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J. Exp. Med.,
Volume 187, Number 12, June 15, 1998 2109-2114
By
From the Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, 1066 Epalinges, Switzerland
Clonally distributed inhibitory receptors negatively regulate natural killer (NK) cell function
via specific interactions with allelic forms of major histocompatibility complex (MHC) class I
molecules. In the mouse, the Ly-49 family of inhibitory receptors is found not only on NK
cells but also on a minor (NK1.1+) T cell subset. Using Ly-49 transgenic mice, we show here
that the development of NK1.1+ T cells, in contrast to NK or conventional T cells, is impaired when their Ly-49 receptors engage self-MHC class I molecules. Impaired NK1.1+ T cell development in transgenic mice is associated with a failure to select the appropriate CD1-reactive
T cell receptor repertoire. In normal mice, NK1.1+ T cell maturation is accompanied by extinction of Ly-49 receptor expression. Collectively, our data imply that developmentally regulated extinction of inhibitory MHC-specific receptors is required for normal NK1.1+ T cell
maturation and selection.
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