J. Exp. Med., Volume 186, Number 12, December 15, 1997 2075-2080

BRIEF DEFINITIVE REPORT:
TRANCE (Tumor Necrosis Factor [TNF]-related Activation-induced Cytokine), a New TNF Family Member Predominantly Expressed in T cells, Is a Dendritic Cell-specific Survival Factor

By Brian R. Wong,^§ Régis Josien, Soo Young Lee,^§ Birthe Sauter, Hong-Li Li, Ralph M. Steinman, and Yongwon Choi^*§

From the ^* Howard Hughes Medical Insitute; the  Laboratory of Cellular Physiology and Immunology; and the ^§ Laboratory of Immunology, The Rockefeller University, New York 10021

TRANCE (tumor necrosis factor [TNF]-related activation-induced cytokine) is a new member of the TNF family that is induced upon T cell receptor engagement and activates c-Jun N-terminal kinase (JNK) after interaction with its putative receptor (TRANCE-R). In addition, TRANCE expression is restricted to lymphoid organs and T cells. Here, we show that high levels of TRANCE-R are detected on mature dendritic cells (DCs) but not on freshly isolated B cells, T cells, or macrophages. Signaling by TRANCE-R appears to be dependent on TNF receptor-associated factor 2 (TRAF2), since JNK induction is impaired in cells from transgenic mice overexpressing a dominant negative TRAF2 protein. TRANCE inhibits apoptosis of mouse bone marrow-derived DCs and human monocyte-derived DCs in vitro. The resulting increase in DC survival is accompanied by a proportional increase in DC-mediated T cell proliferation in a mixed leukocyte reaction. TRANCE upregulates Bcl-x_L expression, suggesting a potential mechanism for enhanced DC survival. TRANCE does not induce the proliferation of or increase the survival of T or B cells. Therefore, TRANCE is a new DC-restricted survival factor that mediates T cell-DC communication and may provide a tool to selectively enhance DC activity.

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• Muller, I., Pfister, S. M., Grohs, U., Zweigner, J., Handgretinger, R., Niethammer, D., Bruchelt, G. (2003). Receptor Activator of Nuclear Factor {kappa}B Ligand Plays a Nonredundant Role in Doxorubicin-induced Apoptosis. Cancer Res. 63: 1772-1775 [Abstract] [Full Text]  
• Messmer, D., Messmer, B., Chiorazzi, N. (2003). The global transcriptional maturation program and stimuli-specific gene expression profiles of human myeloid dendritic cells. Int Immunol 15: 491-503 [Abstract] [Full Text]  
• Varsani, H., Patel, A., van Kooyk, Y., Woo, P., Wedderburn, L. R. (2003). Synovial dendritic cells in juvenile idiopathic arthritis (JIA) express receptor activator of NF-{kappa}B (RANK). Rheumatology (Oxford) 42: 583-590 [Abstract] [Full Text]  
• Yu, Q., Gu, J. X., Kovacs, C., Freedman, J., Thomas, E. K., Ostrowski, M. A. (2003). Cooperation of TNF Family Members CD40 Ligand, Receptor Activator of NF-{kappa}B Ligand, and TNF-{alpha} in the Activation of Dendritic Cells and the Expansion of Viral Specific CD8+ T Cell Memory Responses in HIV-1-Infected and HIV-1-Uninfected Individuals . J. Immunol. 170: 1797-1805 [Abstract] [Full Text]  
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• Matsui, H., Hikichi, Y., Tsuji, I., Yamada, T., Shintani, Y. (2002). LIGHT, a Member of the Tumor Necrosis Factor Ligand Superfamily, Prevents Tumor Necrosis Factor-alpha -mediated Human Primary Hepatocyte Apoptosis, but Not Fas-mediated Apoptosis. J. Biol. Chem. 277: 50054-50061 [Abstract] [Full Text]  
• Crotti, T N, Smith, M D, Weedon, H, Ahern, M J, Findlay, D M, Kraan, M, Tak, P P, Haynes, D R (2002). Receptor activator NF-{kappa}B ligand (RANKL) expression in synovial tissue from patients with rheumatoid arthritis, spondyloarthropathy, osteoarthritis, and from normal patients: semiquantitative and quantitative analysis. Ann Rheum Dis 61: 1047-1054 [Abstract] [Full Text]  
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• Jones, D H., Kong, Y-Y, Penninger, J M (2002). Role of RANKL and RANK in bone loss and arthritis. Ann Rheum Dis 61: ii32-39 [Abstract] [Full Text]  
• Gravallese, E M (2002). Bone destruction in arthritis. Ann Rheum Dis 61: ii84-86 [Abstract] [Full Text]  
• Rizzitelli, A., Berthier, R., Collin, V., Candeias, S. M., Marche, P. N. (2002). T Lymphocytes Potentiate Murine Dendritic Cells to Produce IL-12. J. Immunol. 169: 4237-4245 [Abstract] [Full Text]  
• Arron, J. R., Pewzner-Jung, Y., Walsh, M. C., Kobayashi, T., Choi, Y. (2002). Regulation of the Subcellular Localization of Tumor Necrosis Factor Receptor-associated Factor (TRAF)2 by TRAF1 Reveals Mechanisms of TRAF2 Signaling. J. Exp. Med. 196: 923-934 [Abstract] [Full Text]  
• Williamson, E., Bilsborough, J. M., Viney, J. L. (2002). Regulation of Mucosal Dendritic Cell Function by Receptor Activator of NF-{kappa}B (RANK)/RANK Ligand Interactions: Impact on Tolerance Induction. J. Immunol. 169: 3606-3612 [Abstract] [Full Text]  
• Nopora, A., Brocker, T. (2002). Bcl-2 Controls Dendritic Cell Longevity In Vivo. J. Immunol. 169: 3006-3014 [Abstract] [Full Text]  
• Bykovskaia, S. N., Shurin, G. V., Graner, S., Bunker, M. L., Olson, W., Thomas, R., Shurin, M. R., Marks, S., Storkus, W. J., Shogan, J. (2002). Differentiation of Immunostimulatory Stem-Cell- and Monocyte-Derived Dendritic Cells Involves Maturation of Intracellular Compartments Responsible for Antigen Presentation and Secretion. Stem Cells 20: 380-393 [Abstract] [Full Text]  
• Takami, M., Kim, N., Rho, J., Choi, Y. (2002). Stimulation by Toll-Like Receptors Inhibits Osteoclast Differentiation. J. Immunol. 169: 1516-1523 [Abstract] [Full Text]  
• Wittmann, M., Kienlin, P., Mommert, S., Kapp, A., Werfel, T. (2002). Suppression of IL-12 Production by Soluble CD40 Ligand: Evidence for Involvement of the p44/42 Mitogen-Activated Protein Kinase Pathway. J. Immunol. 168: 3793-3800 [Abstract] [Full Text]  
• Schoppet, M., Preissner, K. T., Hofbauer, L. C. (2002). RANK Ligand and Osteoprotegerin: Paracrine Regulators of Bone Metabolism and Vascular Function. Arterioscler. Thromb. Vasc. Bio. 22: 549-553 [Abstract] [Full Text]  
• Kim, Y.-M., Kim, Y.-M., Lee, Y. M., Kim, H.-S., Kim, J. D., Choi, Y., Kim, K.-W., Lee, S.-Y., Kwon, Y.-G. (2002). TNF-related Activation-induced Cytokine (TRANCE) Induces Angiogenesis through the Activation of Src and Phospholipase C (PLC) in Human Endothelial Cells. J. Biol. Chem. 277: 6799-6805 [Abstract] [Full Text]  
• Kim, H.-J., Yoon, M.-J., Lee, J., Penninger, J. M., Kong, Y.-Y. (2002). Osteoprotegerin Ligand Induces beta -Casein Gene Expression through the Transcription Factor CCAAT/Enhancer-binding Protein beta. J. Biol. Chem. 277: 5339-5344 [Abstract] [Full Text]  
• Park, Y., Lee, S. W., Sung, Y. C. (2002). Cutting Edge: CpG DNA Inhibits Dendritic Cell Apoptosis by Up-Regulating Cellular Inhibitor of Apoptosis Proteins Through the Phosphatidylinositide-3'-OH Kinase Pathway. J. Immunol. 168: 5-8 [Abstract] [Full Text]  
• Kato, K., Takaue, Y., Wakasugi, H. (2001). T-cell-conditioned medium efficiently induces the maturation and function of human dendritic cells. J. Leukoc. Biol. 70: 941-949 [Abstract] [Full Text]  
• Khosla, S. (2001). Minireview: The OPG/RANKL/RANK System. Endocrinology 142: 5050-5055 [Abstract] [Full Text]  
• Hsieh, S.-M., Pan, S.-C., Hung, C.-C., Tsai, H.-C., Chen, M.-Y., Lee, C.-N., Chang, S.-C. (2001). Kinetics of Antigen-Induced Phenotypic and Functional Maturation of Human Monocyte-Derived Dendritic Cells. J. Immunol. 167: 6286-6291 [Abstract] [Full Text]  
• Pettit, A. R., Ji, H., von Stechow, D., Muller, R., Goldring, S. R., Choi, Y., Benoist, C., Gravallese, E. M. (2001). TRANCE/RANKL Knockout Mice Are Protected from Bone Erosion in a Serum Transfer Model of Arthritis. Am. J. Pathol. 159: 1689-1699 [Abstract] [Full Text]  
• Lean, J. M., Fuller, K., Chambers, T. J. (2001). FLT3 ligand can substitute for macrophage colony-stimulating factor in support of osteoclast differentiation and function. Blood 98: 2707-2713 [Abstract] [Full Text]  
• Fiumara, P., Snell, V., Li, Y., Mukhopadhyay, A., Younes, M., Gillenwater, A. M., Cabanillas, F., Aggarwal, B. B., Younes, A. (2001). Functional expression of receptor activator of nuclear factor kappa B in Hodgkin disease cell lines. Blood 98: 2784-2790 [Abstract] [Full Text]  
• Trevejo, J. M., Marino, M. W., Philpott, N., Josien, R., Richards, E. C., Elkon, K. B., Falck-Pedersen, E. (2001). TNF-alpha -dependent maturation of local dendritic cells is critical for activating the adaptive immune response to virus infection. Proc. Natl. Acad. Sci. USA 10.1073/pnas.211423598v1 [Abstract] [Full Text]  
• Medema, J. P., Schuurhuis, D. H., Rea, D., van Tongeren, J., de Jong, J., Bres, S. A., Laban, S., Toes, R. E.M., Toebes, M., Schumacher, T. N.M., Bladergroen, B. A., Ossendorp, F., Kummer, J. A., Melief, C. J.M., Offringa, R. (2001). Expression of the Serpin Serine Protease Inhibitor 6 Protects Dendritic Cells from Cytotoxic T Lymphocyte-induced Apoptosis: Differential Modulation by T Helper Type 1 and Type 2 Cells. J. Exp. Med. 194: 657-668 [Abstract] [Full Text]  
• Ma, Y. L., Cain, R. L., Halladay, D. L., Yang, X., Zeng, Q., Miles, R. R., Chandrasekhar, S., Martin, T. J., Onyia, J. E. (2001). Catabolic Effects of Continuous Human PTH (1-38) in Vivo Is Associated with Sustained Stimulation of RANKL and Inhibition of Osteoprotegerin and Gene-Associated Bone Formation. Endocrinology 142: 4047-4054 [Abstract] [Full Text]  
• Manabe, N., Kawaguchi, H., Chikuda, H., Miyaura, C., Inada, M., Nagai, R., Nabeshima, Y.-i., Nakamura, K., Sinclair, A. M., Scheuermann, R. H., Kuro-o, M. (2001). Connection Between B Lymphocyte and Osteoclast Differentiation Pathways. J. Immunol. 167: 2625-2631 [Abstract] [Full Text]  
• Ndhlovu, L. C., Ishii, N., Murata, K., Sato, T., Sugamura, K. (2001). Critical Involvement of OX40 Ligand Signals in the T Cell Priming Events During Experimental Autoimmune Encephalomyelitis. J. Immunol. 167: 2991-2999 [Abstract] [Full Text]  
• Lee, Z. H., Kwack, K., Kim, K. K., Lee, S. H., Kim, H.-H. (2001). Activation of c-Jun N-Terminal Kinase and Activator Protein 1 by Receptor Activator of Nuclear Factor kappa B. Mol. Pharmacol. 58: 1536-1545 [Abstract] [Full Text]  
• Ikeda, T., Kasai, M., Utsuyama, M., Hirokawa, K. (2001). Determination of Three Isoforms of the Receptor Activator of Nuclear Factor-{{kappa}}B Ligand and Their Differential Expression in Bone and Thymus. Endocrinology 142: 1419-1426 [Abstract] [Full Text]  
• Yun, T. J., Tallquist, M. D., Aicher, A., Rafferty, K. L., Marshall, A. J., Moon, J. J., Ewings, M. K., Mohaupt, M., Herring, S. W., Clark, E. A. (2001). Osteoprotegerin, a Crucial Regulator of Bone Metabolism, Also Regulates B Cell Development and Function. J. Immunol. 166: 1482-1491 [Abstract] [Full Text]  
• Ho, L.-J., Wang, J.-J., Shaio, M.-F., Kao, C.-L., Chang, D.-M., Han, S.-W., Lai, J.-H. (2001). Infection of Human Dendritic Cells by Dengue Virus Causes Cell Maturation and Cytokine Production. J. Immunol. 166: 1499-1506 [Abstract] [Full Text]  
• Chen, N.-J., Huang, M.-W., Hsieh, S.-L. (2001). Enhanced Secretion of IFN-{{gamma}} by Activated Th1 Cells Occurs Via Reverse Signaling Through TNF-Related Activation-Induced Cytokine. J. Immunol. 166: 270-276 [Abstract] [Full Text]  
• Miyamoto, T., Arai, F., Ohneda, O., Takagi, K., Anderson, D. M., Suda, T. (2000). An adherent condition is required for formation of multinuclear osteoclasts in the presence of macrophage colony-stimulating factor and receptor activator of nuclear factor kappa B ligand. Blood 96: 4335-4343 [Abstract] [Full Text]  
• Kim, D., Mebius, R. E., MacMicking, J. D., Jung, S., Cupedo, T., Castellanos, Y., Rho, J., Wong, B. R., Josien, R., Kim, N., Rennert, P. D., Choi, Y. (2000). Regulation of Peripheral Lymph Node Genesis by the Tumor Necrosis Factor Family Member TRANCE. J. Exp. Med. 192: 1467-1478 [Abstract] [Full Text]  
• Fox, S. W., Fuller, K., Bayley, K. E., Lean, J. M., Chambers, T. J. (2000). TGF-{beta}1 and IFN-{gamma} Direct Macrophage Activation by TNF-{alpha} to Osteoclastic or Cytocidal Phenotype. J. Immunol. 165: 4957-4963 [Abstract] [Full Text]  
• Goldring, S. R (2000). The final pathogenetic steps in focal bone erosions in rheumatoid arthritis. Ann Rheum Dis 59: i72-74 [Full Text]  
• Grcevic, D., Lee, S.-K., Marusic, A., Lorenzo, J. A. (2000). Depletion of CD4 and CD8 T Lymphocytes in Mice In Vivo Enhances 1,25-Dihydroxyvitamin D3-Stimulated Osteoclast-Like Cell Formation In Vitro by a Mechanism That Is Dependent on Prostaglandin Synthesis. J. Immunol. 165: 4231-4238 [Abstract] [Full Text]  
• Lanzavecchia, A., Sallusto, F. (2000). Dynamics of T Lymphocyte Responses: Intermediates, Effectors, and Memory Cells. Science 290: 92-97 [Abstract] [Full Text]  

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