J. Exp. Med.
© The Rockefeller University Press
0022-1007/97/03/825/08 $2.00
Volume 185, Number 5, March 3, 1997 825-832

Selective Expression of an Interleukin-12 Receptor Component by Human T Helper 1 Cells

By Lars Rogge,^* Luisella Barberis-Maino,^* Mauro Biffi,^* Nadia Passini,^* David H. Presky, Ueli Gubler, and Francesco Sinigaglia^*

From ^* Roche Milano Ricerche, I-20132 Milan, Italy; and  Department of Inflammation/ Autoimmune Diseases, Hoffmann-La Roche Inc., Nutley, New Jersey 07110

Interleukin-12 (IL-12), a heterodimeric cytokine produced by activated monocytes and dendritic cells, plays a crucial role in regulating interferon (IFN)- production and in the generation of IFN--producing T helper 1 (Th1) cells. Here we show that the IL-12 receptor (IL12R) 2 subunit, a recently cloned binding and signal transducing component of the IL-12R, is expressed on human Th1 but not Th2 clones and is induced during differentiation of human naive cells along the Th1 but not the Th2 pathway. IL-12 and type I but not type II interferons induce expression of the IL-12R 2 chain during in vitro T cell differentiation after antigen receptor triggering. The selective expression and regulation of the IL-12R 2 subunit may help to understand the basis of Th1/Th2 differentiation and may provide therapeutic options for altering the Th1/Th2 balance in several immuno-pathological conditions such as autoimmune diseases and allergies.

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• Wang, K. S., Zorn, E., Ritz, J. (2001). Specific down-regulation of interleukin-12 signaling through induction of phospho-STAT4 protein degradation. Blood 97: 3860-3866 [Abstract] [Full Text]  
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• Banchereau, J., Pulendran, B., Steinman, R., Palucka, K. (2000). Will the Making of Plasmacytoid Dendritic Cells In Vitro Help Unravel Their Mysteries?. J. Exp. Med. 192: F39-F44 [Full Text]  
• Parrello, T., Monteleone, G., Cucchiara, S., Monteleone, I., Sebkova, L., Doldo, P., Luzza, F., Pallone, F. (2000). Up-Regulation of the IL-12 Receptor {beta}2 Chain in Crohn's Disease. J. Immunol. 165: 7234-7239 [Abstract] [Full Text]  
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• Wu, C.-y., Wang, X., Gadina, M., O'Shea, J. J., Presky, D. H., Magram, J. (2000). IL-12 Receptor {beta}2 (IL-12R{beta}2)-Deficient Mice Are Defective in IL-12-Mediated Signaling Despite the Presence of High Affinity IL-12 Binding Sites. J. Immunol. 165: 6221-6228 [Abstract] [Full Text]  
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• Fantuzzi, L., Puddu, P., Varano, B., Del Cornò, M., Belardelli, F., Gessani, S. (2000). IFN-{alpha} and IL-18 exert opposite regulatory effects on the IL-12 receptor expression and IL-12-induced IFN-{gamma} production in mouse macrophages: novel pathways in the regulation of the inflammatory response of macrophages. J. Leukoc. Biol. 68: 707-714 [Abstract] [Full Text]  
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• Avice, M.-N., Rubio, M., Sergerie, M., Delespesse, G., Sarfati, M. (2000). CD47 Ligation Selectively Inhibits the Development of Human Naive T Cells into Th1 Effectors. J. Immunol. 165: 4624-4631 [Abstract] [Full Text]  
• Gollob, J. A., Veenstra, K. G., Jyonouchi, H., Kelly, A. M., Ferrieri, P., Panka, D. J., Altare, F., Fieschi, C., Casanova, J.-L., Frank, D. A., Mier, J. W. (2000). Impairment of STAT Activation by IL-12 in a Patient with Atypical Mycobacterial and Staphylococcal Infections. J. Immunol. 165: 4120-4126 [Abstract] [Full Text]  
• SINIGAGLIA, F., D'AMBROSIO, D. (2000). Regulation of Helper T Cell Differentiation and Recruitment in Airway Inflammation. Am. J. Respir. Crit. Care Med. 162: S157-160 [Abstract] [Full Text]  
• Elhofy, A., Marriott, I., Bost, K. L. (2000). Salmonella Infection Does Not Increase Expression and Activity of the High Affinity IL-12 Receptor. J. Immunol. 165: 3324-3332 [Abstract] [Full Text]  
• KAPSENBERG, M. L., HILKENS, C. M. U., van der POUW KRAAN, T. C. M. T., WIERENGA, E. A., KALINSKI, P. (2000). Atopic Allergy: A Failure of Antigen-Presenting Cells to Properly Polarize Helper T Cells?. Am. J. Respir. Crit. Care Med. 162: S76-80 [Full Text]  
• WIERENGA, E. A., MESSER, G. (2000). Regulation of Interleukin 4 Gene Transcription . Alterations in Atopic Disease?. Am. J. Respir. Crit. Care Med. 162: S81-85 [Full Text]  
• Varga, E. M., Wachholz, P., Nouri-Aria, K. T., Verhoef, A., Corrigan, C. J., Till, S. J., Durham, S. R. (2000). T Cells from Human Allergen-Induced Late Asthmatic Responses Express IL-12 Receptor {beta}2 Subunit mRNA and Respond to IL-12 In Vitro. J. Immunol. 165: 2877-2885 [Abstract] [Full Text]  
• Sareneva, T., Julkunen, I., Matikainen, S. (2000). IFN-{alpha} and IL-12 Induce IL-18 Receptor Gene Expression in Human NK and T Cells. J. Immunol. 165: 1933-1938 [Abstract] [Full Text]  
• Verhagen, C. E., de Boer, T., Smits, H. H., Verreck, F. A.W., Wierenga, E. A., Kurimoto, M., Lammas, D. A., Kumararatne, D. S., Sanal, O., Kroon, F. P., van Dissel, J. T., Sinigaglia, F., Ottenhoff, T. H.M. (2000). Residual Type 1 Immunity in Patients Genetically Deficient for Interleukin 12 Receptor {beta}1 (IL-12R{beta}1): Evidence for an IL-12R{beta}1-independent Pathway of IL-12 Responsiveness in Human T Cells. J. Exp. Med. 192: 517-528 [Abstract] [Full Text]  
• Yamauchi, P. S., Bleharski, J. R., Uyemura, K., Kim, J., Sieling, P. A., Miller, A., Brightbill, H., Schlienger, K., Rea, T. H., Modlin, R. L. (2000). A Role for CD40-CD40 Ligand Interactions in the Generation of Type 1 Cytokine Responses in Human Leprosy. J. Immunol. 165: 1506-1512 [Abstract] [Full Text]  
• Glimcher, L. H., Murphy, K. M. (2000). Lineage commitment in the immune system: the T helper lymphocyte grows up. Genes Dev. 14: 1693-1711 [Full Text]  
• Lee, H. J., Takemoto, N., Kurata, H., Kamogawa, Y., Miyatake, S., O'Garra, A., Arai, N. (2000). GATA-3 Induces T Helper Cell Type 2 (Th2) Cytokine Expression and Chromatin Remodeling in Committed Th1 Cells. J. Exp. Med. 192: 105-116 [Abstract] [Full Text]  
• Rempel, J. D., Wang, M., HayGlass, K. T. (2000). Failure of rIL-12 administration to inhibit established IgE responses in vivo is associated with enhanced IL-4 synthesis by non-B/non-T cells. Int Immunol 12: 1025-1034 [Abstract] [Full Text]  
• Kitani, A., Fuss, I. J., Nakamura, K., Schwartz, O. M., Usui, T., Strober, W. (2000). Treatment of Experimental (Trinitrobenzene Sulfonic Acid) Colitis by Intranasal Administration of Transforming Growth Factor (TGF)-{beta}1 Plasmid: TGF-{beta}1-mediated Suppression of T Helper Cell Type 1 Response Occurs by Interleukin (IL)-10 Induction and IL-12 Receptor {beta}2 Chain Downregulation. J. Exp. Med. 192: 41-52 [Abstract] [Full Text]  
• Ma, H., Kapp, J. A. (2000). Antigenic Epitopes Regulate the Phenotype of CD8+ CTL Primed by Exogenous Antigens. J. Immunol. 164: 5698-5703 [Abstract] [Full Text]  
• Wang, K. S., Frank, D. A., Ritz, J. (2000). Interleukin-2 enhances the response of natural killer cells to interleukin-12 through up-regulation of the interleukin-12 receptor and STAT4. Blood 95: 3183-3190 [Abstract] [Full Text]  
• METWALI, A., BLUM, A. M., LI, J., ELLIOTT, D. E., WEINSTOCK, J. V. (2000). IL-4 regulates VIP receptor subtype 2 mRNA (VPAC2) expression in T cells in murine schistosomiasis. FASEB J. 14: 948-954 [Abstract] [Full Text]  
• Iwasaki, M., Yu, W.-G., Uekusa, Y., Nakajima, C., Yang, Y.-F., Gao, P., Wijesuriya, R., Fujiwara, H., Hamaoka, T. (2000). Differential IL-12 responsiveness of T cells but not of NK cells from tumor-bearing mice in IL-12-responsive versus -unresponsive tumor models. Int Immunol 12: 701-709 [Abstract] [Full Text]  
• Pagenstecher, A., Lassmann, S., Carson, M. J., Kincaid, C. L., Stalder, A. K., Campbell, I. L. (2000). Astrocyte-Targeted Expression of IL-12 Induces Active Cellular Immune Responses in the Central Nervous System and Modulates Experimental Allergic Encephalomyelitis. J. Immunol. 164: 4481-4492 [Abstract] [Full Text]  
• Durbin, J. E., Fernandez-Sesma, A., Lee, C.-K., Rao, T. D., Frey, A. B., Moran, T. M., Vukmanovic, S., Garcia-Sastre, A., Levy, D. E. (2000). Type I IFN Modulates Innate and Specific Antiviral Immunity. J. Immunol. 164: 4220-4228 [Abstract] [Full Text]  
• Skrenta, H., Yang, Y., Pestka, S., Fathman, C. G. (2000). Ligand-Independent Down-Regulation of IFN-{gamma} Receptor 1 Following TCR Engagement. J. Immunol. 164: 3506-3511 [Abstract] [Full Text]  
• Miettinen, M., Lehtonen, A., Julkunen, I., Matikainen, S. (2000). Lactobacilli and Streptococci Activate NF-{kappa}B and STAT Signaling Pathways in Human Macrophages. J. Immunol. 164: 3733-3740 [Abstract] [Full Text]  
• Heath, V. L., Showe, L., Crain, C., Barrat, F. J., Trinchieri, G., O'Garra, A. (2000). Cutting Edge: Ectopic Expression of the IL-12 Receptor-{beta}2 in Developing and Committed Th2 Cells Does Not Affect the Production of IL-4 or Induce the Production of IFN-{gamma}. J. Immunol. 164: 2861-2865 [Abstract] [Full Text]  
• Schiavoni, G., Mattei, F., Di Pucchio, T., Santini, S. M., Bracci, L., Belardelli, F., Proietti, E. (2000). Cyclophosphamide induces type I interferon and augments the number of CD44hi T lymphocytes in mice: implications for strategies of chemoimmunotherapy of cancer. Blood 95: 2024-2030 [Abstract] [Full Text]  
• Nishikomori, R., Ehrhardt, R. O., Strober, W. (2000). T Helper Type 2 Cell Differentiation Occurs in the Presence of Interleukin 12 Receptor {beta}2 Chain Expression and Signaling. J. Exp. Med. 191: 847-858 [Abstract] [Full Text]  
• Tanaka, K., Ogawa, K., Sugamura, K., Nakamura, M., Takano, S., Nagata, K. (2000). Cutting Edge: Differential Production of Prostaglandin D2 by Human Helper T Cell Subsets. J. Immunol. 164: 2277-2280 [Abstract] [Full Text]  
• Tominaga, K., Yoshimoto, T., Torigoe, K., Kurimoto, M., Matsui, K., Hada, T., Okamura, H., Nakanishi, K. (2000). IL-12 synergizes with IL-18 or IL-1{beta} for IFN-{gamma} production from human T cells. Int Immunol 12: 151-160 [Abstract] [Full Text]  
• McRae, B. L., Beilfuss, B. A., Seventer, G. A. v. (2000). IFN-{beta} Differentially Regulates CD40-Induced Cytokine Secretion by Human Dendritic Cells. J. Immunol. 164: 23-28 [Abstract] [Full Text]  
• Castro, A. G., Hauser, T. M., Cocks, B. G., Abrams, J., Zurawski, S., Churakova, T., Zonin, F., Robinson, D., Tangye, S. G., Aversa, G., Nichols, K. E., de Vries, J. E., Lanier, L. L., O'Garra, A. (1999). Molecular and Functional Characterization of Mouse Signaling Lymphocytic Activation Molecule (SLAM): Differential Expression and Responsiveness in Th1 and Th2 Cells. J. Immunol. 163: 5860-5870 [Abstract] [Full Text]  
• Parronchi, P., Brugnolo, F., Annunziato, F., Manuelli, C., Sampognaro, S., Mavilia, C., Romagnani, S., Maggi, E. (1999). Phosphorothioate Oligodeoxynucleotides Promote the In Vitro Development of Human Allergen-Specific CD4+ T Cells into Th1 Effectors. J. Immunol. 163: 5946-5953 [Abstract] [Full Text]  
• Richter, A., Lohning, M., Radbruch, A. (1999). Instruction for Cytokine Expression in T Helper Lymphocytes in Relation to Proliferation and Cell Cycle Progression. J. Exp. Med. 190: 1439-1450 [Abstract] [Full Text]  
• Thibodeaux, D. K., Hunter, S. E., Waldburger, K. E., Bliss, J. L., Trepicchio, W. L., Sypek, J. P., Dunussi-Joannopoulos, K., Goldman, S. J., Leonard, J. P. (1999). Autocrine Regulation of IL-12 Receptor Expression Is Independent of Secondary IFN-{gamma} Secretion and not Restricted to T and NK Cells. J. Immunol. 163: 5257-5264 [Abstract] [Full Text]  
• Leal, I. S., Smedegard, B., Andersen, P., Appelberg, R. (1999). Interleukin-6 and Interleukin-12 Participate in Induction of a Type 1 Protective T-Cell Response during Vaccination with a Tuberculosis Subunit Vaccine. Infect. Immun. 67: 5747-5754 [Abstract] [Full Text]  
• Mitra, D. K., De Rosa, S. C., Luke, A., Balamurugan, A., Khaitan, B. K., Tung, J., Mehra, N. K., Terr, A. I., O'Garra, A., Herzenberg, L. A., Herzenberg, L. A., Roederer, M. (1999). Differential representations of memory T cell subsets are characteristic of polarized immunity in leprosy and atopic diseases. Int Immunol 11: 1801-1810 [Abstract] [Full Text]  
• Colantonio, L., Iellem, A., Clissi, B., Pardi, R., Rogge, L., Sinigaglia, F., D'Ambrosio, D. (1999). Upregulation of Integrin alpha 6/beta 1 and Chemokine Receptor CCR1 by Interleukin-12 Promotes the Migration of Human Type 1 Helper T Cells. Blood 94: 2981-2989 [Abstract] [Full Text]  
• Doyle, A. G., Buttigieg, K., Groves, P., Johnson, B. J., Kelso, A. (1999). The Activated Type 1-polarized CD8+ T Cell Population Isolated from an Effector Site Contains Cells with Flexible Cytokine Profiles. J. Exp. Med. 190: 1081-1092 [Abstract] [Full Text]  
• Skok, J., Poudrier, J., Gray, D. (1999). Dendritic Cell-Derived IL-12 Promotes B Cell Induction of Th2 Differentiation: A Feedback Regulation of Th1 Development. J. Immunol. 163: 4284-4291 [Abstract] [Full Text]  

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