The cutaneous lymphocyte antigen is a skin lymphocyte homing receptor for the vascular lectin endothelial cell-leukocyte adhesion molecule 1

doi:10.1084/jem.174.6.1461

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The cutaneous lymphocyte antigen is a skin lymphocyte homing receptor for the vascular lectin endothelial cell-leukocyte adhesion molecule 1

EL Berg, T Yoshino, LS Rott, MK Robinson, RA Warnock, TK Kishimoto, LJ Picker and EC Butcher
Department of Pathology, Stanford University, California 94305.

A skin-associated population of memory T lymphocytes, defined by expression of the cutaneous lymphocyte antigen (CLA), binds selectively and avidly to the vascular lectin endothelial cell-leukocyte adhesion molecule 1 (ELAM-1), an interaction that may be involved in targeting of CLA+ T cells to cutaneous sites of chronic inflammation. Here we present evidence that CLA itself is the (or a) lymphocyte homing receptor for ELAM-1. Antigen isolated with anti-CLA monoclonal antibody HECA-452 from human tonsillar lysates avidly binds ELAM-1 transfected mouse cells. Anti-CLA antibody blocks T lymphocyte binding to ELAM-1 transfectants. HECA-452 and ELAM-1 binding to lymphocytes or to isolated tonsillar HECA-452 antigen is abrogated by neuraminidase treatment implying a prominent role for sialic acid in CLA structure and function. The dominant form of CLA on T cells is immunologically distinct from the major neutrophil ELAM-1 ligand, the sialyl Lewis x (sLex) antigen (NeuAc alpha 2-3Gal beta 1-4[Fuc alpha 1-3]GlcNAc), which is absent, weakly expressed, or masked on T cells. However, neuraminidase treatment of CLA+ T cells, but not of CLA- T cells, reveals Lewis x (CD15) structures. In combination with the known requirement for terminal NeuAc alpha 2-3Gal and fucose residues attached to N-acetylglucosamine for ELAM-1 and HECA-452 binding, this finding suggests that CLA may comprise an additionally sialylated or otherwise modified form of sLex. The identification of a lymphocyte homing receptor for skin may permit novel approaches to the diagnosis and therapy of cutaneous and inflammatory disorders.
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Takahashi, R., Mizukawa, Y., Yamazaki, Y., Hayakawa, K., Hayakawa, J., Kudo, A., Shiohara, T. (2003). In Vitro Differentiation from Naive to Mature E-Selectin Binding CD4 T Cells: Acquisition of Skin-Homing Properties Occurs Independently of Cutaneous Lymphocyte Antigen Expression. J. Immunol. 171: 5769-5777 [Abstract] [Full Text]
Cai, S., Davis, A. E. III (2003). Complement Regulatory Protein C1 Inhibitor Binds to Selectins and Interferes with Endothelial-Leukocyte Adhesion. J. Immunol. 171: 4786-4791 [Abstract] [Full Text]
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Soler, D., Humphreys, T. L., Spinola, S. M., Campbell, J. J. (2003). CCR4 versus CCR10 in human cutaneous TH lymphocyte trafficking. Blood 101: 1677-1682 [Abstract] [Full Text]
Dimitroff, C. J., Bernacki, R. J., Sackstein, R. (2003). Glycosylation-dependent inhibition of cutaneous lymphocyte-associated antigen expression: implications in modulating lymphocyte migration to skin. Blood 101: 602-610 [Abstract] [Full Text]
Kobzdej, M. M. A., Leppanen, A., Ramachandran, V., Cummings, R. D., McEver, R. P. (2002). Discordant expression of selectin ligands and sialyl Lewis x-related epitopes on murine myeloid cells. Blood 100: 4485-4494 [Abstract] [Full Text]
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Hirata, T., Furie, B. C., Furie, B. (2002). P-, E-, and L-Selectin Mediate Migration of Activated CD8+ T Lymphocytes into Inflamed Skin. J. Immunol. 169: 4307-4313 [Abstract] [Full Text]
Ku, C.-C., Padilla, J. A., Grose, C., Butcher, E. C., Arvin, A. M. (2002). Tropism of Varicella-Zoster Virus for Human Tonsillar CD4+ T Lymphocytes That Express Activation, Memory, and Skin Homing Markers. J. Virol. 76: 11425-11433 [Abstract] [Full Text]
Lundin, B. S., Johansson, C., Svennerholm, A.-M. (2002). Oral Immunization with a Salmonella enterica Serovar Typhi Vaccine Induces Specific Circulating Mucosa-Homing CD4+ and CD8+ T Cells in Humans. Infect. Immun. 70: 5622-5627 [Abstract] [Full Text]
Maki, W., Morales, R. E., Carroll, V. A., Telford, W. G., Knibbs, R. N., Stoolman, L. M., Hwang, S. T. (2002). CCR6 Colocalizes with CD18 and Enhances Adhesion to Activated Endothelial Cells in CCR6-Transduced Jurkat T Cells. J. Immunol. 169: 2346-2353 [Abstract] [Full Text]
Jutila, M. A., Kurk, S., Jackiw, L., Knibbs, R. N., Stoolman, L. M. (2002). L-Selectin Serves as an E-Selectin Ligand on Cultured Human T Lymphoblasts. J. Immunol. 169: 1768-1773 [Abstract] [Full Text]
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Kulidjian, A. A., Issekutz, A. C., Issekutz, T. B. (2002). Differential role of E-selectin and P-selectin in T lymphocyte migration to cutaneous inflammatory reactions induced by cytokines. Int Immunol 14: 751-760 [Abstract] [Full Text]
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Kunkel, E. J., Boisvert, J., Murphy, K., Vierra, M. A., Genovese, M. C., Wardlaw, A. J., Greenberg, H. B., Hodge, M. R., Wu, L., Butcher, E. C., Campbell, J. J. (2002). Expression of the Chemokine Receptors CCR4, CCR5, and CXCR3 by Human Tissue-Infiltrating Lymphocytes. Am. J. Pathol. 160: 347-355 [Abstract] [Full Text]
Dimitroff, C. J., Lee, J. Y., Rafii, S., Fuhlbrigge, R. C., Sackstein, R. (2001). CD44 Is a Major E-Selectin Ligand on Human Hematopoietic Progenitor Cells. J. Cell Biol. 153: 1277-1286 [Abstract] [Full Text]
Jones, N. D., Turvey, S. E., Van Maurik, A., Hara, M., Kingsley, C. I., Smith, C. H., Mellor, A. L., Morris, P. J., Wood, K. J. (2001). Differential Susceptibility of Heart, Skin, and Islet Allografts to T Cell-Mediated Rejection. J. Immunol. 166: 2824-2830 [Abstract] [Full Text]
Andrew, D. P., Ruffing, N., Kim, C. H., Miao, W., Heath, H., Li, Y., Murphy, K., Campbell, J. J., Butcher, E. C., Wu, L. (2001). C-C Chemokine Receptor 4 Expression Defines a Major Subset of Circulating Nonintestinal Memory T Cells of Both Th1 and Th2 Potential. J. Immunol. 166: 103-111 [Abstract] [Full Text]
Rott, L. S., Briskin, M. J., Butcher, E. C. (2000). Expression of {alpha}4{beta}7 and E-selectin ligand by circulating memory B cells: implications for targeted trafficking to mucosal and systemic sites. J. Leukoc. Biol. 68: 807-814 [Abstract] [Full Text]
Fortney, K. R., Young, R. S., Bauer, M. E., Katz, B. P., Hood, A. F., Munson, R. S. Jr., Spinola, S. M. (2000). Expression of Peptidoglycan-Associated Lipoprotein Is Required for Virulence in the Human Model of Haemophilus ducreyi Infection. Infect. Immun. 68: 6441-6448 [Abstract] [Full Text]
Hamann, A., Syrbe, U. (2000). T-cell trafficking into sites of inflammation. Rheumatology (Oxford) 39: 696-699 [Full Text]
Cauli, A., Pitzalis, C., Yanni, G., Awad, M., Panayi, G. S. (2000). CD1 expression in psoriatic and rheumatoid arthritis. Rheumatology (Oxford) 39: 666-673 [Abstract] [Full Text]
Engeman, T. M., Gorbachev, A. V., Gladue, R. P., Heeger, P. S., Fairchild, R. L. (2000). Inhibition of Functional T Cell Priming and Contact Hypersensitivity Responses by Treatment with Anti-Secondary Lymphoid Chemokine Antibody During Hapten Sensitization. J. Immunol. 164: 5207-5214 [Abstract] [Full Text]
Drillenburg, P., Pals, S. T. (2000). Cell adhesion receptors in lymphoma dissemination. Blood 95: 1900-1910 [Abstract] [Full Text]
Morales, J., Homey, B., Vicari, A. P., Hudak, S., Oldham, E., Hedrick, J., Orozco, R., Copeland, N. G., Jenkins, N. A., McEvoy, L. M., Zlotnik, A. (1999). CTACK, a skin-associated chemokine that preferentially attracts skin-homing memory T cells. Proc. Natl. Acad. Sci. USA 96: 14470-14475 [Abstract] [Full Text]
Tu, L., Murphy, P. G., Li, X., Tedder, T. F. (1999). L-Selectin Ligands Expressed by Human Leukocytes Are HECA-452 Antibody-Defined Carbohydrate Epitopes Preferentially Displayed by P-Selectin Glycoprotein Ligand-1. J. Immunol. 163: 5070-5078 [Abstract] [Full Text]
Chu, A., Hong, K., Berg, E. L., Ehrhardt, R. O. (1999). Tissue Specificity of E- and P-Selectin Ligands in Th1-Mediated Chronic Inflammation. J. Immunol. 163: 5086-5093 [Abstract] [Full Text]
Toppila, S., Paavonen, T., Nieminen, M. S., Hayry, P., Renkonen, R. (1999). Endothelial L-Selectin Ligands Are Likely to Recruit Lymphocytes into Rejecting Human Heart Transplants. Am. J. Pathol. 155: 1303-1310 [Abstract] [Full Text]
Langley, R. R., Russell, J., Eppihimer, M. J., Alexander, S. J., Gerritsen, M., Specian, R. D., Granger, D. N. (1999). Quantification of murine endothelial cell adhesion molecules in solid tumors. Am. J. Physiol. Heart Circ. Physiol. 277: H1156-H1166 [Abstract] [Full Text]
Ito, T., Inaba, M., Inaba, K., Toki, J., Sogo, S., Iguchi, T., Adachi, Y., Yamaguchi, K., Amakawa, R., Valladeau, J., Saeland, S., Fukuhara, S., Ikehara, S. (1999). A CD1a+/CD11c+ Subset of Human Blood Dendritic Cells Is a Direct Precursor of Langerhans Cells. J. Immunol. 163: 1409-1419 [Abstract] [Full Text]
Shieh, C.-C., Sadasivan, B. K., Russell, G. J., Schon, M. P., Parker, C. M., Brenner, M. B. (1999). Lymphocyte Adhesion to Epithelia and Endothelia Mediated by the Lymphocyte Endothelial-Epithelial Cell Adhesion Molecule Glycoprotein. J. Immunol. 163: 1592-1601 [Abstract] [Full Text]
Akdis, M., Simon, H.-U., Weigl, L., Kreyden, O., Blaser, K., Akdis, C. A. (1999). Skin Homing (Cutaneous Lymphocyte-Associated Antigen-Positive) CD8+ T Cells Respond to Superantigen and Contribute to Eosinophilia and IgE Production in Atopic Dermatitis. J. Immunol. 163: 466-475 [Abstract] [Full Text]
Hong, K., Chu, A., Ludviksson, B. R., Berg, E. L., Ehrhardt, R. O. (1999). IL-12, Independently of IFN-{gamma}, Plays a Crucial Role in the Pathogenesis of a Murine Psoriasis-Like Skin Disorder. J. Immunol. 162: 7480-7491 [Abstract] [Full Text]
Kantele, A., Zivny, J., Hakkinen, M., Elson, C. O., Mestecky, J. (1999). Differential Homing Commitments of Antigen-Specific T Cells After Oral or Parenteral Immunization in Humans. J. Immunol. 162: 5173-5177 [Abstract] [Full Text]
Robert, C., Fuhlbrigge, R. C., Kieffer, J. D., Ayehunie, S., Hynes, R. O., Cheng, G., Grabbe, S., von Andrian, U. H., Kupper, T. S. (1999). Interaction of Dendritic Cells with Skin Endothelium: A New Perspective on Immunosurveillance. J. Exp. Med. 189: 627-636 [Abstract] [Full Text]
Mukasa, R., Homma, T., Ohtsuki, T., Hosono, O., Souta, A., Kitamura, T., Fukuda, M., Watanabe, S., Morimoto, C. (1999). Core 2-containing O-glycans on CD43 are preferentially expressed in the memory subset of human CD4 T cells. Int Immunol 11: 259-268 [Abstract] [Full Text]
Tu, L., Delahunty, M. D., Ding, H., Luscinskas, F. W., Tedder, T. F. (1999). The Cutaneous Lymphocyte Antigen Is an Essential Component of the L-selectin Ligand Induced on Human Vascular Endothelial Cells. J. Exp. Med. 189: 241-252 [Abstract] [Full Text]
Liao, F., Rabin, R. L., Smith, C. S., Sharma, G., Nutman, T. B., Farber, J. M. (1999). CC-Chemokine Receptor 6 Is Expressed on Diverse Memory Subsets of T Cells and Determines Responsiveness to Macrophage Inflammatory Protein 3{alpha}. J. Immunol. 162: 186-194 [Abstract] [Full Text]
Kantele, A., Hakkinen, M., Moldoveanu, Z., Lu, A., Savilahti, E., Alvarez, R. D., Michalek, S., Mestecky, J. (1998). Differences in Immune Responses Induced by Oral and Rectal Immunizations with Salmonella typhi Ty21a: Evidence for Compartmentalization within the Common Mucosal Immune System in Humans. Infect. Immun. 66: 5630-5635 [Abstract] [Full Text]
Knibbs, R. N., Craig, R. A., Maly, P., Smith, P. L., Wolber, F. M., Faulkner, N. E., Lowe, J. B., Stoolman, L. M. (1998). {alpha}(1,3)-Fucosyltransferase VII-Dependent Synthesis of P- and E-Selectin Ligands on Cultured T Lymphoblasts. J. Immunol. 161: 6305-6315 [Abstract] [Full Text]
Tietz, W., Allemand, Y., Borges, E., von Laer, D., Hallmann, R., Vestweber, D., Hamann, A. (1998). CD4+ T Cells Migrate into Inflamed Skin Only If They Express Ligands for E- and P-Selectin. J. Immunol. 161: 963-970 [Abstract] [Full Text]
Wagers, A. J., Stoolman, L. M., Craig, R., Knibbs, R. N., Kansas, G. S. (1998). An sLex-Deficient Variant of HL60 Cells Exhibits High Levels of Adhesion to Vascular Selectins: Further Evidence That HECA-452 and CSLEX1 Monoclonal Antibody Epitopes Are Not Essential for High Avidity Binding to Vascular Selectins. J. Immunol. 160: 5122-5129 [Abstract] [Full Text]
Sallusto, F., Lenig, D., Mackay, C. R., Lanzavecchia, A. (1998). Flexible Programs of Chemokine Receptor Expression on Human Polarized T Helper 1�and 2�Lymphocytes. J. Exp. Med. 187: 875-883 [Abstract] [Full Text]
Clark, R. A., Fuhlbrigge, R. C., Springer, T. A. (1998). L-Selectin Ligands That Are O-glycoprotease Resistant and Distinct from MECA-79 Antigen are Sufficient for Tethering and Rolling of Lymphocytes on Human High Endothelial Venules. J. Cell Biol. 140: 721-731 [Abstract] [Full Text]
Norman, K. E., Anderson, G. P., Kolb, H. C., Ley, K., Ernst, B. (1998). Sialyl Lewisx (sLex) and an sLex Mimetic, CGP69669A, Disrupt E-Selectin-Dependent Leukocyte Rolling In Vivo. Blood 91: 475-483 [Abstract] [Full Text]
Jutila, M. A., Wilson, E., Kurk, S. (1997). Characterization of an Adhesion Molecule that Mediates Leukocyte Rolling on 24�h Cytokine- or Lipopolysaccharide-stimulated Bovine Endothelial Cells under Flow Conditions. J. Exp. Med. 186: 1701-1711 [Abstract] [Full Text]
Borges, E., Pendl, G., Eytner, R., Steegmaier, M., Zollner, O., Vestweber, D. (1997). The Binding of T Cell-expressed P-selectin Glycoprotein Ligand-1 to E- and P-selectin Is Differentially Regulated. J. Biol. Chem. 272: 28786-28792 [Abstract] [Full Text]
Zollner, O., Vestweber, D. (1996). The E-selectin Ligand-1 Is Selectively Activated in Chinese Hamster Ovary Cells by the alpha (1,3)-Fucosyltransferases IV and VII. J. Biol. Chem. 271: 33002-33008 [Abstract] [Full Text]
Vachino, G., Chang, X.-J., Veldman, G. M., Kumar, R., Sako, D., Fouser, L. A., Berndt, M. C., Cumming, D. A. (1995). P-selectin Glycoprotein Ligand-1 Is the Major Counter-receptor for P-selectin on Stimulated T Cells and Is Widely Distributed in Non-functional Form on Many Lymphocytic Cells. J. Biol. Chem. 270: 21966-21974 [Abstract] [Full Text]
Martens, C. L., Cwirla, S. E., Lee, R. Y.-W., Whitehorn, E., Chen, E. Y.-F., Bakker, A., Martin, E. L., Wagstrom, C., Gopalan, P., Smith, C. W., Tate, E., Koller, K. J., Schatz, P. J., Dower, W. J., Barrett, R. W. (1995). Peptides Which Bind to E-selectin and Block Neutrophil Adhesion. J. Biol. Chem. 270: 21129-21136 [Abstract] [Full Text]
Lasky, L. (1992). Selectins: interpreters of cell-specific carbohydrate information during inflammation. Science 258: 964-969 [Abstract]