of activated B cells into the T zone of secondary lymphoid tissues.

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• Seo, S.-j., Buckler, J., Erikson, J. (2001). Novel Roles for Lyn in B Cell Migration and Lipopolysaccharide Responsiveness Revealed Using Anti-Double-Stranded DNA Ig Transgenic Mice. J. Immunol. 166: 3710-3716 [Abstract] [Full Text]  
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• Mori, S., Nakano, H., Aritomi, K., Wang, C.-R., Gunn, M. D., Kakiuchi, T. (2001). Mice Lacking Expression of the Chemokines CCL21-Ser and CCL19 (plt Mice) Demonstrate Delayed but Enhanced T Cell Immune Responses. J. Exp. Med. 193: 207-218 [Abstract] [Full Text]  
• Nakano, H., Gunn, M. D. (2001). Gene Duplications at the Chemokine Locus on Mouse Chromosome 4: Multiple Strain-Specific Haplotypes and the Deletion of Secondary Lymphoid-Organ Chemokine and EBI-1 Ligand Chemokine Genes in the plt Mutation. J. Immunol. 166: 361-369 [Abstract] [Full Text]  
• Traver, D., Akashi, K., Manz, M., Merad, M., Miyamoto, T., Engleman, E. G., Weissman, I. L. (2000). Development of CD8{alpha}-Positive Dendritic Cells from a Common Myeloid Progenitor. Science 290: 2152-2154 [Abstract] [Full Text]  
• Breitfeld, D., Ohl, L., Kremmer, E., Ellwart, J., Sallusto, F., Lipp, M., Forster, R. (2000). Follicular B Helper T Cells Express CXC Chemokine Receptor 5, Localize to B Cell Follicles, and Support Immunoglobulin Production. J. Exp. Med. 192: 1545-1552 [Abstract] [Full Text]  
• Luther, S. A., Tang, H. L., Hyman, P. L., Farr, A. G., Cyster, J. G. (2000). Coexpression of the chemokines ELC and SLC by T zone stromal cells and deletion of the ELC gene in the plt/plt mouse. Proc. Natl. Acad. Sci. USA 97: 12694-12699 [Abstract] [Full Text]  
• Dieu-Nosjean, M.-C., Massacrier, C., Homey, B., Vanbervliet, B., Pin, J.-J., Vicari, A., Lebecque, S., Dezutter-Dambuyant, C., Schmitt, D., Zlotnik, A., Caux, C. (2000). Macrophage Inflammatory Protein 3{alpha} Is Expressed at Inflamed Epithelial Surfaces and Is the Most Potent Chemokine Known in Attracting Langerhans Cell Precursors. J. Exp. Med. 192: 705-718 [Abstract] [Full Text]  
• Brandes, M., Legler, D. F., Spoerri, B., Schaerli, P., Moser, B. (2000). Activation-dependent modulation of B lymphocyte migration to chemokines. Int Immunol 12: 1285-1292 [Abstract] [Full Text]  
• Flesch, I. E. A., Stober, D., Schirmbeck, R., Reimann, J. (2000). Monocyte inflammatory protein-1{alpha} facilitates priming of CD8+ T cell responses to exogenous viral antigen. Int Immunol 12: 1365-1370 [Abstract] [Full Text]  

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