Peptide-pulsed dendritic cells induce antigen-specific CTL-mediated protective tumor immunity

doi:10.1084/jem.183.1.283

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Peptide-pulsed dendritic cells induce antigen-specific CTL-mediated protective tumor immunity

CM Celluzzi, JI Mayordomo, WJ Storkus, MT Lotze and LD Falo Jr
Department of Dermatology, University of Pittsburgh Medical Center, Pennsylvania 15213, USA.

Cytotoxic T lymphocytes (CTLs) are a critical component of the immune response to tumors. Tumor-derived peptide antigens targeted by CTLs are being defined for several human tumors and are potential immunogens for the induction of specific antitumor immunity. Dendritic cells (DC) are potent antigen-presenting cells (APCs) capable of priming CTL responses in vivo. Here we show that major histocompatibility complex class I- presented peptide antigen pulsed onto dendritic APCs induces protective immunity to lethal challenge by a tumor transfected with the antigen gene. The immunity is antigen specific, requiring expression of the antigen gene by the tumor target, and is eliminated by in vivo depletion of CD8+ T cells. Furthermore, mice that have rejected the transfected tumor are protected from subsequent challenge with the untransfected parent tumor. These results suggest that immunization strategies using antigen-pulsed DC may be useful for inducing tumor- specific immune responses.
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Kalat, M., Kupcu, Z., Schuller, S., Zalusky, D., Zehetner, M., Paster, W., Schweighoffer, T. (2002). In Vivo Plasmid Electroporation Induces Tumor Antigen-specific CD8+ T-Cell Responses and Delays Tumor Growth in a Syngeneic Mouse Melanoma Model. Cancer Res. 62: 5489-5494 [Abstract] [Full Text]
Steller, M. A. (2002). Cervical Cancer Vaccines: Progress and Prospects. Reproductive Sciences 9: 254-264 [Abstract]
Espinoza-Delgado, I. (2002). Cancer Vaccines. The Oncologist 7: 20-33 [Abstract] [Full Text]
Ikuta, Y., Katayama, N., Wang, L., Okugawa, T., Takahashi, Y., Schmitt, M., Gu, X., Watanabe, M., Akiyoshi, K., Nakamura, H., Kuribayashi, K., Sunamoto, J., Shiku, H. (2002). Presentation of a major histocompatibility complex class 1-binding peptide by monocyte-derived dendritic cells incorporating hydrophobized polysaccharide-truncated HER2 protein complex: implications for a polyvalent immuno-cell therapy. Blood 99: 3717-3724 [Abstract] [Full Text]
Prabakaran, I., Menon, C., Xu, S., Gomez-Yafal, A., Czerniecki, B. J., Fraker, D. L. (2002). Mature CD83+ Dendritic Cells Infected With Recombinant gp100 Vaccinia Virus Stimulate Potent Antimelanoma T Cells. Ann. Surg. Oncol. 9: 411-418 [Abstract] [Full Text]
Olasz, E. B., Linton, J., Katz, S. I. (2002). Soluble proteins and haptens on bone marrow-derived dendritic cells are presented to host CD4 T cells in an MHC-restricted manner. Int Immunol 14: 493-502 [Abstract] [Full Text]
Liau, L. M., Jensen, E. R., Kremen, T. J., Odesa, S. K., Sykes, S. N., Soung, M. C., Miller, J. F., Bronstein, J. M. (2002). Tumor Immunity within the Central Nervous System Stimulated by Recombinant Listeria monocytogenes Vaccination. Cancer Res. 62: 2287-2293 [Abstract] [Full Text]
Gong, J., Koido, S., Chen, D., Tanaka, Y., Huang, L., Avigan, D., Anderson, K., Ohno, T., Kufe, D. (2002). Immunization against murine multiple myeloma with fusions of dendritic and plasmacytoma cells is potentiated by interleukin 12. Blood 99: 2512-2517 [Abstract] [Full Text]
Ota, S., Ono, T., Morita, A., Uenaka, A., Harada, M., Nakayama, E. (2002). Cellular Processing of a Multibranched Lysine Core with Tumor Antigen Peptides and Presentation of Peptide Epitopes Recognized by Cytotoxic T Lymphocytes on Antigen-presenting Cells. Cancer Res. 62: 1471-1476 [Abstract] [Full Text]
Merad, M., Sugie, T., Engleman, E. G., Fong, L. (2002). In vivo manipulation of dendritic cells to induce therapeutic immunity. Blood 99: 1676-1682 [Abstract] [Full Text]
Geiger, J. D., Hutchinson, R. J., Hohenkirk, L. F., McKenna, E. A., Yanik, G. A., Levine, J. E., Chang, A. E., Braun, T. M., Mule, J. J. (2001). Vaccination Of Pediatric Solid Tumor Patients with Tumor Lysate-pulsed Dendritic Cells Can Expand Specific T Cells and Mediate Tumor Regression. Cancer Res. 61: 8513-8519 [Abstract] [Full Text]
Hsieh, S.-M., Pan, S.-C., Hung, C.-C., Tsai, H.-C., Chen, M.-Y., Lee, C.-N., Chang, S.-C. (2001). Kinetics of Antigen-Induced Phenotypic and Functional Maturation of Human Monocyte-Derived Dendritic Cells. J. Immunol. 167: 6286-6291 [Abstract] [Full Text]
Clark, R. E., Dodi, I. A., Hill, S. C., Lill, J. R., Aubert, G., Macintyre, A. R., Rojas, J., Bourdon, A., Bonner, P. L. R., Wang, L., Christmas, S. E., Travers, P. J., Creaser, C. S., Rees, R. C., Madrigal, J. A. (2001). Direct evidence that leukemic cells present HLA-associated immunogenic peptides derived from the BCR-ABL b3a2 fusion protein. Blood 98: 2887-2893 [Abstract] [Full Text]
Bonnotte, B., Larmonier, N., Favre, N., Fromentin, A., Moutet, M., Martin, M., Gurbuxani, S., Solary, E., Chauffert, B., Martin, F. (2001). Identification of Tumor-Infiltrating Macrophages as the Killers of Tumor Cells After Immunization in a Rat Model System. J. Immunol. 167: 5077-5083 [Abstract] [Full Text]
Tong, Y., Song, W., Crystal, R. G. (2001). Combined Intratumoral Injection of Bone Marrow-derived Dendritic Cells and Systemic Chemotherapy to Treat Pre-existing Murine Tumors. Cancer Res. 61: 7530-7535 [Abstract] [Full Text]
Fujii, S.-i., Shimizu, K., Shimizu, T., Lotze, M. T. (2001). Interleukin-10 promotes the maintenance of antitumor CD8+ T-cell effector function in situ. Blood 98: 2143-2151 [Abstract] [Full Text]
Tangri, S., Ishioka, G. Y., Huang, X., Sidney, J., Southwood, S., Fikes, J., Sette, A. (2001). Structural Features of Peptide Analogs of Human Histocompatibility Leukocyte Antigen Class I Epitopes that Are More Potent and Immunogenic than Wild-Type Peptide. J. Exp. Med. 194: 833-846 [Abstract] [Full Text]
Schnurr, M., Galambos, P., Scholz, C., Then, F., Dauer, M., Endres, S., Eigler, A. (2001). Tumor Cell Lysate-pulsed Human Dendritic Cells Induce a T-Cell Response against Pancreatic Carcinoma Cells: an in Vitro Model for the Assessment of Tumor Vaccines. Cancer Res. 61: 6445-6450 [Abstract] [Full Text]
Banchereau, J., Palucka, A. K., Dhodapkar, M., Burkeholder, S., Taquet, N., Rolland, A., Taquet, S., Coquery, S., Wittkowski, K. M., Bhardwaj, N., Pineiro, L., Steinman, R., Fay, J. (2001). Immune and Clinical Responses in Patients with Metastatic Melanoma to CD34+ Progenitor-derived Dendritic Cell Vaccine. Cancer Res. 61: 6451-6458 [Abstract] [Full Text]
Motta, I., Andre, F., Lim, A., Tartaglia, J., Cox, W. I., Zitvogel, L., Angevin, E., Kourilsky, P. (2001). Cross-Presentation by Dendritic Cells of Tumor Antigen Expressed in Apoptotic Recombinant Canarypox Virus-Infected Dendritic Cells. J. Immunol. 167: 1795-1802 [Abstract] [Full Text]
Oluwole, O. O., Depaz, H. A., Gopinathan, R., Ali, A., Garrovillo, M., Jin, M.-X., Hardy, M. A., Oluwole, S. F. (2001). Indirect Allorecognition in Acquired Thymic Tolerance: Induction of Donor-Specific Permanent Acceptance of Rat Islets by Adoptive Transfer of Allopeptide-Pulsed Host Myeloid and Thymic Dendritic Cells. Diabetes 50: 1546-1552 [Abstract] [Full Text]
Rudolf, M. P., Fausch, S. C., Da Silva, D. M., Kast, W. M. (2001). Human Dendritic Cells Are Activated by Chimeric Human Papillomavirus Type-16 Virus-Like Particles and Induce Epitope-Specific Human T Cell Responses In Vitro. J. Immunol. 166: 5917-5924 [Abstract] [Full Text]
Zhu, M., Terasawa, H., Gulley, J., Panicali, D., Arlen, P., Schlom, J., Tsang, K. Y. (2001). Enhanced Activation of Human T Cells via Avipox Vector-mediated Hyperexpression of a Triad of Costimulatory Molecules in Human Dendritic Cells. Cancer Res. 61: 3725-3734 [Abstract] [Full Text]
Ju, D. W., Tao, Q., Lou, G., Bai, M., He, L., Yang, Y., Cao, X. (2001). Interleukin 18 Transfection Enhances Antitumor Immunity Induced by Dendritic Cell-Tumor Cell Conjugates. Cancer Res. 61: 3735-3740 [Abstract] [Full Text]
Liu, S., Yu, Y., Zhang, M., Wang, W., Cao, X. (2001). The Involvement of TNF-{{alpha}}-Related Apoptosis-Inducing Ligand in the Enhanced Cytotoxicity of IFN-{{beta}}-Stimulated Human Dendritic Cells to Tumor Cells. J. Immunol. 166: 5407-5415 [Abstract] [Full Text]
Siemens, D. R., Elzey, B. D., Lubaroff, D. M., Bohlken, C., Jensen, R. J., Swanson, A. K., Ratliff, T. L. (2001). Cutting Edge: Restoration of the Ability to Generate CTL in Mice Immune to Adenovirus by Delivery of Virus in a Collagen-Based Matrix. J. Immunol. 166: 731-735 [Abstract] [Full Text]
Stager, S., Smith, D. F., Kaye, P. M. (2000). Immunization with a Recombinant Stage-Regulated Surface Protein from Leishmania donovani Induces Protection Against Visceral Leishmaniasis. J. Immunol. 165: 7064-7071 [Abstract] [Full Text]
Small, E. J., Fratesi, P., Reese, D. M., Strang, G., Laus, R., Peshwa, M. V., Valone, F. H. (2000). Immunotherapy of Hormone-Refractory Prostate Cancer With Antigen-Loaded Dendritic Cells. JCO 18: 3894-3903 [Abstract] [Full Text]
Warren, T. L., Bhatia, S. K., Acosta, A. M., Dahle, C. E., Ratliff, T. L., Krieg, A. M., Weiner, G. J. (2000). APC Stimulated by CpG Oligodeoxynucleotide Enhance Activation of MHC Class I-Restricted T Cells. J. Immunol. 165: 6244-6251 [Abstract] [Full Text]
Brunner, C., Seiderer, J., Schlamp, A., Bidlingmaier, M., Eigler, A., Haimerl, W., Lehr, H.-A., Krieg, A. M., Hartmann, G., Endres, S. (2000). Enhanced Dendritic Cell Maturation by TNF-{alpha} or Cytidine-Phosphate-Guanosine DNA Drives T Cell Activation In Vitro and Therapeutic Anti-Tumor Immune Responses In Vivo. J. Immunol. 165: 6278-6286 [Abstract] [Full Text]
Koido, S., Kashiwaba, M., Chen, D., Gendler, S., Kufe, D., Gong, J. (2000). Induction of Antitumor Immunity by Vaccination of Dendritic Cells Transfected with MUC1 RNA. J. Immunol. 165: 5713-5719 [Abstract] [Full Text]
van Bergen, J., Camps, M., Offringa, R., Melief, C. J. M., Ossendorp, F., Koning, F. (2000). Superior Tumor Protection Induced by a Cellular Vaccine Carrying a Tumor-specific T Helper Epitope by Genetic Exchange of the Class II-associated Invariant Chain Peptide. Cancer Res. 60: 6427-6433 [Abstract] [Full Text]
Nouri-Shirazi, M., Banchereau, J., Bell, D., Burkeholder, S., Kraus, E. T., Davoust, J., Palucka, K. A. (2000). Dendritic Cells Capture Killed Tumor Cells and Present Their Antigens to Elicit Tumor-Specific Immune Responses. J. Immunol. 165: 3797-3803 [Abstract] [Full Text]
Schmitz, M., Diestelkoetter, P., Weigle, B., Schmachtenberg, F., Stevanovic, S., Ockert, D., Rammensee, H.-G., Rieber, E. P. (2000). Generation of Survivin-specific CD8+ T Effector Cells by Dendritic Cells Pulsed with Protein or Selected Peptides. Cancer Res. 60: 4845-4849 [Abstract] [Full Text]
Gong, J., Nikrui, N., Chen, D., Koido, S., Wu, Z., Tanaka, Y., Cannistra, S., Avigan, D., Kufe, D. (2000). Fusions of Human Ovarian Carcinoma Cells with Autologous or Allogeneic Dendritic Cells Induce Antitumor Immunity. J. Immunol. 165: 1705-1711 [Abstract] [Full Text]
Kikuchi, T., Moore, M. A. S., Crystal, R. G. (2000). Dendritic cells modified to express CD40 ligand elicit therapeutic immunity against preexisting murine tumors. Blood 96: 91-99 [Abstract] [Full Text]
Russo, V., Zhou, D., Sartirana, C., Rovere, P., Villa, A., Rossini, S., Traversari, C., Bordignon, C. (2000). Acquisition of intact allogeneic human leukocyte antigen molecules by human dendritic cells. Blood 95: 3473-3477 [Abstract] [Full Text]
Klein, C., Bueler, H., Mulligan, R. C. (2000). Comparative Analysis of Genetically Modified Dendritic Cells and Tumor Cells as Therapeutic Cancer Vaccines. J. Exp. Med. 191: 1699-1708 [Abstract] [Full Text]
Dubinett, S. M., Batra, R. K., Miller, P. W., Sharma, S. (2000). Tumor Antigens in Thoracic Malignancy. Am. J. Respir. Cell Mol. Bio. 22: 524-527 [Full Text]
Timmerman, J. M., Levy, R. (2000). Linkage of Foreign Carrier Protein to a Self-Tumor Antigen Enhances the Immunogenicity of a Pulsed Dendritic Cell Vaccine. J. Immunol. 164: 4797-4803 [Abstract] [Full Text]
Yang, S., Kittlesen, D., Slingluff, C. L. Jr., Vervaert, C. E., Seigler, H. F., Darrow, T. L. (2000). Dendritic Cells Infected with a Vaccinia Vector Carrying the Human gp100 Gene Simultaneously Present Multiple Specificities and Elicit High-Affinity T Cells Reactive to Multiple Epitopes and Restricted by HLA-A2 and -A3. J. Immunol. 164: 4204-4211 [Abstract] [Full Text]
Kusakabe, K.-i., Xin, K.-Q., Katoh, H., Sumino, K., Hagiwara, E., Kawamoto, S., Okuda, K., Miyagi, Y., Aoki, I., Nishioka, K., Klinman, D., Okuda, K. (2000). The Timing of GM-CSF Expression Plasmid Administration Influences the Th1/Th2 Response Induced by an HIV-1-Specific DNA Vaccine. J. Immunol. 164: 3102-3111 [Abstract] [Full Text]
Schnell, S., Young, J. W., Houghton, A. N., Sadelain, M. (2000). Retrovirally Transduced Mouse Dendritic Cells Require CD4+ T Cell Help to Elicit Antitumor Immunity: Implications for the Clinical Use of Dendritic Cells. J. Immunol. 164: 1243-1250 [Abstract] [Full Text]
Seo, N., Tokura, Y., Nishijima, T., Hashizume, H., Furukawa, F., Takigawa, M. (2000). Percutaneous peptide immunization via corneum barrier-disrupted murine skin for experimental tumor immunoprophylaxis. Proc. Natl. Acad. Sci. USA 97: 371-376 [Abstract] [Full Text]
Dong, X., An, B., Salvucci Kierstead, L., Storkus, W. J., Amoscato, A. A., Salter, R. D. (2000). Modification of the Amino Terminus of a Class II Epitope Confers Resistance to Degradation by CD13 on Dendritic Cells and Enhances Presentation to T Cells. J. Immunol. 164: 129-135 [Abstract] [Full Text]
de Cerio, A. L.-D., Casares, N., Lasarte, J. J., Sarobe, P., Perez-Mediavilla, L. A., Ruiz, M., Prieto, J., Borras-Cuesta, F. (1999). Th1 but not Th0 cell help is efficient to induce cytotoxic T lymphocytes by immunization with short synthetic peptides. Int Immunol 11: 2025-2034 [Abstract] [Full Text]
Sharma, S., Stolina, M., Lin, Y., Gardner, B., Miller, P. W., Kronenberg, M., Dubinett, S. M. (1999). T Cell-Derived IL-10 Promotes Lung Cancer Growth by Suppressing Both T Cell and APC Function. J. Immunol. 163: 5020-5028 [Abstract] [Full Text]
Fanger, N. A., Maliszewski, C. R., Schooley, K., Griffith, T. S. (1999). Human Dendritic Cells Mediate Cellular Apoptosis via Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL). J. Exp. Med. 190: 1155-1164 [Abstract] [Full Text]
Toura, I., Kawano, T., Akutsu, Y., Nakayama, T., Ochiai, T., Taniguchi, M. (1999). Cutting Edge: Inhibition of Experimental Tumor Metastasis by Dendritic Cells Pulsed with {alpha}-Galactosylceramide. J. Immunol. 163: 2387-2391 [Abstract] [Full Text]
Subklewe, M., Chahroudi, A., Schmaljohn, A., Kurilla, M. G., Bhardwaj, N., Steinman, R. M. (1999). Induction of Epstein-Barr Virus-Specific Cytotoxic T-Lymphocyte Responses Using Dendritic Cells Pulsed With EBNA-3A Peptides or UV-Inactivated, Recombinant EBNA-3A Vaccinia Virus. Blood 94: 1372-1381 [Abstract] [Full Text]
Borges, L., Miller, R. E., Jones, J., Ariail, K., Whitmore, J., Fanslow, W., Lynch, D. H. (1999). Synergistic Action of fms-Like Tyrosine Kinase 3 Ligand and CD40 Ligand in the Induction of Dendritic Cells and Generation of Antitumor Immunity In Vivo. J. Immunol. 163: 1289-1297 [Abstract] [Full Text]
Eggert, A. A. O., Schreurs, M. W. J., Boerman, O. C., Oyen, W. J. C., de Boer, A. J., Punt, C. J. A., Figdor, C. G., Adema, G. J. (1999). Biodistribution and Vaccine Efficiency of Murine Dendritic Cells Are Dependent on the Route of Administration. Cancer Res. 59: 3340-3345 [Abstract] [Full Text]
Curiel-Lewandrowski, C., Mahnke, K., Labeur, M., Roters, B., Schmidt, W., Granstein, R. D., Luger, T. A., Schwarz, T., Grabbe, S. (1999). Transfection of Immature Murine Bone Marrow-Derived Dendritic Cells with the Granulocyte-Macrophage Colony-Stimulating Factor Gene Potently Enhances Their In Vivo Antigen-Presenting Capacity. J. Immunol. 163: 174-183 [Abstract] [Full Text]
Brossart, P., Heinrich, K. S., Stuhler, G., Behnke, L., Reichardt, V. L., Stevanovic, S., Muhm, A., Rammensee, H.-G., Kanz, L., Brugger, W. (1999). Identification of HLA-A2-Restricted T-Cell Epitopes Derived From the MUC1 Tumor Antigen for Broadly Applicable Vaccine Therapies. Blood 93: 4309-4317 [Abstract] [Full Text]
Chikamatsu, K., Nakano, K., Storkus, W. J., Appella, E., Lotze, M. T., Whiteside, T. L., DeLeo, A. B. (1999). Generation of Anti-p53 Cytotoxic T Lymphocytes from Human Peripheral Blood Using Autologous Dendritic Cells. Clin. Cancer Res. 5: 1281-1288 [Abstract] [Full Text]
Morse, M. A., Deng, Y., Coleman, D., Hull, S., Kitrell-Fisher, E., Nair, S., Schlom, J., Ryback, M.-E., Lyerly, H. K. (1999). A Phase I Study of Active Immunotherapy with Carcinoembryonic Antigen Peptide (CAP-1)-pulsed, Autologous Human Cultured Dendritic Cells in Patients with Metastatic Malignancies Expressing Carcinoembryonic Antigen. Clin. Cancer Res. 5: 1331-1338 [Abstract] [Full Text]
Chakraborty, N. G., Li, L., Sporn, J. R., Kurtzman, S. H., Ergin, M. T., Mukherji, B. (1999). Emergence of Regulatory CD4+ T Cell Response to Repetitive Stimulation with Antigen-Presenting Cells In Vitro: Implications in Designing Antigen-Presenting Cell-Based Tumor Vaccines. J. Immunol. 162: 5576-5583 [Abstract] [Full Text]
Baar, J. (1999). Clinical Applications of Dendritic Cell Cancer Vaccines. The Oncologist 4: 140-144 [Full Text]
Men, Y., Miconnet, I., Valmori, D., Rimoldi, D., Cerottini, J.-C., Romero, P. (1999). Assessment of Immunogenicity of Human Melan-A Peptide Analogues in HLA-A*0201/Kb Transgenic Mice. J. Immunol. 162: 3566-3573 [Abstract] [Full Text]
Mulders, P., Tso, C.-L., Gitlitz, B., Kaboo, R., Hinkel, A., Frand, S., Kiertscher, S., Roth, M. D., deKernion, J., Figlin, R., Belldegrun, A. (1999). Presentation of Renal Tumor Antigens by Human Dendritic Cells Activates Tumor-infiltrating Lymphocytes against Autologous Tumor: Implications for Live Kidney Cancer Vaccines. Clin. Cancer Res. 5: 445-454 [Abstract] [Full Text]
Schultze, J. L., Michalak, S., Lowne, J., Wong, A., Gilleece, M. H., Gribben, J. G., Nadler, L. M. (1999). Human Non-Germinal Center B Cell Interleukin (IL)-12 Production Is Primarily Regulated by T Cell Signals CD40 Ligand, Interferon gamma , and IL-10: Role of B Cells in the Maintenance of �T Cell Responses. J. Exp. Med. 189: 1-12 [Abstract] [Full Text]
Redchenko, I. V., Rickinson, A. B. (1999). Accessing Epstein-Barr Virus-Specific T-Cell Memory with Peptide-Loaded Dendritic Cells. J. Virol. 73: 334-342 [Abstract] [Full Text]
De Veerman, M., Heirman, C., Van Meirvenne, S., Devos, S., Corthals, J., Moser, M., Thielemans, K. (1999). Retrovirally Transduced Bone Marrow-Derived Dendritic Cells Require CD4+ T Cell Help to Elicit Protective and Therapeutic Antitumor Immunity. J. Immunol. 162: 144-151 [Abstract] [Full Text]
Labeur, M. S., Roters, B., Pers, B., Mehling, A., Luger, T. A., Schwarz, T., Grabbe, S. (1999). Generation of Tumor Immunity by Bone Marrow-Derived Dendritic Cells Correlates with Dendritic Cell Maturation Stage. J. Immunol. 162: 168-175 [Abstract] [Full Text]
Peron, J.-M., Esche, C., Subbotin, V. M., Maliszewski, C., Lotze, M. T., Shurin, M. R. (1998). FLT3-Ligand Administration Inhibits Liver Metastases: Role of NK Cells. J. Immunol. 161: 6164-6170 [Abstract] [Full Text]
Cao, X., Zhang, W., He, L., Xie, Z., Ma, S., Tao, Q., Yu, Y., Hamada, H., Wang, J. (1998). Lymphotactin Gene-Modified Bone Marrow Dendritic Cells Act as More Potent Adjuvants for Peptide Delivery to Induce Specific Antitumor Immunity. J. Immunol. 161: 6238-6244 [Abstract] [Full Text]
Brossart, P., Grunebach, F., Stuhler, G., Reichardt, V. L., Mohle, R., Kanz, L., Brugger, W. (1998). Generation of Functional Human Dendritic Cells From Adherent Peripheral Blood Monocytes by CD40 Ligation in the Absence of Granulocyte-Macrophage Colony-Stimulating Factor. Blood 92: 4238-4247 [Abstract] [Full Text]
Wang, J., Saffold, S., Cao, X., Krauss, J., Chen, W. (1998). Eliciting T Cell Immunity Against Poorly Immunogenic Tumors by Immunization with Dendritic Cell-Tumor Fusion Vaccines. J. Immunol. 161: 5516-5524 [Abstract] [Full Text]