J. Exp. Med.
© The Rockefeller University Press
0022-1007/97/10/1277/09 $2.00
Volume 186, Number 8, October 20, 1997 1277-1285

The Common Cytokine Receptor  Chain Controls Survival of / T Cells

By Marie Malissen,^* Pablo Pereira, David J. Gerber,^§ Bernard Malissen,^* and James P. DiSanto

From the ^* Centre d'Immunologie Institut National de la Santé et de la Recherche Médicale-Centre National de la Recherche Scientifique de Marseille Luminy, Case 906, 13288 Marseille Cedex 9, France;  Unité d'Immunologie, Centre National de la Recherche Scientifique Unité Recherche Associée 1961, Institut Pasteur, 75724 Paris, France; ^§ Center for Cancer Research, Massachusetts Institute of Technology, 02139 Cambridge, Massachusetts; and  INSERM U429, Hôpital Necker-Enfants Malades, 75743 Paris, France

We have investigated the role of common  chain (_c)-signaling pathways for the development of T cell receptor for antigen (TCR)-/ T cells. TCR-/-bearing cells were absent from the adult thymus, spleen, and skin of _c-deficient (_c) mice, whereas small numbers of thymocytes expressing low levels of TCR-/ were detected during fetal life. Recent reports have suggested that signaling via interleukin (IL)-7 plays a major role in facilitating TCR-/ development through induction of V-J (variable-joining) rearrangements at the TCR- locus. In contrast, we detected clearly TCR- rearrangements in fetal thymi from _c mice (which fail to signal in response to IL-7) and reduced TCR- rearrangements in adult _c thymi. No gross defects in TCR- or TCR- rearrangements were observed in _c mice of any age. Introduction of productively rearranged TCR V1 or TCR V1/V6 transgenes onto mice bearing the _c mutation did not restore TCR-/ development to normal levels suggesting that _c-dependent pathways provide additional signals to developing / T cells other than for the recombination process. Bcl-2 levels in transgenic thymocytes from _c mice were dramatically reduced compared to _c⁺ transgenic littermates. We favor the concept that _c-dependent receptors are required for the maintenance of TCR-/ cells and contribute to the completion of TCR- rearrangements primarily by promoting survival of cells committed to the TCR-/ lineage.

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