J. Exp. Med., Volume 187, Number 12, June 15, 1998 1977-1983

A Role for Tumor Necrosis Factor Receptor Type 1 in Gut-associated Lymphoid Tissue Development: Genetic Evidence of Synergism with Lymphotoxin  

By Pandelakis A. Koni^* and Richard A. Flavell^*

From the ^* Section of Immunobiology and the  Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06520

Lymphotoxin  (LT) signals via tumor necrosis factor receptors (TNFRs) as a homotrimer and via lymphotoxin  receptor (LTR) as a heterotrimeric LT₁₂ complex. LT-deficient mice lack all lymph nodes (LNs) and Peyer's patches (PPs), and yet LT-deficient mice and TNFR-deficient mice have cervical and mesenteric LN. We now show that mice made deficient in both LT and TNFR type 1 (TNFR1) lack all LNs, revealing redundancy or synergism between TNFR1 and LT, acting presumably via LTR. A complete lack of only PPs in mice heterozygous for both lt and lt, but not lt or lt alone, suggests a similar two-ligand phenomenon in PP development and may explain the incomplete lack of PPs seen in tnfr1^/ mice.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

• Kwa, S.-f., Beverley, P., Smith, A. L. (2006). Peyer's Patches Are Required for the Induction of Rapid Th1 Responses in the Gut and Mesenteric Lymph Nodes during an Enteric Infection.. J. Immunol. 176: 7533-7541 [Abstract] [Full Text]  
• Soderberg, K. A., Linehan, M. M., Ruddle, N. H., Iwasaki, A. (2004). MAdCAM-1 Expressing Sacral Lymph Node in the Lymphotoxin {beta}-Deficient Mouse Provides a Site for Immune Generation Following Vaginal Herpes Simplex Virus-2 Infection. J. Immunol. 173: 1908-1913 [Abstract] [Full Text]  
• Yamamoto, M., Kweon, M.-N., Rennert, P. D., Hiroi, T., Fujihashi, K., McGhee, J. R., Kiyono, H. (2004). Role of Gut-Associated Lymphoreticular Tissues in Antigen-Specific Intestinal IgA Immunity. J. Immunol. 173: 762-769 [Abstract] [Full Text]  
• Chen, M.-C., Hwang, M.-J., Chou, Y.-C., Chen, W.-H., Cheng, G., Nakano, H., Luh, T.-Y., Mai, S.-C., Hsieh, S.-L. (2003). The Role of Apoptosis Signal-regulating Kinase 1 in Lymphotoxin-beta Receptor-mediated Cell Death. J. Biol. Chem. 278: 16073-16081 [Abstract] [Full Text]  
• Hagiwara, Y., McGhee, J. R., Fujihashi, K., Kobayashi, R., Yoshino, N., Kataoka, K., Etani, Y., Kweon, M.-N., Tamura, S., Kurata, T., Takeda, Y., Kiyono, H., Fujihashi, K. (2003). Protective Mucosal Immunity in Aging Is Associated with Functional CD4+ T Cells in Nasopharyngeal-Associated Lymphoreticular Tissue. J. Immunol. 170: 1754-1762 [Abstract] [Full Text]  
• Wang, E. C. Y., Thern, A., Denzel, A., Kitson, J., Farrow, S. N., Owen, M. J. (2001). DR3 Regulates Negative Selection during Thymocyte Development. Mol. Cell. Biol. 21: 3451-3461 [Abstract] [Full Text]  
• Fujihashi, K., Dohi, T., Rennert, P. D., Yamamoto, M., Koga, T., Kiyono, H., McGhee, J. R. (2001). Peyer's patches are required for oral tolerance to proteins. Proc. Natl. Acad. Sci. USA 98: 3310-3315 [Abstract] [Full Text]  
• Yamamoto, M., Rennert, P., McGhee, J. R., Kweon, M.-N., Yamamoto, S., Dohi, T., Otake, S., Bluethmann, H., Fujihashi, K., Kiyono, H. (2000). Alternate Mucosal Immune System: Organized Peyer's Patches Are Not Required for IgA Responses in the Gastrointestinal Tract. J. Immunol. 164: 5184-5191 [Abstract] [Full Text]  
• Lee, B. J., Santee, S., Von Gesjen, S., Ware, C. F., Sarawar, S. R. (2000). Lymphotoxin-alpha -Deficient Mice Can Clear a Productive Infection with Murine Gammaherpesvirus 68 but Fail To Develop Splenomegaly or Lymphocytosis. J. Virol. 74: 2786-2792 [Abstract] [Full Text]  
• Kuprash23, D. V., Alimzhanov2, M. B., Tumanov2, A. V., Anderson, A. O., Pfeffer, K., Nedospasov, S. A. (1999). TNF and Lymphotoxin {beta} Cooperate in the Maintenance of Secondary Lymphoid Tissue Microarchitecture But Not in the Development of Lymph Nodes. J. Immunol. 163: 6575-6580 [Abstract] [Full Text]  
• Ito, D., Back, T. C., Shakhov, A. N., Wiltrout, R. H., Nedospasov, S. A. (1999). Mice with a Targeted Mutation in Lymphotoxin-{alpha} Exhibit Enhanced Tumor Growth and Metastasis: Impaired NK Cell Development and Recruitment. J. Immunol. 163: 2809-2815 [Abstract] [Full Text]  
• Matsumoto, M., Iwamasa, K., Rennert, P. D., Yamada, T., Suzuki, R., Matsushima, A., Okabe, M., Fujita, S., Yokoyama, M. (1999). Involvement of Distinct Cellular Compartments in the Abnormal Lymphoid Organogenesis in Lymphotoxin-{alpha}-Deficient Mice and Alymphoplasia (aly) Mice Defined by the Chimeric Analysis. J. Immunol. 163: 1584-1591 [Abstract] [Full Text]  
• Lindhout, E., van Eijk, M., van Pel, M., Lindeman, J., Dinant, H. J., de Groot, C. (1999). Fibroblast-Like Synoviocytes from Rheumatoid Arthritis Patients Have Intrinsic Properties of Follicular Dendritic Cells. J. Immunol. 162: 5949-5956 [Abstract] [Full Text]  
• Cuff, C. A., Sacca, R., Ruddle, N. H. (1999). Differential Induction of Adhesion Molecule and Chemokine Expression by LT{alpha}3 and LT{alpha}{beta} in Inflammation Elucidates Potential Mechanisms of Mesenteric and Peripheral Lymph Node Development. J. Immunol. 162: 5965-5972 [Abstract] [Full Text]  
• HogenEsch, H., Janke, S., Boggess, D., Sundberg, J. P. (1999). Absence of Peyer's Patches and Abnormal Lymphoid Architecture in Chronic Proliferative Dermatitis (cpdm/cpdm) Mice. J. Immunol. 162: 3890-3896 [Abstract] [Full Text]  
• Koni, P. A., Flavell, R. A. (1999). Lymph Node Germinal Centers Form in the Absence of Follicular Dendritic Cell Networks. J. Exp. Med. 189: 855-864 [Abstract] [Full Text]  

Home | Help | Feedback | Subscriptions | Archive | Search

TABLE OF CONTENTS