Delayed maturation of CD4- CD8- Fc gamma RII/III+ T and natural killer cell precursors in Fc epsilon RI gamma transgenic mice

doi:10.1084/jem.184.5.1725

This Article

	Full Text (PDF)
	Alert me when this article is cited
	Citation Map

Services

	Email this article
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new content in the JEM
	Download to citation manager

Citing Articles

	Citing Articles via HighWire
	Citing Articles via CrossRef
	Citing Articles via Google Scholar

Google Scholar

	Articles by Flamand, V.
	Articles by Love, P. E.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Flamand, V.
	Articles by Love, P. E.


Social Bookmarking

	What's this?

ARTICLES

Delayed maturation of CD4- CD8- Fc gamma RII/III+ T and natural killer cell precursors in Fc epsilon RI gamma transgenic mice

V Flamand, EW Shores, T Tran, K Huang, E Lee, A Grinberg, JP Kinet and PE Love
Laboratory of Molecular Allergy & Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852, USA.

Fc epsilon RI gamma (gamma) is a member of a group of related proteins (the zeta-family dimers) that function as signal-transducing components of both Fc receptors and the T cell antigen receptor (TCR). Analysis of gamma expression during fetal thymus ontogeny revealed that it is expressed in early thymocytes, before the initiation of clonotypic TCR- alpha and TCR-beta gene rearrangement but is down-regulated in most adult thymocytes. To explore a possible role for gamma in thymocyte development, we generated transgenic mice in which this protein was overexpressed at all stages of ontogeny. Overexpression of gamma inhibited the maturation of T cells as well as natural killer (NK) cells. The developmental effects were transgene dose related and correlated with markedly delayed maturation of fetal CD4-CD8- FcRII/III+ thymocytes, cells thought to include the progenitors of both T and NK cells. These results suggest that the zeta and gamma chains serve distinctive functions in thymocyte development and indicate that Fc receptor(s) may play an important role in regulating the differentiation of early progenitor cells within the thymus.
Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Add to Reddit Reddit Add to Technorati Technorati What's this?

This article has been cited by other articles:

Taylor, K. N., Shinde Patil, V. R., Colson, Y. L. (2006). Reconstitution of Allogeneic Hemopoietic Stem Cells: The Essential Role of FcR{gamma} and the TCR beta-Chain-FCp33 Complex. J. Immunol. 177: 1444-1450 [Abstract] [Full Text]
Petersson, K., Ivars, F. (2001). Early TCR {{alpha}}{{beta}} Expression Promotes Maturation of T Cells Expressing Fc{{epsilon}}RI{{gamma}} Containing TCR/CD3 Complexes. J. Immunol. 166: 6616-6624 [Abstract] [Full Text]
She, J., Ruzek, M. C., Velupillai, P., de Aos, I., Wang, B., Harn, D. A., Sancho, J., Biron, C. A., Terhorst, C. (1999). Generation of antigen-specific cytotoxic T lymphocytes and regulation of cytokine production takes place in the absence of CD3{zeta}. Int Immunol 11: 845-857 [Abstract] [Full Text]
de Andres, B., Mueller, A. L., Verbeek, S., Sandor, M., Lynch, R. G. (1998). A Regulatory Role for Fcgamma Receptors CD16 and CD32 in the Development of Murine B Cells. Blood 92: 2823-2829 [Abstract] [Full Text]
Shores, E. W., Ono, M., Kawabe, T., Sommers, C. L., Tran, T., Lui, K., Udey, M. C., Ravetch, J., Love, P. E. (1998). T Cell Development in Mice Lacking All T Cell Receptor zeta �Family Members (zeta , eta , and Fcepsilon RIgamma ). J. Exp. Med. 187: 1093-1101 [Abstract] [Full Text]