Tumor necrosis factor alpha directly and indirectly regulates hematopoietic progenitor cell proliferation: role of colony-stimulating factor receptor modulation

doi:10.1084/jem.175.6.1759

This Article

	Full Text (PDF)
	Alert me when this article is cited
	Citation Map

Services

	Email this article
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new content in the JEM
	Download to citation manager

Citing Articles

	Citing Articles via HighWire
	Citing Articles via CrossRef
	Citing Articles via Google Scholar

Google Scholar

	Articles by Jacobsen, S. E.
	Articles by Keller, J. R.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Jacobsen, S. E.
	Articles by Keller, J. R.


Social Bookmarking

	What's this?

ARTICLES

Tumor necrosis factor alpha directly and indirectly regulates hematopoietic progenitor cell proliferation: role of colony-stimulating factor receptor modulation

SE Jacobsen, FW Ruscetti, CM Dubois and JR Keller
Laboratory of Molecular Immunoregulation, National Cancer Institute- Frederick Cancer Research and Development Center, Maryland 21702.

Tumor necrosis factor alpha (TNF-alpha) has been shown to both stimulate and inhibit the proliferation of hematopoietic progenitor cells (HPCs) in vitro, but its mechanisms of action are not known. We demonstrate that the direct effects of TNF-alpha on murine bone marrow progenitors are only inhibitory and mediated at least in part through downmodulation of colony-stimulating factor receptor (CSF-R) expression. The stimulatory effects of TNF-alpha are indirectly mediated through production of hematopoietic growth factors, which subsequently results in increased granulocyte-macrophage CSF and interleukin 3 receptor expression. In addition, the effects of TNF- alpha (stimulatory or inhibitory) are strictly dependent on the particular CSF stimulating growth as well as the concentration of TNF- alpha present in culture. A model is proposed to explain how TNF-alpha might directly and indirectly regulate HPC growth through modulation of CSF-R expression.
Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Add to Reddit Reddit Add to Technorati Technorati What's this?

This article has been cited by other articles:

Rezzoug, F., Huang, Y., Tanner, M. K., Wysoczynski, M., Schanie, C. L., Chilton, P. M., Ratajczak, M. Z., Fugier-Vivier, I. J., Ildstad, S. T. (2008). TNF-{alpha} Is Critical to Facilitate Hemopoietic Stem Cell Engraftment and Function. J. Immunol. 180: 49-57 [Abstract] [Full Text]
Pearl-Yafe, M., Stein, J., Yolcu, E. S., Farkas, D. L., Shirwan, H., Yaniv, I., Askenasy, N. (2007). Fas Transduces Dual Apoptotic and Trophic Signals in Hematopoietic Progenitors. Stem Cells 25: 3194-3203 [Abstract] [Full Text]
Abbasian, J., Mahmud, D., Mahmud, N., Chunduri, S., Araki, H., Reddy, P., Hoffman, R., Arpinati, M., Ferrara, J. L. M., Rondelli, D. (2006). Allogeneic T cells induce rapid CD34+ cell differentiation into CD11c+CD86+ cells with direct and indirect antigen-presenting function. Blood 108: 203-208 [Abstract] [Full Text]
Umland, O., Heine, H., Miehe, M., Marienfeld, K., Staubach, K. H., Ulmer, A. J. (2004). Induction of various immune modulatory molecules in CD34+ hematopoietic cells. J. Leukoc. Biol. 75: 671-679 [Abstract] [Full Text]
Wilhelmsen, K., van der Geer, P. (2004). Phorbol 12-Myristate 13-Acetate-Induced Release of the Colony-Stimulating Factor 1 Receptor Cytoplasmic Domain into the Cytosol Involves Two Separate Cleavage Events. Mol. Cell. Biol. 24: 454-464 [Abstract] [Full Text]
Wang, H.-C., Dragoo, J., Zhou, Q., Klein, J. R. (2003). An intrinsic thyrotropin-mediated pathway of TNF-alpha production by bone marrow cells. Blood 101: 119-123 [Abstract] [Full Text]
Hu, X., Bryington, M., Fisher, A. B., Liang, X., Zhang, X., Cui, D., Datta, I., Zuckerman, K. S. (2002). Ubiquitin/Proteasome-dependent Degradation of D-type Cyclins Is Linked to Tumor Necrosis Factor-induced Cell Cycle Arrest. J. Biol. Chem. 277: 16528-16537 [Abstract] [Full Text]
Rovida, E., Paccagnini, A., Del Rosso, M., Peschon, J., Dello Sbarba, P. (2001). TNF-{{alpha}}-Converting Enzyme Cleaves the Macrophage Colony-Stimulating Factor Receptor in Macrophages Undergoing Activation. J. Immunol. 166: 1583-1589 [Abstract] [Full Text]
Curti, A., Fogli, M., Ratta, M., Tura, S., Lemoli, R. M. (2001). Stem Cell Factor and FLT3-Ligand Are Strictly Required to Sustain the Long-Term Expansion of Primitive CD34+DR- Dendritic Cell Precursors. J. Immunol. 166: 848-854 [Abstract] [Full Text]
Maguer-Satta, V., Oostendorp, R., Reid, D., Eaves, C. J. (2000). Evidence that ceramide mediates the ability of tumor necrosis factor to modulate primitive human hematopoietic cell fates. Blood 96: 4118-4123 [Abstract] [Full Text]
Rebel, V. I., Hartnett, S., Hill, G. R., Lazo-Kallanian, S. B., Ferrara, J. L.M., Sieff, C. A. (1999). Essential Role for the p55 Tumor Necrosis Factor Receptor in Regulating Hematopoiesis at a Stem Cell Level. J. Exp. Med. 190: 1493-1504 [Abstract] [Full Text]
Hu, X., Tang, M., Fisher, A. B., Olashaw, N., Zuckerman, K. S. (1999). TNF-{alpha}-Induced Growth Suppression of CD34+ Myeloid Leukemic Cell Lines Signals Through TNF Receptor Type I and Is Associated with NF-{kappa}B Activation. J. Immunol. 163: 3106-3115 [Abstract] [Full Text]
Lekstrom-Himes, J., Xanthopoulos, K. G. (1999). CCAAT/Enhancer Binding Protein varepsilon �Is Critical for Effective Neutrophil-Mediated Response to Inflammatory Challenge. Blood 93: 3096-3105 [Abstract] [Full Text]
Peled, A., Gonzalo, J. A., Lloyd, C., Gutierrez-Ramos, J.-C. (1998). The Chemotactic Cytokine Eotaxin Acts as a Granulocyte-Macrophage Colony-Stimulating Factor During Lung Inflammation. Blood 91: 1909-1916 [Abstract] [Full Text]
Dybedal, I., Guan, F., Borge, O. J., Veiby, O. P., Ramsfjell, V., Nagata, S., Jacobsen, S. E. W. (1997). Transforming Growth Factor-beta 1 Abrogates Fas-Induced Growth Suppression and Apoptosis of Murine Bone Marrow Progenitor Cells. Blood 90: 3395-3403 [Abstract] [Full Text]
Marino, M. W., Dunn, A., Grail, D., Inglese, M., Noguchi, Y., Richards, E., Jungbluth, A., Wada, H., Moore, M., Williamson, B., Basu, S., Old, L. J. (1997). Characterization of tumor necrosis factor-deficient�mice. Proc. Natl. Acad. Sci. USA 94: 8093-8098 [Abstract] [Full Text]
Young, J., Steinman, R. (1996). The hematopoietic development of dendritic cells: a distinct pathway for myeloid differentiation. Stem Cells 14: 376-387 [Abstract]