Increase in positive selection of CD8+ T cells in TAP1-mutant mice by human beta 2-microglobulin transgene

doi:10.1084/jem.181.2.787

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Increase in positive selection of CD8+ T cells in TAP1-mutant mice by human beta 2-microglobulin transgene

H Martien van Santen, A Woolsey, PG Rickardt, L Van Kaer, EJ Baas, A Berns, S Tonegawa and HL Ploegh
Center for Cancer Research, Massachusetts Institute of Technology, Cambridge 02139.

Mice harboring a deletion of the gene encoding the transporter associated with antigen presentation-1 (TAP1) are impaired in providing major histocompatibility complex (MHC) class I molecules with peptides of cytosolic origin and lack stable MHC class I cell surface expression. They consequently have a strongly reduced number of CD8+ T cells. To examine whether selection of CD8+ T cells is dependent on TAP- dependent peptides, we partially restored MHC class I cell surface expression in TAP1-deficient mice by introduction of human beta 2- microglobulin. We show that selection of functional CD8+ T cells can be augmented in vivo in the absence of TAP1-dependent peptides.
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