Mechanisms underlying the monocyte-mediated antibody-dependent killing of Plasmodium falciparum asexual blood stages

doi:10.1084/jem.182.2.409

This Article

Full Text (PDF)

Alert me when this article is cited

Citation Map

Services

Email this article

Similar articles in this journal

Similar articles in PubMed

Alert me to new content in the JEM

Download to citation manager

Citing Articles

Citing Articles via HighWire

Citing Articles via CrossRef

Citing Articles via Google Scholar

Google Scholar

Articles by Bouharoun-Tayoun, H.

Articles by Druilhe, P.

Search for Related Content

PubMed

PubMed Citation

Articles by Bouharoun-Tayoun, H.

Articles by Druilhe, P.

Pubmed/NCBI databases

Substance via MeSH

Social Bookmarking

What's this?

ARTICLES

Mechanisms underlying the monocyte-mediated antibody-dependent killing of Plasmodium falciparum asexual blood stages

H Bouharoun-Tayoun, C Oeuvray, F Lunel and P Druilhe
Laboratoire de Parasitologie Bio-Medicale, Institut Pasteur, Paris, France.

The relevance of the antibody-dependent cellular inhibition (ADCI) of Plasmodium falciparum to clinical protection has been previously established by in vitro studies of material obtained during passive transfer of protection by immunoglobulin G in humans. We here report further in vitro investigations aimed at elucidating the mechanisms underlying this ADCI effect. Results obtained so far suggest that (a) merozoite uptake by monocytes (MN) as well as by polymorphonuclear cells has little influence on the course of parasitemia; (b) the ADCI effect is mediated by a soluble factor released by MN; (c) this or these factors are able to block the division of surrounding intraerythrocytic parasites at the one nucleus stage; (d) the critical triggering antigen(s) targeted by effective Abs would appear to be associated with the surface of merozoites, as opposed to that of infected red blood cells; (e) the MN receptor for Abs effective in ADCI is apparently Fc gamma RII, and not RI; (f) MN function is up- and down- regulated by interferon-gamma and interleukin 4, respectively; and (g) of several potential mediators released by MN, only tumor necrosis factor (TNF) proved of relevance. The involvement of TNF in defense may explain the recently described increased frequency of the TNF-2 high- expression promoter in individuals living in endemic regions despite its compromising role in severe malaria.
Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Add to Reddit Reddit Add to Technorati Technorati What's this?

This article has been cited by other articles:

Nebie, I., Diarra, A., Ouedraogo, A., Soulama, I., Bougouma, E. C., Tiono, A. B., Konate, A. T., Chilengi, R., Theisen, M., Dodoo, D., Remarque, E., Bosomprah, S., Milligan, P., Sirima, S. B. (2008). Humoral Responses to Plasmodium falciparum Blood-Stage Antigens and Association with Incidence of Clinical Malaria in Children Living in an Area of Seasonal Malaria Transmission in Burkina Faso, West Africa. Infect. Immun. 76: 759-766 [Abstract] [Full Text]
Pal-Bhowmick, I., Mehta, M., Coppens, I., Sharma, S., Jarori, G. K. (2007). Protective Properties and Surface Localization of Plasmodium falciparum Enolase. Infect. Immun. 75: 5500-5508 [Abstract] [Full Text]
Jafarshad, A., Dziegiel, M. H., Lundquist, R., Nielsen, L. K., Singh, S., Druilhe, P. L. (2007). A Novel Antibody-Dependent Cellular Cytotoxicity Mechanism Involved in Defense against Malaria Requires Costimulation of Monocytes Fc{gamma}RII and Fc{gamma}RIII. J. Immunol. 178: 3099-3106 [Abstract] [Full Text]
MORAIS, C. G., SOARES, I. S., CARVALHO, L. H., FONTES, C. J. F., KRETTLI, A. U., BRAGA, E. M. (2006). ANTIBODIES TO PLASMODIUM VIVAX APICAL MEMBRANE ANTIGEN 1: PERSISTENCE AND CORRELATION WITH MALARIA TRANSMISSION INTENSITY.. Am J Trop Med Hyg 75: 582-587 [Abstract] [Full Text]
Lundquist, R., Nielsen, L. K., Jafarshad, A., SoeSoe, D., Christensen, L. H., Druilhe, P., Dziegiel, M. H. (2006). Human Recombinant Antibodies against Plasmodium falciparum Merozoite Surface Protein 3 Cloned from Peripheral Blood Leukocytes of Individuals with Immunity to Malaria Demonstrate Antiparasitic Properties.. Infect. Immun. 74: 3222-3231 [Abstract] [Full Text]
Pierrot, C., Wilson, S., Lallet, H., Lafitte, S., Jones, F. M., Daher, W., Capron, M., Dunne, D. W., Khalife, J. (2006). Identification of a Novel Antigen of Schistosoma mansoni Shared with Plasmodium falciparum and Evaluation of Different Cross-Reactive Antibody Subclasses Induced by Human Schistosomiasis and Malaria.. Infect. Immun. 74: 3347-3354 [Abstract] [Full Text]
Nogueira, P. A., Piovesan Alves, F., Fernandez-Becerra, C., Pein, O., Rodrigues Santos, N., Pereira da Silva, L. H., Plessman Camargo, E., del Portillo, H. A. (2006). A Reduced Risk of Infection with Plasmodium vivax and Clinical Protection against Malaria Are Associated with Antibodies against the N Terminus but Not the C Terminus of Merozoite Surface Protein 1.. Infect. Immun. 74: 2726-2733 [Abstract] [Full Text]
OUMA, C., KELLER, C. C., OPONDO, D. A., WERE, T., OTIENO, R. O., OTIENO, M. F., ORAGO, A. S. S., ONG'ECHA, J. M., VULULE, J. M., FERRELL, R. E., PERKINS, D. J. (2006). ASSOCIATION OF FC{gamma} RECEPTOR IIA (CD32) POLYMORPHISM WITH MALARIAL ANEMIA AND HIGH-DENSITY PARASITEMIA IN INFANTS AND YOUNG CHILDREN. Am J Trop Med Hyg 74: 573-577 [Abstract] [Full Text]
Tongren, J. E., Drakeley, C. J., McDonald, S. L. R., Reyburn, H. G., Manjurano, A., Nkya, W. M. M., Lemnge, M. M., Gowda, C. D., Todd, J. E., Corran, P. H., Riley, E. M. (2006). Target Antigen, Age, and Duration of Antigen Exposure Independently Regulate Immunoglobulin G Subclass Switching in Malaria. Infect. Immun. 74: 257-264 [Abstract] [Full Text]
Audran, R., Cachat, M., Lurati, F., Soe, S., Leroy, O., Corradin, G., Druilhe, P., Spertini, F. (2005). Phase I Malaria Vaccine Trial with a Long Synthetic Peptide Derived from the Merozoite Surface Protein 3 Antigen. Infect. Immun. 73: 8017-8026 [Abstract] [Full Text]
Tongren, J. E., Corran, P. H., Jarra, W., Langhorne, J., Riley, E. M. (2005). Epitope-Specific Regulation of Immunoglobulin Class Switching in Mice Immunized with Malarial Merozoite Surface Proteins. Infect. Immun. 73: 8119-8129 [Abstract] [Full Text]
TRAN, T. M., OLIVEIRA-FERREIRA, J., MORENO, A., SANTOS, F., YAZDANI, S. S., CHITNIS, C. E., ALTMAN, J. D., MEYER, E. V-S., BARNWELL, J. W., GALINSKI, M. R. (2005). COMPARISON OF IgG REACTIVITIES TO PLASMODIUM VIVAX MEROZOITE INVASION ANTIGENS IN A BRAZILIAN AMAZON POPULATION. Am J Trop Med Hyg 73: 244-255 [Abstract] [Full Text]
Scorza, T., Grubb, K., Smooker, P., Rainczuk, A., Proll, D., Spithill, T. W. (2005). Induction of Strain-Transcending Immunity against Plasmodium chabaudi adami Malaria with a Multiepitope DNA Vaccine. Infect. Immun. 73: 2974-2985 [Abstract] [Full Text]
Cavanagh, D. R., Dodoo, D., Hviid, L., Kurtzhals, J. A. L., Theander, T. G., Akanmori, B. D., Polley, S., Conway, D. J., Koram, K., McBride, J. S. (2004). Antibodies to the N-Terminal Block 2 of Plasmodium falciparum Merozoite Surface Protein 1 Are Associated with Protection against Clinical Malaria. Infect. Immun. 72: 6492-6502 [Abstract] [Full Text]
DORSEY, G., GASASIRA, A. F., MACHEKANO, R., KAMYA, M. R., STAEDKE, S. G., HUBBARD, A. (2004). THE IMPACT OF AGE, TEMPERATURE, AND PARASITE DENSITY ON TREATMENT OUTCOMES FROM ANTIMALARIAL CLINICAL TRIALS IN KAMPALA, UGANDA. Am J Trop Med Hyg 71: 531-536 [Abstract] [Full Text]
Burns, J. M. Jr., Flaherty, P. R., Nanavati, P., Weidanz, W. P. (2004). Protection against Plasmodium chabaudi Malaria Induced by Immunization with Apical Membrane Antigen 1 and Merozoite Surface Protein 1 in the Absence of Gamma Interferon or Interleukin-4. Infect. Immun. 72: 5605-5612 [Abstract] [Full Text]
Soe, S., Theisen, M., Roussilhon, C., Aye, K.-S., Druilhe, P. (2004). Association between Protection against Clinical Malaria and Antibodies to Merozoite Surface Antigens in an Area of Hyperendemicity in Myanmar: Complementarity between Responses to Merozoite Surface Protein 3 and the 220-Kilodalton Glutamate-Rich Protein. Infect. Immun. 72: 247-252 [Abstract] [Full Text]
Pleass, R. J., Ogun, S. A., McGuinness, D. H., van de Winkel, J. G. J., Holder, A. A., Woof, J. M. (2003). Novel antimalarial antibodies highlight the importance of the antibody Fc region in mediating protection. Blood 102: 4424-4430 [Abstract] [Full Text]
DJIMDE, A. A., DOUMBO, O. K., TRAORE, O., GUINDO, A. B., KAYENTAO, K., DIOURTE, Y., NIARE-DOUMBO, S., COULIBALY, D., KONE, A. K., CISSOKO, Y., TEKETE, M., FOFANA, B., DICKO, A., DIALLO, D. A., WELLEMS, T. E., KWIATKOWSKI, D., PLOWE, C. V. (2003). CLEARANCE OF DRUG-RESISTANT PARASITES AS A MODEL FOR PROTECTIVE IMMUNITY IN PLASMODIUM FALCIPARUM MALARIA. Am J Trop Med Hyg 69: 558-563 [Abstract] [Full Text]
Mahanty, S., Saul, A., Miller, L. H. (2003). Progress in the development of recombinant and synthetic blood-stage malaria vaccines. J. Exp. Biol. 206: 3781-3788 [Abstract] [Full Text]
Doolan, D. L., Aguiar, J. C., Weiss, W. R., Sette, A., Felgner, P. L., Regis, D. P., Quinones-Casas, P., Yates, J. R. III, Blair, P. L., Richie, T. L., Hoffman, S. L., Carucci, D. J. (2003). Utilization of genomic sequence information to develop malaria vaccines. J. Exp. Biol. 206: 3789-3802 [Abstract] [Full Text]
Polley, S. D., Tetteh, K. K. A., Cavanagh, D. R., Pearce, R. J., Lloyd, J. M., Bojang, K. A., Okenu, D. M. N., Greenwood, B. M., McBride, J. S., Conway, D. J. (2003). Repeat Sequences in Block 2 of Plasmodium falciparum Merozoite Surface Protein 1 Are Targets of Antibodies Associated with Protection from Malaria. Infect. Immun. 71: 1833-1842 [Abstract] [Full Text]
Rouzine, I. M., McKenzie, F. E. (2003). Link between immune response and parasite synchronization in malaria. Proc. Natl. Acad. Sci. USA 100: 3473-3478 [Abstract] [Full Text]
Yoshida, S., Kobayashi, T., Matsuoka, H., Seki, C., Gosnell, W. L., Chang, S. P., Ishii, A. (2003). T-cell activation and cytokine production via a bispecific single-chain antibody fragment targeted to blood-stage malaria parasites. Blood 101: 2300-2306 [Abstract] [Full Text]
Smith, T. G., Serghides, L., Patel, S. N., Febbraio, M., Silverstein, R. L., Kain, K. C. (2003). CD36-Mediated Nonopsonic Phagocytosis of Erythrocytes Infected with Stage I and IIA Gametocytes of Plasmodium falciparum. Infect. Immun. 71: 393-400 [Abstract] [Full Text]
Kedzierski, L., Black, C. G., Goschnick, M. W., Stowers, A. W., Coppel, R. L. (2002). Immunization with a Combination of Merozoite Surface Proteins 4/5 and 1 Enhances Protection against Lethal Challenge with Plasmodium yoelii. Infect. Immun. 70: 6606-6613 [Abstract] [Full Text]
Soe, S., Singh, S., Camus, D., Horii, T., Druilhe, P. (2002). Plasmodium falciparum Serine Repeat Protein, a New Target of Monocyte-Dependent Antibody-Mediated Parasite Killing. Infect. Immun. 70: 7182-7184 [Abstract] [Full Text]
Xainli, J., Baisor, M., Kastens, W., Bockarie, M., Adams, J. H., King, C. L. (2002). Age-Dependent Cellular Immune Responses to Plasmodium vivax Duffy Binding Protein in Humans. J. Immunol. 169: 3200-3207 [Abstract] [Full Text]
Garraud, O., Perraut, R., Diouf, A., Nambei, W. S., Tall, A., Spiegel, A., Longacre, S., Kaslow, D. C., Jouin, H., Mattei, D., Engler, G. M., Nutman, T. B., Riley, E. M., Mercereau-Puijalon, O. (2002). Regulation of Antigen-Specific Immunoglobulin G Subclasses in Response to Conserved and Polymorphic Plasmodium falciparum Antigens in an In Vitro Model. Infect. Immun. 70: 2820-2827 [Abstract] [Full Text]
Lee, E. A. M., Palmer, D. R., Flanagan, K. L., Reece, W. H. H., Odhiambo, K., Marsh, K., Pinder, M., Gravenor, M. B., Keitel, W. A., Kester, K. E., Diggs, C., Kaslow, D., Apostolopoulos, V., Ballou, W. R., Hill, A. V. S., Krzych, U., Plebanski, M. (2002). Induction of T Helper Type 1 and 2 Responses to 19-Kilodalton Merozoite Surface Protein 1 in Vaccinated Healthy Volunteers and Adults Naturally Exposed to Malaria. Infect. Immun. 70: 1417-1421 [Abstract] [Full Text]
Taylor, P. R., Seixas, E., Walport, M. J., Langhorne, J., Botto, M. (2001). Complement Contributes to Protective Immunity against Reinfection by Plasmodium chabaudi chabaudi Parasites. Infect. Immun. 69: 3853-3859 [Abstract] [Full Text]
Quin, S. J., Langhorne, J. (2001). Different Regions of the Malaria Merozoite Surface Protein 1 of Plasmodium chabaudi Elicit Distinct T-Cell and Antibody Isotype Responses. Infect. Immun. 69: 2245-2251 [Abstract] [Full Text]
Cavanagh, D. R., Dobano, C., Elhassan, I. M., Marsh, K., Elhassan, A., Hviid, L., Khalil, E. A. T. G., Theander, T. G., Arnot, D. E., McBride, J. S. (2001). Differential Patterns of Human Immunoglobulin G Subclass Responses to Distinct Regions of a Single Protein, the Merozoite Surface Protein 1 of Plasmodium falciparum. Infect. Immun. 69: 1207-1211 [Abstract] [Full Text]
Phillips, R. S. (2001). Current Status of Malaria and Potential for Control. Clin. Microbiol. Rev. 14: 208-226 [Abstract] [Full Text]
Badell, E., Oeuvray, C., Moreno, A., Soe, S., van Rooijen, N., Bouzidi, A., Druilhe, P. (2000). Human Malaria in Immunocompromised Mice: An In Vivo Model to Study Defense Mechanisms against Plasmodium falciparum. J. Exp. Med. 192: 1653-1660 [Abstract] [Full Text]
Chatterjee, S., Singh, S., Sohoni, R., Singh, N. J., Vaidya, A., Long, C., Sharma, S. (2000). Antibodies against Ribosomal Phosphoprotein P0 of Plasmodium falciparum Protect Mice against Challenge with Plasmodium yoelii. Infect. Immun. 68: 4312-4318 [Abstract] [Full Text]
Oeuvray, C., Theisen, M., Rogier, C., Trape, J.-F., Jepsen, S., Druilhe, P. (2000). Cytophilic Immunoglobulin Responses to Plasmodium falciparum Glutamate-Rich Protein Are Correlated with Protection against Clinical Malaria in Dielmo, Senegal. Infect. Immun. 68: 2617-2620 [Abstract] [Full Text]
Aucan, C., Traore, Y., Tall, F., Nacro, B., Traore-Leroux, T., Fumoux, F., Rihet, P. (2000). High Immunoglobulin G2 (IgG2) and Low IgG4 Levels Are Associated with Human Resistance to Plasmodium falciparum Malaria. Infect. Immun. 68: 1252-1258 [Abstract] [Full Text]
Kumaratilake, L. M., Ferrante, A. (2000). Opsonization and Phagocytosis of Plasmodium falciparum Merozoites Measured by Flow Cytometry. CVI 7: 9-13 [Abstract] [Full Text]
Kurtis, J. D., Lanar, D. E., Opollo, M., Duffy, P. E. (1999). Interleukin-10 Responses to Liver-Stage Antigen 1�Predict Human Resistance to Plasmodium falciparum. Infect. Immun. 67: 3424-3429 [Abstract] [Full Text]
Healer, J., Graszynski, A., Riley, E. (1999). Phagocytosis Does Not Play a Major Role in Naturally Acquired Transmission-Blocking Immunity to Plasmodium falciparum Malaria. Infect. Immun. 67: 2334-2339 [Abstract] [Full Text]
Shi, Y. P., Hasnain, S. E., Sacci, J. B., Holloway, B. P., Fujioka, H., Kumar, N., Wohlhueter, R., Hoffman, S. L., Collins, W. E., Lal, A. A. (1999). Immunogenicity and in vitro protective efficacy of a recombinant multistage Plasmodium falciparum candidate vaccine. Proc. Natl. Acad. Sci. USA 96: 1615-1620 [Abstract] [Full Text]
Le Scanf, C., Fandeur, T., Bonnefoy, S., Guillotte, M., Mercereau-Puijalon, O. (1999). Novel Target Antigens of the Variant-Specific Immune Response to Plasmodium falciparum Identified by Differential Screening of an Expression Library. Infect. Immun. 67: 64-73 [Abstract] [Full Text]
Omer, F. M., Riley, E. M. (1998). Transforming Growth Factor beta �Production Is Inversely Correlated with Severity of Murine Malaria Infection. J. Exp. Med. 188: 39-48 [Abstract] [Full Text]
Fonjungo, P. N., Stuber, D., McBride, J. S. (1998). Antigenicity of Recombinant Proteins Derived from Rhoptry-Associated Protein 1�of Plasmodium falciparum. Infect. Immun. 66: 1037-1044 [Abstract] [Full Text]
Theisen, M., Soe, S., Oeuvray, C., Thomas, A. W., Vuust, J., Danielsen, S., Jepsen, S., Druilhe, P. (1998). The Glutamate-Rich Protein (GLURP) of Plasmodium falciparum Is a Target for Antibody-Dependent Monocyte-Mediated Inhibition of Parasite Growth In Vitro. Infect. Immun. 66: 11-17 [Abstract] [Full Text]