Serum angiotensin-1 converting enzyme activity processes a human immunodeficiency virus 1 gp160 peptide for presentation by major histocompatibility complex class I molecules

doi:10.1084/jem.175.6.1417

This Article

	Full Text (PDF)
	Alert me when this article is cited
	Citation Map

Services

	Email this article
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new content in the JEM
	Download to citation manager

Citing Articles

	Citing Articles via HighWire
	Citing Articles via CrossRef
	Citing Articles via Google Scholar

Google Scholar

	Articles by Kozlowski, S.
	Articles by Margulies, D. H.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Kozlowski, S.
	Articles by Margulies, D. H.


Social Bookmarking

	What's this?

ARTICLES

Serum angiotensin-1 converting enzyme activity processes a human immunodeficiency virus 1 gp160 peptide for presentation by major histocompatibility complex class I molecules

S Kozlowski, M Corr, T Takeshita, LF Boyd, CD Pendleton, RN Germain, JA Berzofsky and DH Margulies
Molecular Biology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892.

T cell stimulation by the human immunodeficiency virus 1 gp160-derived peptide p18 presented by H-2Dd class I major histocompatibility complex molecules in a cell-free system was found to require proteolytic cleavage. This extracellular processing was mediated by peptidases present in fetal calf serum. In vitro processing of p18 resulted in a distinct reverse phase high performance liquid chromatography profile, from which a biologically active product was isolated and sequenced. This peptide processing can be specifically blocked by the angiotensin- 1 converting enzyme (ACE) inhibitor captopril, and can occur by exposing p18 to purified ACE. The ability of naturally occurring extracellular proteases to convert inactive peptides to T cell antigens has important implications for understanding cytotoxic T lymphocyte responses in vivo, and for rational peptide vaccine design.
Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Add to Reddit Reddit Add to Technorati Technorati What's this?

This article has been cited by other articles:

Shen, X. Z., Lukacher, A. E., Billet, S., Williams, I. R., Bernstein, K. E. (2008). Expression of Angiotensin-converting Enzyme Changes Major Histocompatibility Complex Class I Peptide Presentation by Modifying C Termini of Peptide Precursors. J. Biol. Chem. 283: 9957-9965 [Abstract] [Full Text]
Samino, Y., Lopez, D., Guil, S., Saveanu, L., van Endert, P. M., Del Val, M. (2006). A Long N-terminal-extended Nested Set of Abundant and Antigenic Major Histocompatibility Complex Class I Natural Ligands from HIV Envelope Protein. J. Biol. Chem. 281: 6358-6365 [Abstract] [Full Text]
Samino, Y., Lopez, D., Guil, S., de Leon, P., Del Val, M. (2004). An Endogenous HIV Envelope-derived Peptide without the Terminal NH3+ Group Anchor Is Physiologically Presented by Major Histocompatibility Complex Class I Molecules. J. Biol. Chem. 279: 1151-1160 [Abstract] [Full Text]
Hill, D. M., Kasliwal, T., Schwarz, E., Hebert, A. M., Chen, T., Gubina, E., Zhang, L., Kozlowski, S. (2003). A Dominant Negative Mutant beta 2-Microglobulin Blocks the Extracellular Folding of a Major Histocompatibility Complex Class I Heavy Chain. J. Biol. Chem. 278: 5630-5638 [Abstract] [Full Text]
Chung, D. H., Belyakov, I. M., Derby, M. A., Wang, J., Boyd, L. F., Berzofsky, J. A., Margulies, D. H. (2001). Competitive Inhibition In Vivo and Skewing of the T Cell Repertoire of Antigen-Specific CTL Priming by an Anti-Peptide-MHC Monoclonal Antibody. J. Immunol. 167: 699-707 [Abstract] [Full Text]
Derby, M. A., Wang, J., Margulies, D. H., Berzofsky, J. A. (2001). Two intermediate-avidity cytotoxic T lymphocyte clones with a disparity between functional avidity and MHC tetramer staining. Int Immunol 13: 817-824 [Abstract] [Full Text]
Geginat, G., Schenk, S., Skoberne, M., Goebel, W., Hof, H. (2001). A Novel Approach of Direct Ex Vivo Epitope Mapping Identifies Dominant and Subdominant CD4 and CD8 T Cell Epitopes from Listeria monocytogenes. J. Immunol. 166: 1877-1884 [Abstract] [Full Text]
Belyakov, I. M., Ahlers, J. D., Clements, J. D., Strober, W., Berzofsky, J. A. (2000). Interplay of Cytokines and Adjuvants in the Regulation of Mucosal and Systemic HIV-Specific CTL. J. Immunol. 165: 6454-6462 [Abstract] [Full Text]
Lopez, D., Gil-Torregrosa, B. C., Bergmann, C., Del Val, M. (2000). Sequential Cleavage by Metallopeptidases and Proteasomes Is Involved in Processing HIV-1 ENV Epitope for Endogenous MHC Class I Antigen Presentation. J. Immunol. 164: 5070-5077 [Abstract] [Full Text]
Su, R.-C., Kung, S. K.-P., Silver, E. T., Lemieux, S., Kane, K. P., Miller, R. G. (1999). Ly-49CB6 NK Inhibitory Receptor Recognizes Peptide-Receptive H-2Kb 1. J. Immunol. 163: 5319-5330 [Abstract] [Full Text]
Ayyoub, M., Mazarguil, H., Monsarrat, B., Van den Eynde, B., Gairin, J. E. (1999). A Structure-based Approach to Designing Non-natural Peptides That Can Activate Anti-melanoma Cytotoxic T Cells. J. Biol. Chem. 274: 10227-10234 [Abstract] [Full Text]
Suh, W.-K., Derby, M. A., Cohen-Doyle, M. F., Schoenhals, G. J., Fruh, K., Berzofsky, J. A., Williams, D. B. (1999). Interaction of Murine MHC Class I Molecules with Tapasin and TAP Enhances Peptide Loading and Involves the Heavy Chain {alpha}3 Domain. J. Immunol. 162: 1530-1540 [Abstract] [Full Text]
Alexander-Miller, M. A., Derby, M. A., Sarin, A., Henkart, P. A., Berzofsky, J. A. (1998). Supraoptimal Peptide-Major Histocompatibility Complex Causes a Decrease in Bcl-2 Levels and Allows Tumor Necrosis Factor alpha �Receptor II-mediated Apoptosis of Cytotoxic T Lymphocytes. J. Exp. Med. 188: 1391-1399 [Abstract] [Full Text]
Belyakov, I. M., Wyatt, L. S., Ahlers, J. D., Earl, P., Pendleton, C. D., Kelsall, B. L., Strober, W., Moss, B., Berzofsky, J. A. (1998). Induction of a Mucosal Cytotoxic T-Lymphocyte Response by Intrarectal Immunization with a Replication-Deficient Recombinant Vaccinia Virus Expressing Human Immunodeficiency Virus 89.6�Envelope Protein. J. Virol. 72: 8264-8272 [Abstract] [Full Text]
Mata, M., Travers, P. J., Liu, Q., Frankel, F. R., Paterson, Y. (1998). The MHC Class I-Restricted Immune Response to HIV-gag in BALB/c Mice Selects a Single Epitope That Does Not Have a Predictable MHC-Binding Motif and Binds to Kd Through Interactions Between a Glutamine at P3 and Pocket D. J. Immunol. 161: 2985-2993 [Abstract] [Full Text]
Correale, P., Walmsley, K., Zaremba, S., Zhu, M., Schlom, J., Tsang, K. Y. (1998). Generation of Human Cytolytic T Lymphocyte Lines Directed Against Prostate-Specific Antigen (PSA) Employing a PSA Oligoepitope Peptide. J. Immunol. 161: 3186-3194 [Abstract] [Full Text]
Su, R.-C., Kung, S. K. P., Gariepy, J., Barber, B. H., Miller, R. G. (1998). NK Cells Can Recognize Different Forms of Class I MHC. J. Immunol. 161: 755-766 [Abstract] [Full Text]
Accapezzato, D., Nisini, R., Paroli, M., Bruno, G., Bonino, F., Houghton, M., Barnaba, V. (1998). Generation of an MHC Class II-Restricted T Cell Epitope by Extracellular Processing of Hepatitis {delta} Antigen. J. Immunol. 160: 5262-5266 [Abstract] [Full Text]
Shields, M. J., Assefi, N., Hodgson, W., Kim, E. J., Ribaudo, R. K. (1998). Characterization of the Interactions Between MHC Class I Subunits: A Systematic Approach for the Engineering of Higher Affinity Variants of {beta}2-Microglobulin. J. Immunol. 160: 2297-2307 [Abstract] [Full Text]
Belyakov, I. M., Derby, M. A., Ahlers, J. D., Kelsall, B. L., Earl, P., Moss, B., Strober, W., Berzofsky, J. A. (1998). Mucosal immunization with HIV-1 peptide vaccine induces mucosal and systemic cytotoxic T lymphocytes and protective immunity in mice against intrarectal recombinant HIV-vaccinia challenge. Proc. Natl. Acad. Sci. USA 95: 1709-1714 [Abstract] [Full Text]
Goletz, T. J., Klimpel, K. R., Arora, N., Leppla, S. H., Keith, J. M., Berzofsky, J. A. (1997). Targeting HIV proteins to the major histocompatibility complex class I processing pathway with a novel gp120-anthrax toxin fusion�protein. Proc. Natl. Acad. Sci. USA 94: 12059-12064 [Abstract] [Full Text]
Ahlers, J. D., Takeshita, T., Pendleton, C. D., Berzofsky, J. A. (1997). Enhanced immunogenicity of HIV-1 vaccine construct by modification of the native peptide�sequence. Proc. Natl. Acad. Sci. USA 94: 10856-10861 [Abstract] [Full Text]
Falkenhahn, M., Franke, F., Bohle, R. M., Zhu, Y.-C., Stauss, H. M., Bachmann, S., Danilov, S., Unger, T. (1995). Cellular Distribution of Angiotensin-Converting Enzyme After Myocardial Infarction. Hypertension 25: 219-226 [Abstract] [Full Text]
Wang, J., Whitman, M. C., Natarajan, K., Tormo, J., Mariuzza, R. A., Margulies, D. H. (2002). Binding of the Natural Killer Cell Inhibitory Receptor Ly49A to Its Major Histocompatibility Complex Class I Ligand. CRUCIAL CONTACTS INCLUDE BOTH H-2Dd AND beta 2-MICROGLOBULIN. J. Biol. Chem. 277: 1433-1442 [Abstract] [Full Text]