Adhesion of human basophils, eosinophils, and neutrophils to interleukin 1-activated human vascular endothelial cells: contributions of endothelial cell adhesion molecules

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Adhesion of human basophils, eosinophils, and neutrophils to interleukin 1-activated human vascular endothelial cells: contributions of endothelial cell adhesion molecules

BS Bochner, FW Luscinskas, MA Gimbrone Jr, W Newman, SA Sterbinsky, CP Derse- Anthony, D Klunk and RP Schleimer
Division of Clinical Immunology, Johns Hopkins Asthma and Allergy Center, Baltimore, Maryland 21224.

Cytokines such as interleukin 1 (IL-1) promote adhesiveness in human umbilical vein endothelial cells for leukocytes including basophils, eosinophils, and neutrophils, and induce expression of adherence molecules including ICAM-1 (intercellular adhesion molecule-1), ELAM-1 (endothelial-leukocyte adhesion molecule-1), and VCAM-1 (vascular cell adhesion molecule-1). In the present study, blocking monoclonal antibodies (mAb) recognizing ICAM-1, ELAM-1, and VCAM-1 have been used to compare their roles in IL-1-induced adhesion of human basophils, eosinophils, and neutrophils. IL-1 treatment of endothelial cell monolayers for 4 hours induced a four- to eight-fold increase in adhesion for each cell type. Treatment of endothelial cells with either anti-ICAM-1 or anti-ELAM-1 mAb inhibited IL-1-induced adherence of each cell type. In contrast, treatment with anti-VCAM-1 mAb inhibited basophil and eosinophil (but not neutrophil) adhesion, and was especially effective in blocking eosinophil adhesion. The effects of these mAb were at least additive. Indirect immunofluorescence and flow cytometry demonstrated expression of VLA-4 alpha (very late activation antigen-4 alpha, a counter-receptor for VCAM-1) on eosinophils and basophils but not on neutrophils. These data document distinct roles for ICAM-1, ELAM-1, and VCAM-1 during basophil, eosinophil, and neutrophil adhesion in vitro, and suggest a novel mechanism for the recruitment of eosinophils and basophils to sites of inflammation in vivo.
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Iikura, M., Ebisawa, M., Yamaguchi, M., Tachimoto, H., Ohta, K., Yamamoto, K., Hirai, K. (2004). Transendothelial Migration of Human Basophils. J. Immunol. 173: 5189-5195 [Abstract] [Full Text]
Chi, H., Messas, E., Levine, R. A., Graves, D. T., Amar, S. (2004). Interleukin-1 Receptor Signaling Mediates Atherosclerosis Associated With Bacterial Exposure and/or a High-Fat Diet in a Murine Apolipoprotein E Heterozygote Model: Pharmacotherapeutic Implications. Circulation 110: 1678-1685 [Abstract] [Full Text]
Zwijnenburg, P. J. G., van der Poll, T., Florquin, S., Roord, J. J., van Furth, A. M. (2003). IL-1 Receptor Type 1 Gene-Deficient Mice Demonstrate an Impaired Host Defense Against Pneumococcal Meningitis. J. Immunol. 170: 4724-4730 [Abstract] [Full Text]
Lim, Y.-C., Garcia-Cardena, G., Allport, J. R., Zervoglos, M., Connolly, A. J., Gimbrone, M. A. Jr., Luscinskas, F. W. (2003). Heterogeneity of Endothelial Cells from Different Organ Sites in T-Cell Subset Recruitment. Am. J. Pathol. 162: 1591-1601 [Abstract] [Full Text]
Von der Thusen, J. H., Kuiper, J., Van Berkel, T. J. C., Biessen, E. A. L. (2003). Interleukins in Atherosclerosis: Molecular Pathways and Therapeutic Potential. Pharmacol. Rev. 55: 133-166 [Abstract] [Full Text]
Wyman, T. H., Bjornsen, A. J., Elzi, D. J., Smith, C. W., England, K. M., Kelher, M., Silliman, C. C. (2002). A two-insult in vitro model of PMN-mediated pulmonary endothelial damage: requirements for adherence and chemokine release. Am. J. Physiol. Cell Physiol. 283: C1592-C1603 [Abstract] [Full Text]
Lukacs, N. W., John, A., Berlin, A., Bullard, D. C., Knibbs, R., Stoolman, L. M. (2002). E- and P-Selectins Are Essential for the Development of Cockroach Allergen-Induced Airway Responses. J. Immunol. 169: 2120-2125 [Abstract] [Full Text]
Kanwar, S., Smith, C. W., Shardonofsky, F. R., Burns, A. R. (2001). The Role of Mac-1 (CD11b/CD18) in Antigen-Induced Airway Eosinophilia in Mice. Am. J. Respir. Cell Mol. Bio. 25: 170-177 [Abstract] [Full Text]
Pereira, S., Zhou, M., Mocsai, A., Lowell, C. (2001). Resting Murine Neutrophils Express Functional {{alpha}}4 Integrins that Signal Through Src Family Kinases. J. Immunol. 166: 4115-4123 [Abstract] [Full Text]
Broide, D. H., Stachnick, G., Castaneda, D., Nayar, J., Sriramarao, P. (2001). Inhibition of Eosinophilic Inflammation in Allergen-Challenged TNF Receptor p55/p75- and TNF Receptor p55-Deficient Mice. Am. J. Respir. Cell Mol. Bio. 24: 304-311 [Abstract] [Full Text]
Wang, S., Fan, Y., Han, X., Yang, J., Bilenki, L., Yang, X. (2001). IL-12-Dependent Vascular Cell Adhesion Molecule-1 Expression Contributes to Airway Eosinophilic Inflammation in a Mouse Model of Asthma-Like Reaction. J. Immunol. 166: 2741-2749 [Abstract] [Full Text]
Yang, P.-C., Berin, M. C., Yu, L., Perdue, M. H. (2001). Mucosal Pathophysiology and Inflammatory Changes in the Late Phase of the Intestinal Allergic Reaction in the Rat. Am. J. Pathol. 158: 681-690 [Abstract] [Full Text]
Gerli, R., Gresele, P., Bistoni, O., Paolucci, C., Lanfrancone, L., Fiorucci, S., Muscat, C., Costantini, V. (2001). Salicylates Inhibit T Cell Adhesion on Endothelium Under Nonstatic Conditions: Induction of L-Selectin Shedding by a Tyrosine Kinase-Dependent Mechanism. J. Immunol. 166: 832-840 [Abstract] [Full Text]
Gronert, K., Martinsson-Niskanen, T., Ravasi, S., Chiang, N., Serhan, C. N. (2001). Selectivity of Recombinant Human Leukotriene D4, Leukotriene B4, and Lipoxin A4 Receptors with Aspirin-Triggered 15-epi-LXA4 and Regulation of Vascular and Inflammatory Responses. Am. J. Pathol. 158: 3-9 [Abstract] [Full Text]
Falcone, F. H., Haas, H., Gibbs, B. F. (2000). The human basophil: a new appreciation of its role in immune responses. Blood 96: 4028-4038 [Full Text]
Werr, J., Eriksson, E. E., Hedqvist, P., Lindbom, L. (2000). Engagement of {beta}2 integrins induces surface expression of {beta}1 integrin receptors in human neutrophils. J. Leukoc. Biol. 68: 553-560 [Abstract] [Full Text]
Yamamoto, H., Sedgwick, J. B., Vrtis, R. F., Busse, W. W. (2000). The Effect of Transendothelial Migration on Eosinophil Function. Am. J. Respir. Cell Mol. Bio. 23: 379-388 [Abstract] [Full Text]
Madan, B., Batra, S., Ghosh, B. (2000). 2'-Hydroxychalcone Inhibits Nuclear Factor-kappa B and Blocks Tumor Necrosis Factor-alpha - and Lipopolysaccharide-Induced Adhesion of Neutrophils to Human Umbilical Vein Endothelial Cells. Mol. Pharmacol. 58: 526-534 [Abstract] [Full Text]
Tachimoto, H., Burdick, M. M., Hudson, S. A., Kikuchi, M., Konstantopoulos, K., Bochner, B. S. (2000). CCR3-Active Chemokines Promote Rapid Detachment of Eosinophils from VCAM-1 In Vitro. J. Immunol. 165: 2748-2754 [Abstract] [Full Text]
Kirveskari, J., Bono, P., Granfors, K., Leirisalo-Repo, M., Jalkanen, S., Salmi, M. (2000). Expression of {alpha}4-integrins on human neutrophils. J. Leukoc. Biol. 68: 243-250 [Abstract] [Full Text]
Fahy, O., Hammad, H., Sénéchal, S., Pestel, J., Tonnel, A.-B., Wallaert, B., Tsicopoulos, A. (2000). Synergistic Effect of Diesel Organic Extracts and Allergen Der p 1 on the Release of Chemokines by Peripheral Blood Mononuclear Cells from Allergic Subjects . Involvement of the MAP Kinase Pathway. Am. J. Respir. Cell Mol. Bio. 23: 247-254 [Abstract] [Full Text]
ABRAHAM, W. M., GILL, A., AHMED, A., SIELCZAK, M. W., LAUREDO, I. T., BOTINNIKOVA, Y., LIN, K.-C., PEPINSKY, B., LEONE, D. R., LOBB, R. R., ADAMS, S. P. (2000). A Small-Molecule, Tight-binding Inhibitor of the Integrin alpha 4beta 1 Blocks Antigen-induced Airway Responses and Inflammation in Experimental Asthma in Sheep. Am. J. Respir. Crit. Care Med. 162: 603-611 [Abstract] [Full Text]
Riollet, C., Rainard, P., Poutrel, B. (2000). Differential Induction of Complement Fragment C5a and Inflammatory Cytokines during Intramammary Infections with Escherichia coli and Staphylococcus aureus. CVI 7: 161-167 [Abstract] [Full Text]
Lush, C. W., Cepinskas, G., Kvietys, P. R. (2000). LPS tolerance in human endothelial cells: reduced PMN adhesion, E-selectin expression, and NF-kappa B mobilization. Am. J. Physiol. Heart Circ. Physiol. 278: H853-H861 [Abstract] [Full Text]
Mould, A. W., Ramsay, A. J., Matthaei, K. I., Young, I. G., Rothenberg, M. E., Foster, P. S. (2000). The Effect of IL-5 and Eotaxin Expression in the Lung on Eosinophil Trafficking and Degranulation and the Induction of Bronchial Hyperreactivity. J. Immunol. 164: 2142-2150 [Abstract] [Full Text]
Nicklin, M. J.H., Hughes, D. E., Barton, J. L., Ure, J. M., Duff, G. W. (2000). Arterial Inflammation in Mice Lacking the Interleukin 1 Receptor Antagonist Gene. J. Exp. Med. 191: 303-312 [Abstract] [Full Text]
Sriramarao, P., DiScipio, R. G., Cobb, R. R., Cybulsky, M., Stachnick, G., Castaneda, D., Elices, M., Broide, D. H. (2000). VCAM-1 is more effective than MAdCAM-1 in supporting eosinophil rolling under conditions of shear flow. Blood 95: 592-601 [Abstract] [Full Text]
De Caterina, R., Liao, J. K, Libby, P. (2000). Fatty acid modulation of endothelial activation. Am. J. Clin. Nutr. 71: 213S-223S [Abstract] [Full Text]
Broide, D. H., Campbell, K., Gifford, T., Sriramarao, P. (2000). Inhibition of eosinophilic inflammation in allergen-challenged, IL-1 receptor type 1-deficient mice is associated with reduced eosinophil rolling and adhesion on vascular endothelium. Blood 95: 263-269 [Abstract] [Full Text]
MILLS, P. R., DAVIES, R. J., DEVALIA, J. L. (1999). Airway Epithelial Cells, Cytokines, and Pollutants. Am. J. Respir. Crit. Care Med. 160: S38-43 [Abstract] [Full Text]
Jagels, M. A., Daffern, P. J., Zuraw, B. L., Hugli, T. E. (1999). Mechanisms and Regulation of Polymorphonuclear Leukocyte and Eosinophil Adherence to Human Airway Epithelial Cells. Am. J. Respir. Cell Mol. Bio. 21: 418-427 [Abstract] [Full Text]
Chung, K F, Barnes, P J (1999). Cytokines in asthma. Thorax 54: 825-857 [Full Text]
Nathan, L., Pervin, S., Singh, R., Rosenfeld, M., Chaudhuri, G. (1999). Estradiol Inhibits Leukocyte Adhesion and Transendothelial Migration in Rabbits In Vivo : Possible Mechanisms for Gender Differences in Atherosclerosis. Circ. Res. 85: 377-385 [Abstract] [Full Text]
Chiba, R., Nakagawa, N., Kurasawa, K., Tanaka, Y., Saito, Y., Iwamoto, I. (1999). Ligation of CD31 (PECAM-1) on Endothelial Cells Increases Adhesive Function of alpha vbeta 3 Integrin and Enhances beta 1 Integrin-Mediated Adhesion of Eosinophils to Endothelial Cells. Blood 94: 1319-1329 [Abstract] [Full Text]
Ulfman, L. H., Kuijper, P. H. M., van der Linden, J. A. M., Lammers, J.-W. J., Zwaginga, J. J., Koenderman, L. (1999). Characterization of Eosinophil Adhesion to TNF-{alpha}-Activated Endothelium Under Flow Conditions: {alpha}4 Integrins Mediate Initial Attachment, and E-Selectin Mediates Rolling. J. Immunol. 163: 343-350 [Abstract] [Full Text]
McNulty, C. A., Symon, F. A., Wardlaw, A. J. (1999). Characterization of the Integrin and Activation Steps Mediating Human Eosinophil and Neutrophil Adhesion to Chronically Inflamed Airway Endothelium. Am. J. Respir. Cell Mol. Bio. 20: 1251-1259 [Abstract] [Full Text]
Giembycz, M. A., Lindsay, M. A. (1999). Pharmacology of the Eosinophil. Pharmacol. Rev. 51: 213-340 [Abstract] [Full Text]
Schneider, T., Issekutz, T. B., Issekutz, A. C. (1999). The Role of alpha 4 (CD49d) and beta 2 (CD18) Integrins in Eosinophil and Neutrophil Migration to Allergic Lung Inflammation in the Brown Norway Rat. Am. J. Respir. Cell Mol. Bio. 20: 448-457 [Abstract] [Full Text]
Francis, S. E., Camp, N. J., Dewberry, R. M., Gunn, J., Syrris, P., Carter, N. D., Jeffery, S., Kaski, J. C., Cumberland, D. C., Duff, G. W., Crossman, D. C. (1999). Interleukin-1 Receptor Antagonist Gene Polymorphism and Coronary Artery Disease. Circulation 99: 861-866 [Abstract] [Full Text]
TILLIE-LEBLOND, I., PUGIN, J., MARQUETTE, C.-H., LAMBLIN, C., SAULNIER, F., BRICHET, A., WALLAERT, B., TONNEL, A.-B., GOSSET, P. (1999). Balance between Proinflammatory Cytokines and Their Inhibitors in Bronchial Lavage from Patients with Status Asthmaticus. Am. J. Respir. Crit. Care Med. 159: 487-494 [Abstract] [Full Text]
DiScipio, R. G., Daffern, P. J., Jagels, M. A., Broide, D. H., Sriramarao, P. (1999). A Comparison of C3a and C5a-Mediated Stable Adhesion of Rolling Eosinophils in Postcapillary Venules and Transendothelial Migration In Vitro and In Vivo. J. Immunol. 162: 1127-1136 [Abstract] [Full Text]
Bhunia, A. K., Arai, T., Bulkley, G., Chatterjee, S. (1998). Lactosylceramide Mediates Tumor Necrosis Factor-alpha -induced Intercellular Adhesion Molecule-1 (ICAM-1) Expression and the Adhesion of Neutrophil in Human Umbilical Vein Endothelial Cells. J. Biol. Chem. 273: 34349-34357 [Abstract] [Full Text]
Davenpeck, K. L., Zagorski, J., Schleimer, R. P., Bochner, B. S. (1998). Lipopolysaccharide-Induced Leukocyte Rolling and Adhesion in the Rat Mesenteric Microcirculation: Regulation by Glucocorticoids and Role of Cytokines. J. Immunol. 161: 6861-6870 [Abstract] [Full Text]
Barnes, P. J., Chung, K. F., Page, C. P. (1998). Inflammatory Mediators of Asthma: An Update. Pharmacol. Rev. 50: 515-596 [Abstract] [Full Text]
Ohashi, Y., Nakai, Y., Tanaka, A., Kakinoki, Y., Washio, Y., Kato, A., Masamoto, T., Yamada, K., Hayashi, M. (1998). Serologic Study of the Working Mechanisms of Immunotherapy for Children With Perennial Allergic Rhinitis. Arch Otolaryngol Head Neck Surg 124: 1337-1346 [Abstract] [Full Text]
Kim, M.-K., Brandley, B. K., Anderson, M. B., Bochner, B. S. (1998). Antagonism of Selectin-Dependent Adhesion of Human Eosinophils and Neutrophils by Glycomimetics and Oligosaccharide Compounds. Am. J. Respir. Cell Mol. Bio. 19: 836-841 [Abstract] [Full Text]
Wang, Y., Adair, C. D., Coe, L., Weeks, J. W., Lewis, D. F., Alexander, J. S. (1998). Activation of Endothelial Cells in Preeclampsia: Increased Neutrophil-Endothelial Adhesion Correlates With Up-regulation of Adhesion Molecule P-selectin in Human Umbilical Vein Endothelial Cells Isolated From Preeclampsia. Reproductive Sciences 5: 237-243 [Abstract]
Yamamoto, H., Sedgwick, J. B., Busse, W. W. (1998). Differential Regulation of Eosinophil Adhesion and Transmigration by Pulmonary Microvascular Endothelial Cells. J. Immunol. 161: 971-977 [Abstract] [Full Text]
Blease, K., Seybold, J., Adcock, I. M., Hellewell, P. G., Burke-Gaffney, A. (1998). Interleukin-4 and Lipopolysaccharide Synergize to Induce Vascular Cell Adhesion Molecule-1 Expression in Human Lung Microvascular Endothelial Cells. Am. J. Respir. Cell Mol. Bio. 18: 620-630 [Abstract] [Full Text]
Schratzberger, P., Dunzendorfer, S., Reinisch, N., Kahler, C. M, Herold, M., Wiedermann, C. J (1998). Release of chemoattractants for human monocytes from endothelial cells by interaction with neutrophils. Cardiovasc Res 38: 516-521 [Abstract] [Full Text]
Broide, D. H., Humber, D., Sriramarao, P. (1998). Inhibition of Eosinophil Rolling and Recruitment in P-Selectin- and Intracellular Adhesion Molecule-1-Deficient Mice. Blood 91: 2847-2856 [Abstract] [Full Text]
Davenpeck, K. L., Sterbinsky, S. A., Bochner, B. S. (1998). Rat Neutrophils Express alpha 4 and beta 1 Integrins and Bind to Vascular Cell Adhesion Molecule-1 (VCAM-1) and Mucosal Addressin Cell Adhesion Molecule-1 (MAdCAM-1). Blood 91: 2341-2346 [Abstract] [Full Text]
Broide, D. H., Sullivan, S., Gifford, T., Sriramarao, P. (1998). Inhibition of Pulmonary Eosinophilia in P-Selectin- and ICAM-1-deficient Mice. Am. J. Respir. Cell Mol. Bio. 18: 218-225 [Abstract] [Full Text]
Kelly, S. A., Goldschmidt-Clermont, P. J., Milliken, E. E., Arai, T., Smith, E. H., Bulkley, G. B. (1998). Protein tyrosine phosphorylation mediates TNF-induced endothelial-neutrophil adhesion in vitro. Am. J. Physiol. Heart Circ. Physiol. 274: H513-H519 [Abstract] [Full Text]
Ohashi, Y., Nakai, Y., Tanaka, A., Kakinoki, Y., Ohno, Y., Masamoto, T., Sakamoto, H., Kato, A., Washio, Y., Yamada, K., Hayashi, M. (1998). Clinical Role of Soluble Adhesion Molecules During Immunotherapy for Perennial Allergic Rhinitis. Arch Otolaryngol Head Neck Surg 124: 41-45 [Abstract] [Full Text]
Sanz, M.-J., Hartnell, A., Chisholm, P., Williams, C., Davies, D., Weg, V. B., Feldmann, M., Bolanowski, M. A., Lobb, R. R., Nourshargh, S. (1997). Tumor Necrosis Factor alpha -Induced Eosinophil Accumulation in Rat Skin Is Dependent on alpha 4 Integrin/Vascular Cell Adhesion Molecule-1 Adhesion Pathways. Blood 90: 4144-4152 [Abstract] [Full Text]
Yuan, Q., Austen, K. F., Friend, D. S., Heidtman, M., Boyce, J. A. (1997). Human Peripheral Blood Eosinophils Express a Functional c-kit Receptor for Stem Cell Factor that Stimulates Very Late Antigen 4�(VLA-4)-mediated Cell Adhesion to Fibronectin and Vascular Cell Adhesion Molecule 1�(VCAM-1). J. Exp. Med. 186: 313-323 [Abstract] [Full Text]
CUMMINGS, C. J., SESSLER, C.�N., BEALL, L. D., FISHER, B.�J., BEST, A.�M., FOWLER, A.�A. III (1997). Soluble E-Selectin Levels in Sepsis and Critical Illness . Correlation with Infection and Hemodynamic Dysfunction. Am. J. Respir. Crit. Care Med. 156: 431-437 [Abstract] [Full Text]
CALHOUN, W.�J., LAVINS, B.�J., MINKWITZ, M.�C., EVANS, R., GLEICH, G.�J., COHN, J. (1997). Effect of Zafirlukast (Accolate) on Cellular Mediators of Inflammation . Bronchoalveolar Lavage Fluid Findings after Segmental Antigen Challenge. Am. J. Respir. Crit. Care Med. 157: 1381-1389 [Abstract] [Full Text]
Bennett, B. L., Cruz, R., Lacson, R. G., Manning, A. M. (1997). Interleukin-4 Suppression of Tumor Necrosis Factor alpha -stimulated E-selectin Gene Transcription Is Mediated by STAT6 Antagonism of NF-kappa B. J. Biol. Chem. 272: 10212-10219 [Abstract] [Full Text]
Clark, C. J., Boswell, F., Greer, I. A., Lyall, F. (1997). Treatment of Endothelial Cells With Serum from Women with Preeclampsia: Effect on Neutrophil Adhesion. Reproductive Sciences 4: 27-33 [Abstract]
Gerszten, R. E., Luscinskas, F. W., Ding, H. T., Dichek, D. A., Stoolman, L. M., Gimbrone, M. A. Jr, Rosenzweig, A. (1996). Adhesion of Memory Lymphocytes to Vascular Cell Adhesion Molecule-1�Transduced Human Vascular Endothelial Cells Under Simulated Physiological Flow Conditions In Vitro. Circ. Res. 79: 1205-1215 [Abstract] [Full Text]
Tourkin, A, Bonner, M, Mantrova, E, LeRoy, E., Hoffman, S (1996). Dot-like focal contacts in adherent eosinophils, their redistribution into peripheral belts, and correlated effects on cell migration and protected zone formation. J. Cell Sci. 109: 2169-2177 [Abstract]
Kling, D., Fingerle, J., Harlan, J. M., Lobb, R. R., Lang, F. (1995). Mononuclear Leukocytes Invade Rabbit Arterial Intima During Thickening Formation via CD18- and VLA-4�Dependent Mechanisms and Stimulate Smooth Muscle Migration. Circ. Res. 77: 1121-1128 [Abstract] [Full Text]
Kogan, T. P., Revelle, B. M., Tapp, S., Scott, D., Beck, P. J. (1995). A Single Amino Acid Residue Can Determine the Ligand Specificity of E-selectin. J. Biol. Chem. 270: 14047-14055 [Abstract] [Full Text]
Kwee, L, Baldwin, H., Shen, H., Stewart, C., Buck, C, Buck, C., Labow, M. (1995). Defective development of the embryonic and extraembryonic circulatory systems in vascular cell adhesion molecule (VCAM-1) deficient mice. Development 121: 489-503 [Abstract]
Yang, J., Rayburn, H, Hynes, R. (1995). Cell adhesion events mediated by alpha 4 integrins are essential in placental and cardiac development. Development 121: 549-560 [Abstract]
Takahashi, H., Isobe, T., Horibe, S., Takagi, J., Yokosaki, Y., Sheppard, D., Saito, Y. (2000). Tissue Transglutaminase, Coagulation Factor XIII, and the Pro-polypeptide of von Willebrand Factor Are All Ligands for the Integrins alpha 9beta 1 and alpha 4beta 1. J. Biol. Chem. 275: 23589-23595 [Abstract] [Full Text]