Inhibition of murine B and T lymphopoiesis in vivo by an anti- interleukin 7 monoclonal antibody

doi:10.1084/jem.178.1.257

This Article

	Full Text (PDF)
	Alert me when this article is cited
	Citation Map

Services

	Email this article
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new content in the JEM
	Download to citation manager

Citing Articles

	Citing Articles via HighWire
	Citing Articles via CrossRef
	Citing Articles via Google Scholar

Google Scholar

	Articles by Grabstein, K. H.
	Articles by Morrissey, P. J.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Grabstein, K. H.
	Articles by Morrissey, P. J.


Social Bookmarking

	What's this?

ARTICLES

Inhibition of murine B and T lymphopoiesis in vivo by an anti- interleukin 7 monoclonal antibody

KH Grabstein, TJ Waldschmidt, FD Finkelman, BW Hess, AR Alpert, NE Boiani, AE Namen and PJ Morrissey
Immunex Research and Development Corporation, Seattle, Washington 98101.

The effects of interleukin 7 (IL-7) on the growth and differentiation of murine B cell progenitors has been well characterized using in vitro culture methods. We have investigated the role of IL-7 in vivo using a monoclonal antibody that neutralizes IL-7. We find that treatment of mice with this antibody completely inhibits the development of B cell progenitors from the pro-B cell stage forward. We also provide evidence that all peripheral B cells, including those of the B-1 and conventional lineages, are derived from IL-7-dependent precursors. The results are consistent with the rapid turnover of B cell progenitors in the marrow, but a slow turnover of mature B cells in the periphery. In addition to effects on B cell development, anti-IL-7 treatment substantially reduced thymus cellularity, affecting all major thymic subpopulations.
Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Add to Reddit Reddit Add to Technorati Technorati What's this?

This article has been cited by other articles:

Guerrettaz, L. M., Johnson, S. A., Cambier, J. C. (2008). Acquired hematopoietic stem cell defects determine B-cell repertoire changes associated with aging. Proc. Natl. Acad. Sci. USA 105: 11898-11902 [Abstract] [Full Text]
Sunwoo, J. B., Kim, S., Yang, L., Naik, T., Higuchi, D. A., Rubenstein, J. L., Yokoyama, W. M. (2008). Distal-less homeobox transcription factors regulate development and maturation of natural killer cells. Proc. Natl. Acad. Sci. USA 105: 10877-10882 [Abstract] [Full Text]
Sportes, C., Hakim, F. T., Memon, S. A., Zhang, H., Chua, K. S., Brown, M. R., Fleisher, T. A., Krumlauf, M. C., Babb, R. R., Chow, C. K., Fry, T. J., Engels, J., Buffet, R., Morre, M., Amato, R. J., Venzon, D. J., Korngold, R., Pecora, A., Gress, R. E., Mackall, C. L. (2008). Administration of rhIL-7 in humans increases in vivo TCR repertoire diversity by preferential expansion of naive T cell subsets. J. Exp. Med. 205: 1701-1714 [Abstract] [Full Text]
Boyman, O., Ramsey, C., Kim, D. M., Sprent, J., Surh, C. D. (2008). IL-7/Anti-IL-7 mAb Complexes Restore T Cell Development and Induce Homeostatic T Cell Expansion without Lymphopenia. J. Immunol. 180: 7265-7275 [Abstract] [Full Text]
Wojciechowski, S., Tripathi, P., Bourdeau, T., Acero, L., Grimes, H. L., Katz, J. D., Finkelman, F. D., Hildeman, D. A. (2007). Bim/Bcl-2 balance is critical for maintaining naive and memory T cell homeostasis. J. Exp. Med. 204: 1665-1675 [Abstract] [Full Text]
Tripathi, P., Mitchell, T. C., Finkelman, F., Hildeman, D. A. (2007). Cutting Edge: Limiting Amounts of IL-7 Do Not Control Contraction of CD4+ T Cell Responses. J. Immunol. 178: 4027-4031 [Abstract] [Full Text]
Feng, J., Wang, H., Morse, H. C. III (2007). Functional Deficiency in IL-7 Caused by an N-Ethyl-N-nitrosourea-Induced Point Mutation. Genetics 175: 545-551 [Abstract] [Full Text]
Lucas, P. J., Kim, S.-J., Mackall, C. L., Telford, W. G., Chu, Y.-W., Hakim, F. T., Gress, R. E. (2006). Dysregulation of IL-15-mediated T-cell homeostasis in TGF-beta dominant-negative receptor transgenic mice. Blood 108: 2789-2795 [Abstract] [Full Text]
Staton, P. J., Carpenter, A. B., Jackman, S. H. (2006). IL-7 Is a Critical Factor in Modulating Lesion Development in Skn-Directed Autoimmunity. J. Immunol. 176: 3978-3986 [Abstract] [Full Text]
Ryan, M. R., Shepherd, R., Leavey, J. K., Gao, Y., Grassi, F., Schnell, F. J., Qian, W.-P., Kersh, G. J., Weitzmann, M. N., Pacifici, R. (2005). An IL-7-dependent rebound in thymic T cell output contributes to the bone loss induced by estrogen deficiency. Proc. Natl. Acad. Sci. USA 102: 16735-16740 [Abstract] [Full Text]
French, J. D., Roark, C. L., Born, W. K., O'Brien, R. L. (2005). {gamma}{delta} T cell homeostasis is established in competition with {alpha}{beta} T cells and NK cells. Proc. Natl. Acad. Sci. USA 102: 14741-14746 [Abstract] [Full Text]
Phillips, J. A., Brondstetter, T. I., English, C. A., Lee, H. E., Virts, E. L., Thoman, M. L. (2004). IL-7 Gene Therapy in Aging Restores Early Thymopoiesis without Reversing Involution. J. Immunol. 173: 4867-4874 [Abstract] [Full Text]
El Kassar, N., Lucas, P. J., Klug, D. B., Zamisch, M., Merchant, M., Bare, C. V., Choudhury, B., Sharrow, S. O., Richie, E., Mackall, C. L., Gress, R. E. (2004). A dose effect of IL-7 on thymocyte development. Blood 104: 1419-1427 [Abstract] [Full Text]
Jiang, Q., Li, W. Q., Hofmeister, R. R., Young, H. A., Hodge, D. R., Keller, J. R., Khaled, A. R., Durum, S. K. (2004). Distinct Regions of the Interleukin-7 Receptor Regulate Different Bcl2 Family Members. Mol. Cell. Biol. 24: 6501-6513 [Abstract] [Full Text]
Fuentes-Panana, E. M., Bannish, G., Shah, N., Monroe, J. G. (2004). Basal Ig{alpha}/Ig{beta} Signals Trigger the Coordinated Initiation of Pre-B Cell Antigen Receptor-Dependent Processes. J. Immunol. 173: 1000-1011 [Abstract] [Full Text]
Kondrack, R. M., Harbertson, J., Tan, J. T., McBreen, M. E., Surh, C. D., Bradley, L. M. (2003). Interleukin 7 Regulates the Survival and Generation of Memory CD4 Cells. J. Exp. Med. 198: 1797-1806 [Abstract] [Full Text]
Li, J., Huston, G., Swain, S. L. (2003). IL-7 Promotes the Transition of CD4 Effectors to Persistent Memory Cells. J. Exp. Med. 198: 1807-1815 [Abstract] [Full Text]
Lee, S.-K., Kalinowski, J. F., Jastrzebski, S. L., Puddington, L., Lorenzo, J. A. (2003). Interleukin-7 Is a Direct Inhibitor of in Vitro Osteoclastogenesis. Endocrinology 144: 3524-3531 [Abstract] [Full Text]
Cooper, C. J., Orr, M. T., McMahan, C. J., Fink, P. J. (2003). T Cell Receptor Revision Does Not Solely Target Recent Thymic Emigrants. J. Immunol. 171: 226-233 [Abstract] [Full Text]
Kolar, G R, Capra, J D (2003). The NOD/SCID chimeric mouse model of human B cell development: studies on the VH4 family immunoglobulin repertoire and implications for SLE. Lupus 12: 158-162 [Abstract]
Miller, J. P., Izon, D., DeMuth, W., Gerstein, R., Bhandoola, A., Allman, D. (2002). The Earliest Step in B Lineage Differentiation from Common Lymphoid Progenitors Is Critically Dependent upon Interleukin 7. J. Exp. Med. 196: 705-711 [Abstract] [Full Text]
Morris, S. C., Dragula, N. L., Finkelman, F. D. (2002). IL-4 Promotes Stat6-Dependent Survival of Autoreactive B Cells In Vivo Without Inducing Autoantibody Production. J. Immunol. 169: 1696-1704 [Abstract] [Full Text]
Tan, J. T., Ernst, B., Kieper, W. C., LeRoy, E., Sprent, J., Surh, C. D. (2002). Interleukin (IL)-15 and IL-7 Jointly Regulate Homeostatic Proliferation of Memory Phenotype CD8+ Cells but Are Not Required for Memory Phenotype CD4+ Cells. J. Exp. Med. 195: 1523-1532 [Abstract] [Full Text]
Min, D., Taylor, P. A., Panoskaltsis-Mortari, A., Chung, B., Danilenko, D. M., Farrell, C., Lacey, D. L., Blazar, B. R., Weinberg, K. I. (2002). Protection from thymic epithelial cell injury by keratinocyte growth factor: a new approach to improve thymic and peripheral T-cell reconstitution after bone marrow transplantation. Blood 99: 4592-4600 [Abstract] [Full Text]
Fry, T. J., Mackall, C. L. (2002). Interleukin-7: from bench to clinic. Blood 99: 3892-3904 [Full Text]
Kelly, E., Won, A., Refaeli, Y., Parijs, L. V. (2002). IL-2 and Related Cytokines Can Promote T Cell Survival by Activating AKT. J. Immunol. 168: 597-603 [Abstract] [Full Text]
Hao, Z., Rajewsky, K. (2001). Homeostasis of Peripheral B Cells in the Absence of B Cell Influx from the Bone Marrow. J. Exp. Med. 194: 1151-1164 [Abstract] [Full Text]
Rossi, M. I. D., Medina, K. L., Garrett, K., Kolar, G., Comp, P. C., Shultz, L. D., Capra, J. D., Wilson, P., Schipul, A., Kincade, P. W. (2001). Relatively Normal Human Lymphopoiesis but Rapid Turnover of Newly Formed B Cells in Transplanted Nonobese Diabetic/SCID Mice. J. Immunol. 167: 3033-3042 [Abstract] [Full Text]
Vivien, L., Benoist, C., Mathis, D. (2001). T lymphocytes need IL-7 but not IL-4 or IL-6 to survive in vivo. Int Immunol 13: 763-768 [Abstract] [Full Text]
Sandel, P. C., Gendelman, M., Kelsoe, G., Monroe, J. G. (2001). Definition of a Novel Cellular Constituent of the Bone Marrow That Regulates the Response of Immature B Cells to B Cell Antigen Receptor Engagement. J. Immunol. 166: 5935-5944 [Abstract] [Full Text]
Fry, T. J., Connick, E., Falloon, J., Lederman, M. M., Liewehr, D. J., Spritzler, J., Steinberg, S. M., Wood, L. V., Yarchoan, R., Zuckerman, J., Landay, A., Mackall, C. L. (2001). A potential role for interleukin-7 in T-cell homeostasis. Blood 97: 2983-2990 [Abstract] [Full Text]
Ellis, T. M., Moser, M. T., Le, P. T., Flanigan, R. C., Kwon, E. D. (2001). Alterations in peripheral B cells and B cell progenitors following androgen ablation in mice. Int Immunol 13: 553-558 [Abstract] [Full Text]
Mackall, C. L., Fry, T. J., Bare, C., Morgan, P., Galbraith, A., Gress, R. E. (2001). IL-7 increases both thymic-dependent and thymic-independent T-cell regeneration after bone marrow transplantation. Blood 97: 1491-1497 [Abstract] [Full Text]
Ku, C.-C., Kappler, J., Marrack, P. (2001). The Growth of the Very Large CD8+ T Cell Clones in Older Mice Is Controlled by Cytokines. J. Immunol. 166: 2186-2193 [Abstract] [Full Text]
Sims, J. E., Williams, D. E., Morrissey, P. J., Garka, K., Foxworthe, D., Price, V., Friend, S. L., Farr, A., Bedell, M. A., Jenkins, N. A., Copeland, N. G., Grabstein, K., Paxton, R. J. (2000). Molecular Cloning and Biological Characterization of a Novel Murine Lymphoid Growth Factor. J. Exp. Med. 192: 671-680 [Abstract] [Full Text]
Mori, M., Morris, S. C., Orekhova, T., Marinaro, M., Giannini, E., Finkelman, F. D. (2000). IL-4 Promotes the Migration of Circulating B Cells to the Spleen and Increases Splenic B Cell Survival. J. Immunol. 164: 5704-5712 [Abstract] [Full Text]
Ku, C. C., Murakami, M., Sakamoto, A., Kappler, J., Marrack, P. (2000). Control of Homeostasis of CD8+ Memory T Cells by Opposing Cytokines. Science 288: 675-678 [Abstract] [Full Text]
Goto, E., Kohrogi, H., Hirata, N., Tsumori, K., Hirosako, S., Hamamoto, J., Fujii, K., Kawano, O., Ando, M. (2000). Human Bronchial Intraepithelial T Lymphocytes as a Distinct T-Cell Subset . Their Long-Term Survival in SCID-Hu Chimeras. Am. J. Respir. Cell Mol. Bio. 22: 405-411 [Abstract] [Full Text]
Morris, S. C., Moroldo, M., Giannini, E. H., Orekhova, T., Finkelman, F. D. (2000). In Vivo Survival of Autoreactive B Cells: Characterization of Long-Lived B Cells. J. Immunol. 164: 3035-3046 [Abstract] [Full Text]
Medina, K. L., Strasser, A., Kincade, P. W. (2000). Estrogen influences the differentiation, proliferation, and survival of early B-lineage precursors. Blood 95: 2059-2067 [Abstract] [Full Text]
Wei, C., Zeff, R., Goldschneider, I. (2000). Murine Pro-B Cells Require IL-7 and Its Receptor Complex to Up-Regulate IL-7R{alpha}, Terminal Deoxynucleotidyltransferase, and c{micro} Expression. J. Immunol. 164: 1961-1970 [Abstract] [Full Text]
Porter, B. O., Malek, T. R. (1999). IL-2R{beta}/IL-7R{alpha} Doubly Deficient Mice Recapitulate the Thymic and Intraepithelial Lymphocyte (IEL) Developmental Defects of {gamma}c-/- Mice: Roles for Both IL-2 and IL-15 in CD8{alpha}{alpha} IEL Development. J. Immunol. 163: 5906-5912 [Abstract] [Full Text]
Griebel, P., Beskorwayne, T., Van den Broeke, A., Ferrari, G. (1999). CD40 signaling induces B cell responsiveness to multiple members of the {gamma} chain-common cytokine family. Int Immunol 11: 1139-1147 [Abstract] [Full Text]
Hirayama, F., Aiba, Y., Ikebuchi, K., Sekiguchi, S., Ogawa, M. (1999). Differentiation in Culture of Murine Primitive Lymphohematopoietic Progenitors Toward T-Cell Lineage. Blood 93: 4187-4195 [Abstract] [Full Text]
Kawabata, K., Ujikawa, M., Egawa, T., Kawamoto, H., Tachibana, K., Iizasa, H., Katsura, Y., Kishimoto, T., Nagasawa, T. (1999). A cell-autonomous requirement for CXCR4 in long-term lymphoid and myeloid reconstitution. Proc. Natl. Acad. Sci. USA 96: 5663-5667 [Abstract] [Full Text]
Lu, L., Chaudhury, P., Osmond, D. G. (1999). Regulation of Cell Survival During B Lymphopoiesis: Apoptosis and Bcl-2/Bax Content of Precursor B Cells in Bone Marrow of Mice with Altered Expression of IL-7 and Recombinase-Activating Gene-2. J. Immunol. 162: 1931-1940 [Abstract] [Full Text]
Borghesi, L. A., Yamashita, Y., Kincade, P. W. (1999). Heparan Sulfate Proteoglycans Mediate Interleukin-7- Dependent B Lymphopoiesis. Blood 93: 140-148 [Abstract] [Full Text]
Hacein-Bey, S., Basile, G. D. S., Lemerle, J., Fischer, A., Cavazzana-Calvo, M. (1998). gamma c Gene Transfer in the Presence of Stem Cell Factor, FLT-3L, Interleukin-7 (IL-7), IL-1alpha , and IL-15 Cytokines Restores T-Cell Differentiation From gamma c(-) X-Linked Severe Combined Immunodeficiency Hematopoietic Progenitor Cells in Murine Fetal Thymic Organ Cultures. Blood 92: 4090-4097 [Abstract] [Full Text]
Hikida, M., Nakayama, Y., Yamashita, Y., Kumazawa, Y., Nishikawa, S.-I., Ohmori, H. (1998). Expression of Recombination Activating Genes in Germinal Center B Cells: Involvement of Interleukin 7�(IL-7) and the IL-7 Receptor. J. Exp. Med. 188: 365-372 [Abstract] [Full Text]
Varas, A., Vicente, A., Sacedon, R., Zapata, A. G. (1998). Interleukin-7 Influences the Development of Thymic Dendritic Cells. Blood 92: 93-100 [Abstract] [Full Text]
Kim, K., Lee, C.-k., Sayers, T. J., Muegge, K., Durum, S. K. (1998). The Trophic Action of IL-7 on Pro-T Cells: Inhibition of Apoptosis of Pro-T1, -T2, and -T3 Cells Correlates with Bcl-2 and Bax Levels and Is Independent of Fas and p53 Pathways. J. Immunol. 160: 5735-5741 [Abstract] [Full Text]
Ray, R. J., Stoddart, A., Pennycook, J. L., Huner, H. O., Furlonger, C., Wu, G. E., Paige, C. J. (1998). Stromal Cell-Independent Maturation of IL-7-Responsive Pro-B Cells. J. Immunol. 160: 5886-5897 [Abstract] [Full Text]
Lin, Q., Taniuchi, I., Kitamura, D., Wang, J., Kearney, J. F., Watanabe, T., Cooper, M. D. (1998). T and B Cell Development in BP-1/6C3/Aminopeptidase A-Deficient Mice. J. Immunol. 160: 4681-4687 [Abstract] [Full Text]
McKenna, H. J., Morrissey, P. J. (1998). Flt3 Ligand Plus IL-7 Supports the Expansion of Murine Thymic B Cell Progenitors That Can Mature Intrathymically. J. Immunol. 160: 4801-4809 [Abstract] [Full Text]
McKenna, S. D., Chen, F., Lai, L., Goldschneider, I. (1998). Identification of an IL-7-Associated Pre-Pro-B Cell Growth-Stimulating Factor (PPBSF). I. Production of the Non-IL-7 Component by Bone Marrow Stromal Cells from IL-7 Gene-Deleted Mice. J. Immunol. 160: 2272-2279 [Abstract] [Full Text]
Lai, L., Chen, F., McKenna, S., Goldschneider, I. (1998). Identification of an IL-7-Associated Pre-Pro-B Cell Growth-Stimulating Factor (PPBSF). II. PPBSF Is a Covalently Linked Heterodimer of IL-7 and a Mr 30,000 Cofactor. J. Immunol. 160: 2280-2286 [Abstract] [Full Text]
Lin, Q., Dong, C., Cooper, M. D. (1998). Impairment of �T and B Cell Development by Treatment with a Type I Interferon. J. Exp. Med. 187: 79-87 [Abstract] [Full Text]
Gringhuis, S. I., F.M.H. de Leij, L., Verschuren, E. W., Borger, P., Vellenga, E. (1997). Interleukin-7 Upregulates the Interleukin-2-Gene Expression in Activated Human T Lymphocytes at the Transcriptional Level by Enhancing the DNA Binding Activities of Both Nuclear Factor of Activated T Cells and Activator Protein-1. Blood 90: 2690-2700 [Abstract] [Full Text]
You-Ten, K. E., Muise, E. S., Itie, A., Michaliszyn, E., Wagner, J., Jothy, S., Lapp, W. S., Tremblay, M. L. (1997). Impaired Bone Marrow Microenvironment and Immune Function in T Cell Protein Tyrosine Phosphatase-deficient Mice. J. Exp. Med. 186: 683-693 [Abstract] [Full Text]
Chen, X., Liu, W., Ambrosino, C., Ruocco, M. R., Poli, V., Romani, L., Quinto, I., Barbieri, S., Holmes, K. L., Venuta, S., Scala, G. (1997). Impaired Generation of Bone Marrow B Lymphocytes in Mice Deficient in C/EBPbeta. Blood 90: 156-164 [Abstract] [Full Text]
Maki, K., Sunaga, S., Ikuta, K. (1996). The V-J Recombination of �T Cell Receptor-gamma Genes Is Blocked in Interleukin-7 Receptor-deficient Mice. J. Exp. Med. 184: 2423-2428 [Abstract] [Full Text]
Holzinger, C., Schollhammer, A., Imhof, M., Reinwald, C., Kramer, G., Zuckermann, A., Wolner, E., Steiner, G. (1995). Phenotypic Patterns of Mononuclear Cells in Dilated Cardiomyopathy. Circulation 92: 2876-2885 [Abstract] [Full Text]
van der Lugt, N M, Domen, J, Linders, K, van Roon, M, Robanus-Maandag, E, te Riele, H, van der Valk, M, Deschamps, J, Sofroniew, M, van Lohuizen, M (1994). Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 proto-oncogene.. Genes Dev. 8: 757-769 [Abstract]
Kondo, M, Takeshita, T, Higuchi, M, Nakamura, M, Sudo, T, Nishikawa, S, Sugamura, K (1994). Functional participation of the IL-2 receptor gamma chain in IL-7 receptor complexes. Science 263: 1453-1454 [Abstract]
Noguchi, M, Nakamura, Y, Russell, S., Ziegler, S., Tsang, M, Cao, X, Leonard, W. (1993). Interleukin-2 receptor gamma chain: a functional component of the interleukin-7 receptor. Science 262: 1877-1880 [Abstract]