|
|
|
|
|
|
|
||
By
From the Department of Immunology and Cell Biology, Cell Genesys Inc., Foster City, California
94404
Gene modification of hematopoietic stem cells (HSC) with antigen-specific, chimeric, or "universal" immune receptors (URs) is a novel but untested form of targeted immunotherapy. A
human immunodeficiency virus (HIV) envelope-specific UR consisting of the extracellular
domain of human CD4 linked to the 
chain of the T cell receptor (CD4) was introduced ex
vivo into murine HSC by retroviral transduction. After transplantation into immunodeficient SCID mice, sustained high level expression of CD4 was observed in circulating myeloid and
natural killer cells. CD4-transplanted mice were protected from challenge with a lethal dose of
a disseminated human leukemia expressing HIV envelope. These results demonstrate the ability
of chimeric receptors bearing -signaling domains to activate non-T cell effector populations
in vivo and thereby mediate systemic immunity.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
| TABLE OF CONTENTS |
|
