CD1-restricted CD4+ T cells in major histocompatibility complex class II-deficient mice

doi:10.1084/jem.182.4.993

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CD1-restricted CD4+ T cells in major histocompatibility complex class II-deficient mice

S Cardell, S Tangri, S Chan, M Kronenberg, C Benoist and D Mathis
Institut de Genetique et de Biologie Moleculaire et Cellulaire, Universite Louis Pasteur, Illkirch, CU de Strasbourg, France.

Rather unexpectedly, major histocompatibility complex class II- deficient mice have a significant population of peripheral CD4+ T lymphocytes. We have investigated these cells at the population and clonal levels. CD4+ T lymphocytes from class II-deficient animals are thymically derived, appear early in ontogeny, exhibit the phenotype of resting memory cells, are potentially functional by several criteria, and have a diverse T cell receptor repertoire. They do not include substantially elevated numbers of NK1.1+ cells. Hybridomas derived after polyclonal stimulation of the CD4+ lymphocytes from class II- deficient animals include a subset with an unusual reactivity pattern, responding to splenocytes from many mouse strains including the strain of origin. Most members of this subset recognize the major histocompatibility complex class Ib molecule CD1; their heterogeneous reactivities and T cell receptor usage further suggest the involvement of peptides and/or highly variable posttranslational modifications.
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Zhan, Y., Brady, J. L., Sutherland, R. M., Lew, A. M. (2001). Without CD4 Help, CD8 Rejection of Pig Xenografts Requires CD28 Costimulation But Not Perforin Killing. J. Immunol. 167: 6279-6285 [Abstract] [Full Text]
Matsuda, J. L., Gapin, L., Fazilleau, N., Warren, K., Naidenko, O. V., Kronenberg, M. (2001). Natural killer T cells reactive to a single glycolipid exhibit a highly diverse T cell receptor beta repertoire and small clone size. Proc. Natl. Acad. Sci. USA 10.1073/pnas.221445298v1 [Abstract] [Full Text]
Bensinger, S. J., Bandeira, A., Jordan, M. S., Caton, A. J., Laufer, T. M. (2001). Major Histocompatibility Complex Class II-positive Cortical Epithelium Mediates the Selection of CD4+25+ Immunoregulatory T Cells. J. Exp. Med. 194: 427-438 [Abstract] [Full Text]
Hammond, K. J. L., Pellicci, D. G., Poulton, L. D., Naidenko, O. V., Scalzo, A. A., Baxter, A. G., Godfrey, D. I. (2001). CD1d-Restricted NKT Cells: An Interstrain Comparison. J. Immunol. 167: 1164-1173 [Abstract] [Full Text]
Maurice, M. M., Gould, D. S., Carroll, J., Vugmeyster, Y., Ploegh, H. L. (2001). Positive selection of an MHC class-I restricted TCR in the absence of classical MHC class I molecules. Proc. Natl. Acad. Sci. USA 10.1073/pnas.141143298v1 [Abstract] [Full Text]
Vivien, L., Benoist, C., Mathis, D. (2001). T lymphocytes need IL-7 but not IL-4 or IL-6 to survive in vivo. Int Immunol 13: 763-768 [Abstract] [Full Text]
Park, S.-H., Weiss, A., Benlagha, K., Kyin, T., Teyton, L., Bendelac, A. (2001). The Mouse CD1d-restricted Repertoire Is Dominated by a Few Autoreactive T Cell Receptor Families. J. Exp. Med. 193: 893-904 [Abstract] [Full Text]
Trobonjaca, Z., Leithauser, F., Moller, P., Bluethmann, H., Koezuka, Y., MacDonald, H. R., Reimann, J. (2001). MHC-II-Independent CD4+ T Cells Induce Colitis in Immunodeficient RAG-/- Hosts. J. Immunol. 166: 3804-3812 [Abstract] [Full Text]
Wang, B., Chun, T., Rulifson, I. C., Exley, M., Balk, S. P., Wang, C.-R. (2001). Human CD1d Functions as a Transplantation Antigen and a Restriction Element in Mice. J. Immunol. 166: 3829-3836 [Abstract] [Full Text]
Kronenberg, M., Naidenko, O., Koning, F. (2001). Right on target: Novel approaches for the direct visualization of CD1-specific T cell responses. Proc. Natl. Acad. Sci. USA 98: 2950-2952 [Full Text]
Carnaud, C., Gombert, J.-M., Donnars, O., Garchon, H.-J., Herbelin, A. (2001). Protection Against Diabetes and Improved NK/NKT Cell Performance in NOD.NK1.1 Mice Congenic at the NK Complex. J. Immunol. 166: 2404-2411 [Abstract] [Full Text]
Hameg, A., Apostolou, I., Leite-de-Moraes, M., Gombert, J.-M., Garcia, C., Koezuka, Y., Bach, J.-F., Herbelin, A. (2000). A Subset of NKT Cells That Lacks the NK1.1 Marker, Expresses CD1d Molecules, and Autopresents the {alpha}-Galactosylceramide Antigen. J. Immunol. 165: 4917-4926 [Abstract] [Full Text]
Hu, H.-M., Winter, H., Urba, W. J., Fox, B. A. (2000). Divergent Roles for CD4+ T Cells in the Priming and Effector/Memory Phases of Adoptive Immunotherapy. J. Immunol. 165: 4246-4253 [Abstract] [Full Text]
Zhan, Y., Corbett, A. J., Brady, J. L., Sutherland, R. M., Lew, A. M. (2000). CD4 Help-Independent Induction of Cytotoxic CD8 Cells to Allogeneic P815 Tumor Cells Is Absolutely Dependent on Costimulation. J. Immunol. 165: 3612-3619 [Abstract] [Full Text]
Viret, C., Lantz, O., He, X., Bendelac, A., Janeway, C. A. Jr. (2000). A NK1.1+ Thymocyte-Derived TCR {beta}-Chain Transgene Promotes Positive Selection of Thymic NK1.1+ {alpha}{beta} T Cells. J. Immunol. 165: 3004-3014 [Abstract] [Full Text]
Matsuda, J. L., Naidenko, O. V., Gapin, L., Nakayama, T., Taniguchi, M., Wang, C.-R., Koezuka, Y., Kronenberg, M. (2000). Tracking the Response of Natural Killer T Cells to a Glycolipid Antigen Using CD1d Tetramers. J. Exp. Med. 192: 741-754 [Abstract] [Full Text]
Skold, M., Faizunnessa, N. N., Wang, C.-R., Cardell, S. (2000). CD1d-Specific NK1.1+ T Cells with a Transgenic Variant TCR. J. Immunol. 165: 168-174 [Abstract] [Full Text]
Sieling, P. A., Ochoa, M.-T., Jullien, D., Leslie, D. S., Sabet, S., Rosat, J.-P., Burdick, A. E., Rea, T. H., Brenner, M. B., Porcelli, S. A., Modlin, R. L. (2000). Evidence for Human CD4+ T Cells in the CD1-Restricted Repertoire: Derivation of Mycobacteria-Reactive T Cells from Leprosy Lesions. J. Immunol. 164: 4790-4796 [Abstract] [Full Text]
Muranski, P., Chmielowski, B., Ignatowicz, L. (2000). Mature CD4+ T Cells Perceive a Positively Selecting Class II MHC/Peptide Complex in the Periphery. J. Immunol. 164: 3087-3094 [Abstract] [Full Text]
Witherden, D., van Oers, N., Waltzinger, C., Weiss, A., Benoist, C., Mathis, D. (2000). Tetracycline-controllable Selection of CD4+ T Cells: Half-Life and Survival Signals in the Absence of Major Histocompatibility Complex Class II Molecules. J. Exp. Med. 191: 355-364 [Abstract] [Full Text]
Wang, B., Chun, T., Wang, C.-R. (2000). Comparative Contribution of CD1 on the Development of CD4+ and CD8+ T Cell Compartments. J. Immunol. 164: 739-745 [Abstract] [Full Text]
Melian, A., Geng, Y.-J., Sukhova, G. K., Libby, P., Porcelli, S. A. (1999). CD1 Expression in Human Atherosclerosis : A Potential Mechanism for T Cell Activation by Foam Cells. Am. J. Pathol. 155: 775-786 [Abstract] [Full Text]
Behar, S. M., Dascher, C. C., Grusby, M. J., Wang, C.-R., Brenner, M. B. (1999). Susceptibility of Mice Deficient in CD1D or TAP1 to Infection with Mycobacterium tuberculosis. J. Exp. Med. 189: 1973-1980 [Abstract] [Full Text]
Emoto, M., Mittrucker, H.-W., Schmits, R., Mak, T. W., Kaufmann, S. H. E. (1999). Critical Role of Leukocyte Function-Associated Antigen-1 in Liver Accumulation of CD4+NKT Cells. J. Immunol. 162: 5094-5098 [Abstract] [Full Text]
Chen, Y.-H., Wang, B., Chun, T., Zhao, L., Cardell, S., Behar, S. M., Brenner, M. B., Wang, C.-R. (1999). Expression of CD1d2 on Thymocytes Is Not Sufficient for the Development of NK T Cells in CD1d1-Deficient Mice. J. Immunol. 162: 4560-4566 [Abstract] [Full Text]
Kim, H. S., Garcia, J., Exley, M., Johnson, K. W., Balk, S. P., Blumberg, R. S. (1999). Biochemical Characterization of CD1d Expression in the Absence of beta 2-Microglobulin. J. Biol. Chem. 274: 9289-9295 [Abstract] [Full Text]
Schofield, L., McConville, M. J., Hansen, D., Campbell, A. S., Fraser-Reid, B., Grusby, M. J., Tachado, S. D. (1999). CD1d-Restricted Immunoglobulin G Formation to GPI-Anchored Antigens Mediated by NKT Cells. Science 283: 225-229 [Abstract] [Full Text]
Chiu, Y.-H., Jayawardena, J., Weiss, A., Lee, D., Park, S.-H., Dautry-Varsat, A., Bendelac, A. (1999). Distinct Subsets of CD1d-restricted T Cells Recognize Self-antigens Loaded in Different Cellular Compartments. J. Exp. Med. 189: 103-110 [Abstract] [Full Text]
Chmielowski, B., Muranski, P., Ignatowicz, L. (1999). In the Normal Repertoire of CD4+ T Cells, a Single Class II MHC/Peptide Complex Positively Selects TCRs with Various Antigen Specificities. J. Immunol. 162: 95-105 [Abstract] [Full Text]
Behar, S. M., Podrebarac, T. A., Roy, C. J., Wang, C. R., Brenner, M. B. (1999). Diverse TCRs Recognize Murine CD1. J. Immunol. 162: 161-167 [Abstract] [Full Text]
Chan, S., Correia-Neves, M., Dierich, A., Benoist, C., Mathis, D. (1998). Visualization of CD4/CD8 T Cell Commitment. J. Exp. Med. 188: 2321-2333 [Abstract] [Full Text]
Mostaghel, E. A., Riberdy, J. M., Steeber, D. A., Doyle, C. (1998). Coreceptor-Independent T Cell Activation in Mice Expressing MHC Class II Molecules Mutated in the CD4 Binding Domain. J. Immunol. 161: 6559-6566 [Abstract] [Full Text]
Gilfillan, S., Shen, X., Konig3, R. (1998). Selection and Function of CD4+ T Lymphocytes in Transgenic Mice Expressing Mutant MHC Class II Molecules Deficient in Their Interaction with CD4. J. Immunol. 161: 6629-6637 [Abstract] [Full Text]
Tangri, S., Brossay, L., Burdin, N., Lee, D. J., Corr, M., Kronenberg, M. (1998). Presentation of peptide antigens by mouse CD1 requires endosomal localization and protein antigen processing. Proc. Natl. Acad. Sci. USA 95: 14314-14319 [Abstract] [Full Text]
Brossay, L., Chioda, M., Burdin, N., Koezuka, Y., Casorati, G., Dellabona, P., Kronenberg, M. (1998). CD1d-mediated Recognition of an alpha -Galactosylceramide by Natural Killer T Cells Is Highly Conserved through Mammalian Evolution. J. Exp. Med. 188: 1521-1528 [Abstract] [Full Text]
Burdin, N., Brossay, L., Koezuka, Y., Smiley, S. T., Grusby, M. J., Gui, M., Taniguchi, M., Hayakawa, K., Kronenberg, M. (1998). Selective Ability of Mouse CD1 to Present Glycolipids: {alpha}-Galactosylceramide Specifically Stimulates V{alpha}14+ NK T Lymphocytes. J. Immunol. 161: 3271-3281 [Abstract] [Full Text]
Amano, M., Baumgarth, N., Dick, M. D., Brossay, L., Kronenberg, M., Herzenberg, L. A., Strober, S. (1998). CD1 Expression Defines Subsets of Follicular and Marginal Zone B Cells in the Spleen: {beta}2-Microglobulin-Dependent and Independent Forms. J. Immunol. 161: 1710-1717 [Abstract] [Full Text]
Foucras, G., Coureau, C., Beijleveld, L., Druet, P., Saoudi, A., Guery, J.-C. (1998). {beta}2-Microglobulin-Dependent T Cells Are Not Necessary for Alloantigen-Induced Th2 Responses After Neonatal Induction of Lymphoid Chimerism in Mice. J. Immunol. 161: 1751-1757 [Abstract] [Full Text]
Brossay, L., Tangri, S., Bix, M., Cardell, S., Locksley, R., Kronenberg, M. (1998). Mouse CD1-Autoreactive T Cells Have Diverse Patterns of Reactivity to CD1+ Targets. J. Immunol. 160: 3681-3688 [Abstract] [Full Text]
Riberdy, J. M., Mostaghel, E., Doyle, C. (1998). Disruption of the CD4-major histocompatibility complex class II interaction blocks the development of CD4+ T cells in vivo. Proc. Natl. Acad. Sci. USA 95: 4493-4498 [Abstract] [Full Text]
Roark, J. H., Park, S.-H., Jayawardena, J., Kavita, U., Shannon, M., Bendelac, A. (1998). CD1.1 Expression by Mouse Antigen-Presenting Cells and Marginal Zone B Cells. J. Immunol. 160: 3121-3127 [Abstract] [Full Text]
Park, S.-H., Roark, J. H., Bendelac, A. (1998). Tissue-Specific Recognition of Mouse CD1 Molecules. J. Immunol. 160: 3128-3134 [Abstract] [Full Text]
Lee, D. J., Abeyratne, A., Carson, D. A., Corr, M. (1998). Induction of an Antigen-specific, CD1-restricted Cytotoxic T Lymphocyte Response In vivo. J. Exp. Med. 187: 433-438 [Abstract] [Full Text]
Tourne, S., Miyazaki, T., Wolf, P., Ploegh, H., Benoist, C., Mathis, D. (1997). Functionality of major histocompatibility complex class II molecules in mice doubly deficient for invariant chain and H-2M�complexes. Proc. Natl. Acad. Sci. USA 94: 9255-9260 [Abstract] [Full Text]
Zeng, Z., Castaño, A. R., Segelke, B. W., Stura, E. A., Peterson, P. A., Wilson, I. A. (1997). Crystal Structure of Mouse CD1: An MHC-Like Fold with a Large Hydrophobic Binding Groove. Science 277: 339-345 [Abstract] [Full Text]
Smiley, S. T., Kaplan, M. H., Grusby, M. J. (1997). Immunoglobulin E Production in the Absence of Interleukin-4-Secreting CD1-Dependent Cells. Science 275: 977-979 [Abstract] [Full Text]
Maurice, M. M., Gould, D. S., Carroll, J., Vugmeyster, Y., Ploegh, H. L. (2001). Positive selection of an MHC class-I restricted TCR in the absence of classical MHC class I molecules. Proc. Natl. Acad. Sci. USA 98: 7437-7442 [Abstract] [Full Text]
Matsuda, J. L., Gapin, L., Fazilleau, N., Warren, K., Naidenko, O. V., Kronenberg, M. (2001). Natural killer T cells reactive to a single glycolipid exhibit a highly diverse T cell receptor beta repertoire and small clone size. Proc. Natl. Acad. Sci. USA 98: 12636-12641 [Abstract] [Full Text]