Downregulation of the antigen presenting cell function(s) of pulmonary dendritic cells in vivo by resident alveolar macrophages

doi:10.1084/jem.177.2.397

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Downregulation of the antigen presenting cell function(s) of pulmonary dendritic cells in vivo by resident alveolar macrophages

PG Holt, J Oliver, N Bilyk, C McMenamin, PG McMenamin, G Kraal and T Thepen
Western Australian Research Institute for Child Health, Princess Margaret Hospital, Perth.

Class II major histocompatibility complex (Ia)-bearing dendritic cells (DC) from airway epithelium and lung parenchyma express low-moderate antigen presenting cell (APC) activity when freshly isolated. However, this function is markedly upregulated during overnight culture in a manner analogous to epidermal Langerhans cells. The in vitro "maturation" process is inhibited by coculture with pulmonary alveolar macrophages (PAM) across a semipermeable membrane, and the degree of inhibition achieved can be markedly increased by the presence of tumor necrosis factor alpha. In addition, PAM-mediated suppression of DC function is abrogated via inhibition of the nitric oxide synthetase pathway. Functional maturation of the DC is accompanied by increased expression of surface Ia, which is also inhibited in the presence of PAM. Prior elimination of PAM from DC donors via intratracheal administration of the cytotoxic drug dichloromethylene diphosphonate in liposomes, 24-72 h before lung DC preparation, achieves a comparable upregulation of APC activity, suggesting that (consistent with the in vitro data) the resident PAM population actively suppresses the APC function of lung DC in situ. In support of the feasibility of such a regulatory mechanism, electron microscopic examination of normal lung fixed by intravascular perfusion in the inflated state (which optimally preserves PAM in situ), revealed that the majority are preferentially localized in recesses at the alveolar septal junctions. In this position, the PAM are in intimate association with the alveolar epithelial surface, and are effectively separated by as little as 0.2 microns from underlying interstitial spaces which contain the peripheral lung DC population. A similar juxtaposition of airway intraepithelial DC is demonstrated with underlying submucosal tissue macrophages, where the separation between the two cell populations is effectively the width of the basal lamina.
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Forrester, J V, Lumsden, L, Duncan, L, Dick, A D (2005). Choroidal dendritic cells require activation to present antigen and resident choroidal macrophages potentiate this response. Br. J. Ophthalmol. 89: 369-377 [Abstract] [Full Text]
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Shi, H.-Z. (2004). Eosinophils function as antigen-presenting cells. J. Leukoc. Biol. 76: 520-527 [Abstract] [Full Text]
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Iyonaga, K., McCarthy, K. M., Schneeberger, E. E. (2002). Dendritic Cells and the Regulation of a Granulomatous Immune Response in the Lung. Am. J. Respir. Cell Mol. Bio. 26: 671-679 [Abstract] [Full Text]
Gordon, S B, Read, R C (2002). Macrophage defences against respiratory tract infections: The immunology of childhood respiratory infections. Br Med Bull 61: 45-61 [Abstract] [Full Text]
Bozza, S., Gaziano, R., Spreca, A., Bacci, A., Montagnoli, C., di Francesco, P., Romani, L. (2002). Dendritic Cells Transport Conidia and Hyphae of Aspergillus fumigatus from the Airways to the Draining Lymph Nodes and Initiate Disparate Th Responses to the Fungus. J. Immunol. 168: 1362-1371 [Abstract] [Full Text]
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Jahnsen, F L, Moloney, E D, Hogan, T, Upham, J W, Burke, C M, Holt, P G (2001). Rapid dendritic cell recruitment to the bronchial mucosa of patients with atopic asthma in response to local allergen challenge. Thorax 56: 823-826 [Abstract] [Full Text]
MacKenzie, J. R., Mattes, J., Dent, L. A., Foster, P. S. (2001). Eosinophils Promote Allergic Disease of the Lung by Regulating CD4+ Th2 Lymphocyte Function. J. Immunol. 167: 3146-3155 [Abstract] [Full Text]
Roscic-Mrkic, B., Schwendener, R. A., Odermatt, B., Zuniga, A., Pavlovic, J., Billeter, M. A., Cattaneo, R. (2001). Roles of Macrophages in Measles Virus Infection of Genetically Modified Mice. J. Virol. 75: 3343-3351 [Abstract] [Full Text]
Freek van Iwaarden, J., Claassen, E., Jeurissen, S. H. M., Haagsman, H. P., Kraal, G. (2001). Alveolar Macrophages, Surfactant Lipids, and Surfactant Protein B Regulate the Induction of Immune Responses via the Airways. Am. J. Respir. Cell Mol. Bio. 24: 452-458 [Abstract] [Full Text]
Zhang-Hoover, J., Sutton, A., Stein-Streilein, J. (2001). CD40/CD40 Ligand Interactions Are Critical for Elicitation of Autoimmune-Mediated Fibrosis in the Lung. J. Immunol. 166: 3556-3563 [Abstract] [Full Text]
Tang, C., Inman, M. D., van Rooijen, N., Yang, P., Shen, H., Matsumoto, K., O'Byrne, P. M. (2001). Th Type 1-Stimulating Activity of Lung Macrophages Inhibits Th2-Mediated Allergic Airway Inflammation by an IFN-{{gamma}}-Dependent Mechanism. J. Immunol. 166: 1471-1481 [Abstract] [Full Text]
HOLT, P. G. (2000). Antigen Presentation in the Lung. Am. J. Respir. Crit. Care Med. 162: S151-156 [Abstract] [Full Text]
Hu, B., Sonstein, J., Christensen, P. J., Punturieri, A., Curtis, J. L. (2000). Deficient In Vitro and In Vivo Phagocytosis of Apoptotic T Cells by Resident Murine Alveolar Macrophages. J. Immunol. 165: 2124-2133 [Abstract] [Full Text]
GRIGG, J., RIEDLER, J. (2000). Developmental Airway Cell Biology . The ""Normal"" Young Child. Am. J. Respir. Crit. Care Med. 162: S52-55 [Full Text]
Fortsch, D., Rollinghoff, M., Stenger, S. (2000). IL-10 Converts Human Dendritic Cells into Macrophage-Like Cells with Increased Antibacterial Activity Against Virulent Mycobacterium tuberculosis. J. Immunol. 165: 978-987 [Abstract] [Full Text]
TODATE, A., CHIDA, K., SUDA, T., IMOKAWA, S., SATO, J., IDE, K., TSUCHIYA, T., INUI, N., NAKAMURA, Y., ASADA, K., HAYAKAWA, H., NAKAMURA, H. (2000). Increased Numbers of Dendritic Cells in the Bronchiolar Tissues of Diffuse Panbronchiolitis. Am. J. Respir. Crit. Care Med. 162: 148-153 [Abstract] [Full Text]
Lambrecht, B. N., Pauwels, R. A., Fazekas de St. Groth, B. (2000). Induction of Rapid T Cell Activation, Division, and Recirculation by Intratracheal Injection of Dendritic Cells in a TCR Transgenic Model. J. Immunol. 164: 2937-2946 [Abstract] [Full Text]
KRADIN, R. L., SAKAMOTO, H., PREFFER, F. I., DOMBKOWSKI, D., SPRINGER, K. M., LEARY, C. P. (2000). Accumulation of Macrophages with Dendritic Cell Characteristics in the Pulmonary Response to Listeria. Am. J. Respir. Crit. Care Med. 161: 535-542 [Abstract] [Full Text]
GABBAY, E., HAYDN WALTERS, E., ORSIDA, B., WHITFORD, H., WARD, C., KOTSIMBOS, T. C., SNELL, G. I., WILLIAMS, T. J. (1999). In Stable Lung Transplant Recipients, Exhaled Nitric Oxide Levels Positively Correlate with Airway Neutrophilia and Bronchial Epithelial iNOS. Am. J. Respir. Crit. Care Med. 160: 2093-2099 [Abstract] [Full Text]
Cochand, L., Isler, P., Songeon, F., Nicod, L. P. (1999). Human Lung Dendritic Cells Have an Immature Phenotype with Efficient Mannose Receptors. Am. J. Respir. Cell Mol. Bio. 21: 547-554 [Abstract] [Full Text]
Salik, E., Tyorkin, M., Mohan, S., George, I., Becker, K., Oei, E., Kalb, T., Sperber, K. (1999). Antigen Trafficking and Accessory Cell Function in Respiratory Epithelial Cells. Am. J. Respir. Cell Mol. Bio. 21: 365-379 [Abstract] [Full Text]
Feng, C. G., Bean, A. G.�D., Hooi, H., Briscoe, H., Britton, W. J. (1999). Increase in Gamma Interferon-Secreting CD8+, as Well as CD4+, T Cells in Lungs following Aerosol Infection with Mycobacterium tuberculosis. Infect. Immun. 67: 3242-3247 [Abstract] [Full Text]
Haddad, I. Y., Panoskaltsis-Mortari, A., Ingbar, D. H., Yang, S., Milla, C. E., Blazar, B. R. (1999). High Levels of Peroxynitrite Are Generated in the Lungs of Irradiated Mice Given Cyclophosphamide and Allogeneic T Cells . A Potential Mechanism of Injury after Marrow Transplantation. Am. J. Respir. Cell Mol. Bio. 20: 1125-1135 [Abstract] [Full Text]
Lambrecht, B. N., Carro-Muino, I., Vermaelen, K., Pauwels, R. A. (1999). Allergen-Induced Changes in Bone-Marrow Progenitor and Airway Dendritic Cells in Sensitized Rats. Am. J. Respir. Cell Mol. Bio. 20: 1165-1174 [Abstract] [Full Text]
KRADIN, R.�L., LIU, H.-W., van ROOIJEN, N., SPRINGER, K., ZHAO, L.-H., LEARY, C.�P. (1999). Pulmonary Immunity to Listeria Is Enhanced by Elimination of Alveolar Macrophages. Am. J. Respir. Crit. Care Med. 159: 1967-1974 [Abstract] [Full Text]
Suschek, C. V., Krischel, V., Bruch-Gerharz, D., Berendji, D., Krutmann, J., Kroncke, K.-D., Kolb-Bachofen, V. (1999). Nitric Oxide Fully Protects against UVA-induced Apoptosis in Tight Correlation with Bcl-2 Up-regulation. J. Biol. Chem. 274: 6130-6137 [Abstract] [Full Text]
Suda, T., McCarthy, K., Vu, Q., McCormack, J., Schneeberger, E. E. (1998). Dendritic Cell Precursors Are Enriched in the Vascular Compartment of the Lung. Am. J. Respir. Cell Mol. Bio. 19: 728-737 [Abstract] [Full Text]
Karupiah, G., Chen, J.-H., Mahalingam, S., Nathan, C. F., MacMicking, J. D. (1998). Rapid Interferon gamma -dependent Clearance of Influenza A Virus and Protection from Consolidating Pneumonitis in Nitric Oxide Synthase 2-deficient Mice. J. Exp. Med. 188: 1541-1546 [Abstract] [Full Text]
Bocca, A. L., Hayashi, E. E., Pinheiro, A. G., Furlanetto, A. B., Campanelli, A. P., Cunha, F. Q., Figueiredo, F. (1998). Treatment of Paracoccidioides brasiliensis-Infected Mice with a Nitric Oxide Inhibitor Prevents the Failure of Cell-Mediated Immune Response. J. Immunol. 161: 3056-3063 [Abstract] [Full Text]
MacAry, P. A., Holmes, B. J., Kemeny, D. M. (1998). Ovalbumin-Specific, MHC Class I-Restricted, {alpha}{beta}-Positive, Tc1 and Tc0 CD8+ T Cell Clones Mediate the In Vivo Inhibition of Rat IgE. J. Immunol. 160: 580-587 [Abstract] [Full Text]
Lawrence, T. E., Millecchia, L. L., Frazer, D. G., Fedan, J. S. (1997). Pulmonary Dendritic Cell Distribution and Prevalence in Guinea Pig Airways: Effect of Ovalbumin Sensitization and Challenge. J. Pharmacol. Exp. Ther. 282: 995-1004 [Abstract] [Full Text]
Renzi, P. M., Sebastiao, N., Assaad, A. S., Giaid, A., Hamid, Q. (1997). Inducible Nitric Oxide Synthase mRNA and Immunoreactivity in the Lungs of Rats Eight Hours after Antigen Challenge. Am. J. Respir. Cell Mol. Bio. 17: 36-40 [Abstract] [Full Text]
LIU, H.-W., ANAND, A., BLOCH, K., CHRISTIANI, D., KRADIN, R. (1997). Expression of Inducible Nitric Oxide Synthase by Macrophages in Rat Lung. Am. J. Respir. Crit. Care Med. 156: 223-228 [Abstract] [Full Text]
Young, J., Steinman, R. (1996). The hematopoietic development of dendritic cells: a distinct pathway for myeloid differentiation. Stem Cells 14: 376-387 [Abstract]
Lim, T., Chen, G., McDonald, R., Toews, G. (1996). Granulocyte-macrophage colony-stimulating factor overrides the immunosuppressive function of corticosteroids on rat pulmonary dendritic cells. Stem Cells 14: 292-299 [Abstract]
Massard, G., Tongio, M.-M., Wihlm, J.-M., Morand, G. (1996). The Dendritic Cell Lineage: A Ubiquitous Antigen-Presenting Organization. Ann. Thorac. Surg. 61: 252-258 [Abstract] [Full Text]
Paolucci, C., Rovere, P., De Nadai, C., Manfredi, A. A., Clementi, E. (2000). Nitric Oxide Inhibits the Tumor Necrosis Factor alpha -regulated Endocytosis of Human Dendritic Cells in a Cyclic GMP-dependent Way. J. Biol. Chem. 275: 19638-19644 [Abstract] [Full Text]