|
|
|
|
|
|
|
||
J. Exp. Med.,
Volume 187, Number 10, May 18, 1998 1633-1640
By
§
From the * Division of Pulmonary & Critical Care Medicine, University of Washington, Seattle,
Washington 98104; the Previous studies in murine models, including those using the Infectious Disease Research Institute, Seattle, Washington 98104; the § Corixa Corporation, Seattle, Washington 98104; and the Fred Hutchinson Cancer Research Center,
Seattle, Washington 98104
2 microglobulin knockout
mouse, have suggested an important role for CD8+ T cells in host defense to Mycobacterium tuberculosis (Mtb). At present, little is understood about these cells in the human immune response
to tuberculosis. This report demonstrates the existence of human Mtb-reactive CD8+ T cells.
These cells are present preferentially in persons infected with Mtb and produce interferon 
in
response to stimulation with Mtb-infected target cells. Recognition of Mtb-infected cells by these CD8+ T cells is restricted neither by the major histocompatibility complex (MHC) class I
A, B, or C alleles nor by CD1, although it is inhibited by anti-MHC class I antibody. The
Mtb-specific CD8+ T cells recognize an antigen which is generated in the proteasome, but
which does not require transport through the Golgi-ER. The data suggest the possible use of
nonpolymorphic MHC class Ib antigen presenting structures other than CD1.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
| TABLE OF CONTENTS |
|
