Interleukin-2 regulates CC chemokine receptor expression and chemotactic responsiveness in T lymphocytes

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Interleukin-2 regulates CC chemokine receptor expression and chemotactic responsiveness in T lymphocytes

P Loetscher, M Seitz, M Baggiolini and B Moser
Theodor-Kocher Institute, University of Bern, Switzerland.

Several studies have shown that CC chemokines attract T lymphocytes, and that CD45RO+, memory phenotype cells are considered to be the main responders. The results, however, have often been contradictory and the role of lymphocyte activation and proliferation has remained unclear. Using CD45RO+ blood lymphocytes cultured under different stimulatory conditions, we have now studied chemotaxis as well as chemokine receptor expression. Expression of the RANTES/MIP-1 alpha receptor (CC- CKR1) and the MCP-1 receptor (CC-CKR2) was highly correlated with migration toward RANTES, MCP-1, and other CC chemokines, and was strictly dependent on the presence of IL-2 in the culture medium. Migration and receptor expression were rapidly downregulated when IL-2 was withdrawn, but were fully restored when IL-2 was added again. The effect of IL-2 could be partially mimicked by IL-4, IL-10, or IL-12, but not by IL-13, IFN gamma, IL-1 beta, TNF-alpha, or by exposure to anti-CD3, anti-CD28 or phytohemagglutinin. Activation of fully responsive lymphocytes through the TCR/CD3 complex and CD28 antigen actually had the opposite effect. It rapidly downregulated receptor expression and consequent migration even in the presence of IL-2. In contrast to the effects on CC chemokine receptors, stimulation of CD45RO+ T lymphocytes with IL-2 neither induced the expression of the CXC chemokine receptors, IL8-R1 and IL8-R2, nor chemotaxis to IL-8. The prominent role of IL-2 in CC chemokine responsiveness of lymphocytes suggests that IL-2-mediated expansion is a prerequisite for the recruitment of antigen-activated T cells into sites of immune and inflammatory reactions.
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Xu, Y., Kapp, J. A. (2002). {gamma}{delta} T Cells in Anterior Chamber-Induced Tolerance in CD8+ CTL Responses. IOVS 43: 3473-3479 [Abstract] [Full Text]
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Chensue, S. W. (2001). Molecular Machinations: Chemokine Signals in Host-Pathogen Interactions. Clin. Microbiol. Rev. 14: 821-835 [Abstract] [Full Text]
Dulkys, Y., Kluthe, C., Buschermohle, T., Barg, I., Kno{beta}, S., Kapp, A., Proudfoot, A. E. I., Elsner, J. (2001). IL-3 Induces Down-Regulation of CCR3 Protein and mRNA in Human Eosinophils. J. Immunol. 167: 3443-3453 [Abstract] [Full Text]
Mukai, T., Iwasaki, M., Gao, P., Tomura, M., Yashiro-Ohtani, Y., Ono, S., Murai, M., Matsushima, K., Kurimoto, M., Kogo, M., Matsuya, T., Fujiwara, H., Hamaoka, T. (2001). IL-12 plays a pivotal role in LFA-1-mediated T cell adhesiveness by up-regulation of CCR5 expression. J. Leukoc. Biol. 70: 422-430 [Abstract] [Full Text]
Vaday, G. G., Franitza, S., Schor, H., Hecht, I., Brill, A., Cahalon, L., Hershkoviz, R., Lider, O. (2001). Combinatorial signals by inflammatory cytokines and chemokines mediate leukocyte interactions with extracellular matrix. J. Leukoc. Biol. 69: 885-892 [Abstract] [Full Text]
Thompson, S. D., Luyrink, L. K., Graham, T. B., Tsoras, M., Ryan, M., Passo, M. H., Glass, D. N. (2001). Chemokine Receptor CCR4 on CD4+ T Cells in Juvenile Rheumatoid Arthritis Synovial Fluid Defines a Subset of Cells with Increased IL-4:IFN-{{gamma}} mRNA Ratios. J. Immunol. 166: 6899-6906 [Abstract] [Full Text]
Wilbanks, A., Zondlo, S. C., Murphy, K., Mak, S., Soler, D., Langdon, P., Andrew, D. P., Wu, L., Briskin, M. (2001). Expression Cloning of the STRL33/BONZO/TYMSTR Ligand Reveals Elements of CC, CXC, and CX3C Chemokines. J. Immunol. 166: 5145-5154 [Abstract] [Full Text]
Kito, K., Morishita, K., Nishida, K. (2001). MCP-1 receptor binding affinity is up-regulated by pre-stimulation with MCP-1 in an actin polymerization-dependent manner. J. Leukoc. Biol. 69: 666-674 [Abstract] [Full Text]
Corrigall, V. M., Arastu, M., Khan, S., Shah, C., Fife, M., Smeets, T., Tak, P.-P., Panayi, G. S. (2001). Functional IL-2 Receptor {{beta}} (CD122) and {{gamma}} (CD132) Chains Are Expressed by Fibroblast-Like Synoviocytes: Activation by IL-2 Stimulates Monocyte Chemoattractant Protein-1 Production. J. Immunol. 166: 4141-4147 [Abstract] [Full Text]
Buri, C., Korner, M., Scharli, P., Cefai, D., Uguccioni, M., Mueller, C., Laissue, J. A., Mazzucchelli, L. (2001). CC chemokines and the receptors CCR3 and CCR5 are differentially expressed in the nonneoplastic leukocytic infiltrates of Hodgkin disease. Blood 97: 1543-1548 [Abstract] [Full Text]
Till, S. J., Jopling, L. A., Wachholz, P. A., Robson, R. L., Qin, S., Andrew, D. P., Wu, L., van Neerven, J., Williams, T. J., Durham, S. R., Sabroe, I. (2001). T Cell Phenotypes of the Normal Nasal Mucosa: Induction of Th2 Cytokines and CCR3 Expression by IL-4. J. Immunol. 166: 2303-2310 [Abstract] [Full Text]
Sato, K., Kawasaki, H., Nagayama, H., Enomoto, M., Morimoto, C., Tadokoro, K., Juji, T., Takahashi, T. A. (2001). Chemokine Receptor Expressions and Responsiveness of Cord Blood T Cells. J. Immunol. 166: 1659-1666 [Abstract] [Full Text]
Cheng, S. S., Lai, J. J., Lukacs, N. W., Kunkel, S. L. (2001). Granulocyte-Macrophage Colony Stimulating Factor Up-Regulates CCR1 in Human Neutrophils. J. Immunol. 166: 1178-1184 [Abstract] [Full Text]
SEGERER, S., CUI, Y., HUDKINS, K. L., GOODPASTER, T., EITNER, F., MACK, M., SCHLÖNDORFF, D., ALPERS, C. E. (2000). Expression of the Chemokine Monocyte Chemoattractant Protein-1 and Its Receptor Chemokine Receptor 2 in Human Crescentic Glomerulonephritis. J. Am. Soc. Nephrol. 11: 2231-2242 [Abstract] [Full Text]
Robinson, L. A., Nataraj, C., Thomas, D. W., Howell, D. N., Griffiths, R., Bautch, V., Patel, D. D., Feng, L., Coffman, T. M. (2000). A Role for Fractalkine and Its Receptor (CX3CR1) in Cardiac Allograft Rejection. J. Immunol. 165: 6067-6072 [Abstract] [Full Text]
Schaerli, P., Willimann, K., Lang, A. B., Lipp, M., Loetscher, P., Moser, B. (2000). CXC Chemokine Receptor 5 Expression Defines Follicular Homing T Cells with B Cell Helper Function. J. Exp. Med. 192: 1553-1562 [Abstract] [Full Text]
Unutmaz, D., Xiang, W., Sunshine, M. J., Campbell, J., Butcher, E., Littman, D. R. (2000). The Primate Lentiviral Receptor Bonzo/STRL33 Is Coordinately Regulated with CCR5 and Its Expression Pattern Is Conserved Between Human and Mouse. J. Immunol. 165: 3284-3292 [Abstract] [Full Text]
Franitza, S., Hershkoviz, R., Kam, N.'a., Lichtenstein, N., Vaday, G. G., Alon, R., Lider, O. (2000). TNF-{alpha} Associated with Extracellular Matrix Fibronectin Provides a Stop Signal for Chemotactically Migrating T Cells. J. Immunol. 165: 2738-2747 [Abstract] [Full Text]
Tilton, B., Ho, L., Oberlin, E., Loetscher, P., Baleux, F., Clark-Lewis, I., Thelen, M. (2000). Signal Transduction by CXC Chemokine Receptor 4: Stromal Cell-derived Factor 1 Stimulates Prolonged Protein Kinase B and Extracellular Signal-regulated Kinase 2 Activation in T Lymphocytes. J. Exp. Med. 192: 313-324 [Abstract] [Full Text]
Cerdan, C., Serfling, E., Olive, D. (2000). The C-class chemokine, lymphotactin, impairs the induction of Th1-type lymphokines in human CD4+ T cells. Blood 96: 420-428 [Abstract] [Full Text]
Belperio, J. A., Burdick, M. D., Keane, M. P., Xue, Y. Y., Lynch, J. P. III, Daugherty, B. L., Kunkel, S. L., Strieter, R. M. (2000). The Role of the CC Chemokine, RANTES, in Acute Lung Allograft Rejection. J. Immunol. 165: 461-472 [Abstract] [Full Text]
Andres, P. G., Beck, P. L., Mizoguchi, E., Mizoguchi, A., Bhan, A. K., Dawson, T., Kuziel, W. A., Maeda, N., MacDermott, R. P., Podolsky, D. K., Reinecker, H.-C. (2000). Mice with a Selective Deletion of the CC Chemokine Receptors 5 or 2 Are Protected from Dextran Sodium Sulfate-Mediated Colitis: Lack of CC Chemokine Receptor 5 Expression Results in a NK1.1+ Lymphocyte-Associated Th2-Type Immune Response in the Intestine. J. Immunol. 164: 6303-6312 [Abstract] [Full Text]
Dawson, T. C., Beck, M. A., Kuziel, W. A., Henderson, F., Maeda, N. (2000). Contrasting Effects of CCR5 and CCR2 Deficiency in the Pulmonary Inflammatory Response to Influenza A Virus. Am. J. Pathol. 156: 1951-1959 [Abstract] [Full Text]
Zhang, L., Rogers, T. J. (2000). {kappa}-Opioid Regulation of Thymocyte IL-7 Receptor and C-C Chemokine Receptor 2 Expression. J. Immunol. 164: 5088-5093 [Abstract] [Full Text]
Murdoch, C., Finn, A. (2000). Chemokine receptors and their role in inflammation and infectious diseases. Blood 95: 3032-3043 [Abstract] [Full Text]
Casoli, C., Vicenzi, E., Cimarelli, A., Magnani, G., Ciancianaini, P., Cattaneo, E., Dall'Aglio, P., Poli, G., Bertazzoni, U. (2000). HTLV-II down-regulates HIV-1 replication in IL-2-stimulated primary PBMC of coinfected individuals through expression of MIP-1alpha. Blood 95: 2760-2769 [Abstract] [Full Text]
Secchiero, P., Zella, D., Curreli, S., Mirandola, P., Capitani, S., Gallo, R. C., Zauli, G. (2000). Engagement of CD28 Modulates CXC Chemokine Receptor 4 Surface Expression in Both Resting and CD3-Stimulated CD4+ T Cells. J. Immunol. 164: 4018-4024 [Abstract] [Full Text]
Giltay, E. J., Fonk, J. C. M., von Blomberg, B. M. E., Drexhage, H. A., Schalkwijk, C., Gooren, L. J. G. (2000). In Vivo Effects of Sex Steroids on Lymphocyte Responsiveness and Immunoglobulin Levels in Humans. J. Clin. Endocrinol. Metab. 85: 1648-1657 [Abstract] [Full Text]
Muehlhoefer, A., Saubermann, L. J., Gu, X., Luedtke-Heckenkamp, K., Xavier, R., Blumberg, R. S., Podolsky, D. K., MacDermott, R. P., Reinecker, H.-C. (2000). Fractalkine Is an Epithelial and Endothelial Cell-Derived Chemoattractant for Intraepithelial Lymphocytes in the Small Intestinal Mucosa. J. Immunol. 164: 3368-3376 [Abstract] [Full Text]
Lee, S. C., Brummet, M. E., Shahabuddin, S., Woodworth, T. G., Georas, S. N., Leiferman, K. M., Gilman, S. C., Stellato, C., Gladue, R. P., Schleimer, R. P., Beck, L. A. (2000). Cutaneous Injection of Human Subjects with Macrophage Inflammatory Protein-1{alpha} Induces Significant Recruitment of Neutrophils and Monocytes. J. Immunol. 164: 3392-3401 [Abstract] [Full Text]
Elsner, J., Mack, M., Bruhl, H., Dulkys, Y., Kimmig, D., Simmons, G., Clapham, P. R., Schlondorff, D., Kapp, A., Wells, T. N. C., Proudfoot, A. E. I. (2000). Differential Activation of CC Chemokine Receptors by AOP-RANTES. J. Biol. Chem. 275: 7787-7794 [Abstract] [Full Text]
Murphy, P. M., Baggiolini, M., Charo, I. F., Hebert, C. A., Horuk, R., Matsushima, K., Miller, L. H., Oppenheim, J. J., Power, C. A. (2000). International Union of Pharmacology. XXII. Nomenclature for Chemokine Receptors. Pharmacol. Rev. 52: 145-176 [Abstract] [Full Text]
Nasreen, N., Mohammed, K. A., Galffy, G., Ward, M. J., Antony, V. B. (2000). MCP-1 in pleural injury: CCR2 mediates haptotaxis of pleural mesothelial cells. Am. J. Physiol. Lung Cell. Mol. Physiol. 278: L591-L598 [Abstract] [Full Text]
Yu, C.-R., Peden, K. W. C., Zaitseva, M. B., Golding, H., Farber, J. M. (2000). CCR9A and CCR9B: Two Receptors for the Chemokine CCL25/TECK/Ck{beta}-15 That Differ in Their Sensitivities to Ligand. J. Immunol. 164: 1293-1305 [Abstract] [Full Text]
Proudfoot, A. E. I., Buser, R., Borlat, F., Alouani, S., Soler, D., Offord, R. E., Schroder, J.-M., Power, C. A., Wells, T. N. C. (1999). Amino-terminally Modified RANTES Analogues Demonstrate Differential Effects on RANTES Receptors. J. Biol. Chem. 274: 32478-32485 [Abstract] [Full Text]
Lee, I.-H., Li, W. P., Hisert, K. B., Ivashkiv, L. B. (1999). Inhibition of Interleukin 2 Signaling and Signal Transducer and Activator of Transcription (STAT)5 Activation during T Cell Receptor-mediated Feedback Inhibition of T Cell Expansion. J. Exp. Med. 190: 1263-1274 [Abstract] [Full Text]
Colantonio, L., Iellem, A., Clissi, B., Pardi, R., Rogge, L., Sinigaglia, F., D'Ambrosio, D. (1999). Upregulation of Integrin alpha 6/beta 1 and Chemokine Receptor CCR1 by Interleukin-12 Promotes the Migration of Human Type 1 Helper T Cells. Blood 94: 2981-2989 [Abstract] [Full Text]
Ansel, K. M., McHeyzer-Williams, L. J., Ngo, V. N., McHeyzer-Williams, M. G., Cyster, J. G. (1999). In Vivo-activated CD4 T Cells Upregulate CXC Chemokine Receptor 5 and Reprogram Their Response to Lymphoid Chemokines. J. Exp. Med. 190: 1123-1134 [Abstract] [Full Text]
VILA-CORO, A. J., RODRÍGUEZ-FRADE, J. M., MARTÍN DE ANA, A., MORENO-ORTÍZ, M. C., MARTÍNEZ-A, C., MELLADO, M. (1999). The chemokine SDF-1{alpha} triggers CXCR4 receptor dimerization and activates the JAK/STAT pathway. FASEB J. 13: 1699-1710 [Abstract] [Full Text]
Zella, D., Barabitskaja, O., Casareto, L., Romerio, F., Secchiero, P., Reitz, M. S. Jr., Gallo, R. C., Weichold, F. F. (1999). Recombinant IFN-{alpha} (2b) Increases the Expression of Apoptosis Receptor CD95 and Chemokine Receptors CCR1 and CCR3 in Monocytoid Cells. J. Immunol. 163: 3169-3175 [Abstract] [Full Text]
Penton-Rol, G., Cota, M., Polentarutti, N., Luini, W., Bernasconi, S., Borsatti, A., Sica, A., LaRosa, G. J., Sozzani, S., Poli, G., Mantovani, A. (1999). Up-Regulation of CCR2 Chemokine Receptor Expression and Increased Susceptibility to the Multitropic HIV Strain 89.6 in Monocytes Exposed to Glucocorticoid Hormones. J. Immunol. 163: 3524-3529 [Abstract] [Full Text]
Chung, K F, Barnes, P J (1999). Cytokines in asthma. Thorax 54: 825-857 [Full Text]
Amara, A., Lorthioir, O., Valenzuela, A., Magerus, A., Thelen, M., Montes, M., Virelizier, J.-L., Delepierre, M., Baleux, F., Lortat-Jacob, H., Arenzana-Seisdedos, F. (1999). Stromal Cell-derived Factor-1alpha Associates with Heparan Sulfates through the First beta -Strand of the Chemokine. J. Biol. Chem. 274: 23916-23925 [Abstract] [Full Text]
Hogaboam, C. M., Bone-Larson, C. L., Lipinski, S., Lukacs, N. W., Chensue, S. W., Strieter, R. M., Kunkel, S. L. (1999). Differential Monocyte Chemoattractant Protein-1 and Chemokine Receptor 2 Expression by Murine Lung Fibroblasts Derived from Th1- and Th2-Type Pulmonary Granuloma Models. J. Immunol. 163: 2193-2201 [Abstract] [Full Text]
Hladik, F., Lentz, G., Delpit, E., McElroy, A., McElrath, M. J. (1999). Coexpression of CCR5 and IL-2 in Human Genital But Not Blood T Cells: Implications for the Ontogeny of the CCR5+ Th1 Phenotype. J. Immunol. 163: 2306-2313 [Abstract] [Full Text]
Uguccioni, M., Gionchetti, P., Robbiani, D. F., Rizzello, F., Peruzzo, S., Campieri, M., Baggiolini, M. (1999). Increased Expression of IP-10, IL-8, MCP-1, and MCP-3 in Ulcerative Colitis. Am. J. Pathol. 155: 331-336 [Abstract] [Full Text]
Hadida, F., Vieillard, V., Mollet, L., Clark-Lewis, I., Baggiolini, M., Debre, P. (1999). Cutting Edge: RANTES Regulates Fas Ligand Expression and Killing by HIV-Specific CD8 Cytotoxic T Cells. J. Immunol. 163: 1105-1109 [Abstract] [Full Text]
Chensue, S. W., Warmington, K. S., Allenspach, E. J., Lu, B., Gerard, C., Kunkel, S. L., Lukacs, N. W. (1999). Differential Expression and Cross-Regulatory Function of RANTES During Mycobacterial (Type 1) and Schistosomal (Type 2) Antigen-Elicited Granulomatous Inflammation. J. Immunol. 163: 165-173 [Abstract] [Full Text]
Unutmaz, D., KewalRamani, V. N., Marmon, S., Littman, D. R. (1999). Cytokine Signals Are Sufficient for HIV-1 Infection of Resting Human T Lymphocytes. J. Exp. Med. 189: 1735-1746 [Abstract] [Full Text]
Han, K. H., Han, K. O., Green, S. R., Quehenberger, O. (1999). Expression of the monocyte chemoattractant protein-1 receptor CCR2 is increased in hypercholesterolemia: differential effects of plasma lipoproteins on monocyte function. J. Lipid Res. 40: 1053-1063 [Abstract] [Full Text]
Moriuchi, M., Moriuchi, H., Margolis, D. M., Fauci, A. S. (1999). USF/c-Myc Enhances, While Yin-Yang 1 Suppresses, the Promoter Activity of CXCR4, a Coreceptor for HIV-1 Entry. J. Immunol. 162: 5986-5992 [Abstract] [Full Text]
Nicholls, S. E., Lucas, G., Graham, G. J., Russell, N. H., Mottram, R., Whetton, A. D., Buckle, A.-M. (1999). Macrophage-Inflammatory Protein-1{alpha} Receptor Expression on Normal and Chronic Myeloid Leukemia CD34+ Cells. J. Immunol. 162: 6191-6199 [Abstract] [Full Text]
Lee, B., Sharron, M., Montaner, L. J., Weissman, D., Doms, R. W. (1999). Quantification of CD4, CCR5, and CXCR4 levels on lymphocyte subsets, dendritic cells, and differentially conditioned monocyte-derived macrophages. Proc. Natl. Acad. Sci. USA 96: 5215-5220 [Abstract] [Full Text]
Krzysiek, R., Lefevre, E. A., Zou, W., Foussat, A., Bernard, J., Portier, A., Galanaud, P., Richard, Y. (1999). Antigen Receptor Engagement Selectively Induces Macrophage Inflammatory Protein-1{alpha} (MIP-1{alpha}) and MIP-1{beta} Chemokine Production in Human B Cells. J. Immunol. 162: 4455-4463 [Abstract] [Full Text]
Rabin, R. L., Park, M. K., Liao, F., Swofford, R., Stephany, D., Farber, J. M. (1999). Chemokine Receptor Responses on T Cells Are Achieved Through Regulation of Both Receptor Expression and Signaling. J. Immunol. 162: 3840-3850 [Abstract] [Full Text]
Bradley, L. M., Asensio, V. C., Schioetz, L.-K., Harbertson, J., Krahl, T., Patstone, G., Woolf, N., Campbell, I. L., Sarvetnick, N. (1999). Islet-Specific Th1, But Not Th2, Cells Secrete Multiple Chemokines and Promote Rapid Induction of Autoimmune Diabetes. J. Immunol. 162: 2511-2520 [Abstract] [Full Text]
Perera, L. P., K. Goldman, C., Waldmann, T. A. (1999). IL-15 Induces the Expression of Chemokines and Their Receptors in T Lymphocytes. J. Immunol. 162: 2606-2612 [Abstract] [Full Text]
Cole, S. W., Jamieson, B. D., Zack, J. A. (1999). cAMP Up-Regulates Cell Surface Expression of Lymphocyte CXCR4: Implications for Chemotaxis and HIV-1 Infection. J. Immunol. 162: 1392-1400 [Abstract] [Full Text]
Shea, J. E., Beuzon, C. R., Gleeson, C., Mundy, R., Holden, D. W. (1999). Influence of the Salmonella typhimurium Pathogenicity Island 2�Type III Secretion System on Bacterial Growth in the Mouse. Infect. Immun. 67: 213-219 [Abstract] [Full Text]
Liao, F., Rabin, R. L., Smith, C. S., Sharma, G., Nutman, T. B., Farber, J. M. (1999). CC-Chemokine Receptor 6 Is Expressed on Diverse Memory Subsets of T Cells and Determines Responsiveness to Macrophage Inflammatory Protein 3{alpha}. J. Immunol. 162: 186-194 [Abstract] [Full Text]
Peacock, J. W., Jirik, F. R. (1999). TCR Activation Inhibits Chemotaxis Toward Stromal Cell-Derived Factor-1: Evidence for Reciprocal Regulation Between CXCR4 and the TCR. J. Immunol. 162: 215-223 [Abstract] [Full Text]
Bonecchi, R., Polentarutti, N., Luini, W., Borsatti, A., Bernasconi, S., Locati, M., Power, C., Proudfoot, A., Wells, T. N. C., Mackay, C., Mantovani, A., Sozzani, S. (1999). Up-Regulation of CCR1 and CCR3 and Induction of Chemotaxis to CC Chemokines by IFN-{gamma} in Human Neutrophils. J. Immunol. 162: 474-479 [Abstract] [Full Text]
Pedroza-Martins, L., Gurney, K. B., Torbett, B. E., Uittenbogaart, C. H. (1998). Differential Tropism and Replication Kinetics of Human Immunodeficiency Virus Type 1�Isolates in Thymocytes: Coreceptor Expression Allows Viral Entry, but Productive Infection of Distinct Subsets Is Determined at the Postentry Level. J. Virol. 72: 9441-9452 [Abstract] [Full Text]
Barnes, P. J., Chung, K. F., Page, C. P. (1998). Inflammatory Mediators of Asthma: An Update. Pharmacol. Rev. 50: 515-596 [Abstract] [Full Text]
D'Ambrosio, D., Iellem, A., Bonecchi, R., Mazzeo, D., Sozzani, S., Mantovani, A., Sinigaglia, F. (1998). Cutting Edge: Selective Up-Regulation of Chemokine Receptors CCR4 and CCR8 upon Activation of Polarized Human Type 2 Th Cells. J. Immunol. 161: 5111-5115 [Abstract] [Full Text]
Huang, L., Bosch, I., Hofmann, W., Sodroski, J., Pardee, A. B. (1998). Tat Protein Induces Human Immunodeficiency Virus Type 1�(HIV-1) Coreceptors and Promotes Infection with both Macrophage-Tropic and T-Lymphotropic HIV-1 Strains. J. Virol. 72: 8952-8960 [Abstract] [Full Text]
Durig, J., de Wynter, E. A., Kasper, C., Cross, M. A., Chang, J., Testa, N. G., Heyworth, C. M. (1998). Expression of Macrophage Inflammatory Protein-1alpha Receptors in Human CD34+ Hematopoietic Cells and Their Modulation by Tumor Necrosis Factor-alpha and Interferon-gamma. Blood 92: 3073-3081 [Abstract] [Full Text]
Riley, J. L., Levine, B. L., Craighead, N., Francomano, T., Kim, D., Carroll, R. G., June, C. H. (1998). Naive and Memory CD4 T Cells Differ in Their Susceptibilities to Human Immunodeficiency Virus Type 1�Infection following CD28 Costimulation: Implications for Transmission and Pathogenesis. J. Virol. 72: 8273-8280 [Abstract] [Full Text]
Bodaghi, B., Jones, T. R., Zipeto, D., Vita, C., Sun, L., Laurent, L., Arenzana-Seisdedos, F., Virelizier, J.-L., Michelson, S. (1998). Chemokine Sequestration by Viral Chemoreceptors as a Novel Viral Escape Strategy: Withdrawal of Chemokines from the Environment of Cytomegalovirus-infected Cells. J. Exp. Med. 188: 855-866 [Abstract] [Full Text]