Journal of Experimental Medicine, Vol 175, 353-360, Copyright © 1992 by Rockefeller University Press

ARTICLES

CD28 interaction with B7 costimulates primary allogeneic proliferative responses and cytotoxicity mediated by small, resting T lymphocytes

M Azuma, M Cayabyab, D Buck, JH Phillips and LL Lanier
Department of Immunology, DNAX Research Institute for Molecular and Cellular Biology, Palo Alto, California 94304.

Engagement of the CD3/T cell antigen receptor complex on small, resting T cells is insufficient to trigger cell-mediated cytotoxicity or to induce a proliferative response. In the present study, we have used genetic transfection to demonstrate that interaction of the B7-BB1 B cell activation antigen with the CD28 T cell differentiation antigen costimulates cell-mediated cytotoxicity and proliferation initiated by either anti-CD2 or anti-CD3 monoclonal antibody (mAb). Moreover, a B7- negative Burkitt's lymphoma cell line that fails to stimulate an allogeneic mixed lymphocyte response is rendered a potent stimulator after transfection with B7. The mixed leukocyte reaction proliferative response against the B7 transfectant is inhibited by either anti-CD28 or B7 mAb. We also demonstrate that freshly isolated small, resting human T cells can mediate anti-CD3 or anti-CD2 mAb-redirected cytotoxicity against a murine Fc receptor-bearing mastocytoma transfected with human B7. These preexisting cytotoxic T lymphocytes in peripheral blood are present in both the CD4 and CD8 subsets, but are preferentially within the CD45RO+ "memory" population. While small, resting T cells apparently require costimulation by CD28/B7 interactions, this requirement is lost after T cell activation. Anti- CD3 initiates a cytotoxic response mediated by in vitro cultured T cell clones in the absence of B7 ligand. The existence of functional cytolytic T cells in the small, resting T cell population may be advantageous in facilitating rapid responses to immune challenge.
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• Saito, K., Sakurai, J., Ohata, J., Kohsaka, T., Hashimoto, H., Okumura, K., Abe, R., Azuma, M. (1998). Involvement of CD40 Ligand-CD40 and CTLA4-B7 Pathways in Murine Acute Graft-Versus-Host Disease Induced by Allogeneic T Cells Lacking CD28. J. Immunol. 160: 4225-4231 [Abstract] [Full Text]  
• Peng, X., Remacle, J. E., Kasran, A., Huylebroeck, D., Ceuppens, J. L. (1998). IL-12 Up-Regulates CD40 Ligand (CD154) Expression on Human T Cells. J. Immunol. 160: 1166-1172 [Abstract] [Full Text]  
• Dorfman, D. M., Schultze, J. L., Shahsafaei, A., Michalak, S., Gribben, J. G., Freeman, G. J., Pinkus, G. S., Nadler, L. M. (1997). In Vivo Expression of B7-1 and B7-2 By Follicular Lymphoma Cells Can Prevent Induction of T-Cell Anergy But Is Insufficient to Induce Significant T-Cell Proliferation. Blood 90: 4297-4306 [Abstract] [Full Text]  
• Carbone, E., Ruggiero, G., Terrazzano, G., Palomba, C., Manzo, C., Fontana, S., Spits, H., Karre, K., Zappacosta, S. (1997). A New Mechanism of NK Cell Cytotoxicity Activation: The CD40-CD40 Ligand Interaction. J. Exp. Med. 185: 2053-2060 [Abstract] [Full Text]  
• Boyer, M. W., Vallera, D. A., Taylor, P. A., Gray, G. S., Katsanis, E., Gorden, K., Orchard, P. J., Blazar, B. R. (1997). The Role of B7 Costimulation by Murine Acute Myeloid Leukemia in the Generation and Function of a CD8+ T-Cell Line With Potent In Vivo Graft-Versus-Leukemia Properties. Blood 89: 3477-3485 [Abstract] [Full Text]  
• Prang, N. S., Hornef, M. W., Jager, M., Wagner, H. J., Wolf, H., Schwarzmann, F. M. (1997). Lytic Replication of Epstein-Barr Virus in the Peripheral Blood: Analysis of Viral Gene Expression in B Lymphocytes During Infectious Mononucleosis and in the Normal Carrier State. Blood 89: 1665-1677 [Abstract] [Full Text]  
• Cai, Z., Brunmark, A., Jackson, M. R., Loh, D., Peterson, P. A., Sprent, J. (1996). Transfected Drosophila cells as a probe for defining the minimal requirements for stimulating unprimed CD8+ T cells. Proc. Natl. Acad. Sci. USA 93: 14736-14741 [Abstract] [Full Text]  
• Reiser, H., Stadecker, M. J. (1996). Costimulatory B7 Molecules in the Pathogenesis of Infectious and Autoimmune Diseases. NEJM 335: 1369-1377 [Full Text]  
• Nitta, T., Imai, H., Okamoto, A., Matsuura, M., Nakano, M. (1996). In vivo priming of mice with antigen and lipid A bestows proliferative ability on peritoneal exudate T cells in response to antigen or anti-{alpha} TCR antibody in the absence of macrophages in vitro. Innate Immunity 3: 103-110 [Abstract]  
• Bounou, S., Dumais, N., Tremblay, M. J. (2001). Attachment of Human Immunodeficiency Virus-1 (HIV-1) Particles Bearing Host-encoded B7-2 Proteins Leads to Nuclear Factor-kappa B- and Nuclear Factor of Activated T Cells-dependent Activation of HIV-1 Long Terminal Repeat Transcription. J. Biol. Chem. 276: 6359-6369 [Abstract] [Full Text]  

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