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J. Exp. Med.
© The Rockefeller University Press
0022-1007/96/12/2079/06 $2.00
Volume 184 December 1996 2079-2084

Counterselection against Dµ Is Mediated through Immunoglobulin (Ig)alpha -Igbeta

By Shiaoching Gong, Mercedes Sanchez, and Michel C. Nussenzweig

From the Laboratory of Molecular Immunology, The Howard Hughes Medical Institute, The Rockefeller University, New York 10021

The pre-B cell receptor is a key checkpoint regulator in developing B cells. Early events that are controlled by the pre-B cell receptor include positive selection for cells express membrane immunoglobulin heavy chains and negative selection against cells expressing truncated immunoglobulins that lack a complete variable region (Dµ). Positive selection is known to be mediated by membrane immunoglobulin heavy chains through Igalpha -Igbeta , whereas the mechanism for counterselection against Dµ has not been determined. We have examined the role of the Igalpha -Igbeta signal transducers in counterselection against Dµ using mice that lack Igbeta . We found that Dµ expression is not selected against in developing B cells in Igbeta mutant mice. Thus, the molecular mechanism for counterselection against Dµ in pre-B cells resembles positive selection in that it requires interaction between mDµ and Igalpha -Igbeta .


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