B lymphocytes may escape tolerance by revising their antigen receptors

doi:10.1084/jem.177.4.1165

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B lymphocytes may escape tolerance by revising their antigen receptors

MZ Radic, J Erikson, S Litwin and M Weigert
Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111.

To explore mechanisms that prevent autoreactivity in nonautoimmune mice, endogenous immunoglobulin (Ig) light (L) chains that associate with a transgenic anti-DNA heavy chain were analyzed. The antibodies from splenic B cell hybridomas of such mice did not bind double- stranded DNA (dsDNA) and their L chain sequences showed a biased use of V kappa and J kappa gene segments. The 44 L chains in this survey were coded for by just 18 germline genes. Six of the genes, each belonging to a different V kappa group, were used more than once and accounted for three fourths of all sequences. Based on the distribution of V kappa genes, the L chain repertoire in this line of transgenic mice was estimated at 37 V kappa genes. The most frequently observed gene, a member of the V kappa 12/13 group, was identified in 16 hybrids. In addition, the majority of V kappa genes used J kappa 5. We interpret the skewed representation of V kappa and J kappa gene segments to result from negative selection. Based on the data, we suggest that V kappa rearrangements giving rise to anti-dsDNA reactivity are removed from the repertoire by a corrective mechanism capable of editing self- reactive Ig.
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Bashyam, H. (2007). Receptor editing: How B cells stay tolerant. J. Exp. Med. 204: 1735-1735 [Abstract] [Full Text]
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Samuels, J., Ng, Y.-S., Coupillaud, C., Paget, D., Meffre, E. (2005). Impaired early B cell tolerance in patients with rheumatoid arthritis. J. Exp. Med. 201: 1659-1667 [Abstract] [Full Text]
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McGaha, T. L., Sorrentino, B., Ravetch, J. V. (2005). Restoration of Tolerance in Lupus by Targeted Inhibitory Receptor Expression. Science 307: 590-593 [Abstract] [Full Text]
Zhang, J. Q., Okumura, C., McCarty, T., Shin, M. S., Mukhopadhyay, P., Hori, M., Torrey, T. A., Naghashfar, Z., Zhou, J. X., Lee, C. H., Roopenian, D. C., Morse, H. C. III, Davidson, W. F. (2004). Evidence for Selective Transformation of Autoreactive Immature Plasma Cells in Mice Deficient in Fasl. J. Exp. Med. 200: 1467-1478 [Abstract] [Full Text]
Edry, E., Melamed, D. (2004). Receptor Editing in Positive and Negative Selection of B Lymphopoiesis. J. Immunol. 173: 4265-4271 [Abstract] [Full Text]
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Steeves, M. A., Marion, T. N. (2004). Tolerance to DNA in (NZB x NZW)F1 Mice That Inherit an Anti-DNA VH as a Conventional {micro} H Chain Transgene but Not as a VH Knock-in Transgene. J. Immunol. 172: 6568-6577 [Abstract] [Full Text]
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Quong, M. W., Martensson, A., Langerak, A. W., Rivera, R. R., Nemazee, D., Murre, C. (2004). Receptor Editing and Marginal Zone B Cell Development Are Regulated by the Helix-Loop-Helix Protein, E2A. J. Exp. Med. 199: 1101-1112 [Abstract] [Full Text]
Li, Y., Louzoun, Y., Weigert, M. (2004). Editing Anti-DNA B Cells by V{lambda}x. J. Exp. Med. 199: 337-346 [Abstract] [Full Text]
Paul, E., Lutz, J., Erikson, J., Carroll, M. C. (2004). Germinal center checkpoints in B cell tolerance in 3H9 transgenic mice. Int Immunol 16: 377-384 [Abstract] [Full Text]
Lenze, D, Greiner, A, Knorr, C, Anagnostopoulos, I, Stein, H, Hummel, M (2003). Receptor revision of immunoglobulin heavy chain genes in human MALT lymphomas. Mol. Pathol. 56: 249-255 [Abstract] [Full Text]
Mohiuddin, M. M., Ogawa, H., Yin, D.-P., Galili, U. (2003). Tolerance induction to a mammalian blood group--like carbohydrate antigen by syngeneic lymphocytes expressing the antigen, II: tolerance induction on memory B cells. Blood 102: 229-236 [Abstract] [Full Text]
Phan, T. G., Amesbury, M., Gardam, S., Crosbie, J., Hasbold, J., Hodgkin, P. D., Basten, A., Brink, R. (2003). B Cell Receptor-independent Stimuli Trigger Immunoglobulin (Ig) Class Switch Recombination and Production of IgG Autoantibodies by Anergic Self-Reactive B Cells. J. Exp. Med. 197: 845-860 [Abstract] [Full Text]
Sekiguchi, D. R., Eisenberg, R. A., Weigert, M. (2003). Secondary Heavy Chain Rearrangement: A Mechanism for Generating Anti-double-stranded DNA B Cells. J. Exp. Med. 197: 27-39 [Abstract] [Full Text]
Li, Y., Li, H., Ni, D., Weigert, M. (2002). Anti-DNA B Cells in MRL/lpr Mice Show Altered Differentiation and Editing Pattern. J. Exp. Med. 196: 1543-1552 [Abstract] [Full Text]
Meffre, E., Nussenzweig, M. C. (2002). Deletion of immunoglobulin beta in developing B cells leads to cell death. Proc. Natl. Acad. Sci. USA 99: 11334-11339 [Abstract] [Full Text]
Santori, F. R., Arsov, I., Lili, M., Vukmanovic, S. (2002). Editing Autoreactive TCR Enables Efficient Positive Selection. J. Immunol. 169: 1729-1734 [Abstract] [Full Text]
Heltemes, L. M., Manser, T. (2002). Level of B Cell Antigen Receptor Surface Expression Influences Both Positive and Negative Selection of B Cells During Primary Development. J. Immunol. 169: 1283-1292 [Abstract] [Full Text]
Sekiguchi, D. R., Jainandunsing, S. M., Fields, M. L., Maldonado, M. A., Madaio, M. P., Erikson, J., Weigert, M., Eisenberg, R. A. (2002). Chronic Graft-Versus-Host in Ig Knockin Transgenic Mice Abrogates B Cell Tolerance in Anti-Double-Stranded DNA B Cells. J. Immunol. 168: 4142-4153 [Abstract] [Full Text]
Li, Y., Li, H., Weigert, M. (2002). Autoreactive B Cells in the Marginal Zone that Express Dual Receptors. J. Exp. Med. 195: 181-188 [Abstract] [Full Text]
Borrero, M., Clarke, S. H. (2002). Low-Affinity Anti-Smith Antigen B Cells Are Regulated by Anergy as Opposed to Developmental Arrest or Differentiation to B-1. J. Immunol. 168: 13-21 [Abstract] [Full Text]
Cocca, B. A., Seal, S. N., D'Agnillo, P., Mueller, Y. M., Katsikis, P. D., Rauch, J., Weigert, M., Radic, M. Z. (2001). Structural basis for autoantibody recognition of phosphatidylserine-beta 2 glycoprotein I and apoptotic cells. Proc. Natl. Acad. Sci. USA 98: 13826-13831 [Abstract] [Full Text]
Meffre, E., Chiorazzi, M., Nussenzweig, M. C. (2001). Circulating Human B Cells That Express Surrogate Light Chains Display a Unique Antibody Repertoire. J. Immunol. 167: 2151-2156 [Abstract] [Full Text]
Sandel, P. C., Gendelman, M., Kelsoe, G., Monroe, J. G. (2001). Definition of a Novel Cellular Constituent of the Bone Marrow That Regulates the Response of Immature B Cells to B Cell Antigen Receptor Engagement. J. Immunol. 166: 5935-5944 [Abstract] [Full Text]
Koenig-Marrony, S., Soulas, P., Julien, S., Knapp, A.-M., Garaud, J.-C., Martin, T., Pasquali, J.-L. (2001). Natural Autoreactive B Cells in Transgenic Mice Reproduce an Apparent Paradox to the Clonal Tolerance Theory. J. Immunol. 166: 1463-1470 [Abstract] [Full Text]
Girschick, H. J., Grammer, A. C., Nanki, T., Mayo, M., Lipsky, P. E. (2001). RAG1 and RAG2 Expression by B Cell Subsets from Human Tonsil and Peripheral Blood. J. Immunol. 166: 377-386 [Abstract] [Full Text]
Litzenburger, T., Bluthmann, H., Morales, P., Pham-Dinh, D., Dautigny, A., Wekerle, H., Iglesias, A. (2000). Development of Myelin Oligodendrocyte Glycoprotein Autoreactive Transgenic B Lymphocytes: Receptor Editing In Vivo After Encounter of a Self-Antigen Distinct from Myelin Oligodendrocyte Glycoprotein. J. Immunol. 165: 5360-5366 [Abstract] [Full Text]
Itoh, K., Meffre, E., Albesiano, E., Farber, A., Dines, D., Stein, P., Asnis, S. E., Furie, R. A., Jain, R. I., Chiorazzi, N. (2000). Immunoglobulin Heavy Chain Variable Region Gene Replacement As a Mechanism for Receptor Revision in Rheumatoid Arthritis Synovial Tissue B Lymphocytes. J. Exp. Med. 192: 1151-1164 [Abstract] [Full Text]
Maes, J., Caspi, Y., Rougeon, F., Haimovich, J., Goodhardt, M. (2000). Secondary V(D)J Rearrangements and B Cell Receptor-Mediated Down-Regulation of Recombination Activating Gene-2 Expression in a Murine B Cell Line. J. Immunol. 165: 703-709 [Abstract] [Full Text]
Kenny, J. J., Derby, E. G., Yoder, J. A., Hill, S. A., Fischer, R. T., Tucker, P. W., Claflin, J. L., Longo, D. L. (2000). Positive and negative selection of antigen-specific B cells in transgenic mice expressing variant forms of the VH1 (T15) heavy chain. Int Immunol 12: 873-885 [Abstract] [Full Text]
Nemazee, D., Weigert, M. (2000). Revising B Cell Receptors. J. Exp. Med. 191: 1813-1818 [Abstract] [Full Text]
Wilson, P. C., Wilson, K., Liu, Y.-J., Banchereau, J., Pascual, V., Capra, J. D. (2000). Receptor Revision of Immunoglobulin Heavy Chain Variable Region Genes in Normal Human B Lymphocytes. J. Exp. Med. 191: 1881-1894 [Abstract] [Full Text]
Kenny, J. J., Rezanka, L. J., Lustig, A., Fischer, R. T., Yoder, J., Marshall, S., Longo, D. L. (2000). Autoreactive B Cells Escape Clonal Deletion by Expressing Multiple Antigen Receptors. J. Immunol. 164: 4111-4119 [Abstract] [Full Text]
, , , , , , , , , , , , , , , , , , , (2000). Human Anti-Thyroid Peroxidase Single-Chain Fragment Variable of Ig Isolated from a Combinatorial Library Assembled In-Cell: Insights into the In Vivo. J. Immunol. 164: 4162-4169 [Abstract] [Full Text]
Lantelme, E., Palermo, B., Granziero, L., Mantovani, S., Campanelli, R., Monafo, V., Lanzavecchia, A., Giachino, C. (2000). Cutting Edge: Recombinase-Activating Gene Expression and V(D)J Recombination in CD4+CD3low Mature T Lymphocytes. J. Immunol. 164: 3455-3459 [Abstract] [Full Text]
Morris, S. C., Moroldo, M., Giannini, E. H., Orekhova, T., Finkelman, F. D. (2000). In Vivo Survival of Autoreactive B Cells: Characterization of Long-Lived B Cells. J. Immunol. 164: 3035-3046 [Abstract] [Full Text]
Mandik-Nayak, L., Seo, S.-j., Eaton-Bassiri, A., Allman, D., Hardy, R. R., Erikson, J. (2000). Functional Consequences of the Developmental Arrest and Follicular Exclusion of Anti-Double-Stranded DNA B Cells. J. Immunol. 164: 1161-1168 [Abstract] [Full Text]
Diaw, L., Siwarski, D., Coleman, A., Kim, J., Jones, G. M., Dighiero, G., Huppi, K. (1999). Restricted Immunoglobulin Variable Region (Ig V) Gene Expression Accompanies Secondary Rearrangements of Light Chain Ig V Genes in Mouse Plasmacytomas. J. Exp. Med. 190: 1405-1416 [Abstract] [Full Text]
Brard, F., Shannon, M., Prak, E. L., Litwin, S., Weigert, M. (1999). Somatic Mutation and Light Chain Rearrangement Generate Autoimmunity in Anti�single-stranded DNA Transgenic MRL/lpr Mice. J. Exp. Med. 190: 691-704 [Abstract] [Full Text]
Dorner, T., Farner, N. L., Lipsky, P. E. (1999). Ig {lambda} and Heavy Chain Gene Usage in Early Untreated Systemic Lupus Erythematosus Suggests Intensive B Cell Stimulation. J. Immunol. 163: 1027-1036 [Abstract] [Full Text]
Lopez-Macias, C., Kalinke, U., Cascalho, M., Wabl, M., Hengartner, H., Zinkernagel, R. M., Lamarre, A. (1999). Secondary Rearrangements and Hypermutation Generate Sufficient B Cell Diversity to Mount Protective Antiviral Immunoglobulin Responses. J. Exp. Med. 189: 1791-1798 [Abstract] [Full Text]
Noorchashm, H., Bui, A., Li, H.-L., Eaton, A., Mandik-Nayak, L., Sokol, C., Potts, K. M., Pure, E., Erikson, J. (1999). Characterization of anergic anti-DNA B cells: B cell anergy is a T cell-independent and potentially reversible process. Int Immunol 11: 765-776 [Abstract] [Full Text]
Friedmann, D., Yachimovich, N., Mostoslavsky, G., Pewzner-Jung, Y., Ben-Yehuda, A., Rajewsky, K., Eilat, D. (1999). Production of High Affinity Autoantibodies in Autoimmune New Zealand Black/New Zealand White F1 Mice Targeted with an Anti-DNA Heavy Chain. J. Immunol. 162: 4406-4416 [Abstract] [Full Text]
Cariappa, A., Kim, T. J., Pillai, S. (1999). Accelerated Emigration of B Lymphocytes in the Xid Mouse. J. Immunol. 162: 4417-4423 [Abstract] [Full Text]
Chen, Y., Stollar, B. D. (1999). DNA Binding by the VH Domain of Anti-Z-DNA Antibody and Its Modulation by Association of the VL Domain. J. Immunol. 162: 4663-4670 [Abstract] [Full Text]
King, L. B., Norvell, A., Monroe, J. G. (1999). Antigen Receptor-Induced Signal Transduction Imbalances Associated with the Negative Selection of Immature B Cells. J. Immunol. 162: 2655-2662 [Abstract] [Full Text]
Pewzner-Jung, Y., Friedmann, D., Sonoda, E., Jung, S., Rajewsky, K., Eilat, D. (1998). B Cell Deletion, Anergy, and Receptor Editing in ""Knock In"" Mice Targeted with a Germline-Encoded or Somatically Mutated Anti-DNA Heavy Chain. J. Immunol. 161: 4634-4645 [Abstract] [Full Text]
Retter, M. W., Nemazee, D. (1998). Receptor Editing Occurs Frequently during Normal B Cell Development. J. Exp. Med. 188: 1231-1238 [Abstract] [Full Text]
Xu, H., Li, H., Suri-Payer, E., Hardy, R. R., Weigert, M. (1998). Regulation of Anti-DNA B Cells in Recombination-activating Gene-deficient Mice. J. Exp. Med. 188: 1247-1254 [Abstract] [Full Text]
Meffre, E., Papavasiliou, F., Cohen, P., de Bouteiller, O., Bell, D., Karasuyama, H., Schiff, C., Banchereau, J., Liu, Y.-J., Nussenzweig, M. C. (1998). Antigen Receptor Engagement Turns off the V(D)J Recombination Machinery in Human Tonsil B Cells. J. Exp. Med. 188: 765-772 [Abstract] [Full Text]
Lecerf, J.-M., Chen, Y., Richalet-Secordel, P., Wang, X., Stollar, B. D. (1998). Autoreactivity of Human VH Domains from cDNA Libraries: Analysis with a Bacterial Expression System. J. Immunol. 161: 1274-1283 [Abstract] [Full Text]
Martin, F., Won, W.-J., Kearney, J. F. (1998). Generation of the Germline Peripheral B Cell Repertoire: VH81X-{lambda} B Cells Are Unable to Complete All Developmental Programs. J. Immunol. 160: 3748-3758 [Abstract] [Full Text]
Mandik-Nayak, L., Bui, A., Noorchashm, H., Eaton, A., Erikson, J. (1997). Regulation of Anti-double-stranded DNA B Cells in Nonautoimmune Mice: Localization to the T-B Interface of the Splenic Follicle. J. Exp. Med. 186: 1257-1267 [Abstract] [Full Text]
Melamed, D., Nemazee, D. (1997). Self-antigen does not accelerate immature B cell apoptosis, but stimulates receptor editing as a consequence of developmental�arrest. Proc. Natl. Acad. Sci. USA 94: 9267-9272 [Abstract] [Full Text]
Rassenti, L. Z., Kipps, T. J. (1997). Lack of Allelic Exclusion in B Cell Chronic Lymphocytic Leukemia. J. Exp. Med. 185: 1435-1446 [Abstract] [Full Text]
Stollar, B.D. (1997). An overview of the anti-DNA antibody workshop: expansion of molecular structural analysis. Lupus 6: 346-348
Hikida, M., Mori, M., Takai, T., Tomochika, K.-i., Hamatani, K., Ohmori, H. (1996). Reexpression of RAG-1 and RAG-2 Genes in Activated Mature Mouse B cells. Science 274: 2092-2094 [Abstract] [Full Text]
Kouskoff, V., Lacaud, G., Pape, K., Retter, M., Nemazee, D. (2000). B cell receptor expression level determines the fate of developing B lymphocytes: Receptor editing versus selection. Proc. Natl. Acad. Sci. USA 97: 7435-7439 [Abstract] [Full Text]