Functional expression of the costimulatory molecule, B7/BB1, on murine dendritic cell populations

doi:10.1084/jem.176.4.1215

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Functional expression of the costimulatory molecule, B7/BB1, on murine dendritic cell populations

CP Larsen, SC Ritchie, TC Pearson, PS Linsley and RP Lowry
Department of Surgery, Emory University School of Medicine, Atlanta, Georgia 30322.

Whereas dendritic cells (DC) are known to be potent activators of T cells both in vitro and in vivo, the critical costimulatory molecules expressed on DC are not well characterized. Using immunocytochemical and molecular techniques we find that splenic DC express B7/BB1, the counter-receptor for CD28. Moreover, expression of B7/BB1 is upregulated on epidermal Langerhans cells (LC) during their functional maturation into potent T cell stimulators. In blocking experiments, we find that participation of B7/BB1 is required for optimal proliferation of unprimed, allogeneic T cells in DC-driven, primary mixed leukocyte reactions. These data demonstrate that the regulated expression of B7/BB1 on DC may be important in the initiation of a primary T cell response.
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