Fas ligand mediates activation-induced cell death in human T lymphocytes

doi:10.1084/jem.181.1.71

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Fas ligand mediates activation-induced cell death in human T lymphocytes

MR Alderson, TW Tough, T Davis-Smith, S Braddy, B Falk, KA Schooley, RG Goodwin, CA Smith, F Ramsdell and DH Lynch
Immunex Research and Developmental Corporation, Seattle, Washington 98101.

A significant proportion of previously activated human T cells undergo apoptosis when triggered through the CD3/T cell receptor complex, a process termed activation-induced cell death (AICD). Ligation of Fas on activated T cells by either Fas antibodies or recombinant human Fas- ligand (Fas-L) also results in cytolysis. We demonstrate that these two pathways of apoptosis are causally related. Stimulation of previously activated T cells resulted in the expression of Fas-L mRNA and lysis of Fas-positive target cells. Fas-L antagonists inhibited AICD of T cell clones and staphylococcus enterotoxin B (SEB)-specific T cell lines. The data indicate AICD in previously stimulated T cells is mediated by Fas/Fas-L interactions.
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Kerstan, A., Armbruster, N., Leverkus, M., Hunig, T. (2006). Cyclosporin A Abolishes CD28-Mediated Resistance to CD95-Induced Apoptosis via Superinduction of Caspase-3. J. Immunol. 177: 7689-7697 [Abstract] [Full Text]
Meiffren, G., Flacher, M., Azocar, O., Rabourdin-Combe, C., Faure, M. (2006). Cutting Edge: Abortive Proliferation of CD46-Induced Tr1-Like Cells due to a Defective Akt/Survivin Signaling Pathway. J. Immunol. 177: 4957-4961 [Abstract] [Full Text]
Schade, A. E., Powers, J. J., Wlodarski, M. W., Maciejewski, J. P. (2006). Phosphatidylinositol-3-phosphate kinase pathway activation protects leukemic large granular lymphocytes from undergoing homeostatic apoptosis. Blood 107: 4834-4840 [Abstract] [Full Text]
Zhao, D.-M., Thornton, A. M., DiPaolo, R. J., Shevach, E. M. (2006). Activated CD4+CD25+ T cells selectively kill B lymphocytes. Blood 107: 3925-3932 [Abstract] [Full Text]
Anand, A. R., Ganju, R. K. (2006). HIV-1 gp120-mediated Apoptosis of T Cells Is Regulated by the Membrane Tyrosine Phosphatase CD45. J. Biol. Chem. 281: 12289-12299 [Abstract] [Full Text]
Chen, C., Li, H., Tian, Q., Beardall, M., Xu, Y., Casanova, N., Weigert, M. (2006). Selection of Anti-Double-Stranded DNA B Cells in Autoimmune MRL-lpr/lpr Mice. J. Immunol. 176: 5183-5190 [Abstract] [Full Text]
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Cahuzac, N., Baum, W., Kirkin, V., Conchonaud, F., Wawrezinieck, L., Marguet, D., Janssen, O., Zornig, M., Hueber, A.-O. (2006). Fas ligand is localized to membrane rafts, where it displays increased cell death-inducing activity. Blood 107: 2384-2391 [Abstract] [Full Text]
Migliaccio, M., Alves, P. M. S., Romero, P., Rufer, N. (2006). Distinct Mechanisms Control Human Naive and Antigen-Experienced CD8+ T Lymphocyte Proliferation. J. Immunol. 176: 2173-2182 [Abstract] [Full Text]
Legembre, P., Daburon, S., Moreau, P., Ichas, F., de Giorgi, F., Moreau, J.-F., Taupin, J.-L. (2005). Amplification of Fas-Mediated Apoptosis in Type II Cells via Microdomain Recruitment. Mol. Cell. Biol. 25: 6811-6820 [Abstract] [Full Text]
Baumann, S., Dostert, A., Novac, N., Bauer, A., Schmid, W., Fas, S. C., Krueger, A., Heinzel, T., Kirchhoff, S., Schutz, G., Krammer, P. H. (2005). Glucocorticoids inhibit activation-induced cell death (AICD) via direct DNA-dependent repression of the CD95 ligand gene by a glucocorticoid receptor dimer. Blood 106: 617-625 [Abstract] [Full Text]
Acheampong, E. A., Parveen, Z., Muthoga, L. W., Kalayeh, M., Mukhtar, M., Pomerantz, R. J. (2005). Human Immunodeficiency Virus Type 1 Nef Potently Induces Apoptosis in Primary Human Brain Microvascular Endothelial Cells via the Activation of Caspases. J. Virol. 79: 4257-4269 [Abstract] [Full Text]
Nussbaum, A. K., Whitton, J. L. (2004). The Contraction Phase of Virus-Specific CD8+ T Cells Is Unaffected by a Pan-Caspase Inhibitor. J. Immunol. 173: 6611-6618 [Abstract] [Full Text]
Milojkovic, D., Devereux, S., Westwood, N. B., Mufti, G. J., Thomas, N. S. B., Buggins, A. G. S. (2004). Antiapoptotic Microenvironment of Acute Myeloid Leukemia. J. Immunol. 173: 6745-6752 [Abstract] [Full Text]
Torgler, R., Jakob, S., Ontsouka, E., Nachbur, U., Mueller, C., Green, D. R., Brunner, T. (2004). Regulation of Activation-induced Fas (CD95/Apo-1) Ligand Expression in T Cells by the Cyclin B1/Cdk1 Complex. J. Biol. Chem. 279: 37334-37342 [Abstract] [Full Text]
O'Sullivan, S, Cormican, L, Burke, C M, Poulter, L W (2004). Fluticasone induces T cell apoptosis in the bronchial wall of mild to moderate asthmatics. Thorax 59: 657-661 [Abstract] [Full Text]
Abdel-Latif, M. M. M., Windle, H. J., Fitzgerald, K. A., Ang, Y. S., Eidhin, D. N., Li-Weber, M., Sabra, K., Kelleher, D. (2004). Helicobacter pylori Activates the Early Growth Response 1 Protein in Gastric Epithelial Cells. Infect. Immun. 72: 3549-3560 [Abstract] [Full Text]
Setterblad, N., Blancheteau, V., Delaguillaumie, A., Michel, F., Becart, S., Lombardi, G., Acuto, O., Charron, D., Mooney, N. (2004). Cognate MHC-TCR interaction leads to apoptosis of antigen-presenting cells. J. Leukoc. Biol. 75: 1036-1044 [Abstract] [Full Text]
Xiao, S., Zhang, X., Mann, K. K., Jodo, S., Li, L., Jarjour, W. N., Marshak-Rothstein, A., Sherr, D. H., Ju, S.-T. (2004). Changes in sensitivity of peripheral lymphocytes of autoimmune gld mice to FasL-mediated apoptosis reveal a mechanism for the preferential deletion of CD4-CD8-B220+ T cells. Int Immunol 16: 759-766 [Abstract] [Full Text]
Lu, J., Higashimoto, Y., Appella, E., Celis, E. (2004). Multiepitope Trojan Antigen Peptide Vaccines for the Induction of Antitumor CTL and Th Immune Responses. J. Immunol. 172: 4575-4582 [Abstract] [Full Text]
Yang, S., Haluska, F. G. (2004). Treatment of Melanoma with 5-Fluorouracil or Dacarbazine In Vitro Sensitizes Cells to Antigen-Specific CTL Lysis through Perforin/Granzyme- and Fas-Mediated Pathways. J. Immunol. 172: 4599-4608 [Abstract] [Full Text]
Asanuma, K., Tsuji, N., Endoh, T., Yagihashi, A., Watanabe, N. (2004). Survivin Enhances Fas Ligand Expression via Up-Regulation of Specificity Protein 1-Mediated Gene Transcription in Colon Cancer Cells. J. Immunol. 172: 3922-3929 [Abstract] [Full Text]
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Murillo, O., Arina, A., Tirapu, I., Alfaro, C., Mazzolini, G., Palencia, B., De Cerio, A. L.-D., Prieto, J., Bendandi, M., Melero, I. (2003). Potentiation of Therapeutic Immune Responses against Malignancies with Monoclonal Antibodies. Clin. Cancer Res. 9: 5454-5464 [Abstract] [Full Text]
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Greil, R., Anether, G., Johrer, K., Tinhofer, I. (2003). Tracking death dealing by Fas and TRAIL in lymphatic neoplastic disorders: pathways, targets, and therapeutic tools. J. Leukoc. Biol. 74: 311-330 [Abstract] [Full Text]
Melero, I., Gabari, I., Tirapu, I., Arina, A., Mazzolini, G., Baixeras, E., Feijoo, E., Alfaro, C., Qian, C., Prieto, J. (2003). Anti-ICAM-2 Monoclonal Antibody Synergizes with Intratumor Gene Transfer of Interleukin-12 Inhibiting Activation-induced T-Cell Death. Clin. Cancer Res. 9: 3546-3554 [Abstract] [Full Text]
Tung, T. C., Oshima, K., Cui, G., Laks, H., Sen, L. (2003). Dual upregulation of Fas and Bax promotes alloreactive T cell apoptosis in IL-10 gene targeting of cardiac allografts. Am. J. Physiol. Heart Circ. Physiol. 285: H964-H973 [Abstract] [Full Text]
Baek, K.-H., Shin, H.-J., Yoo, J.-K., Cho, J.-H., Choi, Y.-H., Sung, Y.-C., McKeon, F., Lee, C.-W. (2003). p53 deficiency and defective mitotic checkpoint in proliferating T lymphocytes increase chromosomal instability through aberrant exit from mitotic arrest. J. Leukoc. Biol. 73: 850-861 [Abstract] [Full Text]
Maksimow, M., Santanen, M., Jalkanen, S., Hanninen, A. (2003). Responding naive T cells differ in their sensitivity to Fas engagement: early death of many T cells is compensated by costimulation of surviving T cells. Blood 101: 4022-4028 [Abstract] [Full Text]
Gavrilescu, L. C., Denkers, E. Y. (2003). Interleukin-12 p40- and Fas Ligand-Dependent Apoptotic Pathways Involving STAT-1 Phosphorylation Are Triggered during Infection with a Virulent Strain of Toxoplasma gondii. Infect. Immun. 71: 2577-2583 [Abstract] [Full Text]
Zhang, J., Bardos, T., Shao, Q., Tschopp, J., Mikecz, K., Glant, T. T., Finnegan, A. (2003). IL-4 Potentiates Activated T Cell Apoptosis Via an IL-2-Dependent Mechanism. J. Immunol. 170: 3495-3503 [Abstract] [Full Text]
Fujii, S.-i., Shimizu, K., Koji, F., Kawano, F. (2003). Malignant counterpart of myeloid dendritic cell (DC) belonging to acute myelogenous leukemia (AML) exhibits a dichotomous immunoregulatory potential. J. Leukoc. Biol. 73: 82-90 [Abstract] [Full Text]
Ducoroy, P., Micheau, O., Perruche, S., Dubrez-Daloz, L., de Fornel, D., Dutartre, P., Saas, P., Solary, E. (2003). LF 15-0195 immunosuppressive agent enhances activation-induced T-cell death by facilitating caspase-8 and caspase-10 activation at the DISC level. Blood 101: 194-201 [Abstract] [Full Text]
Pinkoski, M. J., Droin, N. M., Lin, T., Genestier, L., Ferguson, T. A., Green, D. R. (2002). Nonlymphoid Fas ligand in peptide-induced peripheral lymphocyte deletion. Proc. Natl. Acad. Sci. USA 99: 16174-16179 [Abstract] [Full Text]
Refaeli, Y., Van Parijs, L., Alexander, S. I., Abbas, A. K. (2002). Interferon {gamma} Is Required for Activation-induced Death of T Lymphocytes. J. Exp. Med. 196: 999-1005 [Abstract] [Full Text]
Huang, S.-C., Tang, M.-J., Hsu, K.-F., Cheng, Y.-M., Chou, C.-Y. (2002). Fas and Its Ligand, Caspases, and Bcl-2 Expression in Gonadotropin-Releasing Hormone Agonist-Treated Uterine Leiomyoma. J. Clin. Endocrinol. Metab. 87: 4580-4586 [Abstract] [Full Text]
Ryon, J. J., Moss, W. J., Monze, M., Griffin, D. E. (2002). Functional and Phenotypic Changes in Circulating Lymphocytes from Hospitalized Zambian Children with Measles. CVI 9: 994-1003 [Abstract] [Full Text]
Kemp, K., Bruunsgaard, H., Skinhoj, P., Klarlund Pedersen, B. (2002). Pneumococcal Infections in Humans Are Associated with Increased Apoptosis and Trafficking of Type 1 Cytokine-Producing T Cells. Infect. Immun. 70: 5019-5025 [Abstract] [Full Text]
McKallip, R. J., Do, Y., Fisher, M. T., Robertson, J. L., Nagarkatti, P. S., Nagarkatti, M. (2002). Role of CD44 in activation-induced cell death: CD44-deficient mice exhibit enhanced T cell response to conventional and superantigens. Int Immunol 14: 1015-1026 [Abstract] [Full Text]
Lens, S. M. A., Kataoka, T., Fortner, K. A., Tinel, A., Ferrero, I., MacDonald, R. H., Hahne, M., Beermann, F., Attinger, A., Orbea, H.-A., Budd, R. C., Tschopp, J. (2002). The Caspase 8 Inhibitor c-FLIPL Modulates T-Cell Receptor-Induced Proliferation but Not Activation-Induced Cell Death of Lymphocytes. Mol. Cell. Biol. 22: 5419-5433 [Abstract] [Full Text]
Drobyski, W. R., Komorowski, R., Logan, B., Gendelman, M. (2002). Role of the Passive Apoptotic Pathway in Graft-Versus-Host Disease. J. Immunol. 169: 1626-1633 [Abstract] [Full Text]
Griffith, T. S., Fialkov, J. M., Scott, D. L., Azuhata, T., Williams, R. D., Wall, N. R., Altieri, D. C., Sandler, A. D. (2002). Induction and Regulation of Tumor Necrosis Factor-related Apoptosis-inducing Ligand/Apo-2 Ligand-mediated Apoptosis in Renal Cell Carcinoma. Cancer Res. 62: 3093-3099 [Abstract] [Full Text]
Ganea, D., Delgado, M. (2002). VASOACTIVE INTESTINAL PEPTIDE (VIP) AND PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE (PACAP) AS MODULATORS OF BOTH INNATE AND ADAPTIVE IMMUNITY. Crit. Rev. Oral Biol. Med. 13: 229-237 [Abstract] [Full Text]
Gourley, T. S., Patel, D. R., Nickerson, K., Hong, S.-C., Chang, C.-H. (2002). Aberrant Expression of Fas Ligand in Mice Deficient for the MHC Class II Transactivator. J. Immunol. 168: 4414-4419 [Abstract] [Full Text]
Melis, M., Siena, L., Pace, E., Gjomarkaj, M., Profita, M., Pirazzoli, A., Todaro, M., Stassi, G., Bonsignore, G., Vignola, A.M. (2002). Fluticasone induces apoptosis in peripheral T-lymphocytes: a comparison between asthmatic and normal subjects. Eur Respir J 19: 257-266 [Abstract] [Full Text]
Kirchhoff, S., Sebens, T., Baumann, S., Krueger, A., Zawatzky, R., Li-Weber, M., Meinl, E., Neipel, F., Fleckenstein, B., Krammer, P. H. (2002). Viral IFN-Regulatory Factors Inhibit Activation-Induced Cell Death Via Two Positive Regulatory IFN-Regulatory Factor 1-Dependent Domains in the CD95 Ligand Promoter. J. Immunol. 168: 1226-1234 [Abstract] [Full Text]
Meier, P., Dayer, E., Blanc, E., Wauters, J.-P. (2002). Early T Cell Activation Correlates with Expression of Apoptosis Markers in Patients with End-Stage Renal Disease. J. Am. Soc. Nephrol. 13: 204-212 [Abstract] [Full Text]
Krueger, A., Baumann, S., Krammer, P. H., Kirchhoff, S. (2001). FLICE-Inhibitory Proteins: Regulators of Death Receptor-Mediated Apoptosis. Mol. Cell. Biol. 21: 8247-8254 [Full Text]
Monleon, I., Martinez-Lorenzo, M. J., Monteagudo, L., Lasierra, P., Taules, M., Iturralde, M., Pineiro, A., Larrad, L., Alava, M. A., Naval, J., Anel, A. (2001). Differential Secretion of Fas Ligand- or APO2 Ligand/TNF-Related Apoptosis-Inducing Ligand-Carrying Microvesicles During Activation-Induced Death of Human T Cells. J. Immunol. 167: 6736-6744 [Abstract] [Full Text]
Jodo, S., Xiao, S., Hohlbaum, A., Strehlow, D., Marshak-Rothstein, A., Ju, S.-T. (2001). Apoptosis-inducing Membrane Vesicles. A NOVEL AGENT WITH UNIQUE PROPERTIES. J. Biol. Chem. 276: 39938-39944 [Abstract] [Full Text]
Ayroldi, E., Migliorati, G., Bruscoli, S., Marchetti, C., Zollo, O., Cannarile, L., D'Adamio, F., Riccardi, C. (2001). Modulation of T-cell activation by the glucocorticoid-induced leucine zipper factor via inhibition of nuclear factor {kappa}B. Blood 98: 743-753 [Abstract] [Full Text]
Betten, A., Dahlgren, C., Hermodsson, S., Hellstrand, K. (2001). Serotonin protects NK cells against oxidatively induced functional inhibition and apoptosis. J. Leukoc. Biol. 70: 65-72 [Abstract] [Full Text]
Lee, Y.-j., Shacter, E. (2001). Fas Aggregation Does Not Correlate with Fas-Mediated Apoptosis. J. Immunol. 167: 82-89 [Abstract] [Full Text]
Baker, J., Verneris, M. R., Ito, M., Shizuru, J. A., Negrin, R. S. (2001). Expansion of cytolytic CD8+ natural killer T cells with limited capacity for graft-versus-host disease induction due to interferon {gamma} production. Blood 97: 2923-2931 [Abstract] [Full Text]
Kawamura, K., Fukuda, J., Kodama, H., Kumagai, J., Kumagai, A., Tanaka, T. (2001). Expression of Fas and Fas ligand mRNA in rat and human preimplantation embryos. Mol Hum Reprod 7: 431-436 [Abstract] [Full Text]
Pettersen, R. D., Bernard, G., Olafsen, M. K., Pourtein, M., Lie, S. O. (2001). CD99 Signals Caspase-Independent T Cell Death. J. Immunol. 166: 4931-4942 [Abstract] [Full Text]
Zhang, J., Bardos, T., Mikecz, K., Finnegan, A., Glant, T. T. (2001). Impaired Fas Signaling Pathway Is Involved in Defective T Cell Apoptosis in Autoimmune Murine Arthritis. J. Immunol. 166: 4981-4986 [Abstract] [Full Text]
HSU, C.-D., HARIRAH, H., BASHERRA, H., MOR, G. (2001). Serum Soluble Fas Levels in Preeclampsia. Obstet Gynecol 97: 530-532 [Abstract] [Full Text]
Dzialo-Hatton, R., Milbrandt, J., Hockett, R. D. Jr., Weaver, C. T. (2001). Differential Expression of Fas Ligand in Th1 and Th2 Cells Is Regulated by Early Growth Response Gene and NF-AT Family Members. J. Immunol. 166: 4534-4542 [Abstract] [Full Text]
Gourley, T. S., Chang, C.-H. (2001). Cutting Edge: The Class II Transactivator Prevents Activation-Induced Cell Death by Inhibiting Fas Ligand Gene Expression. J. Immunol. 166: 2917-2921 [Abstract] [Full Text]
De Panfilis, G., Caruso, A., Sansoni, P., Pasolini, G., Semenza, D., Torresani, C. (2001). Identification of Fas-L-Expressing Apoptotic T Lymphocytes in Normal Human Peripheral Blood : In Vivo Suicide. Am. J. Pathol. 158: 387-391 [Abstract] [Full Text]
Lundy, S. K., Lerman, S. P., Boros, D. L. (2001). Soluble Egg Antigen-Stimulated T Helper Lymphocyte Apoptosis and Evidence for Cell Death Mediated by FasL+ T and B Cells during Murine Schistosoma mansoni Infection. Infect. Immun. 69: 271-280 [Abstract] [Full Text]
Greer, J. P., Kinney, M. C., Loughran, T. P. Jr. (2001). T Cell and NK Cell Lymphoproliferative Disorders. ASH Education Book 2001: 259-281 [Abstract] [Full Text]
Jendro, M. C., Deutsch, T., Korber, B., Kohler, L., Kuipers, J. G., Krausse-Opatz, B., Westermann, J., Raum, E., Zeidler, H. (2000). Infection of Human Monocyte-Derived Macrophages with Chlamydia trachomatis Induces Apoptosis of T Cells: a Potential Mechanism for Persistent Infection. Infect. Immun. 68: 6704-6711 [Abstract] [Full Text]
Gastman, B. R., Yin, X.-M., Johnson, D. E., Wieckowski, E., Wang, G.-Q., Watkins, S. C., Rabinowich, H. (2000). Tumor-induced Apoptosis of T Cells: Amplification by a Mitochondrial Cascade. Cancer Res. 60: 6811-6817 [Abstract] [Full Text]
Kirchhoff, S., Muller, W. W., Krueger, A., Schmitz, I., Krammer, P. H. (2000). TCR-Mediated Up-Regulation of c-FLIPshort Correlates with Resistance Toward CD95-Mediated Apoptosis by Blocking Death-Inducing Signaling Complex Activity. J. Immunol. 165: 6293-6300 [Abstract] [Full Text]
Teh, H.-S., Seebaran, A., Teh, S.-J. (2000). TNF Receptor 2-Deficient CD8 T Cells Are Resistant to Fas/Fas Ligand-Induced Cell Death. J. Immunol. 165: 4814-4821 [Abstract] [Full Text]
Badley, A. D., Pilon, A. A., Landay, A., Lynch, D. H. (2000). Mechanisms of HIV-associated lymphocyte apoptosis. Blood 96: 2951-2964 [Abstract] [Full Text]
Patel, C. A., Mukhtar, M., Pomerantz, R. J. (2000). Human Immunodeficiency Virus Type 1 Vpr Induces Apoptosis in Human Neuronal Cells. J. Virol. 74: 9717-9726 [Abstract] [Full Text]
Huang, W.-X., Huang, P., Gomes, A., Hillert, J. (2000). Apoptosis mediators FasL and TRAIL are upregulated in peripheral blood mononuclear cells in MS. Neurology 55: 928-934 [Abstract] [Full Text]
Griffith, T. S., Anderson, R. D., Davidson, B. L., Williams, R. D., Ratliff, T. L. (2000). Adenoviral-Mediated Transfer of the TNF-Related Apoptosis-Inducing Ligand/Apo-2 Ligand Gene Induces Tumor Cell Apoptosis. J. Immunol. 165: 2886-2894 [Abstract] [Full Text]
KRUG, N., CRUIKSHANK, W. W., TSCHERNIG, T., ERPENBECK, V. J., BALKE, K., HOHLFELD, J. M., CENTER, D. M., FABEL, H. (2000). Interleukin 16 and T-cell Chemoattractant Activity in Bronchoalveolar Lavage 24 Hours after Allergen Challenge in Asthma. Am. J. Respir. Crit. Care Med. 162: 105-111 [Abstract] [Full Text]
Tateyama, M., Oyaizu, N., McCloskey, T. W., Than, S., Pahwa, S. (2000). CD4 T lymphocytes are primed to express Fas ligand by CD4 cross-linking and to contribute to CD8 T-cell apoptosis via Fas/FasL death signaling pathway. Blood 96: 195-202 [Abstract] [Full Text]
Somma, F., Tuosto, L., Montani, M. S. G., Di Somma, M. M., Cundari, E., Piccolella, E. (2000). Engagement of CD4 Before TCR Triggering Regulates Both Bax- and Fas (CD95)-Mediated. J. Immunol. 164: 5078-5087 [Abstract] [Full Text]
Norian, L. A., Latinis, K. M., Eliason, S. L., Lyson, K., Yang, C., Ratliff, T., Koretzky, G. A. (2000). The Regulation of CD95 (Fas) Ligand Expression in Primary T Cells: Induction of Promoter Activation in CD95LP-Luc Transgenic Mice. J. Immunol. 164: 4471-4480 [Abstract] [Full Text]
Ishimaru, N., Yoneda, T., Saegusa, K., Yanagi, K., Haneji, N., Moriyama, K., Saito, I., Hayashi, Y. (2000). Severe Destructive Autoimmune Lesions with Aging in Murine Sjogren's Syndrome through Fas-Mediated Apoptosis. Am. J. Pathol. 156: 1557-1564 [Abstract] [Full Text]
Yin, D., Tuthill, D., Mufson, R. A., Shi, Y. (2000). Chronic Restraint Stress Promotes Lymphocyte Apoptosis by Modulating CD95 Expression. J. Exp. Med. 191: 1423-1428 [Abstract] [Full Text]
Yoshida, T., Higuchi, T., Hagiyama, H., Strasser, A., Nishioka, K., Tsubata, T. (2000). Rapid B cell apoptosis induced by antigen receptor ligation does not require Fas (CD95/APO-1), the adaptor protein FADD/MORT1 or CrmA-sensitive caspases but is defective in both MRL-+/+ and MRL-lpr/lpr mice. Int Immunol 12: 517-526 [Abstract] [Full Text]
Ribas, A., Butterfield, L. H., Hu, B., Dissette, V. B., Meng, W. S., Koh, A., Andrews, K. J., Lee, M., Amar, S. N., Glaspy, J. A., McBride, W. H., Economou, J. S. (2000). Immune Deviation and Fas-mediated Deletion Limit Antitumor Activity after Multiple Dendritic Cell Vaccinations in Mice. Cancer Res. 60: 2218-2224 [Abstract] [Full Text]
Brunner, T., Kasibhatla, S., Pinkoski, M. J., Frutschi, C., Yoo, N. J., Echeverri, F., Mahboubi, A., Green, D. R. (2000). Expression of Fas Ligand in Activated T Cells Is Regulated by c-Myc. J. Biol. Chem. 275: 9767-9772 [Abstract] [Full Text]
Gastman, B. R., Johnson, D. E., Whiteside, T. L., Rabinowich, H. (2000). Tumor-induced apoptosis of T lymphocytes: elucidation of intracellular apoptotic events. Blood 95: 2015-2023 [Abstract] [Full Text]
Jenkins, M., Keir, M., McCune, J. M. (2000). A Membrane-bound Fas Decoy Receptor Expressed by Human Thymocytes. J. Biol. Chem. 275: 7988-7993 [Abstract] [Full Text]
Parra, B., Lin, M. T., Stohlman, S. A., Bergmann, C. C., Atkinson, R., Hinton, D. R. (2000). Contributions of Fas-Fas Ligand Interactions to the Pathogenesis of Mouse Hepatitis Virus in the Central Nervous System. J. Virol. 74: 2447-2450 [Abstract] [Full Text]
Delgado, M., Ganea, D. (2000). Vasoactive Intestinal Peptide and Pituitary Adenylate Cyclase-Activating Polypeptide Inhibit Antigen-Induced Apoptosis of Mature T Lymphocytes by Inhibiting Fas Ligand Expression. J. Immunol. 164: 1200-1210 [Abstract] [Full Text]
Perlman, H., Pagliari, L. J., Georganas, C., Mano, T., Walsh, K., Pope, R. M. (1999). FLICE-inhibitory Protein Expression during Macrophage Differentiation Confers Resistance to Fas-mediated Apoptosis. J. Exp. Med. 190: 1679-1688 [Abstract] [Full Text]
Hoshino, Y., Morishima, T., Kimura, H., Nishikawa, K., Tsurumi, T., Kuzushima, K. (1999). Antigen-Driven Expansion and Contraction of CD8+-Activated T Cells in Primary EBV Infection. J. Immunol. 163: 5735-5740 [Abstract] [Full Text]
Ayroldi, E., D'Adamio, F., Zollo, O., Agostini, M., Moraca, R., Cannarile, L., Migliorati, G., Delfino, D. V., Riccardi, C. (1999). Cloning and Expression of a Short Fas Ligand: A New Alternatively Spliced Product of the Mouse Fas Ligand Gene. Blood 94: 3456-3467 [Abstract] [Full Text]
Kreuwel, H. T. C., Morgan, D. J., Krahl, T., Ko, A., Sarvetnick, N., Sherman, L. A. (1999). Comparing the Relative Role of Perforin/Granzyme Versus Fas/Fas Ligand Cytotoxic Pathways in CD8+ T Cell-Mediated Insulin-Dependent Diabetes Mellitus. J. Immunol. 163: 4335-4341 [Abstract] [Full Text]
Wakamatsu, S.-i., Makino, M., Tei, C., Baba, M. (1999). Monocyte-Driven Activation-Induced Apoptotic Cell Death of Human T-Lymphotropic Virus Type I-Infected T Cells. J. Immunol. 163: 3914-3919 [Abstract] [Full Text]
Sanzenbacher, R., Kabelitz, D., Janssen, O. (1999). SLP-76 Binding to p56lck: A Role for SLP-76 in CD4-Induced Desensitization of the TCR/CD3 Signaling Complex. J. Immunol. 163: 3143-3152 [Abstract] [Full Text]