The p47phox mouse knock-out model of chronic granulomatous disease

doi:10.1084/jem.182.3.751

This Article

	Full Text (PDF)
	Alert me when this article is cited
	Citation Map

Services

	Email this article
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new content in the JEM
	Download to citation manager

Citing Articles

	Citing Articles via HighWire
	Citing Articles via CrossRef
	Citing Articles via Google Scholar

Google Scholar

	Articles by Jackson, S. H.
	Articles by Holland, S. M.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Jackson, S. H.
	Articles by Holland, S. M.


Social Bookmarking

	What's this?

ARTICLES

The p47phox mouse knock-out model of chronic granulomatous disease

SH Jackson, JI Gallin and SM Holland
Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892-1886, USA.

Chronic granulomatous disease (CGD) is caused by a congenital defect in phagocyte reduced nicotinamide dinucleotide phosphate (NADPH) oxidase production of superoxide and related species. It is characterized by recurrent life-threatening bacterial and fungal infections and tissue granuloma formation. We have created a mouse model of CGD by targeted disruption of p47phox, one of the genes in which mutations cause human CGD. Identical to the case in human CGD, leukocytes from p47phox-/- mice produced no superoxide and killed staphylococci ineffectively. p47phox-/- mice developed lethal infections and granulomatous inflammation similar to those encountered in human CGD patients. This model mirrors human CGD and confirms a critical role for the phagocyte NADPH oxidase in mammalian host defense.
Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Add to Reddit Reddit Add to Technorati Technorati What's this?

This article has been cited by other articles:

Dale, D. C., Boxer, L., Liles, W. C. (2008). The phagocytes: neutrophils and monocytes. Blood 112: 935-945 [Abstract] [Full Text]
Omori, K., Ohira, T., Uchida, Y., Ayilavarapu, S., Batista, E. L. Jr., Yagi, M., Iwata, T., Liu, H., Hasturk, H., Kantarci, A., Van Dyke, T. E. (2008). Priming of neutrophil oxidative burst in diabetes requires preassembly of the NADPH oxidase. J. Leukoc. Biol. 84: 292-301 [Abstract] [Full Text]
Fuhrman, B., Khateeb, J., Shiner, M., Nitzan, O., Karry, R., Volkova, N., Aviram, M. (2008). Urokinase Plasminogen Activator Upregulates Paraoxonase 2 Expression in Macrophages Via an NADPH Oxidase-Dependent Mechanism. Arterioscler. Thromb. Vasc. Bio. 28: 1361-1367 [Abstract] [Full Text]
Zwaferink, H., Stockinger, S., Reipert, S., Decker, T. (2008). Stimulation of Inducible Nitric Oxide Synthase Expression by Beta Interferon Increases Necrotic Death of Macrophages upon Listeria monocytogenes Infection. Infect. Immun. 76: 1649-1656 [Abstract] [Full Text]
Ward, P. P., Mendoza-Meneses, M., Park, P. W., Conneely, O. M. (2008). Stimulus-Dependent Impairment of the Neutrophil Oxidative Burst Response in Lactoferrin-Deficient Mice. Am. J. Pathol. 172: 1019-1029 [Abstract] [Full Text]
Baumer, A. T., ten Freyhaus, H., Sauer, H., Wartenberg, M., Kappert, K., Schnabel, P., Konkol, C., Hescheler, J., Vantler, M., Rosenkranz, S. (2008). Phosphatidylinositol 3-Kinase-dependent Membrane Recruitment of Rac-1 and p47phox Is Critical for {alpha}-Platelet-derived Growth Factor Receptor-induced Production of Reactive Oxygen Species. J. Biol. Chem. 283: 7864-7876 [Abstract] [Full Text]
Xu, L., Fang, H., Frucht, D. M. (2008). Anthrax Lethal Toxin Increases Superoxide Production in Murine Neutrophils via Differential Effects on MAPK Signaling Pathways. J. Immunol. 180: 4139-4147 [Abstract] [Full Text]
Chitano, P., Wang, L., Mason, S. N., Auten, R. L., Potts, E. N., Foster, W. M., Sturrock, A., Kennedy, T. P., Hoidal, J. R., Murphy, T. M. (2008). Airway smooth muscle relaxation is impaired in mice lacking the p47phox subunit of NAD(P)H oxidase. Am. J. Physiol. Lung Cell. Mol. Physiol. 294: L139-L148 [Abstract] [Full Text]
Narni-Mancinelli, E., Campisi, L., Bassand, D., Cazareth, J., Gounon, P., Glaichenhaus, N., Lauvau, G. (2007). Memory CD8+ T cells mediate antibacterial immunity via CCL3 activation of TNF/ROI+ phagocytes. J. Exp. Med. 204: 2075-2087 [Abstract] [Full Text]
Oellerich, M. F., Jacobi, C. A., Freund, S., Niedung, K., Bach, A., Heesemann, J., Trulzsch, K. (2007). Yersinia enterocolitica Infection of Mice Reveals Clonal Invasion and Abscess Formation. Infect. Immun. 75: 3802-3811 [Abstract] [Full Text]
Woods, C. G., Burns, A. M., Bradford, B. U., Ross, P. K., Kosyk, O., Swenberg, J. A., Cunningham, M. L., Rusyn, I. (2007). WY-14,643 Induced Cell Proliferation and Oxidative Stress in Mouse Liver are Independent of NADPH Oxidase. Toxicol Sci 98: 366-374 [Abstract] [Full Text]
Hultqvist, M., Backlund, J., Bauer, K., Gelderman, K. A., Holmdahl, R. (2007). Lack of Reactive Oxygen Species Breaks T Cell Tolerance to Collagen Type II and Allows Development of Arthritis in Mice. J. Immunol. 179: 1431-1437 [Abstract] [Full Text]
Zarember, K. A., Sugui, J. A., Chang, Y. C., Kwon-Chung, K. J., Gallin, J. I. (2007). Human Polymorphonuclear Leukocytes Inhibit Aspergillus fumigatus Conidial Growth by Lactoferrin-Mediated Iron Depletion. J. Immunol. 178: 6367-6373 [Abstract] [Full Text]
Doerries, C., Grote, K., Hilfiker-Kleiner, D., Luchtefeld, M., Schaefer, A., Holland, S. M., Sorrentino, S., Manes, C., Schieffer, B., Drexler, H., Landmesser, U. (2007). Critical Role of the NAD(P)H Oxidase Subunit p47phox for Left Ventricular Remodeling/Dysfunction and Survival After Myocardial Infarction. Circ. Res. 100: 894-903 [Abstract] [Full Text]
de Oliveira-Marques, V., Cyrne, L., Marinho, H. S., Antunes, F. (2007). A Quantitative Study of NF-{kappa}B Activation by H2O2: Relevance in Inflammation and Synergy with TNF-{alpha}. J. Immunol. 178: 3893-3902 [Abstract] [Full Text]
Roberts, R. A., Ganey, P. E., Ju, C., Kamendulis, L. M., Rusyn, I., Klaunig, J. E. (2007). Role of the Kupffer Cell in Mediating Hepatic Toxicity and Carcinogenesis. Toxicol Sci 96: 2-15 [Abstract] [Full Text]
Segal, B. H., Davidson, B. A., Hutson, A. D., Russo, T. A., Holm, B. A., Mullan, B., Habitzruther, M., Holland, S. M., Knight, P. R. III (2007). Acid aspiration-induced lung inflammation and injury are exacerbated in NADPH oxidase-deficient mice. Am. J. Physiol. Lung Cell. Mol. Physiol. 292: L760-L768 [Abstract] [Full Text]
Bedard, K., Krause, K.-H. (2007). The NOX Family of ROS-Generating NADPH Oxidases: Physiology and Pathophysiology. Physiol. Rev. 87: 245-313 [Abstract] [Full Text]
Utomo, A., Cullere, X., Glogauer, M., Swat, W., Mayadas, T. N. (2006). Vav Proteins in Neutrophils Are Required for Fc{gamma}R-Mediated Signaling to Rac GTPases and Nicotinamide Adenine Dinucleotide Phosphate Oxidase Component p40(phox). J. Immunol. 177: 6388-6397 [Abstract] [Full Text]
Weighardt, H., Kaiser-Moore, S., Schlautkotter, S., Rossmann-Bloeck, T., Schleicher, U., Bogdan, C., Holzmann, B. (2006). Type I IFN Modulates Host Defense and Late Hyperinflammation in Septic Peritonitis. J. Immunol. 177: 5623-5630 [Abstract] [Full Text]
Vogel, S. M., Orrington-Myers, J., Broman, M., Malik, A. B. (2006). De novo ICAM-1 synthesis in the mouse lung: model of assessment of protein expression in lungs. Am. J. Physiol. Lung Cell. Mol. Physiol. 291: L496-L501 [Abstract] [Full Text]
Reinehr, R., Becker, S., Braun, J., Eberle, A., Grether-Beck, S., Haussinger, D. (2006). Endosomal Acidification and Activation of NADPH Oxidase Isoforms Are Upstream Events in Hyperosmolarity-induced Hepatocyte Apoptosis. J. Biol. Chem. 281: 23150-23166 [Abstract] [Full Text]
Ellson, C. D., Davidson, K., Ferguson, G. J., O'Connor, R., Stephens, L. R., Hawkins, P. T. (2006). Neutrophils from p40phox-/- mice exhibit severe defects in NADPH oxidase regulation and oxidant-dependent bacterial killing. J. Exp. Med. 203: 1927-1937 [Abstract] [Full Text]
Kishida, K. T., Hoeffer, C. A., Hu, D., Pao, M., Holland, S. M., Klann, E. (2006). Synaptic Plasticity Deficits and Mild Memory Impairments in Mouse Models of Chronic Granulomatous Disease. Mol. Cell. Biol. 26: 5908-5920 [Abstract] [Full Text]
Grote, K., Ortmann, M., Salguero, G., Doerries, C., Landmesser, U., Luchtefeld, M., Brandes, R. P., Gwinner, W., Tschernig, T., Brabant, E.-G., Klos, A., Schaefer, A., Drexler, H., Schieffer, B. (2006). Critical role for p47phox in renin-angiotensin system activation and blood pressure regulation. Cardiovasc Res 71: 596-605 [Abstract] [Full Text]
Sancho-Shimizu, V., Malo, D. (2006). Sequencing, Expression, and Functional Analyses Support the Candidacy of Ncf2 in Susceptibility to Salmonella Typhimurium Infection in Wild-Derived Mice.. J. Immunol. 176: 6954-6961 [Abstract] [Full Text]
Weissmann, N., Zeller, S., Schafer, R. U., Turowski, C., Ay, M., Quanz, K., Ghofrani, H. A., Schermuly, R. T., Fink, L., Seeger, W., Grimminger, F. (2006). Impact of Mitochondria and NADPH Oxidases on Acute and Sustained Hypoxic Pulmonary Vasoconstriction. Am. J. Respir. Cell Mol. Bio. 34: 505-513 [Abstract] [Full Text]
Dennis, C. G., Greco, W. R., Brun, Y., Youn, R., Slocum, H. K., Bernacki, R. J., Lewis, R., Wiederhold, N., Holland, S. M., Petraitiene, R., Walsh, T. J., Segal, B. H. (2006). Effect of Amphotericin B and Micafungin Combination on Survival, Histopathology, and Fungal Burden in Experimental Aspergillosis in the p47phox-/- Mouse Model of Chronic Granulomatous Disease. Antimicrob. Agents Chemother. 50: 422-427 [Abstract] [Full Text]
He, L., Dinger, B., Sanders, K., Hoidal, J., Obeso, A., Stensaas, L., Fidone, S., Gonzalez, C. (2005). Effect of p47phox gene deletion on ROS production and oxygen sensing in mouse carotid body chemoreceptor cells. Am. J. Physiol. Lung Cell. Mol. Physiol. 289: L916-L924 [Abstract] [Full Text]
Sheppard, F. R., Kelher, M. R., Moore, E. E., McLaughlin, N. J. D., Banerjee, A., Silliman, C. C. (2005). Structural organization of the neutrophil NADPH oxidase: phosphorylation and translocation during priming and activation. J. Leukoc. Biol. 78: 1025-1042 [Abstract] [Full Text]
Yang, T., Zhang, A., Honeggar, M., Kohan, D. E., Mizel, D., Sanders, K., Hoidal, J. R., Briggs, J. P., Schnermann, J. B. (2005). Hypertonic Induction of COX-2 in Collecting Duct Cells by Reactive Oxygen Species of Mitochondrial Origin. J. Biol. Chem. 280: 34966-34973 [Abstract] [Full Text]
De Ciuceis, C., Amiri, F., Brassard, P., Endemann, D. H., Touyz, R. M., Schiffrin, E. L. (2005). Reduced Vascular Remodeling, Endothelial Dysfunction, and Oxidative Stress in Resistance Arteries of Angiotensin II-Infused Macrophage Colony-Stimulating Factor-Deficient Mice: Evidence for a Role in Inflammation in Angiotensin-Induced Vascular Injury. Arterioscler. Thromb. Vasc. Bio. 25: 2106-2113 [Abstract] [Full Text]
Crandall, H., Ma, Y., Dunn, D. M., Sundsbak, R. S., Zachary, J. F., Olofsson, P., Holmdahl, R., Weis, J. H., Weiss, R. B., Teuscher, C., Weis, J. J. (2005). Bb2Bb3 Regulation of Murine Lyme Arthritis Is Distinct from Ncf1 and Independent of the Phagocyte Nicotinamide Adenine Dinucleotide Phosphate Oxidase. Am. J. Pathol. 167: 775-785 [Abstract] [Full Text]
Bignell, E., Negrete-Urtasun, S., Calcagno, A. M., Arst, H. N. Jr., Rogers, T., Haynes, K. (2005). Virulence Comparisons of Aspergillus nidulans Mutants Are Confounded by the Inflammatory Response of p47phox-/- Mice. Infect. Immun. 73: 5204-5207 [Abstract] [Full Text]
Bennouna, S., Denkers, E. Y. (2005). Microbial Antigen Triggers Rapid Mobilization of TNF-{alpha} to the Surface of Mouse Neutrophils Transforming Them into Inducers of High-Level Dendritic Cell TNF-{alpha} Production. J. Immunol. 174: 4845-4851 [Abstract] [Full Text]
Teufelhofer, O., Parzefall, W., Kainzbauer, E., Ferk, F., Freiler, C., Knasmuller, S., Elbling, L., Thurman, R., Schulte-Hermann, R. (2005). Superoxide generation from Kupffer cells contributes to hepatocarcinogenesis: studies on NADPH oxidase knockout mice. Carcinogenesis 26: 319-329 [Abstract] [Full Text]
Lekstrom-Himes, J. A., Kuhns, D. B., Alvord, W. G., Gallin, J. I. (2005). Inhibition of Human Neutrophil IL-8 Production by Hydrogen Peroxide and Dysregulation in Chronic Granulomatous Disease. J. Immunol. 174: 411-417 [Abstract] [Full Text]
Dinauer, M. C. (2005). Chronic Granulomatous Disease and Other Disorders of Phagocyte Function. ASH Education Book 2005: 89-95 [Abstract] [Full Text]
Lindgren, H., Stenmark, S., Chen, W., Tarnvik, A., Sjostedt, A. (2004). Distinct Roles of Reactive Nitrogen and Oxygen Species To Control Infection with the Facultative Intracellular Bacterium Francisella tularensis. Infect. Immun. 72: 7172-7182 [Abstract] [Full Text]
Gillman, B. M., Batchelder, J., Flaherty, P., Weidanz, W. P. (2004). Suppression of Plasmodium chabaudi Parasitemia Is Independent of the Action of Reactive Oxygen Intermediates and/or Nitric Oxide. Infect. Immun. 72: 6359-6366 [Abstract] [Full Text]
Bauer, A. K., Malkinson, A. M., Kleeberger, S. R. (2004). Susceptibility to neoplastic and non-neoplastic pulmonary diseases in mice: genetic similarities. Am. J. Physiol. Lung Cell. Mol. Physiol. 287: L685-L703 [Abstract] [Full Text]
Chatterjee, S., Fisher, A. B. (2004). ROS to the rescue. Am. J. Physiol. Lung Cell. Mol. Physiol. 287: L704-L705 [Full Text]
Rothfork, J. M., Timmins, G. S., Harris, M. N., Chen, X., Lusis, A. J., Otto, M., Cheung, A. L., Gresham, H. D. (2004). Inactivation of a bacterial virulence pheromone by phagocyte-derived oxidants: New role for the NADPH oxidase in host defense. Proc. Natl. Acad. Sci. USA 101: 13867-13872 [Abstract] [Full Text]
Hultqvist, M., Olofsson, P., Holmberg, J., Backstrom, B. T., Tordsson, J., Holmdahl, R. (2004). Enhanced autoimmunity, arthritis, and encephalomyelitis in mice with a reduced oxidative burst due to a mutation in the Ncf1 gene. Proc. Natl. Acad. Sci. USA 101: 12646-12651 [Abstract] [Full Text]
Missall, T. A., Lodge, J. K., McEwen, J. E. (2004). Mechanisms of Resistance to Oxidative and Nitrosative Stress: Implications for Fungal Survival in Mammalian Hosts. Eukaryot Cell 3: 835-846 [Full Text]
Rusyn, I., Asakura, S., Pachkowski, B., Bradford, B. U., Denissenko, M. F., Peters, J. M., Holland, S. M., Reddy, J. K., Cunningham, M. L., Swenberg, J. A. (2004). Expression of Base Excision DNA Repair Genes Is a Sensitive Biomarker for in Vivo Detection of Chemical-induced Chronic Oxidative Stress: Identification of the Molecular Source of Radicals Responsible for DNA Damage by Peroxisome Proliferators. Cancer Res. 64: 1050-1057 [Abstract] [Full Text]
Felix, K., Polack, A., Pretsch, W., Jackson, S. H., Feigenbaum, L., Bornkamm, G.-W., Janz, S. (2004). Moderate Hypermutability of a Transgenic lacZ Reporter Gene in Myc-Dependent Inflammation-Induced Plasma Cell Tumors in Mice. Cancer Res. 64: 530-537 [Abstract] [Full Text]
Hwang, J., Saha, A., Boo, Y. C., Sorescu, G. P., McNally, J. S., Holland, S. M., Dikalov, S., Giddens, D. P., Griendling, K. K., Harrison, D. G., Jo, H. (2003). Oscillatory Shear Stress Stimulates Endothelial Production of O2- from p47phox-dependent NAD(P)H Oxidases, Leading to Monocyte Adhesion. J. Biol. Chem. 278: 47291-47298 [Abstract] [Full Text]
Plewes, K. A., Barr, S. D., Gedamu, L. (2003). Iron Superoxide Dismutases Targeted to the Glycosomes of Leishmania chagasi Are Important for Survival. Infect. Immun. 71: 5910-5920 [Abstract] [Full Text]
van de Loo, F. A. J., Bennink, M. B., Arntz, O. J., Smeets, R. L., Lubberts, E., Joosten, L. A. B., van Lent, P. L. E. M., Coenen-de Roo, C. J. J., Cuzzocrea, S., Segal, B. H., Holland, S. M., van den Berg, W. B. (2003). Deficiency of NADPH Oxidase Components p47phox and gp91phox Caused Granulomatous Synovitis and Increased Connective Tissue Destruction in Experimental Arthritis Models. Am. J. Pathol. 163: 1525-1537 [Abstract] [Full Text]
Schaper, M., Leib, S. L., Meli, D. N., Brandes, R. P., Tauber, M. G., Christen, S. (2003). Differential Effect of p47phox and gp91phox Deficiency on the Course of Pneumococcal Meningitis. Infect. Immun. 71: 4087-4092 [Abstract] [Full Text]
Grote, K., Flach, I., Luchtefeld, M., Akin, E., Holland, S. M., Drexler, H., Schieffer, B. (2003). Mechanical Stretch Enhances mRNA Expression and Proenzyme Release of Matrix Metalloproteinase-2 (MMP-2) via NAD(P)H Oxidase-Derived Reactive Oxygen Species. Circ. Res. 92 : e80-e86 [Abstract] [Full Text]
Brown, J. R., Goldblatt, D., Buddle, J., Morton, L., Thrasher, A. J. (2003). Diminished production of anti-inflammatory mediators during neutrophil apoptosis and macrophage phagocytosis in chronic granulomatous disease (CGD). J. Leukoc. Biol. 73: 591-599 [Abstract] [Full Text]
Kleeberger, S.R. (2003). Genetic aspects of susceptibility to air pollution. Eur Respir J 21: 52S-56s [Abstract] [Full Text]
Dechend, R., Viedt, C., Muller, D. N., Ugele, B., Brandes, R. P., Wallukat, G., Park, J.-K., Janke, J., Barta, P., Theuer, J., Fiebeler, A., Homuth, V., Dietz, R., Haller, H., Kreuzer, J., Luft, F. C. (2003). AT1 Receptor Agonistic Antibodies From Preeclamptic Patients Stimulate NADPH Oxidase. Circulation 107: 1632-1639 [Abstract] [Full Text]
Wheeler, M. D., Thurman, R. G. (2003). Up-regulation of CD14 in Liver Caused by Acute Ethanol Involves Oxidant-dependent AP-1 Pathway. J. Biol. Chem. 278: 8435-8441 [Abstract] [Full Text]
Welte, T., Zhang, S. S. M., Wang, T., Zhang, Z., Hesslein, D. G. T., Yin, Z., Kano, A., Iwamoto, Y., Li, E., Craft, J. E., Bothwell, A. L. M., Fikrig, E., Koni, P. A., Flavell, R. A., Fu, X.-Y. (2003). STAT3 deletion during hematopoiesis causes Crohn's disease-like pathogenesis and lethality: A critical role of STAT3 in innate immunity. Proc. Natl. Acad. Sci. USA 100: 1879-1884 [Abstract] [Full Text]
Roes, J., Choi, B. K., Power, D., Xu, P., Segal, A. W. (2003). Granulocyte Function in Grancalcin-Deficient Mice. Mol. Cell. Biol. 23: 826-830 [Abstract] [Full Text]
Segal, B. H., Ding, L., Holland, S. M. (2003). Phagocyte NADPH Oxidase, but Not Inducible Nitric Oxide Synthase, Is Essential for Early Control of Burkholderia cepacia and Chromobacterium violaceum Infection in Mice. Infect. Immun. 71: 205-210 [Abstract] [Full Text]
SATO, K., KADIISKA, M. B., GHIO, A. J., CORBETT, J., FANN, Y. C., HOLLAND, S. M., THURMAN, R. G., MASON, R. P. (2002). In vivo lipid-derived free radical formation by NADPH oxidase in acute lung injury induced by lipopolysaccharide: a model for ARDS. FASEB J. 16: 1713-1720 [Abstract] [Full Text]
Gomes, M. S., Appelberg, R. (2002). NRAMP1- or cytokine-induced bacteriostasis of Mycobacterium avium by mouse macrophages is independent of the respiratory burst. Microbiology 148: 3155-3160 [Abstract] [Full Text]
Sanders, K. A., Sundar, K. M., He, L., Dinger, B., Fidone, S., Hoidal, J. R. (2002). Role of components of the phagocytic NADPH oxidase in oxygen sensing. J. Appl. Physiol. 93: 1357-1364 [Abstract] [Full Text]
Landmesser, U., Cai, H., Dikalov, S., McCann, L., Hwang, J., Jo, H., Holland, S. M., Harrison, D. G. (2002). Role of p47phox in Vascular Oxidative Stress and Hypertension Caused by Angiotensin II. Hypertension 40: 511-515 [Abstract] [Full Text]
Yang, S., Panoskaltsis-Mortari, A., Shukla, M., Blazar, B. R., Haddad, I. Y. (2002). Exuberant Inflammation in Nicotinamide Adenine Dinucleotide Phosphate-Oxidase-Deficient Mice After Allogeneic Marrow Transplantation. J. Immunol. 168: 5840-5847 [Abstract] [Full Text]
Frey, R. S., Rahman, A., Kefer, J. C., Minshall, R. D., Malik, A. B. (2002). PKC{zeta} Regulates TNF-{alpha}-Induced Activation of NADPH Oxidase in Endothelial Cells. Circ. Res. 90: 1012-1019 [Abstract] [Full Text]
Ju, J. Y., Polhamus, C., Marr, K. A., Holland, S. M., Bennett, J. E. (2002). Efficacies of Fluconazole, Caspofungin, and Amphotericin B in Candida glabrata-Infected p47phox-/- Knockout Mice. Antimicrob. Agents Chemother. 46: 1240-1245 [Abstract] [Full Text]
van Diepen, A., van der Straaten, T., Holland, S. M., Janssen, R., van Dissel, J. T. (2002). A Superoxide-Hypersusceptible Salmonella enterica Serovar Typhimurium Mutant Is Attenuated but Regains Virulence in p47phox-/- Mice. Infect. Immun. 70: 2614-2621 [Abstract] [Full Text]
Hampton, M. B., Vissers, M. C. M., Keenan, J. I., Winterbourn, C. C. (2002). Oxidant-mediated phosphatidylserine exposure and macrophage uptake of activated neutrophils: possible impairment in chronic granulomatous disease. J. Leukoc. Biol. 71: 775-781 [Abstract] [Full Text]
Gao, X.-p., Standiford, T. J., Rahman, A., Newstead, M., Holland, S. M., Dinauer, M. C., Liu, Q.-h., Malik, A. B. (2002). Role of NADPH Oxidase in the Mechanism of Lung Neutrophil Sequestration and Microvessel Injury Induced by Gram-Negative Sepsis: Studies in p47phox-/- and gp91phox-/- Mice. J. Immunol. 168: 3974-3982 [Abstract] [Full Text]
Segal, B. H., Kuhns, D. B., Ding, L., Gallin, J. I., Holland, S. M. (2002). Thioglycollate peritonitis in mice lacking C5, 5-lipoxygenase, or p47phox: complement, leukotrienes, and reactive oxidants in acute inflammation. J. Leukoc. Biol. 71: 410-416 [Abstract] [Full Text]
Harbord, M., Novelli, M., Canas, B., Power, D., Davis, C., Godovac-Zimmermann, J., Roes, J., Segal, A. W. (2002). Ym1 Is a Neutrophil Granule Protein That Crystallizes in p47phox-deficient Mice. J. Biol. Chem. 277: 5468-5475 [Abstract] [Full Text]
Ramsey, K. H., Sigar, I. M., Rana, S. V., Gupta, J., Holland, S. M., Byrne, G. I. (2001). Role for Inducible Nitric Oxide Synthase in Protection from Chronic Chlamydia trachomatis Urogenital Disease in Mice and Its Regulation by Oxygen Free Radicals. Infect. Immun. 69: 7374-7379 [Abstract] [Full Text]
Krieglstein, C. F., Cerwinka, W. H., Laroux, F. S., Salter, J. W., Russell, J. M., Schuermann, G., Grisham, M. B., Ross, C. R., Granger, D. N. (2001). Regulation of Murine Intestinal Inflammation by Reactive Metabolites of Oxygen and Nitrogen: Divergent Roles of Superoxide and Nitric Oxide. J. Exp. Med. 194: 1207-1218 [Abstract] [Full Text]
Koay, M. A., Christman, J. W., Segal, B. H., Venkatakrishnan, A., Blackwell, T. R., Holland, S. M., Blackwell, T. S. (2001). Impaired Pulmonary NF-{kappa}B Activation in Response to Lipopolysaccharide in NADPH Oxidase-Deficient Mice. Infect. Immun. 69: 5991-5996 [Abstract] [Full Text]
Saito, M., Ohga, S., Endoh, M., Nakayama, H., Mizunoe, Y., Hara, T., Yoshida, S.-i. (2001). H2O2-nonproducing Streptococcus pyogenes strains: survival in stationary phase and virulence in chronic granulomatous disease. Microbiology 147: 2469-2477 [Abstract] [Full Text]
Lavigne, M. C., Malech, H. L., Holland, S. M., Leto, T. L. (2001). Genetic Demonstration of p47phox-Dependent Superoxide Anion Production in Murine Vascular Smooth Muscle Cells. Circulation 104: 79-84 [Abstract] [Full Text]
Dinauer, M. C., Gifford, M. A., Pech, N., Li, L. L., Emshwiller, P. (2001). Variable correction of host defense following gene transfer and bone marrow transplantation in murine X-linked chronic granulomatous disease. Blood 97: 3738-3745 [Abstract] [Full Text]
Rusyn, I., Kadiiska, M. B., Dikalova, A., Kono, H., Yin, M., Tsuchiya, K., Mason, R. P., Peters, J. M., Gonzalez, F. J., Segal, B. H., Holland, S. M., Thurman, R. G. (2001). Phthalates Rapidly Increase Production of Reactive Oxygen Species in Vivo: Role of Kupffer Cells. Mol. Pharmacol. 59: 744-750 [Abstract] [Full Text]
Stokes, K. Y., Clanton, E. C., Russell, J. M., Ross, C. R., Granger, D. N. (2001). NAD(P)H Oxidase-Derived Superoxide Mediates Hypercholesterolemia-Induced Leukocyte-Endothelial Cell Adhesion. Circ. Res. 88: 499-505 [Abstract] [Full Text]
Lekstrom-Himes, J. A. (2001). The Role of C/EBP{{varepsilon}} in the Terminal Stages of Granulocyte Differentiation. Stem Cells 19: 125-133 [Abstract] [Full Text]
Skokos, D., Le Panse, S., Villa, I., Rousselle, J.-C., Peronet, R., David, B., Namane, A., Mecheri, S. (2001). Mast Cell-Dependent B and T Lymphocyte Activation Is Mediated by the Secretion of Immunologically Active Exosomes. J. Immunol. 166: 868-876 [Abstract] [Full Text]
Hoffmeyer, M. R., Jones, S. P., Ross, C. R., Sharp, B., Grisham, M. B., Laroux, F. S., Stalker, T. J., Scalia, R., Lefer, D. J. (2000). Myocardial Ischemia/Reperfusion Injury in NADPH Oxidase-Deficient Mice. Circ. Res. 87: 812-817 [Abstract] [Full Text]
Weighardt, H., Feterowski, C., Veit, M., Rump, M., Wagner, H., Holzmann, B. (2000). Increased Resistance Against Acute Polymicrobial Sepsis in Mice Challenged with Immunostimulatory CpG Oligodeoxynucleotides Is Related to an Enhanced Innate Effector Cell Response. J. Immunol. 165: 4537-4543 [Abstract] [Full Text]
Rusyn, I., Yamashina, S., Segal, B. H., Schoonhoven, R., Holland, S. M., Cattley, R. C., Swenberg, J. A., Thurman, R. G. (2000). Oxidants from Nicotinamide Adenine Dinucleotide Phosphate Oxidase Are Involved in Triggering Cell Proliferation in the Liver Due to Peroxisome Proliferators. Cancer Res. 60: 4798-4803 [Abstract] [Full Text]
Nathan, C., Shiloh, M. U. (2000). Reactive oxygen and nitrogen intermediates in the relationship between mammalian hosts and microbial pathogens. Proc. Natl. Acad. Sci. USA 97: 8841-8848 [Abstract] [Full Text]
Akgur, F. M., Brown, M. F., Zibari, G. B., McDonald, J. C., Epstein, C. J., Ross, C. R., Granger, D. N. (2000). Role of superoxide in hemorrhagic shock-induced P-selectin expression. Am. J. Physiol. Heart Circ. Physiol. 279: H791-H797 [Abstract] [Full Text]
Darrah, P. A., Hondalus, M. K., Chen, Q., Ischiropoulos, H., Mosser, D. M. (2000). Cooperation between Reactive Oxygen and Nitrogen Intermediates in Killing of Rhodococcus equi by Activated Macrophages. Infect. Immun. 68: 3587-3593 [Abstract] [Full Text]
Kirk, E. A., Dinauer, M. C., Rosen, H., Chait, A., Heinecke, J. W., LeBoeuf, R. C. (2000). Impaired Superoxide Production Due to a Deficiency in Phagocyte NADPH Oxidase Fails to Inhibit Atherosclerosis in Mice. Arterioscler. Thromb. Vasc. Bio. 20: 1529-1535 [Abstract] [Full Text]
van der Veen, R. C., Dietlin, T. A., Hofman, F. M., Pen, L., Segal, B. H., Holland, S. M. (2000). Superoxide Prevents Nitric Oxide-Mediated Suppression of Helper T Lymphocytes: Decreased Autoimmune Encephalomyelitis in Nicotinamide Adenine Dinucleotide Phosphate Oxidase Knockout Mice. J. Immunol. 164: 5177-5183 [Abstract] [Full Text]
Segal, B. H., Sakamoto, N., Patel, M., Maemura, K., Klein, A. S., Holland, S. M., Bulkley, G. B. (2000). Xanthine Oxidase Contributes to Host Defense against Burkholderia cepacia in the p47phox-/- Mouse Model of Chronic Granulomatous Disease. Infect. Immun. 68: 2374-2378 [Abstract] [Full Text]
Hsich, E., Segal, B. H., Pagano, P. J., Rey, F. E., Paigen, B., Deleonardis, J., Hoyt, R. F., Holland, S. M., Finkel, T. (2000). Vascular Effects Following Homozygous Disruption of p47phox : An Essential Component of NADPH Oxidase. Circulation 101: 1234-1236 [Abstract] [Full Text]
Cooper, A. M., Segal, B. H., Frank, A. A., Holland, S. M., Orme, I. M. (2000). Transient Loss of Resistance to Pulmonary Tuberculosis in p47phox-/- Mice. Infect. Immun. 68: 1231-1234 [Abstract] [Full Text]
Dinauer, M. C., Lekstrom-Himes, J. A., Dale, D. C. (2000). Inherited Neutrophil Disorders: Molecular Basis and New Therapies. ASH Education Book 2000: 303-318 [Abstract] [Full Text]
Dinauer, M. C., Li, L. L., Bjorgvinsdottir, H., Ding, C., Pech, N. (1999). Long-Term Correction of Phagocyte NADPH Oxidase Activity by Retroviral-Mediated Gene Transfer in Murine X-Linked Chronic Granulomatous Disease. Blood 94: 914-922 [Abstract] [Full Text]
Bliss, S. K., Marshall, A. J., Zhang, Y., Denkers, E. Y. (1999). Human Polymorphonuclear Leukocytes Produce IL-12, TNF-{alpha}, and the Chemokines Macrophage-Inflammatory Protein-1{alpha} and -1{beta} in Response to Toxoplasma gondii Antigens. J. Immunol. 162: 7369-7375 [Abstract] [Full Text]
Lekstrom-Himes, J., Xanthopoulos, K. G. (1999). CCAAT/Enhancer Binding Protein varepsilon �Is Critical for Effective Neutrophil-Mediated Response to Inflammatory Challenge. Blood 93: 3096-3105 [Abstract] [Full Text]
Segal, B. H., Doherty, T. M., Wynn, T. A., Cheever, A. W., Sher, A., Holland, S. M. (1999). The p47phox-/- Mouse Model of Chronic Granulomatous Disease Has Normal Granuloma Formation and Cytokine Responses to Mycobacterium avium and Schistosoma mansoni Eggs. Infect. Immun. 67: 1659-1665 [Abstract] [Full Text]