The sequence of the Mycoplasma arthritidis superantigen, MAM: identification of functional domains and comparison with microbial superantigens and plant lectin mitogens

doi:10.1084/jem.183.3.1105

This Article

Full Text (PDF)

Alert me when this article is cited

Citation Map

Services

Email this article

Similar articles in this journal

Similar articles in PubMed

Alert me to new content in the JEM

Download to citation manager

Citing Articles

Citing Articles via HighWire

Citing Articles via CrossRef

Citing Articles via Google Scholar

Google Scholar

Articles by Cole, B. C.

Articles by Atkin, C. L.

Search for Related Content

PubMed

PubMed Citation

Articles by Cole, B. C.

Articles by Atkin, C. L.

Pubmed/NCBI databases

Nucleotide	Protein
Substance via MeSH

Social Bookmarking

What's this?

ARTICLES

The sequence of the Mycoplasma arthritidis superantigen, MAM: identification of functional domains and comparison with microbial superantigens and plant lectin mitogens

BC Cole, KL Knudtson, A Oliphant, AD Sawitzke, A Pole, M Manohar, LS Benson, E Ahmed and CL Atkin
University of Utah School of Medicine, Department of Internal Medicine, Salt Lake City, 84132, USA.

Mycoplasma arthritidis, an agent of chronic proliferative arthritis of rodents, secretes a potent soluble superantigen, MAM, that is active for both murine and human T and B lymphocytes. We now report the complete nucleotide and amino acid sequence of MAM and show it to be distinct from other proteins and not closely related phylogenetically to other superantigens. Two functional domains on MAM are identified based on the ability of peptides encompassing these regions to inhibit lymphocyte proliferation by the intact MAM molecule. One of these domains shares short sequences or epitopes with other microbial superantigens. The second domain contains the consensus legume lectin motif-beta, which is important for T cell activation by concanavalin (Con) A. MAM and Con A peptides containing this motif are functionally cross reactive, suggesting a novel secondary pathway for T cell activation by MAM.
Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Add to Reddit Reddit Add to Technorati Technorati What's this?

This article has been cited by other articles:

Dybvig, K., Zuhua, C., Lao, P., Jordan, D. S., French, C. T., Tu, A.-H. T., Loraine, A. E. (2008). Genome of Mycoplasma arthritidis. Infect. Immun. 76: 4000-4008 [Abstract] [Full Text]
Kreiss, M., Asmuss, A., Krejci, K., Lindemann, D., Miyoshi-Akiyama, T., Uchiyama, T., Rink, L., Broeren, C. P. M., Herrmann, T. (2004). Contrasting contributions of complementarity-determining region 2 and hypervariable region 4 of rat BV8S2+ (V{beta}8.2) TCR to the recognition of myelin basic protein and different types of bacterial superantigens. Int Immunol 16: 655-663 [Abstract] [Full Text]
Langlois, M.-A., Fakhry, Y. E., Mourad, W. (2003). Zinc-binding Sites in the N Terminus of Mycoplasma arthritidis-derived Mitogen Permit the Dimer Formation Required for High Affinity Binding to HLA-DR and for T Cell Activation. J. Biol. Chem. 278: 22309-22315 [Abstract] [Full Text]
Rottem, S. (2003). Interaction of Mycoplasmas With Host Cells. Physiol. Rev. 83: 417-432 [Abstract] [Full Text]
Mu, H.-H., Sawitzke, A. D., Cole, B. C. (2001). Presence of Lpsd Mutation Influences Cytokine Regulation In Vivo by the Mycoplasma arthritidis Mitogen Superantigen and Lethal Toxicity in Mice Infected with M. arthritidis. Infect. Immun. 69: 3837-3844 [Abstract] [Full Text]
Mu, H.-H., Sawitzke, A. D., Cole, B. C. (2000). Modulation of Cytokine Profiles by the Mycoplasma Superantigen Mycoplasma arthritidis Mitogen Parallels Susceptibility to Arthritis Induced by M. arthritidis. Infect. Immun. 68: 1142-1149 [Abstract] [Full Text]
Piec, G., Mirkovitch, J., Palacio, S., Muhlradt, P. F., Felix, R. (1999). Effect of MALP-2, a Lipopeptide from Mycoplasma fermentans, on Bone Resorption In Vitro. Infect. Immun. 67: 6281-6285 [Abstract] [Full Text]
Razin, S., Yogev, D., Naot, Y. (1998). Molecular Biology and Pathogenicity of Mycoplasmas. Microbiol. Mol. Biol. Rev. 62: 1094-1156 [Abstract] [Full Text]
Muhlradt, P. F., Kiess, M., Meyer, H., Sussmuth, R., Jung, G. (1998). Structure and Specific Activity of Macrophage-Stimulating Lipopeptides from Mycoplasma hyorhinis. Infect. Immun. 66: 4804-4810 [Abstract] [Full Text]
Hodtsev, A. S., Choi, Y., Spanopoulou, E., Posnett, D. N. (1998). Mycoplasma Superantigen Is a CDR3-dependent Ligand for the T Cell Antigen Receptor. J. Exp. Med. 187: 319-327 [Abstract] [Full Text]
Muhlradt, P. F., Kiess, M., Meyer, H., Sussmuth, R., Jung, G. (1997). Isolation, Structure Elucidation, and Synthesis of a Macrophage Stimulatory Lipopeptide from Mycoplasma fermentans Acting at Picomolar Concentration. J. Exp. Med. 185: 1951-1958 [Abstract] [Full Text]