Turnover of naive- and memory-phenotype T cells

doi:10.1084/jem.179.4.1127

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Turnover of naive- and memory-phenotype T cells

DF Tough and J Sprent
Department of Immunology, Scripps Research Institute, La Jolla, California 92037.

On the basis of their surface markers, T lymphocytes are divided into subsets of "naive" and "memory cells". We have defined the interrelationship and relative life spans of naive and memory T cells by examining the surface markers on murine T cells incorporating bromodeoxyuridine, a DNA precursor, given in the drinking water. Three findings are reported. First, using a new method we show that the release of newly formed naive T cells from the unmanipulated thymus is very low (confirming the findings of others with surgical approaches). Second, in thymectomized mice, T cells with a naive phenotype remain in interphase for prolonged periods; however, some of these cells divide and retain (or regain) their "naive" markers. Third, most T cells with a memory phenotype divide rapidly, but others remain in interphase for many weeks. Collectively, the data indicate that long-lived T cells have multiple phenotypes and contain a mixture of memory cells, naive (virgin) cells, and memory cells masquerading as naive cells.
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Unger, W. W. J., Hauet-Broere, F., Jansen, W., van Berkel, L. A., Kraal, G., Samsom, J. N. (2003). Early Events in Peripheral Regulatory T Cell Induction via the Nasal Mucosa. J. Immunol. 171: 4592-4603 [Abstract] [Full Text]
Schott, E., Bonasio, R., Ploegh, H. L. (2003). Elimination In Vivo of Developing T Cells by Natural Killer Cells. J. Exp. Med. 198: 1213-1224 [Abstract] [Full Text]