Regulation of T cell receptor delta gene rearrangement by c-Myb

doi:10.1084/jem.183.1.289

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Regulation of T cell receptor delta gene rearrangement by c-Myb

C Hernandez-Munain, P Lauzurica and MS Krangel
Department of Immunology, Duke University Medical Center, Durham, North Carolina 27710, USA.

Developmental activation of VDJ recombination at the T cell receptor (TCR) delta locus is controlled by an intronic transcriptional enhancer (E delta). Transcriptional activation by E delta is dependent on c-Myb. To determine whether c-Myb plays a role in the activation of TCR-delta gene rearrangement, we compared VDJ recombination in transgenic mice carrying two versions of a human TCR-delta gene minilocus recombination substrate. One includes a wild-type E delta, whereas the other carries an E delta with a mutation that abrogates c-Myb binding. We demonstrate that an intact Myb binding site is necessary for efficient rearrangement of the minilocus substrate, suggesting that c-Myb plays a crucial role in activating VDJ recombination at the endogenous TCR- delta locus.
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