Altered hepatic transport of immunoglobulin A in mice lacking the J chain

doi:10.1084/jem.182.6.1905

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Altered hepatic transport of immunoglobulin A in mice lacking the J chain

BA Hendrickson, DA Conner, DJ Ladd, D Kendall, JE Casanova, B Corthesy, EE Max, MR Neutra, CE Seidman and JG Seidman
Division of Infectious Diseases, Children's Hospital, Boston, Massachusetts, USA.

We have created J chain knockout mice to define the physiologic role of the J chain in immunoglobulin synthesis and transport. The J chain is covalently associated with pentameric immunoglobulin (Ig) M and dimeric IgA and is also expressed in most IgG-secreting cells. J chain- deficient mice have normal serum IgM and IgG levels but markedly elevated serum IgA. Although polymeric IgA was present in the mutant mice, a larger proportion of their serum IgA was monomeric than was found in wild-type mouse serum. Bile and fecal IgA levels were decreased in J chain-deficient mice compared with wild-type mice, suggesting inefficient transport of J chain-deficient IgA by hepatic polymeric immunoglobulin receptors (pIgR). The pIgR-mediated transport of serum-derived IgA from wild-type and mutant mice was assessed in Madin-Darby canine kidney (MDCK) cells transfected with the pIgR. These studies revealed selective transport by pIgR-expressing MDCK cells of wild-type IgA but not J chain-deficient IgA. We conclude that although the J chain is not required for IgA dimerization, it does affect the efficiency of polymerization or have a role in maintaining IgA dimer stability. Furthermore, the J chain is essential for efficient hepatic pIgR transport of IgA.
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Berdoz, J., Blanc, C. T., Reinhardt, M., Kraehenbuhl, J.-P., Corthesy, B. (1999). In vitro comparison of the antigen-binding and stability properties of the various molecular forms of IgA antibodies assembled and produced in CHO cells. Proc. Natl. Acad. Sci. USA 96: 3029-3034 [Abstract] [Full Text]
Sorensen, V., Sundvold, V., Michaelsen, T. E., Sandlie, I. (1999). Polymerization of IgA and IgM: Roles of Cys309/Cys414 and the Secretory Tailpiece. J. Immunol. 162: 3448-3455 [Abstract] [Full Text]
Wang, D. Q-H., Cohen, D. E., Lammert, F., Carey, M. C. (1999). No pathophysiologic relationship of soluble biliary proteins to cholesterol crystallization in human bile. J. Lipid Res. 40: 415-425 [Abstract] [Full Text]
Hexham, J. M., White, K. D., Carayannopoulos, L. N., Mandecki, W., Brisette, R., Yang, Y.-S., Capra, J. D. (1999). A Human Immunoglobulin (Ig)A Calpha 3 Domain Motif Directs Polymeric Ig Receptor-mediated Secretion. J. Exp. Med. 189: 747-752 [Abstract] [Full Text]
Wiersma, E. J., Collins, C., Fazel, S., Shulman, M. J. (1998). Structural and Functional Analysis of J Chain-Deficient IgM. J. Immunol. 160: 5979-5989 [Abstract] [Full Text]
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Ha, C.-L., Woodward, B. (1997). Reduction in the Quantity of the Polymeric Immunoglobulin Receptor Is Sufficient to Account for the Low Concentration of Intestinal Secretory Immunoglobulin A in a Weanling Mouse Model of Wasting Protein-Energy Malnutrition. J. Nutr. 127: 427-435 [Abstract] [Full Text]
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