J. Exp. Med.
© The Rockefeller University Press
0022-1007/97/01/165/06 $2.00
Volume 185 January 1997 165-170

BRIEF DEFINITIVE REPORT:
Follicular Dendritic Cells Specifically Express the Long CR2/CD21 Isoform

By Yong-Jun Liu,^* Jiangchun Xu, Odette de Bouteiller,^* Christi L. Parham, Géraldine Grouard,^* Odile Djossou,^* Blandine de Saint-Vis,^* Serge Lebecque,^* Jacques Banchereau,^* and Kevin W. Moore

From ^* Schering-Plough, Laboratory for Immunological Research, 69571 Dardilly Cedex, France; and  DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, California, 94304-1104

This paper describes an antibody (mAb 7D6) that specifically recognizes human follicular dendritic cells (FDCs). By expression cloning, a cDNA clone encoding for the long human CR2/ CD21 isoform (CD21L) that contains an additional exon (10a) was isolated. We demonstrated that FDCs selectively express CD21L, while B cells selectively express the short CR2/CD21 lacking exon 10a (CD21S). By screening mouse Ltk cells transfected with the CD21L cDNA, we further showed that the other two anti-human FDC mAbs DRC-1 and KiM4 also recognize CD21L. Thus, CD21L represents the first characterized human FDC-specific molecule, which may confer unique functions of FDCs in germinal center development.

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