Nitric oxide in Tanzanian children with malaria: inverse relationship between malaria severity and nitric oxide production/nitric oxide synthase type 2 expression

doi:10.1084/jem.184.2.557

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Nitric oxide in Tanzanian children with malaria: inverse relationship between malaria severity and nitric oxide production/nitric oxide synthase type 2 expression

NM Anstey, JB Weinberg, MY Hassanali, ED Mwaikambo, D Manyenga, MA Misukonis, DR Arnelle, D Hollis, MI McDonald and DL Granger
Division of Infectious Diseases & International Health, Duke University Medical Center, Durham, North Carolina 27710, USA.

Nitric oxide (NO)-related activity has been shown to be protective against Plasmodium falciparum in vitro. It has been hypothesized, however, that excess NO production contributes to the pathogenesis of cerebral malaria. The purpose of this study was to compare markers of NO production [urinary and plasma nitrate + nitrite (NOx)], leukocyte- inducible nitric oxide synthase type 2 (NOS2), and plasma TNF-alpha and IL-10 levels with disease severity in 191 Tanzanian children with and without malaria. Urine NOx excretion and plasma NOx levels (corrected for renal impairment) were inversely related to disease severity, with levels highest in subclinical infection and lowest in fatal cerebral malaria. Results could not be explained by differences in dietary nitrate ingestion among the groups. Plasma levels of IL-10, a cytokine known to suppress NO synthesis, increased with disease severity. Leukocyte NOS2 antigen was detectable in all control children tested and in all those with subclinical infection, but was undetectable in all but one subject with cerebral malaria. This suppression of NO synthesis in cerebral malaria may contribute to pathogenesis. In contrast, high fasting NOx levels and leukocyte NOS2 in healthy controls and asymptomatic infection suggest that increased NO synthesis might protect against clinical disease. NO appears to have a protective rather than pathological role in African children with malaria.
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Okamoto, M., Tsuchiya, K., Kanematsu, Y., Izawa, Y., Yoshizumi, M., Kagawa, S., Tamaki, T. (2005). Nitrite-derived nitric oxide formation following ischemia-reperfusion injury in kidney. Am. J. Physiol. Renal Physiol. 288: F182-F187 [Abstract] [Full Text]
Boutlis, C. S., Weinberg, J. B., Baker, J., Bockarie, M. J., Mgone, C. S., Cheng, Q., Anstey, N. M. (2004). Nitric Oxide Production and Nitric Oxide Synthase Activity in Malaria-Exposed Papua New Guinean Children and Adults Show Longitudinal Stability and No Association with Parasitemia. Infect. Immun. 72: 6932-6938 [Abstract] [Full Text]
PARIKH, S., DORSEY, G., ROSENTHAL, P. J. (2004). HOST POLYMORPHISMS AND THE INCIDENCE OF MALARIA IN UGANDAN CHILDREN. Am J Trop Med Hyg 71: 750-753 [Abstract] [Full Text]
Sharma, A., Eapen, A., Subbarao, S. K. (2004). Parasite Killing in Plasmodium vivax Malaria by Nitric Oxide: Implication of Aspartic Protease Inhibition. J Biochem 136: 329-334 [Abstract] [Full Text]
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Clark, I. A., Alleva, L. M., Mills, A. C., Cowden, W. B. (2004). Pathogenesis of Malaria and Clinically Similar Conditions. Clin. Microbiol. Rev. 17: 509-539 [Abstract] [Full Text]
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Qadoumi, M., Becker, I., Donhauser, N., Rollinghoff, M., Bogdan, C. (2002). Expression of Inducible Nitric Oxide Synthase in Skin Lesions of Patients with American Cutaneous Leishmaniasis. Infect. Immun. 70: 4638-4642 [Abstract] [Full Text]
Njoku, C. J., Saville, W. J. A., Reed, S. M., Oglesbee, M. J., Rajala-Schultz, P. J., Stich, R. W. (2002). Reduced Levels of Nitric Oxide Metabolites in Cerebrospinal Fluid Are Associated with Equine Protozoal Myeloencephalitis. CVI 9: 605-610 [Abstract] [Full Text]
Fang, F. C., Vazquez-Torres, A. (2002). Nitric oxide production by human macrophages: there's NO doubt about it. Am. J. Physiol. Lung Cell. Mol. Physiol. 282: L941-L943 [Full Text]
Hart, M. H. (2002). Plasma Nitrate May Be a Marker for Infectious Diarrhea. AAP Grand Rounds 7: 18-18 [Full Text]
Hickman-Davis, J. M., Fang, F. C., Nathan, C., Shepherd, V. L., Voelker, D. R., Wright, J. R. (2001). Lung surfactant and reactive oxygen-nitrogen species: antimicrobial activity and host-pathogen interactions. Am. J. Physiol. Lung Cell. Mol. Physiol. 281: L517-L523 [Abstract] [Full Text]
Haque, A., Echchannaoui, H., Seguin, R., Schwartzman, J., Kasper, L. H., Haque, S. (2001). Cerebral Malaria in Mice : Interleukin-2 Treatment Induces Accumulation of {{gamma}}{{delta}} T Cells in the Brain and Alters Resistant Mice to Susceptible-Like Phenotype. Am. J. Pathol. 158: 163-172 [Abstract] [Full Text]
May, J. M., Qu, Z.-C., Xia, L., Cobb, C. E. (2000). Nitrite uptake and metabolism and oxidant stress in human erythrocytes. Am. J. Physiol. Cell Physiol. 279: C1946-C1954 [Abstract] [Full Text]
Chen, Q., Schlichtherle, M., Wahlgren, M. (2000). Molecular Aspects of Severe Malaria. Clin. Microbiol. Rev. 13: 439-450 [Abstract] [Full Text]
Chiwakata, C. B., Hemmer, C. J., Dietrich, M. (2000). High Levels of Inducible Nitric Oxide Synthase mRNA Are Associated with Increased Monocyte Counts in Blood and Have a Beneficial Role in Plasmodium falciparum Malaria. Infect. Immun. 68: 394-399 [Abstract] [Full Text]
Chaturvedi, R. R., Shore, D. F., Lincoln, C., Mumby, S., Kemp, M., Brierly, J., Petros, A., Gutteridge, J. M.G., Hooper, J., Redington, A. N. (1999). Acute Right Ventricular Restrictive Physiology After Repair of Tetralogy of Fallot : Association With Myocardial Injury and Oxidative Stress. Circulation 100: 1540-1547 [Abstract] [Full Text]
Perkins, D. J., Kremsner, P. G., Schmid, D., Misukonis, M. A., Kelly, M. A., Weinberg, J. B. (1999). Blood Mononuclear Cell Nitric Oxide Production and Plasma Cytokine Levels in Healthy Gabonese Children with Prior Mild or Severe Malaria. Infect. Immun. 67: 4977-4981 [Abstract] [Full Text]
Burgner, D., Rockett, K., Kwiatkowski, D. (1999). Nitric oxide and infectious diseases. Arch. Dis. Child. 81: 185-188 [Full Text]
Ho, M., White, N. J. (1999). Molecular mechanisms of cytoadherence in malaria. Am. J. Physiol. Cell Physiol. 276: C1231-C1242 [Abstract] [Full Text]
Nowicki, B., Singhal, J., Fang, L., Nowicki, S., Yallampalli, C. (1999). Inverse Relationship between Severity of Experimental Pyelonephritis and Nitric Oxide Production in C3H/HeJ Mice. Infect. Immun. 67: 2421-2427 [Abstract] [Full Text]
Facchetti, F., Vermi, W., Fiorentini, S., Chilosi, M., Caruso, A., Duse, M., Notarangelo, L. D., Badolato, R. (1999). Expression of Inducible Nitric Oxide Synthase in Human Granulomas and Histiocytic Reactions. Am. J. Pathol. 154: 145-152 [Abstract] [Full Text]
Reiss, C. S., Komatsu, T. (1998). Does Nitric Oxide Play a Critical Role in Viral Infections?. J. Virol. 72: 4547-4551 [Full Text]
Fried, M., Muga, R. O., Misore, A. O., Duffy, P. E. (1998). Malaria Elicits Type 1 Cytokines in the Human Placenta: IFN-{gamma} and TNF-{alpha} Associated with Pregnancy Outcomes. J. Immunol. 160: 2523-2530 [Abstract] [Full Text]
Sharara, A. I., Perkins, D. J., Misukonis, M. A., Chan, S. U., Dominitz, J. A., Weinberg, J. B. (1997). Interferon (IFN)-alpha Activation of Human Blood Mononuclear Cells In Vitro and In Vivo for Nitric Oxide Synthase (NOS) Type 2�mRNA and Protein Expression: Possible Relationship of Induced NOS2 to the Anti-Hepatitis C Effects of IFN-alpha In Vivo. J. Exp. Med. 186: 1495-1502 [Abstract] [Full Text]
Gilkeson, G. S., Mudgett, J. S., Seldin, M. F., Ruiz, P., Alexander, A. A., Misukonis, M. A., Pisetsky, D. S., Weinberg, J. B. (1997). Clinical and Serologic Manifestations of Autoimmune Disease in MRL-lpr/lpr Mice Lacking Nitric Oxide Synthase Type 2�. J. Exp. Med. 186: 365-373 [Abstract] [Full Text]
Adler, H., Beland, J. L., Del-Pan, N. C., Kobzik, L., Brewer, J. P., Martin, T. R., Rimm, I. J. (1997). Suppression of Herpes Simplex Virus Type 1�(HSV-1)-induced Pneumonia in Mice by Inhibition of Inducible Nitric Oxide Synthase (iNOS, NOS2). J. Exp. Med. 185: 1533-1540 [Abstract] [Full Text]
Hickman-Davis, J. M., O'Reilly, P., Davis, I. C., Peti-Peterdi, J., Davis, G., Young, K. R., Devlin, R. B., Matalon, S. (2002). Killing of Klebsiella pneumoniae by human alveolar macrophages. Am. J. Physiol. Lung Cell. Mol. Physiol. 282: L944-L956 [Abstract] [Full Text]