Increased interleukin 4 and immunoglobulin E production in transgenic mice overexpressing NK1 T cells

doi:10.1084/jem.184.4.1285

This Article

	Full Text (PDF)
	Alert me when this article is cited
	Citation Map

Services

	Email this article
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new content in the JEM
	Download to citation manager

Citing Articles

	Citing Articles via HighWire
	Citing Articles via CrossRef
	Citing Articles via Google Scholar

Google Scholar

	Articles by Bendelac, A.
	Articles by Lantz, O.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Bendelac, A.
	Articles by Lantz, O.


Social Bookmarking

	What's this?

ARTICLES

Increased interleukin 4 and immunoglobulin E production in transgenic mice overexpressing NK1 T cells

A Bendelac, RD Hunziker and O Lantz
Department of Molecular Biology, Princeton University, New Jersey 08544, USA.

Natural Killer (NK)1.1+ (NK1) T cells are a specialized subset of alpha/beta T cells that coexpress surface receptors that are normally associated with the NK cell lineage of the innate immune system. On recognition of the conserved, major histocompatibility complex class I- like CD1 molecule, these cells are able to release explosive bursts of interleukin 4 (IL-4), a cytokine that promotes the T helper type 2 (Th2) effector class of an immune response. A unique feature of their T cell receptor (TCR) repertoire is the expression of an invariant TCR alpha chain, V alpha 14-J alpha 281, and of a restricted but polyclonal set of V beta gene families, V beta 8, V beta 7, and V beta 2. Here, we show that transgenic expression of this TCR alpha chain during thymic development is sufficient information to bias the differentiation of mainstream thymocytes towards the NK1 developmental pathway. It markedly increases the frequency of cells with the NK1 pattern of T cell differentiation and also has drastic consequences for the selection of the V beta repertoire. Transgenic CD4 cells exhibited a 10- 100-fold increase in IL-4 production on mitogen stimulation in vitro and in vivo, and baseline levels of the Th2-controlled serum immunoglobulin isotypes, IgE and IgG1, were also selectively elevated in vivo.
Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Add to Reddit Reddit Add to Technorati Technorati What's this?

This article has been cited by other articles:

Wakao, H., Wakao, R., Sakata, S., Iwabuchi, K., Oda, A., Fujita, H. (2008). In vitro induction of natural killer T cells from embryonic stem cells prepared using somatic cell nuclear transfer. FASEB J. 22: 2223-2231 [Abstract] [Full Text]
Leadbetter, E. A., Brigl, M., Illarionov, P., Cohen, N., Luteran, M. C., Pillai, S., Besra, G. S., Brenner, M. B. (2008). NK T cells provide lipid antigen-specific cognate help for B cells. Proc. Natl. Acad. Sci. USA 105: 8339-8344 [Abstract] [Full Text]
Wakao, H., Kawamoto, H., Sakata, S., Inoue, K., Ogura, A., Wakao, R., Oda, A., Fujita, H. (2007). A Novel Mouse Model for Invariant NKT Cell Study. J. Immunol. 179: 3888-3895 [Abstract] [Full Text]
Thedrez, A., de Lalla, C., Allain, S., Zaccagnino, L., Sidobre, S., Garavaglia, C., Borsellino, G., Dellabona, P., Bonneville, M., Scotet, E., Casorati, G. (2007). CD4 engagement by CD1d potentiates activation of CD4+ invariant NKT cells. Blood 110: 251-258 [Abstract] [Full Text]
VanderLaan, P. A., Reardon, C. A., Sagiv, Y., Blachowicz, L., Lukens, J., Nissenbaum, M., Wang, C.-R., Getz, G. S. (2007). Characterization of the Natural Killer T-Cell Response in an Adoptive Transfer Model of Atherosclerosis. Am. J. Pathol. 170: 1100-1107 [Abstract] [Full Text]
Zullo, A. J., Benlagha, K., Bendelac, A., Taparowsky, E. J. (2007). Sensitivity of NK1.1-Negative NKT Cells to Transgenic BATF Defines a Role for Activator Protein-1 in the Expansion and Maturation of Immature NKT Cells in the Thymus. J. Immunol. 178: 58-66 [Abstract] [Full Text]
Wei, D. G., Curran, S. A., Savage, P. B., Teyton, L., Bendelac, A. (2006). Mechanisms imposing the V{beta} bias of V{alpha}14 natural killer T cells and consequences for microbial glycolipid recognition. J. Exp. Med. 203: 1197-1207 [Abstract] [Full Text]
Kawachi, I., Maldonado, J., Strader, C., Gilfillan, S. (2006). MR1-Restricted V{alpha}19i Mucosal-Associated Invariant T Cells Are Innate T Cells in the Gut Lamina Propria That Provide a Rapid and Diverse Cytokine Response. J. Immunol. 176: 1618-1627 [Abstract] [Full Text]
Benlagha, K., Wei, D. G., Veiga, J., Teyton, L., Bendelac, A. (2005). Characterization of the early stages of thymic NKT cell development. J. Exp. Med. 202: 485-492 [Abstract] [Full Text]
Wei, D. G., Lee, H., Park, S.-H., Beaudoin, L., Teyton, L., Lehuen, A., Bendelac, A. (2005). Expansion and long-range differentiation of the NKT cell lineage in mice expressing CD1d exclusively on cortical thymocytes. J. Exp. Med. 202: 239-248 [Abstract] [Full Text]
Ronet, C., Darche, S., de Moraes, M. L., Miyake, S., Yamamura, T., Louis, J. A., Kasper, L. H., Buzoni-Gatel, D. (2005). NKT Cells Are Critical for the Initiation of an Inflammatory Bowel Response against Toxoplasma gondii. J. Immunol. 175: 899-908 [Abstract] [Full Text]
Bezbradica, J. S., Hill, T., Stanic, A. K., Van Kaer, L., Joyce, S. (2005). Commitment toward the natural T (iNKT) cell lineage occurs at the CD4+8+ stage of thymic ontogeny. Proc. Natl. Acad. Sci. USA 102: 5114-5119 [Abstract] [Full Text]
Hashimoto, D., Asakura, S., Miyake, S., Yamamura, T., Van Kaer, L., Liu, C., Tanimoto, M., Teshima, T. (2005). Stimulation of Host NKT Cells by Synthetic Glycolipid Regulates Acute Graft-versus-Host Disease by Inducing Th2 Polarization of Donor T Cells. J. Immunol. 174: 551-556 [Abstract] [Full Text]
Duarte, N., Stenstrom, M., Campino, S., Bergman, M.-L., Lundholm, M., Holmberg, D., Cardell, S. L. (2004). Prevention of Diabetes in Nonobese Diabetic Mice Mediated by CD1d-Restricted Nonclassical NKT Cells. J. Immunol. 173: 3112-3118 [Abstract] [Full Text]
Fischer, K., Scotet, E., Niemeyer, M., Koebernick, H., Zerrahn, J., Maillet, S., Hurwitz, R., Kursar, M., Bonneville, M., Kaufmann, S. H. E., Schaible, U. E. (2004). Mycobacterial phosphatidylinositol mannoside is a natural antigen for CD1d-restricted T cells. Proc. Natl. Acad. Sci. USA 101: 10685-10690 [Abstract] [Full Text]
Gadue, P., Yin, L., Jain, S., Stein, P. L. (2004). Restoration of NK T Cell Development in fyn-Mutant Mice by a TCR Reveals a Requirement for Fyn During Early NK T Cell Ontogeny. J. Immunol. 172: 6093-6100 [Abstract] [Full Text]
Mayerova, D., Hogquist, K. A. (2004). Central Tolerance to Self-Antigen Expressed by Cortical Epithelial Cells. J. Immunol. 172: 851-856 [Abstract] [Full Text]
Forestier, C., Park, S.-H., Wei, D., Benlagha, K., Teyton, L., Bendelac, A. (2003). T Cell Development in Mice Expressing CD1d Directed by a Classical MHC Class II Promoter. J. Immunol. 171: 4096-4104 [Abstract] [Full Text]
Wilson, M. T., Johansson, C., Olivares-Villagomez, D., Singh, A. K., Stanic, A. K., Wang, C.-R., Joyce, S., Wick, M. J., Van Kaer, L. (2003). The response of natural killer T cells to glycolipid antigens is characterized by surface receptor down-modulation and expansion. Proc. Natl. Acad. Sci. USA 100: 10913-10918 [Abstract] [Full Text]
Johnston, B., Kim, C. H., Soler, D., Emoto, M., Butcher, E. C. (2003). Differential Chemokine Responses and Homing Patterns of Murine TCR{alpha}{beta} NKT Cell Subsets. J. Immunol. 171: 2960-2969 [Abstract] [Full Text]
Yoshimoto, T., Min, B., Sugimoto, T., Hayashi, N., Ishikawa, Y., Sasaki, Y., Hata, H., Takeda, K., Okumura, K., Van Kaer, L., Paul, W. E., Nakanishi, K. (2003). Nonredundant Roles for CD1d-restricted Natural Killer T Cells and Conventional CD4+ T Cells in the Induction of Immunoglobulin E Antibodies in Response to Interleukin 18 Treatment of Mice. J. Exp. Med. 197: 997-1005 [Abstract] [Full Text]
Ranson, T., Vosshenrich, C. A. J., Corcuff, E., Richard, O., Laloux, V., Lehuen, A., Di Santo, J. P. (2003). IL-15 availability conditions homeostasis of peripheral natural killer T cells. Proc. Natl. Acad. Sci. USA 100: 2663-2668 [Abstract] [Full Text]
Kuwata, K., Watanabe, H., Jiang, S.-Y., Yamamoto, T., Tomiyama-Miyaji, C., Abo, T., Miyazaki, T., Naito, M. (2003). AIM Inhibits Apoptosis of T Cells and NKT Cells in Corynebacterium-Induced Granuloma Formation in Mice. Am. J. Pathol. 162: 837-847 [Abstract] [Full Text]
Capone, M., Cantarella, D., Schumann, J., Naidenko, O. V., Garavaglia, C., Beermann, F., Kronenberg, M., Dellabona, P., MacDonald, H. R., Casorati, G. (2003). Human Invariant V{alpha}24-J{alpha}Q TCR Supports the Development of CD1d-Dependent NK1.1+ and NK1.1- T Cells in Transgenic Mice. J. Immunol. 170: 2390-2398 [Abstract] [Full Text]
Dascher, C. C., Hiromatsu, K., Xiong, X., Sugita, M., Buhlmann, J. E., Dodge, I. L., Lee, S. Y., Roura-Mir, C., Watts, G. F., Roy, C. J., Behar, S. M., Clemens, D. L., Porcelli, S. A., Brenner, M. B. (2002). Conservation of CD1 Intracellular Trafficking Patterns Between Mammalian Species. J. Immunol. 169: 6951-6958 [Abstract] [Full Text]
Gadola, S. D., Dulphy, N., Salio, M., Cerundolo, V. (2002). V{alpha}24-J{alpha}Q-Independent, CD1d-Restricted Recognition of {alpha}-Galactosylceramide by Human CD4+ and CD8{alpha}{beta}+ T Lymphocytes. J. Immunol. 168: 5514-5520 [Abstract] [Full Text]
Benlagha, K., Kyin, T., Beavis, A., Teyton, L., Bendelac, A. (2002). A Thymic Precursor to the NK T Cell Lineage. Science 296: 553-555 [Abstract] [Full Text]
Skeen, M. J., Rix, E. P., Freeman, M. M., Ziegler, H. K. (2001). Exaggerated Proinflammatory and Th1 Responses in the Absence of gamma /delta T Cells after Infection with Listeria monocytogenes. Infect. Immun. 69: 7213-7223 [Abstract] [Full Text]
Kawakami, K., Kinjo, Y., Uezu, K., Yara, S., Miyagi, K., Koguchi, Y., Nakayama, T., Taniguchi, M., Saito, A. (2001). Monocyte Chemoattractant Protein-1-Dependent Increase of V{alpha}14 NKT Cells in Lungs and Their Roles in Th1 Response and Host Defense in Cryptococcal Infection. J. Immunol. 167: 6525-6532 [Abstract] [Full Text]
Matsuda, J. L., Gapin, L., Fazilleau, N., Warren, K., Naidenko, O. V., Kronenberg, M. (2001). Natural killer T cells reactive to a single glycolipid exhibit a highly diverse T cell receptor beta repertoire and small clone size. Proc. Natl. Acad. Sci. USA 10.1073/pnas.221445298v1 [Abstract] [Full Text]
Park, S.-H., Weiss, A., Benlagha, K., Kyin, T., Teyton, L., Bendelac, A. (2001). The Mouse CD1d-restricted Repertoire Is Dominated by a Few Autoreactive T Cell Receptor Families. J. Exp. Med. 193: 893-904 [Abstract] [Full Text]
Laloux, V., Beaudoin, L., Jeske, D., Carnaud, C., Lehuen, A. (2001). NK T Cell-Induced Protection Against Diabetes in V{{alpha}}14-J{{alpha}}281 Transgenic Nonobese Diabetic Mice Is Associated with a Th2 Shift Circumscribed Regionally to the Islets and Functionally to Islet Autoantigen. J. Immunol. 166: 3749-3756 [Abstract] [Full Text]
Fritz, R. B., Zhao, M.-L. (2001). Regulation of Experimental Autoimmune Encephalomyelitis in the C57BL/6J Mouse by NK1.1+, DX5+, {{alpha}}{{beta}}+ T Cells. J. Immunol. 166: 4209-4215 [Abstract] [Full Text]
Ronet, C., Mempel, M., Thieblemont, N., Lehuen, A., Kourilsky, P., Gachelin, G. (2001). Role of the Complementarity-Determining Region 3 (CDR3) of the TCR-{{beta}} Chains Associated with the V{{alpha}}14 Semi-Invariant TCR {{alpha}}-Chain in the Selection of CD4+ NK T Cells. J. Immunol. 166: 1755-1762 [Abstract] [Full Text]
Yang, O. O., Racke, F. K., Nguyen, P. T., Gausling, R., Severino, M. E., Horton, H. F., Byrne, M. C., Strominger, J. L., Wilson, S. B. (2000). CD1d on Myeloid Dendritic Cells Stimulates Cytokine Secretion from and Cytolytic Activity of V{alpha}24J{alpha}Q T Cells: A Feedback Mechanism for Immune Regulation. J. Immunol. 165: 3756-3762 [Abstract] [Full Text]
Viret, C., Lantz, O., He, X., Bendelac, A., Janeway, C. A. Jr. (2000). A NK1.1+ Thymocyte-Derived TCR {beta}-Chain Transgene Promotes Positive Selection of Thymic NK1.1+ {alpha}{beta} T Cells. J. Immunol. 165: 3004-3014 [Abstract] [Full Text]
Matsuda, J. L., Naidenko, O. V., Gapin, L., Nakayama, T., Taniguchi, M., Wang, C.-R., Koezuka, Y., Kronenberg, M. (2000). Tracking the Response of Natural Killer T Cells to a Glycolipid Antigen Using CD1d Tetramers. J. Exp. Med. 192: 741-754 [Abstract] [Full Text]
Skold, M., Faizunnessa, N. N., Wang, C.-R., Cardell, S. (2000). CD1d-Specific NK1.1+ T Cells with a Transgenic Variant TCR. J. Immunol. 165: 168-174 [Abstract] [Full Text]
Liu, Z.-X., Govindarajan, S., Okamoto, S., Dennert, G. (2000). NK Cells Cause Liver Injury and Facilitate the Induction of T Cell-Mediated Immunity to a Viral Liver Infection. J. Immunol. 164: 6480-6486 [Abstract] [Full Text]
Molano, A., Park, S.-H., Chiu, Y.-H., Nosseir, S., Bendelac, A., Tsuji, M. (2000). Cutting Edge: The IgG Response to the Circumsporozoite Protein Is MHC Class II-Dependent and CD1d-Independent: Exploring the Role of GPIs in NK T Cell Activation and Antimalarial Responses. J. Immunol. 164: 5005-5009 [Abstract] [Full Text]
Lacy, D. A., Wang, Z.-E., Symula, D. J., McArthur, C. J., Rubin, E. M., Frazer, K. A., Locksley, R. M. (2000). Faithful Expression of the Human 5q31 Cytokine Cluster in Transgenic Mice. J. Immunol. 164: 4569-4574 [Abstract] [Full Text]
Wild, J. S., Sigounas, A., Sur, N., Siddiqui, M. S., Alam, R., Kurimoto, M., Sur, S. (2000). IFN-{gamma}-Inducing Factor (IL-18) Increases Allergic Sensitization, Serum IgE, Th2 Cytokines, and Airway Eosinophilia in a Mouse Model of Allergic Asthma. J. Immunol. 164: 2701-2710 [Abstract] [Full Text]
Dascher, C. C., Hiromatsu, K., Naylor, J. W., Brauer, P. P., Brown, K. A., Storey, J. R., Behar, S. M., Kawasaki, E. S., Porcelli, S. A., Brenner, M. B., LeClair6, K. P. (1999). Conservation of a CD1 Multigene Family in the Guinea Pig. J. Immunol. 163: 5478-5488 [Abstract] [Full Text]
Degermann, S., Sollami, G., Karjalainen, K. (1999). Impaired NK1.1 T Cell Development in Mice Transgenic for a T Cell Receptor {beta} Chain Lacking the Large, Solvent-exposed C{beta} FG Loop. J. Exp. Med. 190: 1357-1362 [Abstract] [Full Text]
Carnaud, C., Lee, D., Donnars, O., Park, S.-H., Beavis, A., Koezuka, Y., Bendelac, A. (1999). Cutting Edge: Cross-Talk Between Cells of the Innate Immune System: NKT Cells Rapidly Activate NK Cells. J. Immunol. 163: 4647-4650 [Abstract] [Full Text]
Falcone, M., Yeung, B., Tucker, L., Rodriguez, E., Sarvetnick, N. (1999). A Defect in Interleukin 12�induced Activation and Interferon {gamma} Secretion of Peripheral Natural Killer T Cells in Nonobese Diabetic Mice Suggests New Pathogenic Mechanisms for Insulin-dependent Diabetes Mellitus. J. Exp. Med. 190: 963-972 [Abstract] [Full Text]
Tilloy, F., Treiner, E., Park, S.-H., Garcia, C., Lemonnier, F., de la Salle, H., Bendelac, A., Bonneville, M., Lantz, O. (1999). An Invariant T Cell Receptor alpha �Chain Defines a Novel TAP-independent Major Histocompatibility Complex Class Ib-restricted alpha /beta T Cell Subpopulation in Mammals. J. Exp. Med. 189: 1907-1921 [Abstract] [Full Text]
Benlagha, K., Weiss, A., Beavis, A., Teyton, L., Bendelac, A. (1999). In Vivo Identification of Glycolipid Antigen-specific T Cells Using Fluorescent CD1d Tetramers. J. Exp. Med. 191: 1895-1904 [Abstract] [Full Text]
Moodycliffe, A. M., Maiti, S., Ullrich, S. E. (1999). Splenic NK1.1-Negative, TCR{alpha}{beta} Intermediate CD4+ T Cells Exist in Naive NK1.1 Allelic Positive and Negative Mice, with the Capacity to Rapidly Secrete Large Amounts of IL-4 and IFN-{gamma} Upon Primary TCR Stimulation. J. Immunol. 162: 5156-5163 [Abstract] [Full Text]
Kim, H. S., Garcia, J., Exley, M., Johnson, K. W., Balk, S. P., Blumberg, R. S. (1999). Biochemical Characterization of CD1d Expression in the Absence of beta 2-Microglobulin. J. Biol. Chem. 274: 9289-9295 [Abstract] [Full Text]
Boursalian, T. E., Bottomly, K. (1999). Survival of Naive CD4 T Cells: Roles of Restricting Versus Selecting MHC Class II and Cytokine Milieu. J. Immunol. 162: 3795-3801 [Abstract] [Full Text]
Korsgren, M., Persson, C. G.A., Sundler, F., Bjerke, T., Hansson, T., Chambers, B. J., Hong, S., Van Kaer, L., Ljunggren, H.-G., Korsgren, O. (1999). Natural Killer Cells Determine Development of Allergen-induced Eosinophilic Airway Inflammation in Mice. J. Exp. Med. 189: 553-562 [Abstract] [Full Text]
Chiu, Y.-H., Jayawardena, J., Weiss, A., Lee, D., Park, S.-H., Dautry-Varsat, A., Bendelac, A. (1999). Distinct Subsets of CD1d-restricted T Cells Recognize Self-antigens Loaded in Different Cellular Compartments. J. Exp. Med. 189: 103-110 [Abstract] [Full Text]
Lehuen, A., Lantz, O., Beaudoin, L., Laloux, V., Carnaud, C., Bendelac, A., Bach, J.-F., Monteiro, R. C. (1998). Overexpression of Natural Killer T Cells Protects Valpha 14-Jalpha 281 Transgenic Nonobese Diabetic Mice against Diabetes. J. Exp. Med. 188: 1831-1839 [Abstract] [Full Text]
Brossay, L., Chioda, M., Burdin, N., Koezuka, Y., Casorati, G., Dellabona, P., Kronenberg, M. (1998). CD1d-mediated Recognition of an alpha -Galactosylceramide by Natural Killer T Cells Is Highly Conserved through Mammalian Evolution. J. Exp. Med. 188: 1521-1528 [Abstract] [Full Text]
Burdin, N., Brossay, L., Koezuka, Y., Smiley, S. T., Grusby, M. J., Gui, M., Taniguchi, M., Hayakawa, K., Kronenberg, M. (1998). Selective Ability of Mouse CD1 to Present Glycolipids: {alpha}-Galactosylceramide Specifically Stimulates V{alpha}14+ NK T Lymphocytes. J. Immunol. 161: 3271-3281 [Abstract] [Full Text]
Iwabuchi, C., Iwabuchi, K., Nakagawa, K.-i., Takayanagi, T., Nishihori, H., Tone, S., Ogasawara, K., Good, R. A., Onoe, K. (1998). Intrathymic selection of NK1.1+alpha /beta T cell antigen receptor (TCR)+ cells in transgenic mice bearing TCR specific for chicken ovalbumin and restricted to I-Ad. Proc. Natl. Acad. Sci. USA 95: 8199-8204 [Abstract] [Full Text]
Brossay, L., Tangri, S., Bix, M., Cardell, S., Locksley, R., Kronenberg, M. (1998). Mouse CD1-Autoreactive T Cells Have Diverse Patterns of Reactivity to CD1+ Targets. J. Immunol. 160: 3681-3688 [Abstract] [Full Text]
Park, S.-H., Roark, J. H., Bendelac, A. (1998). Tissue-Specific Recognition of Mouse CD1 Molecules. J. Immunol. 160: 3128-3134 [Abstract] [Full Text]
Zeng, D., Dick, M., Cheng, L., Amano, M., Dejbakhsh-Jones, S., Huie, P., Sibley, R., Strober, S. (1998). Subsets of Transgenic T Cells That Recognize CD1 Induce or Prevent Murine Lupus: Role of Cytokines. J. Exp. Med. 187: 525-536 [Abstract] [Full Text]
Wang, M., Ellison, C. A., Gartner, J. G., HayGlass, K. T. (1998). Natural Killer Cell Depletion Fails to Influence Initial CD4 T Cell Commitment In Vivo in Exogenous Antigen-Stimulated Cytokine and Antibody Responses. J. Immunol. 160: 1098-1105 [Abstract] [Full Text]
Lantz, O., Sharara, L. I., Tilloy, F., Andersson, A., DiSanto, J. P. (1997). Lineage Relationships and Differentiation of Natural Killer (NK) T Cells: Intrathymic Selection and Interleukin (IL)-4 Production in the Absence of NKR-P1 and Ly49 Molecules. J. Exp. Med. 185: 1395-1402 [Abstract] [Full Text]
Coffman, R. L., Weid, T. (1997). Multiple Pathways for the Initiation of T Helper 2�(Th2) Responses. J. Exp. Med. 185: 373-376 [Full Text]
Matsuda, J. L., Gapin, L., Fazilleau, N., Warren, K., Naidenko, O. V., Kronenberg, M. (2001). Natural killer T cells reactive to a single glycolipid exhibit a highly diverse T cell receptor beta repertoire and small clone size. Proc. Natl. Acad. Sci. USA 98: 12636-12641 [Abstract] [Full Text]