A new family of genes coding for an antigen recognized by autologous cytolytic T lymphocytes on a human melanoma

doi:10.1084/jem.182.3.689

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A new family of genes coding for an antigen recognized by autologous cytolytic T lymphocytes on a human melanoma

B Van den Eynde, O Peeters, O De Backer, B Gaugler, S Lucas and T Boon
Ludwig Institute for Cancer Research, Brussels Branch, Belgium.

Human melanoma MZ2-MEL expresses several distinct antigens that are recognized by autologous cytolytic T lymphocytes (CTL). Some of these antigens are encoded by genes MAGE-1, MAGE-3, and BAGE, which are expressed in a large fraction of tumors of various histological types but are silent in normal adult tissues with the exception of testis. We report here the identification of the gene coding for MZ2-F, another antigen recognized by autologous CTL on MZ2-MEL cells. This gene, which was named GAGE-1, is not related to any presently known gene. It belongs to a family of genes that are expressed in a variety of tumors but not in normal tissues, except for the testis. Antigenic peptide YRPRPRRY, which is encoded by GAGE-1, is recognized by anti-MZ2-F CTL on class I molecule HLA-Cw6. The two genes of the GAGE family that code for this peptide, namely GAGE-1 and GAGE-2, are expressed in a significant proportion of melanomas (24%), sarcomas (25%), non-small cell lung cancers (19%), head and neck tumors (19%), and bladder tumors (12%). About 50% of melanoma patients carry on their tumor at least one of the presently defined antigens encoded by the MAGE, BAGE, and GAGE genes.
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Naka, N., Joyama, S., Tsukamoto, Y., Yoshioka, K., Hashimoto, N., Ujiiye, T., Hayashi, T., Kawase, M., Mano, M., Ishiguro, S., Myoui, A., Ueda, T., Yoshikawa, H., Araki, N., Itoh, K. (2005). Quantification of SSX mRNA Expression in Human Bone and Soft Tissue Tumors Using Nucleic Acid Sequence-Based Amplification. J. Mol. Diagn. 7: 187-197 [Abstract] [Full Text]
Chiang, E. Y., Stroynowski, I. (2005). Protective Immunity against Disparate Tumors Is Mediated by a Nonpolymorphic MHC Class I Molecule. J. Immunol. 174: 5367-5374 [Abstract] [Full Text]
Sigalotti, L., Fratta, E., Coral, S., Tanzarella, S., Danielli, R., Colizzi, F., Fonsatti, E., Traversari, C., Altomonte, M., Maio, M. (2004). Intratumor Heterogeneity of Cancer/Testis Antigens Expression in Human Cutaneous Melanoma Is Methylation-Regulated and Functionally Reverted by 5-Aza-2'-deoxycytidine. Cancer Res. 64: 9167-9171 [Abstract] [Full Text]
Utsunomiya, T., Inoue, H., Tanaka, F., Yamaguchi, H., Ohta, M., Okamoto, M., Mimori, K., Mori, M. (2004). Expression of Cancer-Testis Antigen (CTA) Genes in Intrahepatic Cholangiocarcinoma. Ann. Surg. Oncol. 11: 934-940 [Abstract] [Full Text]
Ebstein, F., Sapede, C., Royer, P.-J., Marcq, M., Ligeza-Poisson, C., Barbieux, I., Cellerin, L., Dabouis, G., Gregoire, M. (2004). Cytotoxic T Cell Responses against Mesothelioma by Apoptotic Cell-pulsed Dendritic Cells. Am. J. Respir. Crit. Care Med. 169: 1322-1330 [Abstract] [Full Text]
Song, X., Sui, A., Garen, A. (2004). Binding of mouse VL30 retrotransposon RNA to PSF protein induces genes repressed by PSF: Effects on steroidogenesis and oncogenesis. Proc. Natl. Acad. Sci. USA 101: 621-626 [Abstract] [Full Text]
Wheeler, C. J., Black, K. L., Liu, G., Ying, H., Yu, J. S., Zhang, W., Lee, P. K. (2003). Thymic CD8+ T Cell Production Strongly Influences Tumor Antigen Recognition and Age-Dependent Glioma Mortality. J. Immunol. 171: 4927-4933 [Abstract] [Full Text]
Nagel, H, Laskawi, R, Eiffert, H, Schlott, T (2003). Analysis of the tumour suppressor genes, FHIT and WT-1, and the tumour rejection genes, BAGE, GAGE-1/2, HAGE, MAGE-1, and MAGE-3, in benign and malignant neoplasms of the salivary glands. Mol. Pathol. 56: 226-231 [Abstract] [Full Text]
Tatsumi, T., Herrem, C. J., Olson, W. C., Finke, J. H., Bukowski, R. M., Kinch, M. S., Ranieri, E., Storkus, W. J. (2003). Disease Stage Variation in CD4+ and CD8+ T-Cell Reactivity to the Receptor Tyrosine Kinase EphA2 in Patients with Renal Cell Carcinoma. Cancer Res. 63: 4481-4489 [Abstract] [Full Text]
Duan, Z., Duan, Y., Lamendola, D. E., Yusuf, R. Z., Naeem, R., Penson, R. T., Seiden, M. V. (2003). Overexpression of MAGE/GAGE Genes in Paclitaxel/Doxorubicin-resistant Human Cancer Cell Lines. Clin. Cancer Res. 9: 2778-2785 [Abstract] [Full Text]
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Xie, X., Wacker, H.-H., Huang, S., Regitz, E., Preuss, K.-D., Romeike, B., Parwaresch, R., Tiemann, M., Pfreundschuh, M. (2003). Differential Expression of Cancer Testis Genes in Histological Subtypes of Non-Hodgkin's Lymphomas. Clin. Cancer Res. 9: 167-173 [Abstract] [Full Text]
Somers, V. A., Brandwijk, R. J., Joosten, B., Moerkerk, P. T., Arends, J.-W., Menheere, P., Pieterse, W. O., Claessen, A., Scheper, R. J., Hoogenboom, H. R., Hufton, S. E. (2002). A Panel of Candidate Tumor Antigens in Colorectal Cancer Revealed by the Serological Selection of a Phage Displayed cDNA Expression Library. J. Immunol. 169: 2772-2780 [Abstract] [Full Text]
Coral, S., Sigalotti, L., Altomonte, M., Engelsberg, A., Colizzi, F., Cattarossi, I., Maraskovsky, E., Jager, E., Seliger, B., Maio, M. (2002). 5-aza-2'-Deoxycytidine-induced Expression of Functional Cancer Testis Antigens in Human Renal Cell Carcinoma: Immunotherapeutic Implications. Clin. Cancer Res. 8: 2690-2695 [Abstract] [Full Text]
Dutoit, V., Rubio-Godoy, V., Pittet, M. J., Zippelius, A., Dietrich, P.-Y., Legal, F. A., Guillaume, P., Romero, P., Cerottini, J.-C., Houghten, R. A., Pinilla, C., Valmori, D. (2002). Degeneracy of Antigen Recognition as the Molecular Basis for the High Frequency of Naive A2/Melan-A Peptide Multimer+ CD8+ T Cells in Humans. J. Exp. Med. 196: 207-216 [Abstract] [Full Text]
Egland, K. A., Kumar, V., Duray, P., Pastan, I. (2002). Characterization of Overlapping XAGE-1 Transcripts Encoding a Cancer Testis Antigen Expressed in Lung, Breast, and Other Types of Cancers. Molecular Cancer Therapeutics 1: 441-450 [Abstract] [Full Text]
Kao, H., Marto, J. A., Hoffmann, T. K., Shabanowitz, J., Finkelstein, S. D., Whiteside, T. L., Hunt, D. F., Finn, O. J. (2001). Identification of Cyclin B1 as a Shared Human Epithelial Tumor-Associated Antigen Recognized by T Cells. J. Exp. Med. 194: 1313-1324 [Abstract] [Full Text]
Jager, D, Jager, E, Knuth, A (2001). Immune responses to tumour antigens: implications for antigen specific immunotherapy of cancer. J. Clin. Pathol. 54: 669-674 [Abstract] [Full Text]
Cao, J.-n., Gao, T.-w., Stanbridge, E. J., Irie, R. (2001). RBP1L1, a Retinoblastoma-Binding Protein-Related Gene Encoding an Antigenic Epitope Abundantly Expressed in Human Carcinomas and Normal Testis. JNCI J Natl Cancer Inst 93: 1159-1165 [Abstract] [Full Text]
Riddell, S. R. (2001). Progress in cancer vaccines by enhanced self-presentation. Proc. Natl. Acad. Sci. USA 98: 8933-8935 [Full Text]
Ono, T., Kurashige, T., Harada, N., Noguchi, Y., Saika, T., Niikawa, N., Aoe, M., Nakamura, S., Higashi, T., Hiraki, A., Wada, H., Kumon, H., Old, L. J., Nakayama, E. (2001). Identification of proacrosin binding protein sp32 precursor as a human cancer/testis antigen. Proc. Natl. Acad. Sci. USA 98: 3282-3287 [Abstract] [Full Text]
Kessler, J. H., Beekman, N. J., Bres-Vloemans, S. A., Verdijk, P., van Veelen, P. A., Kloosterman-Joosten, A. M., Vissers, D. C.J., ten Bosch, G. J.A., Kester, M. G.D., Sijts, A., Drijfhout, J. W., Ossendorp, F., Offringa, R., Melief, C. J.M. (2001). Efficient Identification of Novel HLA-A*0201-presented Cytotoxic T Lymphocyte Epitopes in the Widely Expressed Tumor Antigen PRAME by Proteasome-mediated Digestion Analysis. J. Exp. Med. 193: 73-88 [Abstract] [Full Text]
Valmori, D., Dutoit, V., Rubio-Godoy, V., Chambaz, C., Liénard, D., Guillaume, P., Romero, P., Cerottini, J.-C., Rimoldi, D. (2001). Frequent Cytolytic T-Cell Responses to Peptide MAGE-A10254-262 in Melanoma. Cancer Res. 61: 509-512 [Abstract] [Full Text]
Anne Westbrook, V., Diekman, A. B., Naaby-Hansen, S., Coonrod, S. A., Klotz, K. L., Thomas, T. S., Norton, E. J., Flickinger, C. J., Herr, J. C. (2001). Differential Nuclear Localization of the Cancer/Testis-Associated Protein, SPAN-X/CTp11, in Transfected Cells and in 50% of Human Spermatozoa. Biol. Reprod. 64: 345-358 [Abstract] [Full Text]
Cochlovius, B., Stassar, M., Christ, O., Raddrizzani, L., Hammer, J., Mytilineos, I., Zoller, M. (2000). In Vitro and In Vivo Induction of a Th Cell Response Toward Peptides of the Melanoma-Associated Glycoprotein 100 Protein Selected by the TEPITOPE Program. J. Immunol. 165: 4731-4741 [Abstract] [Full Text]
Sahin, U., Koslowski, M., Türeci, O., Eberle, T., Zwick, C., Romeike, B., Moringlane, J.-R., Schwechheimer, K., Feiden, W., Pfreundschuh, M. (2000). Expression of Cancer Testis Genes in Human Brain Tumors. Clin. Cancer Res. 6: 3916-3922 [Abstract] [Full Text]
Gnjatic, S., Nagata, Y., Jager, E., Stockert, E., Shankara, S., Roberts, B. L., Mazzara, G. P., Lee, S. Y., Dunbar, P. R., Dupont, B., Cerundolo, V., Ritter, G., Chen, Y.-T., Knuth, A., Old, L. J. (2000). Strategy for monitoring T cell responses to NY-ESO-1 in patients with any HLA class I allele. Proc. Natl. Acad. Sci. USA 97: 10917-10922 [Abstract] [Full Text]
Nishizaka, S., Gomi, S., Harada, K., Oizumi, K., Itoh, K., Shichijo, S. (2000). A New Tumor-Rejection Antigen Recognized by Cytotoxic T Lymphocytes Infiltrating into a Lung Adenocarcinoma. Cancer Res. 60: 4830-4837 [Abstract] [Full Text]
Schmitz, M., Diestelkoetter, P., Weigle, B., Schmachtenberg, F., Stevanovic, S., Ockert, D., Rammensee, H.-G., Rieber, E. P. (2000). Generation of Survivin-specific CD8+ T Effector Cells by Dendritic Cells Pulsed with Protein or Selected Peptides. Cancer Res. 60: 4845-4849 [Abstract] [Full Text]
Chiari, R., Hames, G., Stroobant, V., Texier, C., Maillère, B., Boon, T., Coulie, P. G. (2000). Identification of a Tumor-specific Shared Antigen Derived From an Eph Receptor and Presented to CD4 T Cells on HLA Class II Molecules. Cancer Res. 60: 4855-4863 [Abstract] [Full Text]
Poszepczynska, E., Bagot, M., Echchakir, H., Martinvalet, D., Ramez, M., Charue, D., Boumsell, L., Bensussan, A. (2000). Functional characterization of an IL-7-dependent CD4+CD8alpha alpha + Th3-type malignant cell line derived from a patient with a cutaneous T-cell lymphoma. Blood 96: 1056-1063 [Abstract] [Full Text]
Kawano, K., Gomi, S., Tanaka, K., Tsuda, N., Kamura, T., Itoh, K., Yamada, A. (2000). Identification of a New Endoplasmic Reticulum-resident Protein Recognized by HLA-A24-restricted Tumor-infiltrating Lymphocytes of Lung Cancer. Cancer Res. 60: 3550-3558 [Abstract] [Full Text]
Martelange, V., De Smet, C., De Plaen, E., Lurquin, C., Boon, T. (2000). Identification on a Human Sarcoma of Two New Genes with Tumor-specific Expression. Cancer Res. 60: 3848-3855 [Abstract] [Full Text]
Heidecker, L., Brasseur, F., Probst-Kepper, M., Gueguen, M., Boon, T., Van den Eynde, B. J. (2000). Cytolytic T Lymphocytes Raised Against a Human Bladder Carcinoma Recognize an Antigen Encoded by Gene MAGE-A12. J. Immunol. 164: 6041-6045 [Abstract] [Full Text]
Baurain, J.-F., Colau, D., van Baren, N., Landry, C., Martelange, V., Vikkula, M., Boon, T., Coulie, P. G. (2000). High Frequency of Autologous Anti-Melanoma CTL Directed Against an Antigen Generated by a Point Mutation in a New Helicase Gene. J. Immunol. 164: 6057-6066 [Abstract] [Full Text]
Jager, E., Nagata, Y., Gnjatic, S., Wada, H., Stockert, E., Karbach, J., Dunbar, P. R., Lee, S. Y., Jungbluth, A., Jager, D., Arand, M., Ritter, G., Cerundolo, V., Dupont, B., Chen, Y.-T., Old, L. J., Knuth, A. (2000). Monitoring CD8 T cell responses to NY-ESO-1: Correlation of humoral and cellular immune responses. Proc. Natl. Acad. Sci. USA 97: 4760-4765 [Abstract] [Full Text]
Panelli, M. C., Bettinotti, M. P., Lally, K., Ohnmacht, G. A., Li, Y., Robbins, P., Riker, A., Rosenberg, S. A., Marincola, F. M. (2000). A Tumor-Infiltrating Lymphocyte from a Melanoma Metastasis with Decreased Expression of Melanoma Differentiation Antigens Recognizes MAGE-12. J. Immunol. 164: 4382-4392 [Abstract] [Full Text]
Colella, T. A., Bullock, T. N.J., Russell, L. B., Mullins, D. W., Overwijk, W. W., Luckey, C. J., Pierce, R. A., Restifo, N. P., Engelhard, V. H. (2000). Self-Tolerance to the Murine Homologue of a Tyrosinase-derived Melanoma Antigen: Implications for Tumor Immunotherapy. J. Exp. Med. 191: 1221-1232 [Abstract] [Full Text]
Stenner-Liewen, F., Luo, G., Sahin, U., Tureci, O., Koslovski, M., Kautz, I., Liewen, H., Pfreundschuh, M. (2000). Definition of Tumor-associated Antigens in Hepatocellular Carcinoma. Cancer Epidemiol. Biomarkers Prev. 9: 285-290 [Abstract] [Full Text]
Jager, D., Stockert, E., Scanlan, M. J., Gure, A. O., Jager, E., Knuth, A., Old, L. J., Chen, Y.-T. (1999). Cancer-Testis Antigens and ING1 Tumor Suppressor Gene Product Are Breast Cancer Antigens: Characterization of Tissue-specific ING1 Transcripts and a Homologue Gene. Cancer Res. 59: 6197-6204 [Abstract] [Full Text]
Zendman, A. J. W., Cornelissen, I. M. H. A., Weidle, U. H., Ruiter, D. J., van Muijen, G. N. P. (1999). CTp11, a Novel Member of the Family of Human Cancer/Testis Antigens. Cancer Res. 59: 6223-6229 [Abstract] [Full Text]
De Smet, C., Lurquin, C., Lethe, B., Martelange, V., Boon, T. (1999). DNA Methylation Is the Primary Silencing Mechanism for a Set of Germ Line- and Tumor-Specific Genes with a CpG-Rich Promoter. Mol. Cell. Biol. 19: 7327-7335 [Abstract] [Full Text]
Chiari, R., Foury, F., De Plaen, E., Baurain, J.-F., Thonnard, J., G. Coulie, P. (1999). Two Antigens Recognized by Autologous Cytolytic T Lymphocytes on a Melanoma Result from a Single Point Mutation in an Essential Housekeeping Gene. Cancer Res. 59: 5785-5792 [Abstract] [Full Text]
Gomi, S., Nakao, M., Niiya, F., Imamura, Y., Kawano, K., Nishizaka, S., Hayashi, A., Sobao, Y., Oizumi, K., Itoh, K. (1999). A Cyclophilin B Gene Encodes Antigenic Epitopes Recognized by HLA-A24-Restricted and Tumor-Specific CTLs. J. Immunol. 163: 4994-5004 [Abstract] [Full Text]
Yamazaki, K., Spruill, G., Rhoderick, J., Spielman, J., Savaraj, N., Podack, E. R. (1999). Small Cell Lung Carcinomas Express Shared and Private Tumor Antigens Presented by HLA-A1 or HLA-A2. Cancer Res. 59: 4642-4650 [Abstract] [Full Text]
van Baren, N., Brasseur, F., Godelaine, D., Hames, G., Ferrant, A., Lehmann, F., Andre, M., Ravoet, C., Doyen, C., Spagnoli, G. C., Bakkus, M., Thielemans, K., Boon, T. (1999). Genes Encoding Tumor-Specific Antigens Are Expressed in Human Myeloma Cells. Blood 94: 1156-1164 [Abstract] [Full Text]
Yang, D., Nakao, M., Shichijo, S., Sasatomi, T., Takasu, H., Matsumoto, H., Mori, K., Hayashi, A., Yamana, H., Shirouzu, K., Itoh, K. (1999). Identification of a Gene Coding for a Protein Possessing Shared Tumor Epitopes Capable of Inducing HLA-A24-restricted Cytotoxic T Lymphocytes inCancer Patients. Cancer Res. 59: 4056-4063 [Abstract] [Full Text]
Ghossein, R. A., Bhattacharya, S., Rosai, J. (1999). Molecular Detection of Micrometastases and Circulating Tumor Cells in Solid Tumors. Clin. Cancer Res. 5: 1950-1960 [Abstract] [Full Text]
Cheung, I. Y., Cheung, N.-K. V., Ghossein, R. A., Satagopan, J. M., Bhattacharya, S., Coit, D. G. (1999). Association between Molecular Detection of GAGE and Survival in Patients with Malignant Melanoma: A Retrospective Cohort Study. Clin. Cancer Res. 5: 2042-2047 [Abstract] [Full Text]
De Backer, O., Arden, K. C., Boretti, M., Vantomme, V., De Smet, C., Czekay, S., Viars, C. S., De Plaen, E., Brasseur, F., Chomez, P., Van den Eynde, B., Boon, T., van der Bruggen, P. (1999). Characterization of the GAGE Genes That Are Expressed in Various Human Cancers and in Normal Testis. Cancer Res. 59: 3157-3165 [Abstract] [Full Text]
Tanzarella, S., Russo, V., Lionello, I., Dalerba, P., Rigatti, D., Bordignon, C., Traversari, C. (1999). Identification of a Promiscuous T-Cell Epitope Encoded by Multiple Members of the MAGE Family. Cancer Res. 59: 2668-2674 [Abstract] [Full Text]
Huang, L.-Q., Brasseur, F., Serrano, A., De Plaen, E., van der Bruggen, P., Boon, T., Van Pel, A. (1999). Cytolytic T Lymphocytes Recognize an Antigen Encoded by MAGE-A10 on a Human Melanoma. J. Immunol. 162: 6849-6854 [Abstract] [Full Text]
Brinkmann, U., Vasmatzis, G., Lee, B., Pastan, I. (1999). Novel Genes in the PAGE and GAGE Family of Tumor Antigens Found by Homology Walking in the dbEST Database. Cancer Res. 59: 1445-1448 [Abstract] [Full Text]
Baar, J. (1999). Clinical Applications of Dendritic Cell Cancer Vaccines. The Oncologist 4: 140-144 [Full Text]
Bilsborough, J., Van Pel, A., Uyttenhove, C., Boon, T., Van den Eynde, B. J. (1999). Identification of a Second Major Tumor-Specific Antigen Recognized by CTLs on Mouse Mastocytoma P815. J. Immunol. 162: 3534-3540 [Abstract] [Full Text]
Greten, T. F., Jaffee, E. M. (1999). Cancer Vaccines. JCO 17: 1047-1047 [Abstract] [Full Text]
Chaux, P., Vantomme, V., Stroobant, V., Thielemans, K., Corthals, J., Luiten, R., Eggermont, A. M.M., Boon, T., van der Bruggen, P. (1999). Identification of MAGE-3 Epitopes Presented by HLA-DR Molecules to CD4+ T Lymphocytes. J. Exp. Med. 189: 767-778 [Abstract] [Full Text]
Scarcella, D. L., Chow, C. W., Gonzales, M. F., Economou, C., Brasseur, F., Ashley, D. M. (1999). Expression of MAGE and GAGE in High-Grade Brain Tumors: A Potential Target for Specific Immunotherapy and Diagnostic Markers. Clin. Cancer Res. 5: 335-341 [Abstract] [Full Text]
Castelli, C., Tarsini, P., Mazzocchi, A., Rini, F., Rivoltini, L., Ravagnani, F., Gallino, F., Belli, F., Parmiani, G. (1999). Novel HLA-Cw8-Restricted T Cell Epitopes Derived from Tyrosinase-Related Protein-2 and gp100 Melanoma Antigens. J. Immunol. 162: 1739-1748 [Abstract] [Full Text]
Musette, P., Bachelez, H., Flageul, B., Delarbre, C., Kourilsky, P., Dubertret, L., Gachelin, G. (1999). Immune-Mediated Destruction of Melanocytes in Halo Nevi Is Associated with the Local Expansion of a Limited Number of T Cell Clones. J. Immunol. 162: 1789-1794 [Abstract] [Full Text]
Dalmau, J., Gultekin, S. H., Voltz, R., Hoard, R., DesChamps, T., Balmaceda, C., Batchelor, T., Gerstner, E., Eichen, J., Frennier, J., Posner, J. B., Rosenfeld, M. R. (1999). Ma1, a novel neuron- and testis-specific protein, is recognized by the serum of patients with paraneoplastic neurological disorders. Brain 122: 27-39 [Abstract] [Full Text]
Munz, C., Obst, R., Osen, W., Stevanovic, S., Rammensee, H.-G. (1999). Alloreactivity as a Source of High Avidity Peptide-Specific Human CTL. J. Immunol. 162: 25-34 [Abstract] [Full Text]
Wang, R.-F., Johnston, S. L., Zeng, G., Topalian, S. L., Schwartzentruber, D. J., Rosenberg, S. A. (1998). A Breast and Melanoma-Shared Tumor Antigen: T Cell Responses to Antigenic Peptides Translated from Different Open Reading Frames. J. Immunol. 161: 3596-3606 [Abstract] [Full Text]
Correale, P., Walmsley, K., Zaremba, S., Zhu, M., Schlom, J., Tsang, K. Y. (1998). Generation of Human Cytolytic T Lymphocyte Lines Directed Against Prostate-Specific Antigen (PSA) Employing a PSA Oligoepitope Peptide. J. Immunol. 161: 3186-3194 [Abstract] [Full Text]
Brinkmann, U., Vasmatzis, G., Lee, B., Yerushalmi, N., Essand, M., Pastan, I. (1998). PAGE-1, an X chromosome-linked GAGE-like gene that is expressed in normal and neoplastic prostate, testis, and uterus. Proc. Natl. Acad. Sci. USA 95: 10757-10762 [Abstract] [Full Text]
Bohm, W., Thoma, S., Leithauser, F., Moller, P., Schirmbeck, R., Reimann, J. (1998). T Cell-Mediated, IFN-{gamma}-Facilitated Rejection of Murine B16 Melanomas. J. Immunol. 161: 897-908 [Abstract] [Full Text]
Chen, M. E., Lin, S.-H., Chung, L. W.�K., Sikes, R. A. (1998). Isolation and Characterization of PAGE-1 and GAGE-7. NEW GENES EXPRESSED IN THE LNCaP PROSTATE CANCER PROGRESSION MODEL THAT SHARE HOMOLOGY WITH MELANOMA-ASSOCIATED ANTIGENS. J. Biol. Chem. 273: 17618-17625 [Abstract] [Full Text]
Gueguen, M., Patard, J.-J., Gaugler, B., Brasseur, F., Renauld, J.-C., Van Cangh, P. J., Boon, T., Van den Eynde, B. J. (1998). An Antigen Recognized by Autologous CTLs on a Human Bladder Carcinoma. J. Immunol. 160: 6188-6194 [Abstract] [Full Text]
Chen, Y.-T., Gure, A. O., Tsang, S., Stockert, E., Jager, E., Knuth, A., Old, L. J. (1998). Identification of multiple cancer/testis antigens by allogeneic antibody screening of a melanoma cell line library. Proc. Natl. Acad. Sci. USA 95: 6919-6923 [Abstract] [Full Text]
Bagot, M., Echchakir, H., Mami-Chouaib, F., Delfau-Larue, M.-H., Charue, D., Bernheim, A., Chouaib, S., Boumsell, L., Bensussan, A. (1998). Isolation of Tumor-Specific Cytotoxic CD4+ and CD4+CD8dim+ T-Cell Clones Infiltrating a Cutaneous T-Cell Lymphoma. Blood 91: 4331-4341 [Abstract] [Full Text]
Old, L. J., Chen, Y.-T. (1998). New Paths in Human Cancer Serology. J. Exp. Med. 187: 1163-1167 [Full Text]
de Zoeten, E. F., Carr-Brendel, V., Cohen, E. P. (1998). Resistance to Melanoma in Mice Immunized with Semiallogeneic Fibroblasts Transfected with DNA from Mouse Melanoma Cells. J. Immunol. 160: 2915-2922 [Abstract] [Full Text]
Warren, E. H., Greenberg, P. D., Riddell, S. R. (1998). Cytotoxic T-Lymphocyte-Defined Human Minor Histocompatibility Antigens With a Restricted Tissue Distribution. Blood 91: 2197-2207 [Abstract] [Full Text]
Kittlesen, D. J., Thompson, L. W., Gulden, P. H., Skipper, J. C. A., Colella, T. A., Shabanowitz, J. A., Hunt, D. F., Engelhard, V. H., Slingluff, C. L. Jr. (1998). Human Melanoma Patients Recognize an HLA-A1-Restricted CTL Epitope from Tyrosinase Containing Two Cysteine Residues: Implications for Tumor Vaccine Development. J. Immunol. 160: 2099-2106 [Abstract] [Full Text]
Morgan, D. J., Kreuwel, H. T. C., Fleck, S., Levitsky, H. I., Pardoll, D. M., Sherman, L. A. (1998). Activation of Low Avidity CTL Specific for a Self Epitope Results in Tumor Rejection But Not Autoimmunity. J. Immunol. 160: 643-651 [Abstract] [Full Text]
Wang, R.-F., Johnston, S. L., Southwood, S., Sette, A., Rosenberg, S. A. (1998). Recognition of an Antigenic Peptide Derived from Tyrosinase-Related Protein-2 by CTL in the Context of HLA-A31 and -A33. J. Immunol. 160: 890-897 [Abstract] [Full Text]
Osanto, S. (1997). Vaccine Trials for the Clinician: Prospects for Tumor Antigens. The Oncologist 2: 284-299 [Abstract] [Full Text]
Chen, Y.-T., Scanlan, M. J., Sahin, U., Tureci, O., Gure, A. O., Tsang, S., Williamson, B., Stockert, E., Pfreundschuh, M., Old, L. J. (1997). A testicular antigen aberrantly expressed in human cancers detected by autologous antibody�screening. Proc. Natl. Acad. Sci. USA 94: 1914-1918 [Abstract] [Full Text]
Dubey, P., Hendrickson, R. C., Meredith, S. C., Siegel, C. T., Shabanowitz, J., Skipper, J. C.A., Engelhard, V. H., Hunt, D. F., Schreiber, H. (1997). The Immunodominant Antigen of an Ultraviolet-induced Regressor Tumor Is Generated by a Somatic Point Mutation in the DEAD Box Helicase p68. J. Exp. Med. 185: 695-706 [Abstract] [Full Text]
Bloom, M. B., Perry-Lalley, D., Robbins, P. F., Li, Y., El-Gamil, M., Rosenberg, S. A., Yang, J. C. (1997). Identification of Tyrosinase-related Protein 2�as a Tumor Rejection Antigen for the B16 Melanoma. J. Exp. Med. 185: 453-460 [Abstract] [Full Text]
Wang, R.-F., Appella, E., Kawakami, Y., Kang, X., Rosenberg, S. A. (1996). Identification of TRP-2 as a Human Tumor Antigen Recognized by Cytotoxic T Lymphocytes. J. Exp. Med. 184: 2207-2216 [Abstract] [Full Text]
Sadovnikova, E., Stauss, H. J. (1996). Peptide-specific cytotoxic T lymphocytes restricted by nonself major histocompatibility complex class I molecules: Reagents for tumor�immunotherapy. Proc. Natl. Acad. Sci. USA 93: 13114-13118 [Abstract] [Full Text]